Clinical trials: Cardiovascular Disease Risk Reduction
Venous Thromboembolism
StAtins for Venous Event Reduction in Patients With Venous Thromboembolism Pilot Study
The SAVER pilot is a randomized, open-label pilot study to determine the feasibility of recruitment. In addition to feasibility data, the investigators will carefully collect clinical data to determine if rosuvastatin can reduce…
- Trial name
- SAVER (NCT02679664)
- Testing
- Rosuvastatin
- Where
- 6 sites in Canada, Norway
- Volunteers
- 312 people
- Sponsor
- Ottawa Hospital Research Institute
Hypertension, Stroke
Culturally Tailoring a Stroke Intervention in Community Senior Centers
Stroke is a cruel disease that disproportionately kills and disables African-Americans, Latinos, Chinese-Americans and Korean-Americans; seniors with high blood pressure are at particularly high risk.
- Conditions
- Hypertension, Stroke, Sedentary Lifestyle, Aged
- Trial name
- SPIRP (NCT02181062)
- Testing
- Walking Intervention
- Where
- 4 sites in United States
- Volunteers
- 240 people
- Sponsor
- University of California, Los Angeles
Hypertension
e-Counseling Promotes Blood Pressure Reduction and Therapeutic Lifestyle Change in Hypertension
This proposed clinical trial, REACH, will enroll 538 persons with hypertension. All subjects will continue with their prescribed medications.
- Trial name
- REACH (NCT01541540)
- Testing
- e-Counseling plus Usual Care, Control
- Where
- 4 sites in Canada
- Volunteers
- 264 people
- Sponsor
- University Health Network, Toronto
Obesity, Cardiovascular Risk Factors
Planned CORR: Planned Care for Obesity and Risk Reduction
The researchers propose a randomized controlled trial to evaluate how well an intervention, Planned Care for Obesity \& Risk Reduction (Planned CORR), supports primary care treatment of obesity in adults with at least one…
- Trial name
- Planned CORR (NCT01134029)
- Testing
- Stepped Care
- Where
- United States
- Volunteers
- 262 people
- Sponsor
- University of California, San Diego
Hypertension
A Pilot Study of Changing Medication Adherence In Hypertensive African-American Patients
We will conduct an empirical test of the two intervention approaches under study. Specifically, we seek to determine the potential differential impact of positive affect induction and self affirmation.
- Trial name
- NCT00248937
- Testing
- Positive affect and self-affect induction
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Weill Medical College of Cornell University
Cardiovascular Diseases, Coronary Heart Disease Risk Reduction
Population-Based Modeling of Cholesterol Lowering in the United States
To evaluate the cost-effectiveness of cholesterol-lowering strategies in the United States population. The study used the Coronary Heart Disease (CHD) Policy Model, a state-transition computer simulation model used to obtain…
- Conditions
- Cardiovascular Diseases, Coronary Heart Disease Risk Reduction, Heart Diseases, Coronary Disease
- Trial name
- NCT00005463
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Obesity
Behavioral Weight Loss and Stigma Reduction
This is a randomized controlled trial to test the effects on long-term weight loss of a novel stigma-reduction intervention combined with standard BWL treatment, as compared to BWL alone.
- Trial name
- NCT03704064
- Testing
- Stigma-Reduction Intervention, Behavioral Weight Loss (BWL)
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Pennsylvania
Cardiovascular Disease, Cerebrovascular Accident
A Study to Determine the Degree of Additional Reduction in CV Risk in Lowering LDL Below Minimum Target Levels
The primary objective of this study is to determine the degree of additional reduction in cardiovascular risk that was accrued to patients by lowering their LDL-C beyond the currently accepted minimum target level for patients…
- Conditions
- Cardiovascular Disease, Cerebrovascular Accident, Coronary Heart Disease
- Trial name
- TNT (NCT00327691)
- Testing
- Atorvastatin
- Where
- 314 sites in United States, Australia and 12 more
- Volunteers
- 8,600 people
- Sponsor
- Pfizer
Coronary Artery Bypass, Myocardial Infarction
The Effect Of Acadesine On Reducing Cardiovascular and Cerebrovascular Adverse Events In Coronary Artery Bypass Graft (CABG) Surgery (Study P05633 AM1)(TERMINATED)
The purpose of this study is to determine whether acadesine is effective in reducing the cardiovascular and cerebrovascular adverse events in high-risk participants undergoing CABG surgery.
- Conditions
- Coronary Artery Bypass, Myocardial Infarction, Ventricular Dysfunction, Left, Stroke
- Trial name
- RED-CABG (NCT00872001)
- Testing
- Acadesine, Normal Saline
- Volunteers
- 3,080 people
- Sponsor
- Merck Sharp & Dohme LLC
LDL Cholesterol
Cardiovascular Risk Prevention With a Mediterranean Dietary Pattern Reduced in Saturated Fat
The Cardiovascular Risk Prevention With a Mediterranean Dietary Pattern Reduced in Saturated Fat (CADIMED) study is a randomized, controlled intervention trial aiming to develop a dietary intervention that promotes saturated fat…
- Trial name
- CADIMED (NCT05778656)
- Testing
- Cardiovascular Risk Prevention with a Mediterranean Dietary Pattern Reduced in Saturated Fat
- Where
- Spain
- Volunteers
- 157 people
- Sponsor
- Universidad de Granada
Cardiovascular Disease
Heart Health Buddies: Peer Support to Decrease CVD Risk
This pilot study will use a hybrid reciprocal peer support and peer coach model to initiate and sustain heart-healthy behavioral changes in Veterans.
