Clinical trials: Cardiovascular Disease (CVD)
Abdominal Aortic Aneurysms
Validation of Fenestrations Positioning by Numerical Simulation
Fenestrated endovascular repair (FEVAR) is nowadays a recognized option to treat juxtarenal, pararenal or suprarenal abdominal aortic aneurysms in patients at high risk for conventional repair.
- Trial name
- FenSim (NCT03469245)
- Testing
- numerical simulation
- Where
- 9 sites in Austria, France and 3 more
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
ST Elevation Myocardial Infarction
Long-term Clinical Outcomes of intraVascular Ultrasound-guided vs Angiography-guided Primary pErcutaneous Intervention in Patients With Acute ST Segment Elevated Myocardial Infarction
To examine the impact of IVUS guidance on clinical outcomes in the patient with Acute ST Segment Elevated Myocardial Infarction.
- Trial name
- LOVEinSTEMI (NCT04063345)
- Testing
- IVUS-guided PCI, Angiography-guided PCI
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Breast Cancer, Heart Failure
CardioPROTECTion with Dapagliflozin in Breast Cancer Patients Treated with AnthrAcycline - PROTECTAA TRIAL
The purpose of this study is to evaluate the effect of dapagliflozin on the incidence of cancer therapeutics-related cardiac dysfunction in patients with breast cancer receiving anthracycline treatment.
- Trial name
- PROTECTAA (NCT06304857)
- Testing
- Dapagliflozin
- Where
- 3 sites in Poland
- Volunteers
- 188 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Haemorrhagic Hereditary Telangiectasia
Institutional Registry of Haemorrhagic Hereditary Telangiectasia
The purpose of this study is to create an institutional and population-based registry of Haemorrhagic Hereditary Telangiectasia with a prospective survey based on epidemiological data, risk factors, diagnosis, prognosis…
- Trial name
- NCT01761981
- Where
- Argentina
- Volunteers
- 590 people
- Sponsor
- Hospital Italiano de Buenos Aires
Coronary Artery Disease, Chest Pain
Imaging Studies With GE C-Hawk Gamma Camera Compared to Routine Clinical Exam
Comparison study of myocardial perfusion SPECT imaging with current clinical use camera and new camera.
- Trial name
- NCT00256581
- Testing
- Additional rest and stress image sets on new camera
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Wisconsin, Madison
Thoracoabdominal Aortic Aneurysms
A PROpensity Score Matching Analysis on ENDovascular vs Open Thoraco-Abdominal Aortic Aneurysm Repair (PRO-ENDO TAAA Study)
The purpose of the registry is to compare the surgical and endovascular approaches to the treatment of thoracoabdominal aortic aneurysms.
- Trial name
- PRO-ENDO TAAA (NCT05266781)
- Testing
- Surgical repair, Endovascular repair
- Where
- Italy
- Volunteers
- 650 people
- Sponsor
- IRCCS San Raffaele
Aortic Valve Stenosis
TAVI Without Balloon Predilatation (of the Aortic Valve ) SAPIEN 3
Balloon predilatation of the aortic valve has been regarded as an essential step during the transcatheter aortic valve implantation (TAVI) procedure.
- Trial name
- DIRECTAVI (NCT02729519)
- Testing
- TAVI
- Where
- France
- Volunteers
- 250 people
- Sponsor
- University Hospital, Montpellier
Aortic Aneurysm
ELECT Trial - Embolization of the Lumbar Arteries Before EVAR
Prospective, Randomized, Single-center Study for the Treatment of Subjects with Abdominal Aortic Aneurysm: Embolization of the Lumbar Arteries Before EVAR: A Prospectively Randomized Trial Comparing Platinum-Fibered Microcoils…
- Trial name
- NCT03842930
- Testing
- Endovascular embolization
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University of Leipzig
Stroke
Hybrid Robot+FES Stroke Rehabilitation
The investigators have developed a novel robot-guided stretching under intelligent control and combine it with active movement training, which helped increase joint ROM, reduce spasticity and joint stiffness, increase muscle…
- Trial name
- NCT04550728
- Testing
- Ankle robot training group, Ankle robot training and functional electrical stimulation(FES) group
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Maryland, Baltimore
Diabetes Mellitus, Coronary Disease
Empagliflozin Versus Sitagliptin Therapy for Improvement of Myocardial Perfusion Reserve in Diabetic Patients With Coronary Artery Disease
This trial evaluates the effects of Empagliflozin versus Sitagliptin, in addition to standard of care, on global myocardial perfusion reserve using dynamic single-photon emission computed tomography (SPECT) images.
