Clinical trials: Cardiovascular Disease Risk Factors
Sub-optimal Vitamin D Status, Pre-diabetes
Effect of Vitamin D3 Supplementation on Insulin Resistance- The DIR Study
Insulin resistance is a state where the body does not respond as it should to the insulin it produces. Individuals who are insulin resistant are at increased risk of both heart disease and type 2 diabetes; importantly, diabetes…
- Conditions
- Sub-optimal Vitamin D Status, Pre-diabetes, Insulin Resistance
- Trial name
- NCT01889810
- Testing
- Vitamin D3 supplementation
- Where
- United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Hypertension in Type 2 Diabetes, Diabetes Mellitus Type 2
The SWITCH (Substitution of High With Low Ultra-processed Soy Protein Foods In a Guideline-based Diet inTervention for Cardiometabolic Health) Trial
This is a randomized, controlled, parallel study with 3 experimental arms aimed to assess the effect of a digital dietary intervention (web-based app, online behavior change curriculum) enhanced with 10 servings of vegetables and…
- Conditions
- Hypertension in Type 2 Diabetes, Diabetes Mellitus Type 2, Dyslipidemia, Hypertension
- Trial name
- SWITCH (NCT06907862)
- Testing
- Reference Treatment, Control, Active Treatment
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- University of Toronto
Atherosclerosis
GISSI Outliers CAPIRE
The risk of developing clinical manifestations of ischemic heart disease is currently assessed by using integrated multifactorial prediction models based on the presence of non-modifiable risk factors, such as age, gender and a…
- Trial name
- CAPIRE (NCT02157662)
- Where
- 10 sites in Italy, Switzerland
- Volunteers
- 544 people
- Sponsor
- Gruppo di Ricerca GISSI
Myocardial Infarction
GlObal Secondary Prevention strategiEs to Limit Event Recurrence After Myocardial Infarction. GOSPEL Study
Cardiac rehabilitation programmes are a proven treatment for individuals with recent myocardial infarction, resulting in reduced morbidity and mortality compared to usual care.
- Trial name
- NCT00421876
- Testing
- multifactorial continued educational - behavioural programme
- Where
- 74 sites in Italy, Switzerland
- Volunteers
- 3,200 people
- Sponsor
- Heart Care Foundation
Cardiovascular Disease, Type 2 Diabetes
Effects of Pistachios on Cardiovascular Responses to Stress in Type 2 Diabetes
This study is investigating the effects of three different diets, including a diet with pistachios, on cardiovascular disease risk markers in people with type 2 diabetes.
- Trial name
- Pistachio (NCT00956735)
- Testing
- Pistachio
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Penn State University
Waldenstrom Macroglobulinemia, Chronic Lymphocytic Leukemia
Clinical, Laboratory and Epidemiologic Characterization of Individuals and Families at High Risk of Hematologic Cancer
Background: Individuals may be prone to develop blood or lymph node cancers (leukemia or lymphoma) for a variety of reasons, including genetic predisposition to these cancers, environmental exposures or other medical conditions.
- Conditions
- Waldenstrom Macroglobulinemia, Chronic Lymphocytic Leukemia, Hodgkin Disease, NonHodgkin Lymphoma
- Trial name
- NCT00039676
- Where
- 2 sites in United States
- Volunteers
- 1,836 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Cardiovascular Diseases
Effect of Exercise or Metformin on Nocturnal Blood Pressure and Other Risk Factors for CVD Among Obese Adolescents
The objective is to, among obese adolescents, study impact of regular physical activity or metformin therapy on nocturnal blood pressure and related cardiovascular disease risk factors.
- Trial name
- NCT00889876
- Testing
- Metformin group, Exercise
- Where
- Sweden
- Volunteers
- 26 people
- Sponsor
- Maria Sandberg Westerstahl
Hypopituitarism, Pituitary Tumors
Effect of 5 Years of GH Replacement on Atherosclerosis
Adult patients with hypopituitarism under adequate conventional hormone replacement therapy have reduced life expectancy due to excess vascular events (1-4).
- Conditions
- Hypopituitarism, Pituitary Tumors, Growth Hormone Deficiency
- Trial name
- 5yrGH (NCT00462475)
- Testing
- Recombinant Growth Hormone, Genotropin (Pfizer)
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federico II University
Ischemic Attack, Transient
Short-Term Prognosis Evaluation of Transient Ischemic Attack Patients Using ABCD2 Score
The purpose of this study is to determine whether the ABCD2 score can be used in patients with transient ischemic attack, admitted to Beijing anzhen hospital, to evaluate the prognosis, risk factor of those patients.
- Trial name
- NCT00553241
- Where
- China
- Volunteers
- 1 people
- Sponsor
- Capital Medical University
Cardiovascular Diseases, Depression
Omega-3 Fatty Acids to Improve Depression and Reduce Cardiovascular Risk Factors
This study will determine the effects of omega-3 fatty acid (FA) augmentation of sertraline on depression and cardiac endpoints after myocardial infarction (MI).