- Trial name
- HHB (NCT03646656)
- Testing
- reciprocal peer support and non reciprocal coach support
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- VA Office of Research and Development
Heart Failure, Heart Failure With Reduced Ejection Fraction
AI-ECG for Time-Resolved Prediction of HFrEF
This study aims to develop and validate a deep learning-based electrocardiogram (ECG) model for predicting the future risk of heart failure with reduced ejection fraction (HFrEF).
- Conditions
- Heart Failure, Heart Failure With Reduced Ejection Fraction, Left Ventricular Dysfunction, Cardiac Remodeling
- Trial name
- NCT07519434
- Where
- China
- Volunteers
- 286,709 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Cardiovascular Risk Reduction, Cardiovascular Risk
A Community Cardiovascular Disease Risk Reduction Program in Older Adults Engaged in Congregate Nutrition Services (CAN-DO)
Investigators plan to test the effect of a Cardiovascular disease (CVD) risk reduction program targeted to improve nutrition and self-management of chronic cardiovascular conditions among older adults participating in congregate…
- Trial name
- Can-Do (NCT07168044)
- Testing
- CAN-DO
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Martha Biddle
Stroke, TIA
Reducing Risk of Recurrence
Adults who have had a previous stroke or transient ischemic attack (TIA) remain at risk for having a second serious event, especially if they have uncontrolled blood pressure or cholesterol.
- Conditions
- Stroke, TIA, Hypertension, Hyperlipidemia
- Trial name
- RRR (NCT01122394)
- Testing
- TI, AP
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- VA Office of Research and Development
Atherosclerotic Cardiovascular Disease, Coronary Artery Disease
The Young Heart Study
The purpose of our project is to better understand the characteristics of the young patients with coronary artery disease presenting for cardiac catheterization at our institution and to put forth a program to optimize their risk…
- Trial name
- NCT04462159
- Testing
- Risk Reduction Program
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwell Health
Mild Cognitive Impairment, Alzheimer's Disease
Reducing Risk for Alzheimer's Disease in High-Risk Women Through Yogic Meditation Training
The purpose of this pilot study will be to test whether Kundalini yoga (KY) and Kirtan Kriya (KK) yogic meditation is superior to Memory Enhancement Training (MET) for improving cognitive functioning, health (including…
- Trial name
- NCT03503669
- Testing
- Memory Training, Kundalini yoga and meditation
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of California, Los Angeles
Cardiovascular Risk, Cardiovascular Disease Prevention
Digital Prevention Program With Telephonic Coaching
This study evaluates a digital health prevention program combining digital tools and structured telephonic coaching to support adult participants in improving health-related behaviors and well-being.
- Conditions
- Cardiovascular Risk, Cardiovascular Disease Prevention, Health Behavior Change, Lifestyle (Sedentary Behavior and Physical Activity)
- Trial name
- NCT07393646
- Testing
- Digital Health Platform, Telephonic Coaching
- Where
- France
- Volunteers
- 2,688 people, healthy volunteers welcome
- Sponsor
- Vivoptim Solutions
Cardiovascular Risk Factor
Pharmacist Enhanced Service for Cardiovascular Risk Reduction
Pharmacist services such as medication review, counselling and treatment adherence clinics can improve clinical, health related quality of life and economic outcomes.
- Trial name
- NCT04220788
- Testing
- Enhanced pharmacist service, Usual care
- Where
- Malaysia
- Sponsor
- Monash University
AKI, CHD - Congenital Heart Disease
NO During CPB in Neonates to Reduce Risk of AKI
Acute kidney injury (AKI) following cardiac surgery for congenital heart defects (CHD) in children affects up to 60% of high risk-patients and is a major cause of both short- and long-term morbidity and mortality.
- Conditions
- AKI, CHD - Congenital Heart Disease, Surgery
- Trial name
- NCT04216927
- Testing
- Nitric Oxide, Oxygen
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cardiovascular Diseases, Lifestyle Risk Reduction
Effects of 9-18 Weeks of Intensive Cardiac Rehabilitation After a Major Cardiovascular Event in Patients With CVD
Implement an intensive cardiac rehabilitation program at Arkansas Heart Hospital (AHH) to find out if the AHH-ICR is equivalent to the CMS approved programs when it comes to results.
- Trial name
- AHH-ICR (NCT05708313)
- Testing
- lifestyle modification
- Where
- United States
- Volunteers
- 198 people
- Sponsor
- Arkansas Heart Hospital