Clinical trials: Cardiovascular Disease (CVD)
Multiple Myeloma
Cardiac Toxicity and Prognostic Value of New Echocardiographic Indicators in the Treatment of Primary Multiple Myeloma
Multiple myeloma (MM) is a malignant proliferative plasma cell disease, which accounts for approximately 10% and ranks secondly of hematological malignancies in many countries.
- Trial name
- NCT06039735
- Testing
- Chemotherapy and/or autologous hematopoietic stem cell transplantation
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Qilu Hospital of Shandong University
Diabetic Foot Ulcer Neuropathic
Hyperbaric Oxygen Therapy in Diabetic Foot
This study seeks to assess changes in genes that are related to inflammation and oxidative stress in patients with type 2 Diabetes with diabetic foot treated with hyperbaric chamber
- Trial name
- HBOTDF (NCT06502808)
- Testing
- Hyperbaric oxygen therapy
- Where
- Mexico
- Volunteers
- 15 people
- Sponsor
- National Polytechnic Institute, Mexico
Peripheral Vascular Diseases
A Non-Randomized Study of the NightHawk Peripheral Plaque Excision System During Plaque Excision of Peripheral Arterial Disease
To assess the proximity of the catheter to the vessel wall and to correlate excised tissue with images collected by the integrated Optical coherence Tomography (OCT) imaging system.
- Trial name
- NightHawk (NCT00516308)
- Testing
- NightHawk
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- FoxHollow Technologies
Deep Vein Thrombosis, Venous Thrombosis
A Randomized, Open-Label, Parallel-Group, Multi-Center Study for the Evaluation of Efficacy and Safety of Edoxaban Monotherapy Versus Low Molecular Weight (LMW) Heparin/Warfarin in Subjects With Symptomatic Deep-Vein Thrombosis
Assess the relative change in thrombus volume as determined by two assessments (Baseline and Day 14-21) with magnetic resonance venography (MRV) in subjects with deep-vein thrombosis (DVT) treated with either an edoxaban…
- Trial name
- eTRIS (NCT01662908)
- Testing
- edoxaban tosylate, enoxaparin/unfractionated heparin, warfarin
- Where
- 34 sites in United States, Canada
- Volunteers
- 85 people
- Sponsor
- Daiichi Sankyo
Coronary Artery Disease, Coronary Disease
Sapphire 3 CTO Study
A prospective, open label, multi-center, single arm, observational study designed to evaluate the acute safety and device performance of the Sapphire 3 0.85, 1.0 and 1.25mm diameter coronary dilatation catheter in predilatation…
- Conditions
- Coronary Artery Disease, Coronary Disease, Myocardial Ischemia, Heart Diseases
- Trial name
- NCT06358508
- Testing
- Sapphire 3 Coronary Dilatation Catheter
- Where
- 14 sites in United States, Spain
- Volunteers
- 170 people
- Sponsor
- OrbusNeich
Cardiovascular Diseases, Heart Diseases
Observational Cohort Study of Sodium, Weight and Cardiovascular Disease
To investigate cardiovascular events among individuals with low sodium intake or large weight changes in a prospective observational follow-up of subjects from the Trials of Hypertension Prevention (TOHP) study.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00006308
- Sponsor
- Brigham and Women's Hospital
Coronary Artery Disease
Flaxseed Consumption, Alone and in Combination With the Mediterranean-like Diet, on Some Indicators Related to Atherosclerosis
Flaxseed consumption has beneficial effects on cardiovascular risk factors. In addition, the benefit of the Mediterranean-like diet in primary and secondary prevention of cardiovascular diseases has been shown.The purpose of this…
- Trial name
- NCT03392025
- Testing
- Flaxseed, the Mediterranean-like diet
- Where
- Iran
- Volunteers
- 87 people
- Sponsor
- Javad Nasrollahzadeh
Myocardial Infarction
Prevalence and Long-term Impact of Non-atherosclerotic CAD
Despite a relatively high prevalence of non-atherosclerotic coronary artery disease (NACAD) among young women, the majority of these abnormalities were misdiagnosed in this population, and thus treatments were not targeted…
- Trial name
- PRYME (NCT01479140)
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- Cardiology Research UBC
Cardiovascular Diseases
Effects of Aerobic Versus Resistance Training in Post Percutaneous Coronary Intervention Obese Patients
The randomized clinical trial (RCT) endeavors to enroll 50 participants, divided equally into aerobic exercise and resistance exercise groups.
- Trial name
- NCT06308276
- Testing
- Aerobic Training, Resistance Training
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Riphah International University
Hereditary Angioedema, HAE
A Gene Therapy Study of BMN 331 in Subjects With Hereditary Angioedema
This is a Phase 1/2, single-arm, open-label, dose-escalation and dose-expansion study of BMN 331 for the treatment of hereditary angioedema (HAE) due to C1 Esterase Inhibitor (C1-INH) protein deficiency.