- Conditions
- Cardiovascular Diseases, Depression, Heart Diseases, Myocardial Infarction
- Trial name
- NCT00116857
- Testing
- Sertraline/omega-3, Sertraline/Corn Oil
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- Washington University School of Medicine
Atrial Fibrillation, Obesity and Obesity-related Medical Conditions
Metabolic Surgery for Atrial Fibrillation Elimination
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. It is estimated that between 3 and 6 million Americans are currently living with AF, while 12 million people in the United States will have AF in 2030.
- Trial name
- METSAFE (NCT07027969)
- Testing
- Roux-en-Y Gastric Bypass or Sleeve Gastrectomy, Anti-Obesity Medication (AOM) treatment
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ali Aminian
Functional Decline, Hospitalization-associated Disability
Incidence and Risk Factors for Hospitalization-Associated Disability
This prospective cohort study aims to determine the incidence of hospitalization-associated disability and its association with risk factors at the patient level and with care and hospital processes.
- Conditions
- Functional Decline, Hospitalization-associated Disability, Iatrogenic Disease
- Trial name
- NCT02572999
- Testing
- Not applicable (observational design)
- Where
- Belgium
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Insomnia, Hypersomnia
Sleep Disorders and Their Cardiovascular Correlates in Atahualpa.
Little is known on the prevalence of sleep disorders and their role in the increased prevalence of cardiovascular diseases in the developing world.
- Conditions
- Insomnia, Hypersomnia, Sleep-disordered Breathing, Stroke
- Trial name
- NCT01877616
- Testing
- diagnostic test
- Where
- Ecuador
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Hospital Clínica Kennedy
COVID-19
Cardiovascular Risk Factors and Severe COVID-19. A Nationwide Registry-based Case-Control Study
In this study we cross-reference several nationwide high-quality Swedish registers in order to study risk factors for severe Covid-19 outcomes.
- Trial name
- NCT04426084
- Testing
- Hypertension, Diabetes type 2, Obesity
- Where
- Sweden
- Volunteers
- 22,784 people
- Sponsor
- Karolinska Institutet
Cardiovascular Diseases
The Morehouse-Emory Cardiovascular Center for Health Equity Study: Clinical Intervention Project
This study will recruit from participants in the Morehouse-Emory Cardiovascular (MECA) study for a clinical intervention examining cardiac outcomes between participants who are randomized to received Health360x (a web-based and…
- Trial name
- MECA (NCT03308812)
- Testing
- Health360x, Health Coach
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- Emory University
Obesity, Childhood, Bariatric Surgery Candidate
Long-Term Outcomes of LSG in Pediatric Patients
This project aims to assess the short- and long-term safety and efficacy of bariatric surgery in children and adolescents compared to adults.
- Conditions
- Obesity, Childhood, Bariatric Surgery Candidate, Cardiovascular Risk Factor
- Trial name
- NCT04136704
- Testing
- Sleeve gastrectomy
- Where
- Saudi Arabia
- Volunteers
- 10,000 people
- Sponsor
- King Saud University
Coronary Disease, Cardiovascular Diseases
Evaluating a Web-Based Educational Program for Adults at Risk for Coronary Heart Disease (The Heart to Heart Feasibility Study)
Coronary heart disease (CHD) is the leading cause of death in the United States, but fewer than half of all individuals at risk for CHD take advantage of proven strategies to lower their chances of developing this disease.
- Trial name
- NCT00494052
- Testing
- Heart to Heart (Web-Based Decision Aid), Physician Education Session
- Where
- 2 sites in United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Inflammatory and Acquired Dysimmune Diseases
Evaluation and Management of Cardiovascular Risk Factors in Inflammatory and Acquired Dysimmune Diseases (CARMIN)
The hypothesis is that chronic inflammatory dysimmune state promotes the development of cardiovascular complications. The biological assumption is based on the fact that chronic inflammation promotes lesions of the vessel wall…
- Trial name
- CARMIN (NCT02835547)
- Testing
- Data collection
- Volunteers
- 600 people
- Sponsor
- Hospices Civils de Lyon
Oncologic Disorders, Cardiovascular Diseases
Impact of a Comprehensive Cardiac Rehabilitation Program Framework Among High Cardiovascular Risk Cancer Survivors
Many cancer survivors are at risk for cardiovascular disease (CVD); it is therefore important to identify patients at increased risk for cardiotoxicity, especially in the setting of CVRF or pre-existing CVD, and to design…
- Trial name
- NCT05132998
- Testing
- Cardiac Rehabilitation Program, Community exercise intervention
- Where
- Portugal
- Volunteers
- 80 people
- Sponsor
- Associacao de Investigacao de Cuidados de Suporte em Oncologia
Diabetic Foot, Diabetic Foot Ulcer
Digital Foot Check by Using the D-Foot, a New Software
Patients with diabetes should be thoroughly examined before they are provided with insoles and shoes. In the study the feet are examined with the help of a new software, the D-Foot. D-Foot includes questions and surveys.
- Conditions
- Diabetic Foot, Diabetic Foot Ulcer, Diabetic Foot Ulcer Neuropathic, Neuropathy;Peripheral
- Trial name
- D-Foot2019 (NCT04054804)
- Testing
- D-Foot
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Sahlgrenska University Hospital
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