Clinical trials: Cardiovascular Disease, Obesity
Cardiovascular Diseases, Heart Diseases
National Heart, Lung, and Blood Institute Twin Study
To assess genetic effects on the variation of cardiovascular and pulmonary risk factors in a cohort of 514 pairs of white male veteran twins.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Lung Diseases, Hypertension
- Trial name
- NCT00005124
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Heart Diseases
Divergence of Blood Pressure By Race in Adolescent Girls
To continue examinations of 670 girls enrolled in the National Growth and Health Study (NGHS) for four more years, adding measurements of total peripheral resistance, cardiac output, DEXA scans for fat-free mass and fat mass…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Obesity
- Trial name
- NCT00005470
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Overweight , Obesity, Class I Obesity
Dietary Guidelines for Americans-Ultra Processed Study
The purpose of this research is to test how processing food can affect how one's body responds to it.
- Trial name
- DGA-UP (NCT07252037)
- Testing
- Low-processed DGA Diet, Ultra-processed DGA Diet
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- USDA Grand Forks Human Nutrition Research Center
Heart Failure and Preserved Ejection Fraction, Obesity (Disorder)
OBESE-HFpEF: Towards Preventing Obesity Related HFpEF
Obesity, severe overweight, is a growing problem worldwide and increases the risk of heart failure, especially a type called heart failure with preserved ejection fraction (HFpEF). In HFpEF, the heart becomes stiffer.
- Conditions
- Heart Failure and Preserved Ejection Fraction, Obesity (Disorder), Heart Failure
- Trial name
- OBESE-HFpEF (NCT07539766)
- Where
- Netherlands
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Zuyderland Medisch Centrum
Metabolic Syndrome
A Mediterranean Diet-Based Culinary Intervention in Adults With Metabolic Syndrome
Metabolic syndrome is a major public health concern associated with an increased risk of cardiovascular disease, type 2 diabetes, and premature mortality.
- Trial name
- CUINAMET (NCT07702695)
- Testing
- Mediterranean diet-based culinary intervention, Standard nutritional counseling
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Cardiovascular Diseases, Heart Diseases
APEX: Adiposity Prevention by Exercise in Black Girls
To determine whether a one year afternoon exercise program will reduce adiposity in African American girls, ages 8 to 10.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity
- Trial name
- NCT00006405
- Testing
- Exercise
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Sedentary Behaviors
PATHWAYS--FULL SCALE STUDY
To implement a culturally appropriate school-based, multicenter, randomized trial that promotes healthful eating behaviors and increases physical activity to prevent obesity in pre-adolescent upper elementary American Indian…
- Conditions
- Cardiovascular Diseases, Sedentary Behaviors, Obesity
- Trial name
- NCT00000545
- Testing
- exercise, diet
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiovascular Diseases, Heart Diseases
Epidemiology of Stress and the Metabolic Syndrome
To examine the effects of psychological stress on the metabolic syndrome.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Obesity, Hypertension
- Trial name
- NCT00073775
- Volunteers
- 3,075 people
- Sponsor
- University of Florida
Metabolic Syndrome
Evaluation of 3-V Bioscience-2640 to Reduce de Novo Lipogenesis in Subjects With Characteristics of Metabolic Syndrome
Metabolic syndrome increases the risk for development of heart disease. Another condition associated with metabolic syndrome is fatty liver disease which is also referred to as nonalcoholic fatty liver disease (NAFLD).
- Trial name
- NCT02948569
- Testing
- 3-V Bioscience-2640
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Missouri-Columbia
Polycystic Ovary Syndrome,, Insulin Resistance,
IR, Inflammatory and Cardiovascular Markers in PCOS Among Obese and Non-obese Women
FPCOS is associated with an adverse cardiometabolic profile, consisting of increased total or central adiposity, increased insulin resistance and abnormal glucose metabolism.
- Trial name
- NCT01989039
- Where
- Taiwan
- Volunteers
- 800 people
- Sponsor
- Taipei Medical University WanFang Hospital
Diabetes Mellitus, Type 2, Liver Fibrosis
Effect of an Early Time Restricted Eating Mediterranean Diet Compared to Naltrexone/Bupropion on Liver Fibrosis in People With Cardiometabolic Risk Factors in a Hospital Outpatient Clinic (MEDFAST-study)
In the Netherlands, there are many people with cardiometabolic diseases. More than half of these people also have fatty liver. This is a build-up of fat in the liver (steatosis) and can lead to long-term scarring (fibrosis) and…
- Conditions
- Diabetes Mellitus, Type 2, Liver Fibrosis, Liver Steatoses, Hepatic Steatosis
- Trial name
- MEDFAST (NCT06845345)
- Testing
- early time restricted Mediterranean diet, Mysimba
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- Carmen Dietvorst
Type 2 Diabetes Mellitus, Obesity
Date Seed Extract Effectiveness in Controlling Diabetes and Cardiovascular Risk in T2DM
Globally, chronic noncommunicable diseases rank as the leading cause of morbidity and mortality. Diabetes is reaching high epidemic proportions across the globe.
