Clinical trials: Cardiovascular Disease Risk Factors
Kidney Failure, Chronic, Hyperphosphatemia
Pragmatic Randomised Trial of High Or Standard PHosphAte Targets in End-stage Kidney Disease (PHOSPHATE)
During end-stage kidney disease, clinical guidelines suggest reducing elevated phosphate levels in the blood. However, the effect of lowering blood phosphate levels on important patient-centred outcomes has never been tested.
- Trial name
- PHOSPHATE (NCT03573089)
- Testing
- Liberal phosphate target, Intensive phosphate target
- Where
- 126 sites in Australia, Brazil and 7 more
- Volunteers
- 3,600 people
- Sponsor
- The University of Queensland
Diabetes Mellitus, Periodontal Diseases
Periodontitis as Signal for an Underlying Disease
This study investigates the differences between subjects with and without periodontitis in: the prevalence of (pre)diabetes mellitus, the risk of atherosclerotic cardiovascular disease, the prevalence of metabolic syndrome and…
- Conditions
- Diabetes Mellitus, Periodontal Diseases, Cardiovascular Diseases, Obstructive Sleep Apnea Syndrome
- Trial name
- PACMEL (NCT03459638)
- Testing
- Screening for DM, ASCVD, MetS and OSAS
- Where
- Netherlands
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Academic Centre for Dentistry in Amsterdam
Leukemia, Lymphoma
Cardiovascular Effects of CART Cell Therapy
This is an observational study aiming to prospectively define the rate of occurrence, natural history and progression of cardiac dysfunction in adults, and to identify the patients at high risk of developing cardiovascular…
- Conditions
- Leukemia, Lymphoma, Cardiotoxicity, Risk Factor, Cardiovascular
- Trial name
- CVE-CART (NCT04026737)
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Coronary Artery Disease, Microcirculation Resistance
COronoary Microcirculation Analysis NETwork
COMA.NET (Coronary Microcirculation Analysis Network) is a prospective, randomized, open-label, parallel-group clinical trial designed to determine whether endotype-guided pharmacotherapy is superior to standard care in improving…
- Conditions
- Coronary Artery Disease, Microcirculation Resistance, Microcirculation; Biomarkers; Myocardial Ischemia, Microcirculatory Dysfunction
- Trial name
- COMA-NET (NCT07498231)
- Testing
- Coronary microvascular function assessment
- Where
- Poland
- Volunteers
- 180 people
- Sponsor
- Medical University of Bialystok
Cardiovascular Diseases
Evaluating the Effectiveness of a Computerized Medication Adherence System at Reducing Cardiovascular Disease Risk Factors
High blood pressure and high cholesterol are both causes of cardiovascular disease (CVD), and it is important for people with these conditions to adhere to their medication regimens.
- Trial name
- NCT00796172
- Testing
- Medication Adherence System (MAS), Usual Care
- Where
- United States
- Volunteers
- 308 people
- Sponsor
- PHCC LP
Coronary Artery Disease
Effects of Beta-Blocker Therapy and Phosphodiesterase Inhibition on Cardiac Neurohormonal Activation
Previous clinical investigations have demonstrated the utility of β-adrenergic blockade in reducing perioperative ischaemic events, ultimately translating into a decrease in cardiac morbidity and mortality.
- Trial name
- NCT00348101
- Testing
- Combined therapy with enoximone and esmolol
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Klinikum Ludwigshafen
Cardiovascular Risk Factor, Heart Diseases
Effect of Macadamia Nut on Cardiometabolic Risk Factors
This research study will test the effects of macadamia nuts on adiposity, and traditional and emergent risk factors of cardiometabolic disease in adult men and women
- Conditions
- Cardiovascular Risk Factor, Heart Diseases, Inflammation
- Trial name
- MAC (NCT03801837)
- Testing
- Macadamia Nut, Control Diet
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
PCOS
Exogenous Ketone Supplementation in Females with Polycystic Ovary Syndrome
Polycystic ovary syndrome (PCOS) affects 1 in 5 females of reproductive age. Commonly characterized as a disorder of infertility, PCOS is often accompanied by 3 potent cardiovascular disease (CVD) risk factors: insulin…
- Trial name
- NCT06155708
- Testing
- Ketone, Water
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGill University
Cardiovascular Diseases
Assessing the Effectiveness of Concurrent Peer Review for Patients With Cardiovascular Disease and Diabetes
We will assess the impact of concurrent peer review vists on blood pressure, cholesterol and diabetes control. Concurrent peer review (CPR) visits refer to special offic visits by patients to a clinician (physician, nurse…
- Trial name
- NCT00508014
- Testing
- Usual Care, Concurrent Peer Review visit
- Where
- United States
- Volunteers
- 727 people
- Sponsor
- University of Rochester
Cardiovascular Risk Factors, Coronary Artery Disease
Correlation of Artherosclerotic Plaque Volume and Intima Media Thickness With Soluble P-selectin
The proposed project is a prospective observational, single-center cohort study aimed to examine the progression of atherosclerotic alterations of the carotid arteries (IMT, plaque volume) during a follow-up of up to four years…
- Conditions
