Clinical trials: Cardiovascular Disease Risk Factors
Rheumatoid Arthritis
Effect of Monoclonal Anti-IL6 Antibody (Tocilizumab) on the Cardiovascular Risk in Patients With Rheumatoid Arthritis
The purpose of this study is to determine whether tocilizumab changes the cardiovascular risk factors on patients with arthritis rheumatoid.
- Trial name
- TOCRIVAR (NCT01752335)
- Testing
- Braquial ecography
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Hospital Universitario de Canarias
Myocarditis, Pericarditis
A Study on the Clinical Course, Outcomes and Risk Factors of Myocarditis and Pericarditis After Moderna COVID-19 Vaccine
The main goal of this study is to describe the clinical course, outcomes and risk factors for myocarditis and pericarditis associated with Moderna vaccination targeting SARS-CoV-2.
- Trial name
- NCT06113692
- Testing
- mRNA-1273
- Where
- 5 sites in Denmark, Norway and 2 more
- Volunteers
- 1,169 people
- Sponsor
- ModernaTX, Inc.
Cardiovascular Disease, High Cardiovascular Risk
A Study to Evaluate the Effect of Long-term Treatment With BELVIQ (Lorcaserin HCl) on the Incidence of Major Adverse Cardiovascular Events and Conversion to Type 2 Diabetes Mellitus in Obese and Overweight Subjects With Cardiovascular Disease or Multiple Cardiovascular Risk Factors
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group study in overweight and obese subjects with cardiovascular (CV) disease and/or multiple CV risk factors.
- Conditions
- Cardiovascular Disease, High Cardiovascular Risk, Obesity, Overweight
- Trial name
- CAMELLIA-TIMI (NCT02019264)
- Testing
- Lorcaserin hydrochloride
- Where
- 499 sites in United States, Australia and 6 more
- Volunteers
- 14,673 people
- Sponsor
- Eisai Inc.
Coronary Artery Disease, Ischemic Heart Disease
Volatilome and Single-Lead Electrocardiogram Optimize Ischemic Heart Disease Diagnosis Using Machine Learning Models
This is a prospective, case-control, single-center, observational, non-randomized study. It is designed to evaluate the diagnostic accuracy of functional tests involving physical exertion monitored via a 12-lead ECG, combined…
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease, Chronic Coronary Disease, Angina Pectoris
- Trial name
- NCT06181799
- Testing
- Mass spectrometry using the PTR TOF-1000 (IONICON PTR-TOF-MS - Trace VOC Analyzer, Eduard-Bodem-Gasse 3, 6020 Innsbruck, Austria (Europe).
- Where
- Russia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Cardiovascular Diseases, Heart Diseases
VLDL and LDL Particle Types as Coronary Heart Disease Risk Factors
To evaluate very low density lipoprotein (VLDL) and low density lipoprotein (LDL) particle types as predictors of initial coronary events.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Coronary Disease, Myocardial Infarction
- Trial name
- NCT00065793
- Volunteers
- 1,478 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Coronary Artery Disease
Effect of Digital Technologies on Risk Factor Modification
DigTech investigates the effect of a text message-based intervention to encourage lifestyle change on objective measures of cardiovascular risk in individuals with coronary heart disease (CHD) after percutaneous coronary…
- Trial name
- NCT03871907
- Testing
- Digital technology
- Where
- Russia
- Volunteers
- 700 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Retinal Vein Occlusion
Retinal Thrombosis and Atherosclerosis
The retinal vein occlusion (RVO) is the second most common retinal disease after diabetic retinopathy, and is a common cause of unilateral visual loss.
- Trial name
- HEART-VISION (NCT02257333)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Roma La Sapienza
Pulmonary Embolism
Thrombus Localization and Accompaying Disorders and Risk Factors
ABSTRACT Pulmonary embolism shows a wide spectrum ranging from clinically asymptomatic thrombus to massive thrombus, leading to cardiogenic shock.
- Trial name
- NCT02388841
- Testing
- Pulmonary embolism
- Where
- Turkey (Türkiye)
- Volunteers
- 148 people
- Sponsor
- Aysel Sünnetçioğlu
Metabolic Syndrome X, Lifestyle-related Condition
Metabolic Risk Management, Physical Exercise and Lifestyle Counselling in Low-active Adults; Controlled Randomized Trial
The purpose of this study is evaluate the effectiveness of different doses of supervised exercise training intensity -concomitant to lifestyle counselling- as a Primary Health Care intervention tool for the management of the…
- Conditions
- Metabolic Syndrome X, Lifestyle-related Condition, Lifestyle Risk Reduction, Cardiovascular Risk Factor
- Trial name
- BELLUGAT (NCT02832453)
- Testing
- Lifestyle, Aerobic interval training, Traditional continous training
- Where
- Spain
- Volunteers
- 77 people
- Sponsor
- INEFC-Lleida
Stroke
Patient Education Following a Stroke
The rapid diagnosis and treatment of acute ischemic stroke are critical in the reduction of morbidity, disability and stroke associated mortality Under-education about stroke may prevent people from recognizing symptoms early…
- Trial name
- EPIC (NCT02834273)
- Testing
- stroke education workshops
- Where
- France
- Volunteers
- 199 people
- Sponsor
- Hopital Foch
Child, Only, Obesity
Microvascular Reactivity in Prepubertal Children
This is a cross-sectional study aimed to investigate microvascular reactivity in prepubertal children according to adiposity status.
