Clinical trials: Cardiovascular Disease, Obesity
Type 2 Diabetes
Effect of Vildagliptin Versus Dapagliflozin as Add on Therapy to Metformin on Cardiovascular Risk Factors
The overarching hypothesis of this study is that vildagliptin (vilda) as add on therapy to metformin (met) in Egyptian type 2 diabetic obese patient will produce an equal, if not better, glycemic control and will reduce…
- Trial name
- NCT07077525
- Testing
- Dapagliflozin + Metformin, Vildagliptin + Metformin
- Where
- Egypt
- Volunteers
- 196 people
- Sponsor
- Al-Azhar University
Obesity, Cardiovascular Diseases
HIIT Effects on Cardiometabolic Health
The primary aim of this randomized clinical trial is to compare the effects of three different HIIT protocols and a control group on cardiometabolic health in young adults with obesity.
- Conditions
- Obesity, Cardiovascular Diseases, Metabolic Disease, High-intensity Interval Training
- Trial name
- NCT05838950
- Testing
- high-intensity interval training intervention
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Syracuse University
Spinal Cord Injuries (SCI), Spinal Cord Injury
Transcutaneous Spinal Electrical Stimulation to Improve Exercise Function After Spinal Cord Injury.
Our overall objective is to decrease the prevalence of multiple sedentary-related diseases that are secondary consequences of spinal cord injury (SCI).
- Conditions
- Spinal Cord Injuries (SCI), Spinal Cord Injury, Spinal Injury
- Trial name
- NCT07692191
- Testing
- Transcutaneous spinal electrical stimulation (TSES)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Hypertension, Obesity, Adolescent
National Blood Pressure Screening in Children to Improve Paediatric Healthcare in South Africa
The Childhood Hypertension Consortium of South Africa (CHCSA) was established to foster relationships between the healthcare sector and schools through community engagement and outreach as well as contributing to the…
- Conditions
- Hypertension, Obesity, Adolescent, Obesity, Childhood
- Trial name
- NCT05982847
- Testing
- Blood pressure screening
- Where
- 11 sites in South Africa, Switzerland
- Volunteers
- 22,464 people, healthy volunteers welcome
- Sponsor
- North-West University, South Africa
Obesity
Effects of Exercise on Arterial Function and Insulin Resistance Syndrome in Pre-pubertal Obese Children
The main purpose of this project is to investigate the effects of an exercise program on arterial function and cardiovascular diseases risk factors in obese and lean pre-pubertal children.
- Trial name
- NCT00801645
- Testing
- Exercise
- Where
- Switzerland
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Obesity, Overweight
Tirzepatide vs Semaglutide in Individuals at Cardiovascular Risk But Without Diabetes.
Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials.
- Trial name
- NCT07619508
- Testing
- Tirzepatide, Semaglutide
- Where
- United States
- Volunteers
- 100,000 people
- Sponsor
- Brigham and Women's Hospital
Breast Neoplasm Female
Effect of Mindful Eating on Weight Management in Breast Cancer Survivors
This pilot study examined changes in anthropometric measures as a result of and feasibility/ acceptability of a mindful eating intervention for overweight and obese postmenopausal breast cancer survivors.
- Trial name
- NCT03972540
- Testing
- Mindful eating intervention
- Volunteers
- 13 people
- Sponsor
- University of Georgia
Hypertension, Prehypertension
EMPower: Electronic Media Powering Positive Health Changes in Youth
The purpose of this study is to evaluate the effectiveness of a technology-based behavioral Healthy Lifestyle intervention on adiposity (body mass index z-score), blood pressure (mean clinic systolic BP), and heart size (LVM) in…
- Conditions
- Hypertension, Prehypertension, Overweight, Obesity
- Trial name
- NCT02444689
- Testing
- Electronic Media Application, Standard of care education
- Where
- United States
- Volunteers
- 91 people
- Sponsor
- Johns Hopkins University
Hypertension, Diabetes Mellitus
The Good Food Rx: Food-as-medicine Program
This pilot study seeks to recruit 25 participants who meet program criteria by alleviating chronic morbidities that plague this region by providing participants with nutritional food boxes partnered with nutrition education…
- Conditions
- Hypertension, Diabetes Mellitus, Obesity
- Trial name
- NCT05541458
- Testing
- Food as medicine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arkansas
Cardiovascular Diseases, Heart Diseases
Dose/Response of Exercise on Long Term Weight Loss
To examine the dose-response of exercise on long-term weight loss in overweight adult women.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity
- Trial name
- NCT00006315
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Aging, Cardiovascular Diseases
Cardiovascular and InflammAging Study
Evidence from previous studies supports a strong relationship between fruit and vegetable consumption and reduced cardiac risk. This could be mediated via improvements on blood pressure, platelet function and vascular reactivity.