- Cardiovascular Risk Factors, Coronary Artery Disease, Cerebrovascular Disease, Peripheral Artery Disease
- Trial name
- NCT01895725
- Where
- Austria
- Volunteers
- 443 people
- Sponsor
- Medical University Innsbruck
Healthy
Sodium vs Potassium Education to Improve Vascular Health
The goal of this clinical trial is to determine if a self-selected high potassium diet is easier to achieve and more effective at improving vascular health than a low sodium diet in generally healthy young adults who typically…
- Trial name
- NCT07221448
- Testing
- High potassium dietary education/counseling, Low sodium dietary education/counseling
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Florida State University
Cardiovascular Diseases
Low Fat Milk Intake and Cardio Vascular Risk (CVR) Indicators in Children
Substituting whole milk intake for defatted milk will improve indicators of cardiovascular risk, i.e. total cholesterol, triglycerides, Low Density Lipoprotein (LDL) and High Density Lipoprotein (HDL)cholesterol, apolipoproteins…
- Trial name
- NCT01178515
- Testing
- Modification of the content of fat in milk, Modification of the content of cows milk, Modification of the fat content of cows´ milk
- Where
- Mexico
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Salud Publica, Mexico
Stroke, Low-Density-Lipoprotein-cholesterol Level
Cardiovascular Risk Factors in Middle Eastern Patients With Stroke
Stroke is a well-known a leading cause of death and disability in the Middle East. There remain many knowledge gaps in evaluating the prevalence of risk factors among patients with stroke in the Middle East.
- Conditions
- Stroke, Low-Density-Lipoprotein-cholesterol Level, Risk Factors
- Trial name
- JoSMMART (NCT07298668)
- Where
- Jordan
- Volunteers
- 2,000 people
- Sponsor
- Jordan Collaborating Cardiology Group
Aortic Dissection
Pre-hospital Management of Aortic Dissection
Background : Time between symptoms onset and treatment initiation is crucial in Acute aortic dissection (AAD). An anti-hypertensive treatment can be rapidly initiated before the arrival in Emergency Department (ED).
- Trial name
- FFDA (NCT04304443)
- Where
- 2 sites in France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Atrial Fibrillation
Risk Factors That Contribute to the Maintenance of Sinus Rhythm
This is a prospective clinical research study. The objective of this study is to evaluate if clinical risk factors as well as structural features on echocardiography affect the maintenance of sinus rhythm after electrical…
- Trial name
- Afib (NCT04655443)
- Testing
- Standard Care
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Danbury Hospital
Diabetes Mellitus, Cardiovascular Diseases
Towards Optimal Screening and Management of Coronary Artery Disease in Diabetes: TOSCANA Study
There are currently only few data on the coronary artery calcium score in patient with diabetes in France, and the diagnostic and therapeutic attitudes towards a high coronary artery calcium score are not standardized and depend…
- Trial name
- TOSCANA (NCT05314140)
- Testing
- Coronary artery calcium score evaluation
- Where
- 9 sites in France
- Sponsor
- French Cardiology Society
Ischemic Heart Disease
Telemonitoring During Phase 2-3 Cardiac Rehabilitation
In this study, 80 coronary artery disease patients with successful coronary revascularisation (by CABG or PCI) will be included.
- Trial name
- TeleRehabII (NCT01252030)
- Testing
- physical activity monitors, No physical activity monitors
- Where
- Belgium
- Volunteers
- 80 people
- Sponsor
- Jessa Hospital
Hypertriglyceridemia
Docosahexenoic Acid (DHA) Supplementation and Cardiovascular Disease in Men With High Triglycerides
The purpose of this study is to determine the effects of supplementing diets of hyperlipidemic men with DHA (docosahexenoic acid) on risk factors for cardiovascular disease.
- Trial name
- NCT00728338
- Testing
- Docosahexenoic acid (DHA), Olive oil
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Overweight and Obesity, Cardiovascular Risk Factor
The Emirates Heart Health Project: A Family-based Diet and Exercise Intervention in Obese and Overweight Patients
Data from Abu Dhabi's Department of Health document that the leading cause of death among the population of the emirate of Abu Dhabi is cardiovascular disease (CVD).
- Trial name
- EHHP (NCT04688684)
- Testing
- Family-based diet and exercise intervention
- Where
- United Arab Emirates
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- United Arab Emirates University
Coronary Disease, Cardiovascular Diseases
Evaluating a Web-Based Educational Program for Adults at Risk for Coronary Heart Disease (The Heart to Heart Feasibility Study)
Coronary heart disease (CHD) is the leading cause of death in the United States, but fewer than half of all individuals at risk for CHD take advantage of proven strategies to lower their chances of developing this disease.
- Trial name
- NCT00494052
- Testing
- Heart to Heart (Web-Based Decision Aid), Physician Education Session
- Where
- 2 sites in United States
- Volunteers
- 186 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
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