Clinical trials: Cardiovascular Disease Risk Factors
Aortic Valve Disease
Aortic Valve Diseases RISk facTOr assessmenT and Prognosis modeL Construction
This study is a multicenter cohort study including patients diagnosed with aortic valve disease during hospitalization, including aortic insufficiency and aortic valve stenosis.
- Trial name
- ARISTOTLE (NCT06069232)
- Where
- 7 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Sun Yat-sen University
Cardiovascular Risk Factors
Effect of Biophenol-rich Pomegranate Extract Intake on Blood Pressure, Hormones, Body Composition and Quality of Life in Healthy Volunteers.
Biophenols can act as powerful antioxidants. Pomegranate (Punica granatum) provides a rich and varied source of biophenols with the most abundant being ellagitannins, tannins, anthocyanins, ellagic and gallic acids.
- Trial name
- POM-01Expl (NCT02005939)
- Testing
- Pomegranate extract
- Where
- United Kingdom
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Cardiovascular Risk Factor
Choline and Cardiometabolic Health
Trimethylamine-N-oxide (TMAO), a metabolite produced by gut microbial metabolism of dietary choline, has recently been causally linked to atherosclerosis in animal models and has been shown to be predictive of cardiovascular…
- Trial name
- NCT04764162
- Testing
- Choline
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Health Behaviors, Risk Factors
Targeted Health Dialogues in Primary Care
The County Council of Region Skåne, Sweden, has recently initiated Targeted Health Dialogues in primary care. The prevention program includes health dialogues provided by specially trained personnel, collection of clinical and…
- Conditions
- Health Behaviors, Risk Factors, Cardiovascular Diseases, Cancer
- Trial name
- NCT04912739
- Testing
- Targeted health dialogues
- Where
- Sweden
- Volunteers
- 18,000 people
- Sponsor
- Region Skane
Type 1 Diabetes, Cardiovascular Risk Factor
Determinants of Cardiovascular Disease Risk Factors Among Youth With Type 1 Diabetes
Type 1 diabetes mellitus (T1D) is the most common form of diabetes among children and youth, and it is increasing around the world, particularly among children under 5 years.
- Trial name
- CARDEA (NCT04304729)
- Where
- Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Cardiovascular Risk Factor, Heart Diseases
Effect of Macadamia Nut on Cardiometabolic Risk Factors
This research study will test the effects of macadamia nuts on adiposity, and traditional and emergent risk factors of cardiometabolic disease in adult men and women
- Conditions
- Cardiovascular Risk Factor, Heart Diseases, Inflammation
- Trial name
- MAC (NCT03801837)
- Testing
- Macadamia Nut, Control Diet
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Stroke
Understanding Changes in Heart Function After Exercise in People With Stroke
Little is known about how exercise can affect heart function in stroke survivors. This study will look at changes in cardiovascular fitness and function after 6 months of exercise.
- Trial name
- NCT01189045
- Testing
- Aerobic Exercise Program, Non-aerobic Exercise Program
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Cardiovascular Diseases
Wearable Devices to Promote Physical Activity
This study evaluates the effect of a new wearable device, that measures physical activity level based on heart rates, on relevant health outcomes including cardiorespiratory fitness.
- Trial name
- HUNT4-PAI (NCT03270202)
- Testing
- PAI group, Usual care
- Where
- Norway
- Volunteers
- 175 people
- Sponsor
- Norwegian University of Science and Technology
Cardiovascular Risk Factor, Prediabetes
Active You: A Novel Exercise Program for African Americans
Barriers to physical activity (PA) among African Americans (AAs) have been extensively studied, yet there is a paucity of innovative PA interventions designed to address them.
- Conditions
- Cardiovascular Risk Factor, Prediabetes, Overweight and Obesity, Sedentary Behavior
- Trial name
- NCT04280783
- Testing
- The Physical Activity for The Heart (PATH) intervention, Be Active Your Way Booklet
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Metabolic Syndrome, Cardiovascular Disease
Identifying Biomarkers and Cardiovascular Risk Factors in Childhood Metabolic Syndrome
Metabolic syndrome (MetS) is highly prevalent all over the world. MetS is largely under-diagnosed in children and adolescents. Obesity and hypertension are two important requirements for criteria of MetS.
- Trial name
- NCT02518854
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Dyslipidemias, Hyperlipidemias
PLATOREL® STUDY IN CARDIOVASCULAR RISΚ ASSESMENT
Dyslipidemias are a major risk factor for the onset of cardiovascular disease, while early diagnosis and appropriate treatment approaches significantly reduce cardiovascular morbidity and mortality.
- Conditions
- Dyslipidemias, Hyperlipidemias, Risk Factor, Cardiovascular, Quality of Life
- Trial name
- PLATINUM (NCT03329729)
- Testing
- Rosuvastatin
- Where
- Greece
- Volunteers
- 4,700 people
- Sponsor
- Elpen Pharmaceutical Co. Inc.