- Conditions
- Aging, Cardiovascular Diseases, Overweight or Obesity
- Trial name
- NCT04763291
- Testing
- Juice Plus+ Fruit, Vegetable and Berry blends, Juice Plus+ Omega blend
- Where
- 2 sites in Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Green Beat
Hypertension, Pregnancy
Exercise in Pregnancy for Reduction of Blood Pressure in Obese Patients
Preeclampsia and other high blood pressure disorders of pregnancy are a significant cause of both maternal and fetal complications of pregnancy.
- Conditions
- Hypertension, Pregnancy, Preeclampsia, Exercise
- Trial name
- NCT01261884
- Testing
- Exercise support, Exercise intervention
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Sedentary Behavior, Behavior, Health
Stand Up Kansas: An Intervention to Reduce Sedentary Behavior in the Home Work Environment
This project will examine the effectiveness of an intervention to reduce sedentary behavior in Kansas State University employees who are primarily working from home. We will recruit 100 employees to participate.
- Conditions
- Sedentary Behavior, Behavior, Health, Cholesterolemia, Obesity
- Trial name
- NCT04641689
- Testing
- Desk Only, Program Only
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kansas State University
Obesity
A High Protein Diet and Weight Maintenance
An investigation into long term weight maintenance using a high protein or high carbohydrate diet, after a large and rapid weight loss.
- Trial name
- NCT00625235
- Testing
- VLED followed by a high protein or high carbohydrate diet
- Where
- Australia
- Volunteers
- 180 people
- Sponsor
- University of Melbourne
Overweight, Obesity
Glycemic Load, Weight Loss and Cardiovascular Disease Risk
To investigate the hypothesis that reducing the glycemic load of the diet will improve changes in body composition and cardio-vascular risk factors.
- Trial name
- NCT00254215
- Testing
- high protein & low glycemic index diets
- Where
- Australia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Sydney
Obesity, Adolescent, Lifestyle, Healthy
Mediterranean Enriched Diet for Tackling Youth Obesity
The prevalence of obesity is one of the main public health problems worldwide, reaching 18% among young people between 5 and 19 years of age in 2016. One possibility of effective treatment can be the Mediterranean diet (MD).
- Conditions
- Obesity, Adolescent, Lifestyle, Healthy, Diet, Healthy, Cardiovascular Risk Factor
- Trial name
- MED4Youth (NCT04719052)
- Testing
- Diet and behavioural intervention
- Where
- Spain
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Overweight, Obesity, Noncomunicable Diseases
A Culturally Significant Cardiovascular Dance-based Intervention in Obese Women
The objective of this study is to analyze a culturally relevant cardiovascular dance-based intervention called Fitfolk in overweight or obese Mapuche women from a rural community in Padre las Casas.
- Trial name
- CC-Dance (NCT06903455)
- Testing
- Fit-folk cardio dance, Conventional physical exercise
- Where
- Chile
- Volunteers
- 22 people
- Sponsor
- Universidad Catolica Silva Henriquez
Obesity, Diabetes Mellitus, Type 2
A Study of the Safety and Effectiveness of Topiramate on Insulin Sensitivity in Overweight or Obese Patients With Type 2 Diabetes
The purpose of this study is to investigate (1) the effect of topiramate on insulin sensitivity in overweight or obese patients with type 2 diabetes mellitus and (2) the safety of topiramate in type 2 diabetic patients.
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Diabetes Mellitus, Adult-Onset
- Trial name
- NCT00236626
- Testing
- topiramate
- Volunteers
- 38 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Blood Pressure, High Blood Pressure
Remote Dietary Counseling to Promote Healthy Diet and Blood Pressure
American College of Cardiology/American Heart Association (ACC/AHA) hypertension guidelines recommend lifestyle modification for patients with elevated blood pressure.
- Conditions
- Blood Pressure, High Blood Pressure, Dietary Modification, Overweight and Obesity
- Trial name
- NCT03700710
- Testing
- Self-Guided Approach, Dietitian-led Approach
- Where
- 2 sites in United States
- Volunteers
- 187 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
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