Clinical trials: Cardiovascular Disease (CVD)
Arterial Occlusive Disease, Intermittent Claudication
ARREST PAD (Peripheral Arterial Disease)
This trial will test the hypothesis that inflammation and insulin resistance contribute to reduced walking distance in subjects with intermittent claudication by impairing vascular reactivity and skeletal muscle metabolic…
- Conditions
- Arterial Occlusive Disease, Intermittent Claudication, Insulin Resistance
- Trial name
- NCT00153166
- Testing
- atorvastatin and pioglitazone
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Stroke
Very Intensive Variable Repetitive AmbulatioN Training
The overall objective of this subproject is to evaluate the individual and paired contributions of intensity and variability of stepping training on lower extremity (LE) function, health and community participation in patients…
- Trial name
- VIVRANT (NCT02507466)
- Testing
- exercise
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Shirley Ryan AbilityLab
Hypertension, Renal Insufficiency, Chronic
A Research Study to Show Aprocitentan is Efficacious and Safe to Treat Patients With Uncontrolled Blood Pressure and Chronic Kidney Disease.
The purpose of this research study is to show the blood pressure lowering effect of aprocitentan, a new drug, when added to the background antihypertensive therapy in patients with uncontrolled blood pressure and chronic kidney…
- Trial name
- INSPIRE-CKD (NCT04162366)
- Testing
- Aprocitentan 25 mg
- Sponsor
- Idorsia Pharmaceuticals Ltd.
Trauma
Rotational Thromboelastometry Activated Transfusion In Trauma Trial
This is a randomized controlled trial to compare viscoelastic (VE) guided resuscitation to fixed-ratio resuscitation in trauma patients with hemorrhagic shock on the utilization of blood products, effects on coagulation and…
- Trial name
- ROTATE-IT (NCT03765866)
- Testing
- Thromboelastometry guided transfusion
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Texas Southwestern Medical Center
HIV/AIDS, Hypertension
Systems Analysis and Improvement Approach for the Hypertension Care Cascade
As undiagnosed and untreated hypertension is one of the largest drivers of cardiovascular disease in sub-Saharan Africa approaches are needed to optimize the hypertension care cascade.
- Trial name
- SAIA-HTN (NCT04088656)
- Testing
- Systems Analysis and Improvement Approach for Hypertension Screening and Treatment Optimization
- Where
- 16 sites in Mozambique
- Volunteers
- 305 people
- Sponsor
- University of Washington
Acute Ischemic Stroke, Cerebral Infarction
Safely Quenching Complement in Stroke Survivors
This study will include adults (ages 18-80) who have had a stroke caused by a large blood clot blocking blood flow in the brain.
- Trial name
- SUCCESS (NCT07495722)
- Testing
- Pegcetacoplan Injection [Empaveli]
- Volunteers
- 20 people
- Sponsor
- Columbia University
Stroke, Upper Extremity Dysfunction
Exoskeleton-assisted Upper Limb Rehabilitation After Stroke
In recent studies, it has been observed that robotic devices make a positive contribution to motor recovery and the activities of daily living.
- Trial name
- NCT04353622
- Testing
- Exoskeleton robot for upper extremity, Conventional physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Marmara University
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis, ANCA-Associated Glomerulonephritis
Stratified Therapy on Pediatric AAGN
Clinical information of children with ANCA-associated nephritis admitted to Children's Hospital Affiliated to Chongqing Medical University and partner centers from January 1, 2023 to December 31, 2023 was collected: To evaluate…
- Trial name
- STPARS (NCT05969522)
- Testing
- GlucoCorticoid
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Wang Mo
Aortic Dissection, Thrombosis in Left Atrium and Right Axillary Artery
Multi-detector Computer Tomography Protocol Project: Chest Imaging Technique and Case Presentation
Multi-detector computer tomography protocol project: Chest imaging technique and case presentation.
- Conditions
- Aortic Dissection, Thrombosis in Left Atrium and Right Axillary Artery, Double IVC, May-Thurner Syndrome
- Trial name
- NCT01206751
- Testing
- Chest imaging technique and case presentation
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Taipei Medical University WanFang Hospital
Hypertension
Effect of Peer Mentoring and Blood Pressure Self-monitoring on Hypertension Control.
Cardiovascular diseases are increasing throughout the developing world and are the cause of almost 16.7 million deaths each year, of which 80% occur in low and middle-income countries.
