Clinical trials: Cardiovascular Disease Risk Factors
Heart Diseases, Type2 Diabetes
Psychosocial, Environmental, and Chronic Disease Trends in Puerto Rico
The overall goal is to identify trends and longitudinal associations in psychosocial, food-related, and cardiometabolic risk factors that can guide public health priorities and future research needs aimed at reducing…
- Conditions
- Heart Diseases, Type2 Diabetes, Hypertension, Obesity
- Trial name
- PROSPECT (NCT03794531)
- Where
- Puerto Rico
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Vascular Disease, Peripheral, Physical Inactivity
Inter-individual Physiological Response to a Training and Detraining Period in Cardiometabolic Risk Factors Subjects
Background: Although exercise training is a well described therapy for some cardiometabolic diseases such as obesity, type 2 diabetes, arterial hypertension, and metabolic syndrome, there is scarcity of knowledge about the…
- Conditions
- Vascular Disease, Peripheral, Physical Inactivity, Arterial Hypertension, Endothelial Dysfunction
- Trial name
- VASCU-HEALTH (NCT05710653)
- Testing
- Exercise training intervention
- Where
- Chile
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cristian Alvarez
Ankylosing Spondyliti
Effect of Exercise on Disease Activity and Cardiovascular Risk Factors in Patients With Ankylosing Spondylitis
Background: Exercise is recommended as a cornerstone in the treatment of ankylosing spondylitis together with medication. Last years, increased risk of cardiovascular diseases in patient with inflammatory diseases is reported…
- Trial name
- NCT01436942
- Testing
- Exercise
- Where
- Norway
- Volunteers
- 34 people
- Sponsor
- Diakonhjemmet Hospital
Stroke, Ischemic
Cognitive Strategies for Optimizing Brain Health And Managing Transgenerational Vascular Risk Factors Post-Stroke
People living with the cognitive effects of stroke are at risk for recurrent stroke and further cognitive decline. Also problematic is that stroke risk clusters in families and biological family members of people who have…
- Trial name
- CHAMPS-TR (NCT06479174)
- Testing
- CHAMPS-TR
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Embolism Vein, Air Embolism
Study on the Incidence and Risk Factors of Systemic Arterial Gas Embolism in Bronchoscopy Procedures
Systemic Arterial Gas Embolism (SAGE) is a rare but fatal complication characterized by the accidental entry of gas into the left heart system, which then travels through the systemic arterial circulation, leading to embolisms in…
- Trial name
- NCT07555990
- Where
- China
- Volunteers
- 3,258 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Type 2 Diabetes Mellitus (T2DM)
Phase III Trial of SGLT2 Inhibitor and Thiazolidinedione Fixed-Dose Combination vs. Monotherapy in Type 2 Diabetes Patients on Metformin
This clinical trial is studying whether combining two commonly used diabetes medications into a single pill works better than taking them separately for people with type 2 diabetes who are already on metformin.
- Trial name
- CONTROL (NCT07057479)
- Testing
- Fixed-dose combination of SGLT2 inhibitor and thiazolidinedione, Control Group 1 Intervention - SGLT2 inhibitor monotherapy, Control Group 2 Intervention - Thiazolidinedione monotherapy
- Where
- Brazil
- Sponsor
- Eurofarma Laboratorios S.A.
Colchicine, ICH - Intracerebral Hemorrhage
Colchicine for the Reduction of Dependency and Vascular Events After an Acute Intracerebral Hemorrhage
Data indicate that patients with intracerebral hemorrhage (ICH) are at high risk for thromboembolic events and disability that is not being sufficiently mitigated by current treatment strategies.
- Conditions
- Colchicine, ICH - Intracerebral Hemorrhage, Stroke, Dependence
- Trial name
- CoVasc-ICH2 (NCT06587737)
- Testing
- Colchicine 0.5 MG
- Volunteers
- 1,125 people
- Sponsor
- Population Health Research Institute
Hypercholesterolemia, Cardiovascular Risk Factor
Effect of Totum-070 on Lipid Metabolism in Moderate Hypercholesterolemic Subjects
This clinical study aims to assess the efficacy of TOTUM-070, a mix of 5 plant extracts, on lipid metabolism in moderate hypercholesterolemic subjects.
- Conditions
- Hypercholesterolemia, Cardiovascular Risk Factor, Dyslipidemias, Overweight and Obesity
- Trial name
- HEART (NCT04760951)
- Testing
- TOTUM-070
- Where
- 4 sites in France, Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Valbiotis
Obesity
Weight Loss Effects on Heart and Blood Vessel Function in Obesity
Obesity is a growing epidemic and is associated with an increased risk of heart attack and stroke. The investigators know that obesity leads to abnormalities in how the blood vessels and the heart function and that these…
- Trial name
- NCT00782262
- Testing
- KicStart™
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Adelaide
Cardiovascular Disease
Study of Artery Conditions of 'At-risk' Asian People Not on Lipid-lowering Drugs
The purpose of this study is to obtain the distribution of measurements of the intima media thickness of carotid arteries in people with high cardiovascular risk.