- Trial name
- HAErmony-1 (NCT05121376)
- Testing
- Dose 1 of BMN 331, Dose 2 of BMN 331, Dose 3 of BMN 331
- Where
- 16 sites in United States, Australia and 1 more
- Volunteers
- 44 people
- Sponsor
- BioMarin Pharmaceutical
Stroke
Evaluation of the Genu Neurexa Orthosis in Post Stroke Patients
Post stroke patients often suffer from decrease in strength, loss of balance and gait asymmetry. Accordingly, these patients are at high risk for falls and fall-related injury. The presence of spastic or retracted muscles, e.g.
- Trial name
- NCT01395576
- Testing
- Genu Neurexa orthosis
- Where
- Israel
- Volunteers
- 60 people
- Sponsor
- Hadassah Medical Organization
Pulmonary Embolism
Protection From Pulmonary Embolism With the Permanent OptEase™ Filter (PROOF)
The main objective of this study is to monitor the safety and effectiveness of the OptEase™ Permanent Vena Cava (IVC) Filter
- Trial name
- NCT00233740
- Testing
- OPTEASE Vena Cava Filter
- Volunteers
- 150 people
- Sponsor
- Cordis US Corp.
Stroke, Hemiparesis After Stroke
The Impact of Neuronavigation in rTMS for Hemiplegic Stroke Patients.
This is a randomized, controlled trial investigating the efficacy and precision of neuronavigation -guided repetitive transcranial magnetic stimulation (rTMS) for motor recovery in patients with subacute stroke hemiparesis.
- Trial name
- NeurorTMS-HS (NCT07284017)
- Testing
- Neuronavigation-Assisted rTMS for Stroke Hemiparesis, Standard Localization rTMS for Stroke Hemiparesis
- Volunteers
- 30 people
- Sponsor
- Taichung Veterans General Hospital
Abdominal Aortic Aneurysm Without Rupture
New MRI Techniques for Diagnosis and Treatment of Patients With Abdominal Aortic Aneurysms
An abdominal aortic aneurysm (AAA) is a pathological dilatation of the aorta in the belly which can rupture leading to bleeding within the belly. To prevent rupture elective surgery can be performed.
- Trial name
- MARVY (NCT05976711)
- Testing
- Magnetic resonance imaging (with PROUD software)
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Multiple Myeloma
Clinical Research of Pomalidomide Maintenance Therapy for Primary Multiple Myeloma
The trial is a single-center, single-arm, prospective clinical study with a planned enrollment of 15 patients with primary Multiple myeloma(MM), aiming to investigate the efficacy and safety of maintenance therapy with…
- Trial name
- NCT05378971
- Testing
- Pomalidomide
- Where
- China
- Volunteers
- 15 people
- Sponsor
- LanZhou University
Hyperlipidemias, Metabolic Syndrome X
Effect of Vegetable Oils for Use by the Snack Food Industry on Plasma Lipid Levels and Inflammatory Markers
The current study is designed to assess the effect of a conventional cooking oil (hydrogenated oil) and a reformulated fat low in trans fatty acids on cardiovascular disease risk factors.
- Conditions
- Hyperlipidemias, Metabolic Syndrome X, Cardiovascular Diseases
- Trial name
- NCT00175071
- Testing
- Comparison of cooking oils
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tufts University
Myocardium; Injury, Coronary Artery Disease
Minimal Invasive Imaging of Coronary Artery Disease in Patients With Asymptomatic Myocardial Injury After Major Non-cardiac Surgery.
This is a cross-sectional pilot study to assess coronary artery disease with minimal invasive techniques in patients with asymptomatic troponin elevation after noncardiac surgery.
- Trial name
- AMI-NCS (NCT01960309)
- Testing
- Minimal invasive cardiac imaging
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- UMC Utrecht
Hypoxic-Ischemic Encephalopathy
Safety and Efficacy of Hypothermia to Treat Neonatal Hypoxic-Ischemic Encephalopathy
The purpose of this study is to investigate the effectiveness and safety of selective head cooling (SHC) in neonatal hypoxic-ischemic encephalopathy (HIE).
- Trial name
- NCT00890409
- Testing
- Cooling cap (YJW608-04B)
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Fudan University
Hypertension
Value of Potassium Magnesium Citrate in Preventing and Treating Hypertension in African Americans
In the DASH (Dietary Approaches to Stop Hypertension) trials, a diet rich in fruits, vegetables, nuts and dairy products, and limited in fat content, was shown to be useful in controlling hypertension, particularly in African…
- Trial name
- NCT05145309
- Testing
- KMgCit
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Branch Retinal Vein Occlusion, Macular Edema
Ranibizumab for Macular Edema Secondary to Branch Retinal Vein Occlusion in Patients With Fair Vision
The purpose of this study is to determine the effect of ranibizumab for the treatment of macular edema (ME) secondary to branch retinal vein occlusion (BRVO) in patients with initial fair visual acuity.
- Trial name
- RVOFV (NCT01795209)
- Testing
- Ranibizumab, Rescue laser
- Where
- 2 sites in South Korea
- Volunteers
- 19 people
- Sponsor
- Seoul National University Bundang Hospital
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