- Trial name
- NCT03297229
- Testing
- Peer mentoring, Self-monitoring
- Where
- 10 sites in Argentina
- Volunteers
- 442 people
- Sponsor
- Institute for Clinical Effectiveness and Health Policy
Coronary Artery Disease, Stable Angina Pectoris
A Comparative Evaluation of the Extent of Neointima Formation at 1 Month and 2 Months After Implantation Using OCT
The objective of this study is a comparative evaluation of BuMA Supreme™ stent and of Xience V/Prime stent in terms of the extent of neointima formation at 1 or 2 months after implanting in relatively high bleeding risk patients…
- Conditions
- Coronary Artery Disease, Stable Angina Pectoris, Unstable Angina Pectoris
- Trial name
- NCT02747329
- Testing
- BuMA Supreme™ stent, Xience V/Prime stent
- Where
- China
- Volunteers
- 82 people
- Sponsor
- Sino Medical Sciences Technology Inc.
Block Complete Heart, Atrial Fibrillation
International Ledless Pacemaker Registry
The Micra MC1VR01 or Micra AVMC1AVR1 Transcatheter Pacing System (Medtronic, Inc., Minneapolis, MN, USA) has become a major breakthrough as an alternative to standard transvenous pacemakers.
- Trial name
- i-LEAPER (NCT05528029)
- Testing
- Leadless Pacemaker (Micra)
- Where
- 12 sites in Belgium, Italy and 1 more
- Volunteers
- 2,000 people
- Sponsor
- Luigi Sacco University Hospital
Ehlers-Danlos Syndrome
Evaluation of the Effect of Custom Compression Garments on Standing Static Balance in Ehlers Danlos Syndrome
Studies have shown the existence of a proprioceptive deficit in patients with Ehlers Danlos Syndrome (EDS) (genetic pathology of connective tissue with hypermobility, multifactor joint instability).
- Trial name
- EDS (NCT03986229)
- Testing
- Evaluate the variation in the travel speed of the "center of pressure" with and without compression garments.
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Toulouse
Hypertension
To Determine the Effectiveness of TENS vs EMS on Hemodynamics Parameters of Hypertension
This study aimed to evaluate the comparative effectiveness of Transcutaneous Electrical Nerve Stimulation (TENS) and Electrical Muscle Stimulation (EMS) on hemodynamic parameters in patients with hypertension.
- Trial name
- NCT07037329
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS), Electrical Muscle Stimulation (EMS)
- Where
- Pakistan
- Volunteers
- 42 people
- Sponsor
- Superior University
STEMI
Prognostic Value of Lactate Levels in Patients With STEMI Undergoing Primary PCI
To assess the prognostic value of systemic arterial lactate levels in patients with ST segment elevation myocardial infarction undergoing primary PCI and correlate with the results of primary PCI and 30 days MACE follow up.
- Trial name
- NCT05503329
- Testing
- arterial lactate level
- Where
- Egypt
- Volunteers
- 300 people
- Sponsor
- Ahmed Maher Teaching Hospital
Acute Coronary Syndrome
Allopurinol in Acute Coronary Syndrome
The pathogenesis of coronary heart disease is closely related to inflammation. IL-1 beta is an effective target for anti-inflammatory treatment of coronary heart disease.
- Trial name
- NCT03745729
- Testing
- allopurinol sustained-release capsules
- Where
- China
- Volunteers
- 162 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Ischemic Stroke
Immunological Biomarkers in Patients With Acute Ischemic Stroke
Stroke is accompanied by local inflammatory response and systemic immunosuppression. Immunosuppression markers are associated with the occurrence of medical complications (infections), whereas inflammatory markers are associated…
- Trial name
- NCT01894529
- Where
- Spain
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Stroke
Kinesiophobia and Balance in Stroke Patients
This is a cross-sectional clinical study planned to include 138 stroke patients receiving inpatient treatment at the Istanbul Physical Therapy and Rehabilitation Training and Research Hospital.Data on kinesiophobia (Tampa…
- Trial name
- NCT07241429
- Testing
- Survey using a questionnaire.
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Stroke
Mirror Therapy and CIMT in Chronic Stroke Patients
The aim of this research is to find and compare the effect of mirror therapy and constrained induced movement therapy in upper limb rehabilitation among chronic stroke patient .Study conducted in THQ Hospital Depalpur.
- Trial name
- NCT05053529
- Testing
- Mirror therapy, CIMT group
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Acute Ischemic Stroke, Intracranial Atherosclerosis ICAS
Effect of Balloon Angioplasty vs Stenting Following Residual Stenosis After Endovascular Treatment of Intracranial Atherosclerotic Acute Ischemic Stroke
The ANGEL-ICAS trial is a multicenter, prospective, randomized, open-label, blinded-endpoint study designed to determine whether rescue balloon angioplasty is noninferior to rescue stenting in patients with intracranial…
- Trial name
- ANGEL-ICAS (NCT07026331)
- Testing
- balloon angioplasty, Stent
- Where
- China
- Volunteers
- 486 people
- Sponsor
- Beijing Anzhen Hospital
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