- Trial name
- CIMT (NCT00970918)
- Testing
- Measurement of the Carotid Intima Media thickness, Blood sample testing for hs-CRP
- Where
- 19 sites in China, India and 7 more
- Volunteers
- 2,609 people
- Sponsor
- AstraZeneca
Endometrial Cancer, Genetic Predisposition
Molecular Classification in Relation to Prevention of Endometrial Cancer Recurrence and Lifestyle Factors
Endometrial cancer (EC) is one of the most prevalent cancers in women worldwide with a significantly increasing incidence, especially in developed countries.
- Conditions
- Endometrial Cancer, Genetic Predisposition, Risk Behavior
- Trial name
- MPEC (NCT06680791)
- Where
- Czechia
- Volunteers
- 280 people
- Sponsor
- Lukas Vanek
Obesity, Heart Diseases
The Effect of Xenical on Weight and Risk Factors
The purpose of this study is to determine the effect of using the weight loss medication Xenical (generic name - orlistat) on weight loss and change in heart disease risk factors in patients of the Healthy Heart Program Lipid…
- Trial name
- NCT00152360
- Testing
- Orlistat
- Where
- Canada
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Arteriovenous Fistula, Hemodialysis
Identifying Risk Factors (RF) for Early Haemodialysis Arteriovenous Fistula Failure (eAVFF)
Arteriovenous fisutla (AVF) is the vascular access of choice for hemodialysis but has a high early failure (eAVFF) rate. eAVFF can be defined as thrombosis/stenosis and Doppler ultrasound (DUS)-based failure-to-mature parameters…
- Conditions
- Arteriovenous Fistula, Hemodialysis, End Stage Chronic Renal Failure
- Trial name
- eAVFF-RF (NCT05552482)
- Testing
- Identification of predictive factors
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Centre Hospitalier Régional Metz-Thionville
Off Pump Coronary Artery Bypass Surgery
Heparin Resistance: Predictors and Outcomes
The investigators evaluated clinical impact of reduced heparin responsiveness (HRreduced) on the incidence of perioperative myocardial infarction (MI) and restenosis at 6 months after off-pump coronary artery bypass graft surgery…
- Trial name
- NCT01044888
- Testing
- Heparin
- Where
- South Korea
- Volunteers
- 199 people
- Sponsor
- Yonsei University
Schizophrenia, Schizoaffective Disorder
Magnesium Variations and Cardiometabolic Risk in Patients With Antipsychotic Drugs
Background: Antipsychotics can induce metabolic disorders such as obesity, hyperglycemia, dyslipidemia or metabolic syndrome. It has been observed that treatment with antipsychotic could be accompanied by a decrease in the…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT02986490
- Testing
- Blood sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Hypertension, Coronary Artery Disease
Cardiovascular Epidemiology in Russian Federation
The study addresses epidemiology of cardiovascular risk factors and major cardiovascular diseases in Russian Federation (urban and rural population). 12 regions of 1600 participants in each will be included.
- Conditions
- Hypertension, Coronary Artery Disease, Diabetes, Heart Failure
- Trial name
- ESSE-RF (NCT02449460)
- Where
- 2 sites in Russia
- Volunteers
- 18,000 people, healthy volunteers welcome
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Leukemia, Hodgkin's Lymphoma
Abdominal Obesity and Cardiovascular Risk Factors in Women Who Survived Cancer or a Related Illness Following Total Body Irradiation and Stem Cell Transplant
The purpose of this study is to better understand why some women who survived cancer or a related illness later develop diabetes, problems with their cholesterol, or other problems that may lead to heart disease.
- Conditions
- Leukemia, Hodgkin's Lymphoma, Non-Hodgkin's Lymphoma, Myelodysplastic Syndrome
- Trial name
- NCT00510315
- Testing
- Questionnaires, Laboratory tests, Abdominal MRI
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Type 2 Diabetes
Vitamin D Supplementation on Cardiovascular Risk Factors
The purpose of the present pilot study is to determine the effect of vitamin D supplementation (4000 IU or 6000 IU once daily for 6 months) on reducing heart disease risk and in improving blood glucose control in type 2 Diabetes…
- Trial name
- NCT01412710
- Testing
- Cholecalciferol
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Florida International University
Cardiovascular Risk Factors, Stroke
The "Know Your Numbers" Program in Atahualpa
Persons voluntarily attending the Community Center of the Atahualpa Project during one calendar year will be evaluated by trained personnel to check their cardiovascular health status.
- Conditions
- Cardiovascular Risk Factors, Stroke, Ischemic Heart Disease
- Trial name
- NCT01831908
- Testing
- Lifestyle counseling
- Where
- Ecuador
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Hospital Clínica Kennedy
Pulmonary Hypertension
Smoking: a Risk Factor for Pulmonary Arterial Hypertension?
Environmental factors may play a role in the genesis of pulmonary hypertension, especially in endothelial dysfunction. One widespread environmental factor associated with systemic endothelial dysfunction is cigarette smoke.
- Trial name
- DACH (NCT01484899)
- Where
- 9 sites in Austria, Germany and 1 more
- Volunteers
- 500 people
- Sponsor
- University of Zurich
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