- Conditions
- Child, Only, Obesity, Endothelial Dysfunction
- Trial name
- MicroChild (NCT03171441)
- Testing
- nailfold videocapillaroscopy, inflammatory biomarkers
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Cardiovascular Risk Factor, Menopause Related Conditions
The Clinical Utility of Resistance Training for Improving Cardiovascular Disease Risk in Post-Menopausal Women
Given the heightened cardiovascular disease (CVD) risk in post-menopausal women, studies are needed to explore novel, feasible methods for reducing risk in this population.
- Conditions
- Cardiovascular Risk Factor, Menopause Related Conditions, Neuromuscular Function, Aerobic Capacity
- Trial name
- NCT03752060
- Testing
- Resistance Exercise, Aerobic Exercise
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Tricuspid Regurgitation
Tricuspid RegurgitAtion rIsk modeL Study (TRAIL Study)
This study is a multicenter cohort study including patients diagnosed with tricuspid regurgitation during hospitalization. The primary outcome of the study is all-cause death, and the secondary outcome is cardiovascular events.
- Trial name
- NCT06926959
- Where
- 7 sites in China
- Volunteers
- 3,000 people
- Sponsor
- Sun Yat-sen University
Metabolic Cardiovascular Syndrome
Metabolic Syndrome Diagnosis and Education Trial
This study is being done to gain knowledge on how effective different approaches of providing a diagnosis and varying educational tools that include DVDs and multimedia or printed instruction sheets on your readiness to increase…
- Trial name
- NCT00943254
- Testing
- High-Tech Education, Low-Tech Education
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Type 2 Diabetes Mellitus (T2DM)
Phase III Trial of SGLT2 Inhibitor and Thiazolidinedione Fixed-Dose Combination vs. Monotherapy in Type 2 Diabetes Patients on Metformin
This clinical trial is studying whether combining two commonly used diabetes medications into a single pill works better than taking them separately for people with type 2 diabetes who are already on metformin.
- Trial name
- CONTROL (NCT07057479)
- Testing
- Fixed-dose combination of SGLT2 inhibitor and thiazolidinedione, Control Group 1 Intervention - SGLT2 inhibitor monotherapy, Control Group 2 Intervention - Thiazolidinedione monotherapy
- Where
- Brazil
- Sponsor
- Eurofarma Laboratorios S.A.
Epilepsy in Children, Coagulation and Hemorrhagic Disorders
The Prevalence and Risk Factors of Coagulopathy in Pediatric Epilepsy Surgery Patients
The hematologic consequences of novel Anti-seizure medications (ASMs) are rarely reported. Whether coagulation dysfunctions increase the risk of peri-operative bleeding remains controversial.
- Conditions
- Epilepsy in Children, Coagulation and Hemorrhagic Disorders, Epilepsy; Seizure, Antiepileptic Adverse Reaction
- Trial name
- NCT05675254
- Where
- China
- Volunteers
- 494 people
- Sponsor
- Children's Hospital of Fudan University
Cardiovascular Diseases
Internet Based Vascular Risk Factor Intervention and Self Management Study
The objective of the study is to evaluate the efficacy and cost-effectiveness of an internet based vascular risk factor program on top of usual care compared to usual care alone for treatment of vascular risk factors in patients…
- Trial name
- IRIS (NCT00785031)
- Testing
- internet based vascular risk factor intervention
- Where
- 2 sites in Netherlands
- Volunteers
- 330 people
- Sponsor
- UMC Utrecht
Obesity, Childhood, Cardiac Disease
Chronotropic Incompetence During Exercise Testing in Obese Adolescents
In adolescents with obesity cardiopulmonary exercise testing (CPET) has become an important clinical examination providing valuable information with regard to the integrative exercise responses, including the pulmonary…
- Conditions
- Obesity, Childhood, Cardiac Disease, Cardiovascular Risk Factor
- Trial name
- NCT04185753
- Testing
- The prevalence of chronotropic incompetence during maximal cardiopulmonary exercise testing
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Hasselt University
Left Ventricular Dysfunction, Myocardial Infarction
St. Vincent's Screening To Prevent Heart Failure Study
The STOP-HF study is a prospective, randomized, controlled trial recruiting asymptomatic individuals with risk factors for left ventricular dysfunction from 50 primary care clinics in Dublin and south east Ireland.
- Conditions
- Left Ventricular Dysfunction, Myocardial Infarction, Hypertension, Diabetes
- Trial name
- STOP-HF (NCT00921960)
- Testing
- Intervention Care
- Where
- Ireland
- Volunteers
- 1,378 people
- Sponsor
- St Vincent's University Hospital, Ireland
Obesity, Body Weight
Metabolic and Bio-behavioral Effects of Following Recommendations in the Dietary Guidelines for Americans
This study, at the Western Human Nutrition Research Center (WHNRC), will focus on whether or not achieving and maintaining a healthy body weight is the most important health promoting recommendation of the Dietary Guidelines for…
- Trial name
- DGA4ME (NCT04293224)
- Testing
- DGA Mediterranean diet pattern, energy balance, DGA Mediterranean diet pattern, negative energy balance, TAD diet pattern, negative energy balance
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
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