Acute Ischemic Stroke
An Application That Can Provide Early Warning of Temperature Health Risks and Give Protective Suggestions or Personalized Suggestions Based on Patients' Own Secondary Prevention Risk Factors Was Applied to Intervene, and the Intervention Effect of APP on Stroke Recurrence Risk Was Analyzed
This study employs individualized temperature health risk early warning and risk factor management interventions for stroke, and explores their actual intervention effects.
- Trial name
- NCT06904664
- Testing
- Individualized temperature health risk early warning and risk factor management, Temperature health risk early warning, Risk factor management
- Volunteers
- 10,184 people
- Sponsor
- Xuanwu Hospital, Beijing
Atherosclerotic Cardiovascular Disease
A Retrospective Cohort Study Evaluating Major Adverse Cardiovascular Events and Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease Without Prior Ischemic Events (OPTIMUS RISK - Italy)
This study will evaluate cardiovascular outcomes among individuals with clinically established atherosclerotic cardiovascular disease (ASCVD) who have not previously experienced a myocardial infarction (MI) or ischemic stroke.
- Trial name
- NCT07906132
- Where
- Italy
- Volunteers
- 93,000 people
- Sponsor
- Sanofi
Thorax Injuries, Embolism Vein
Retrospectively Analyze the Risk Factors of VTE in 5774 Patients With Thoracic Trauma From 33 Hospitals in China, and Established a Risk Prediction Model
Retrospectively analyze the risk factors of VTE in 5774 patients with thoracic trauma from 33 hospitals in China, and established a risk prediction model
- Conditions
- Thorax Injuries, Embolism Vein, Embolism, Pulmonary, Rib Fractures
- Trial name
- MCTTVTE (NCT05770232)
- Where
- China
- Volunteers
- 5,774 people
- Sponsor
- Shanghai Jiao Tong University Affiliated Sixth People's Hospital
Cardiovascular Diseases, Cardiovascular Risk Factor
Elaboration and Analysis of a New Cardiac Risk Stratification Protocol Based on Clinical and Physical Variables
This research project has as objective the elaboration and analysis of a new cardiac risk stratification protocol based on clinical and physical variables to predict the occurrence of signs and symptoms during a cardiac…
- Trial name
- NCT04790643
- Testing
- Exercise-based cardiac rehabilitation program (Stage 1), Exercise-based cardiac rehabilitation program (Stage 2)
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Aortic Regurgitation
Mild and Moderate Aortic Regurgitation: Risk Factors for Progress and Outcome
This observational study aims to evaluate risk factors of progress and adverse outcome of aortic regurgitation
- Trial name
- NCT07104968
- Where
- Sweden
- Volunteers
- 35,000 people
- Sponsor
- Uppsala University
Heart Failure, Cardiovascular Risk Factor
Cardiovascular Profiles in Rheumatoid Arthritis
Cardiovascular disease is the leading cause of death in RA patients. This increased risk may be apparent even before the clinical recognition of RA.
- Conditions
- Heart Failure, Cardiovascular Risk Factor, Rheumatoid Arthritis, Myocardium; Injury
- Trial name
- RA-HF (NCT03960515)
- Volunteers
- 400 people
- Sponsor
- Maria Betânia Almeida Dias Ferreira
Coronary Artery Disease, Percutaneous Coronary Intervention
Study of the Long-term Effects of P2Y12 Inhibitor Monotherapy and Coagulation Markers After Percutaneous Coronary Angioplasty.
Patients who undergo percutaneous coronary intervention (PCI) are commonly treated with antiplatelet therapy to prevent stent thrombosis and recurrence of events.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndromes, Antiplatelet Therapy
- Trial name
- HI-TECH 2 (NCT07582835)
- Testing
- Clopidogrel, Ticagrelor, Prasugrel
- Where
- Switzerland
- Volunteers
- 355 people
- Sponsor
- Cardiocentro Ticino
Cardiovascular Diseases, Heart Diseases
ACE Inhibition and Novel Cardiovascular Risk Factors
To determine the effects of an angiotensin converting enzyme inhibitor (ACE inhibitor), fosinopril, on multiple blood markers in 286 adults at high risk for cardiovascular disease.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension
- Trial name
- NCT00051389
- Testing
- Fosinopril
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Schizophrenia, Schizoaffective Disorder
Magnesium Variations and Cardiometabolic Risk in Patients With Antipsychotic Drugs
Background: Antipsychotics can induce metabolic disorders such as obesity, hyperglycemia, dyslipidemia or metabolic syndrome. It has been observed that treatment with antipsychotic could be accompanied by a decrease in the…
- Conditions
- Schizophrenia, Schizoaffective Disorder, Bipolar Disorder
- Trial name
- NCT02986490
- Testing
- Blood sample
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
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