- Trial name
- ELITE (NCT03208465)
- Testing
- Empagliflozin, Sitagliptin
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- CHEOL WHAN LEE, M.D., Ph.D
Cardiovascular Disease, Inflammation
Safety and Feasibility of an Endotoxemia Model
The purpose of this study is to establish the safety and feasibility of low dose LPS administration to a small subset of humans in preparation for a larger USDA funded study examining what is the lowest effective dose of EPA +…
- Trial name
- NCT01329965
- Testing
- LPS (reference endotoxin, E. coli O113:H10:K:neg, manufactured under GMP)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Penn State University
Intracranial Aneurysm, Subarachnoid Hemorrhage
Familial Intracranial Aneurysm Study II
The purposes of this study are to identify possible genes that may increase the risk of aneurysm development in the brain, and to determine the effect of environmental factors such as cigarette smoking and high blood pressure on…
- Trial name
- NCT00071565
- Where
- 16 sites in United States
- Volunteers
- 5,875 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Stroke
A Closed Loop Neural Activity Triggered Stroke Rehabilitation Device
The purpose of this research is to determine if two non-invasive brain stimulation techniques, muscle stimulation of the arm and neuro-stimulation through the tongue, can increase the extent of stroke recovery.
- Trial name
- NCT02098265
- Testing
- Functional Electric Stimulation (FES), Behavioral Assessments, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Fluid Loss, Symptom Complex, Triple
Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation
Administration of intravascular (IV) fluid is the most common emergency department (ED) procedure. IV fluids are integral to increasing effective blood volume and ensuring organ perfusion in patients with volume depletion and…
- Conditions
- Fluid Loss, Symptom Complex, Triple, Emergencies
- Trial name
- NCT03133767
- Testing
- Lactated Ringer Solution, Normal Saline 0.9% Infusion Solution Bag
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Nicholas M Mohr
Coronary Artery Disease
Traditional Tibetan Medicine for Patients With Coronary Artery Disease
Coronary artery disease has a high death toll in the Western world. Changes in lifestyle, particularly in nutrition and physical activity may significantly reduce a severe coronary atherosclerosis within one year without the use…
- Trial name
- TTM in CAD (NCT00810992)
- Testing
- Nutritional and behavioral program A, Nutritional and behavioral program B
- Where
- Germany
- Volunteers
- 524 people
- Sponsor
- University Hospital Tuebingen
Reperfusion Injury
Role of Volatile Anesthetics for Hepatic Protection
This study aims to evaluate the attenuation of ischemic-reperfusion injury in the liver after sevoflurane preconditioning. In the presence of sevoflurane, an attenuation of liver injury is hypothesized (diminished increase of…
- Trial name
- NCT00516711
- Testing
- Sevoflurane
- Where
- Switzerland
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Zurich
Cardiovascular Diseases, Heart Diseases
Polyunsaturates and KCL to Control Mild Hypertension
To test the efficacy of omega-3 fatty acids in untreated mild hypertensives and magnesium, calcium, and potassium supplementation supplementation in non-hypertensives.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Vascular Diseases
- Trial name
- NCT00000511
- Testing
- mineral supplements, Trial 1: fatty acids, omega-3; Trial 2: Mineral supplements, dietary supplements
- Sponsor
- Brigham and Women's Hospital
Heart Disease
Effect of the Dietary Supplement SAMe on Blood Homocysteine Levels
The purpose of this study is to determine if the oral intake of the dietary supplement SAMe increases blood homocysteine levels in healthy human subjects.
- Trial name
- NCT00284011
- Testing
- SAMe
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Anal Fissure, Anal Fistula
Ultrasound Guided Caudal Block for Benign Anal Surgery
Interventional study that evaluate analgesia and side effects of Ultrasound guided Caudal block preoperatively in benign canal anal surgery
- Conditions
- Anal Fissure, Anal Fistula, Hemorrhoids, Pain, Postoperative
- Trial name
- NCT03345511
- Testing
- Ultrasound Guided Caudal Block
- Where
- Colombia
- Volunteers
- 23 people
- Sponsor
- Universidad de Antioquia
Hypertrophic Cardiomyopathy
Study of Myocardial Deformation Parameters in Patients With Hypertrophic Cardiomyopathy
The purpose of the study is to investigate the potential correlations of global longitudinal strain and peak left atrial strain, measured by speckle tracking echocardiography with the severity of hypertrophic cardiomyopathy and…
- Trial name
- NCT04112511
- Where
- Greece
- Volunteers
- 250 people
- Sponsor
- AHEPA University Hospital
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