- Trial name
- NCT06590519
- Testing
- Date Seed Extract
- Where
- Malaysia
- Volunteers
- 160 people
- Sponsor
- Universiti Putra Malaysia
Health Problems in Pregnancy, Pregnancy Outcomes
Peking University Birth Cohort in Tongzhou
The PKUBC-T is a prospective cohort study carried out in Tongzhou district of Beijing, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal…
- Conditions
- Health Problems in Pregnancy, Pregnancy Outcomes, Gestational Diabetes, Gestational Hypertension
- Trial name
- PKUBC-T (NCT03814395)
- Testing
- No intervention
- Where
- China
- Volunteers
- 5,426 people, healthy volunteers welcome
- Sponsor
- Peking University
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Metabolic Syndrome, Dyslipidemias
12 Weeks of Resistance Band Exercise Impacts on Metabolic Syndrome Progression in Postmenopausal Women
The purpose of this study was to examine the impacts of a 12-week resistance band exercise program on insulin resistance, blood lipid profiles, body composition, and blood pressure in postmenopausal women with obesity.
- Conditions
- Metabolic Syndrome, Dyslipidemias, Insulin Resistance, Hypertension
- Trial name
- NCT04014686
- Testing
- No exercise intervention group, Resistance band exercise intervention group
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Pusan National University
HIV-1-infection, Antiviral Drug Adverse Reaction
Contribution of Dolutegravir to Obesity and Cardiovascular Disease
The goal of the study is to combine a collaborative and translational approach to evaluate the effect antiretroviral regimen switch to a dolutegravir containing regimen compared to continued treatment with a non- dolutegravir…
- Conditions
- HIV-1-infection, Antiviral Drug Adverse Reaction, Vascular Diseases, Cardiovascular Abnormalities
- Trial name
- NCT04340388
- Testing
- Dolutegravir 50 MG, Antiretroviral/Anti HIV
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Augusta University
Obesity, Overweight
Method-of-Use Study Assessing the Effect of Naltrexone Sustained Release (SR)/ Bupropion SR on Body Weight and Cardiovascular Risk Factors in Overweight and Obese Subjects
The purpose of this Phase 3b study is to assess the effects of combination therapy with naltrexone SR/bupropion SR (NB) used in conjunction with a comprehensive lifestyle intervention (CLI) and in a manner consistent with its…
- Trial name
- NCT01764386
- Testing
- NB, CLI, Usual Care
- Where
- 15 sites in United States
- Volunteers
- 242 people
- Sponsor
- Orexigen Therapeutics, Inc
Obesity, Abdominal, Hyperlipidemias
Obesity-related Health Benefits of Apples
Obesity is characterized by an underlying inflammatory state in which various inflammatory signaling molecules, termed cytokines, affect metabolic processes central to type 2 diabetes and cardiovascular disease; leading causes of…
- Conditions
- Obesity, Abdominal, Hyperlipidemias, Inflammation, Dysbiosis
- Trial name
- NCT03523403
- Testing
- Apples
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- University of Guelph
Obesity
Spirulina Supplementation and Cardiovascular Risk in Obese Caucasians With Treated Hypertension
Potential protective cardiovascular effect of Spirulina maxima supplementation was studied in a double-blind placebo-controlled trial of obese subjects with treated hypertension, each randomized to receive spirulina or a placebo.
- Trial name
- NCT02575690
- Testing
- Spirulina
- Volunteers
- 50 people
- Sponsor
- Poznan University of Medical Sciences
Insulin Resistance, Type 2 Diabetes
Fish Gelatin Supplement and Omega-3 Supplement in Obese or Overweight Subjects With Insulin Resistance
The present study was conducted to test whether a fish gelatin supplement combined with an omega-3 polyunsaturated fatty acid supplement can exert beneficial and sex-specific effects on insulin sensitivity, glucose tolerance…
- Trial name
- NCT01215903
- Testing
- Fish gelatin and omega-3 polyunsaturated fatty acid, Omega-3 polyunsaturated fatty acid
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Laval University