Clinical trials: Cardiovascular Diseases Risk
Resistant Hypertension, Primary Aldosteronism
Prospective Study on Primary Aldosteronism in Resistant Hypertension
Prevalence of primary aldosteronism (PA) in resistant hypertension is not clear. In addition, emerging evidence supports the role of elevated serum aldosterone in promoting cardiovascular disease, independently from high blood…
- Conditions
- Resistant Hypertension, Primary Aldosteronism, Refractory Hypertension, Hypertensive End-Organ Damage
- Trial name
- PrePARe (NCT04213963)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Turin, Italy
Cardiac Disease, High Risk Sex
The Effects of Individualized Oxygen Dynamic on Prognosis of Patients With High-risk Cardiac Surgery
Anesthesia-related factors have been linked to poor perioperative outcomes. Our observational study suggested that the cumulative duration of a triple-low state [intraoperative low mean arterial pressure (MAP), low bispectral…
- Trial name
- NCT03103633
- Testing
- mean artery pressure, bispectral index, Brain oxygen saturation
- Where
- China
- Volunteers
- 286 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Diabetes Mellitus, Periodontal Diseases
Periodontitis as Signal for an Underlying Disease
This study investigates the differences between subjects with and without periodontitis in: the prevalence of (pre)diabetes mellitus, the risk of atherosclerotic cardiovascular disease, the prevalence of metabolic syndrome and…
- Conditions
- Diabetes Mellitus, Periodontal Diseases, Cardiovascular Diseases, Obstructive Sleep Apnea Syndrome
- Trial name
- PACMEL (NCT03459638)
- Testing
- Screening for DM, ASCVD, MetS and OSAS
- Where
- Netherlands
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Academic Centre for Dentistry in Amsterdam
Chronic Renal Insufficiency, Disorder Related to Renal Transplantation
Bone and Cardiovascular Disease After Kidney Transplant
Bone disorder is a significant problem in chronic kidney disease (CKD), becoming almost universal in stage 5 CKD patients. Besides the healthcare costs, bone disorder is associated with life-threatening complications, including…
- Conditions
- Chronic Renal Insufficiency, Disorder Related to Renal Transplantation, Metabolic Bone Diseases, Vascular Disease
- Trial name
- NCT02751099
- Testing
- transplanted patients
- Where
- Portugal
- Volunteers
- 80 people
- Sponsor
- Centro Hospitalar de Lisboa Central
ISS Stage III Plasma Cell Myeloma, Multiple Myeloma
Combination Treatment Therapy Approaches for the Treatment of High-Risk Multiple Myeloma, REACH Trial
This phase II trial test whether combination chemotherapy works to improve blood test results in patients with high-risk multiple myeloma.
- Trial name
- NCT05497804
- Testing
- Bone Marrow Aspiration and Biopsy, Carfilzomib, Computed Tomography
- Where
- 3 sites in United States
- Volunteers
- 17 people
- Sponsor
- Mayo Clinic
Percutaneous Coronary Intervention, High Bleeding Risk
Bivalirudin Versus Heparin During PCI in High Bleeding Risk Patients With Acute Coronary Syndromes
Background. Randomized data on the optimal parenteral anticoagulant during percutaneous coronary intervention (PCI) in high bleeding risk (HBR) patients with acute coronary syndromes (ACS) are lacking. Methods.
- Conditions
- Percutaneous Coronary Intervention, High Bleeding Risk, Acute Coronary Syndromes, Anticoagulant Therapy
- Trial name
- BRIGHT-HBR (NCT07383155)
- Testing
- Anticoagulant Therapy
- Volunteers
- 5,270 people
- Sponsor
- Shenyang Northern Hospital
Type 1 Diabetes Mellitus
Using Wearable Sensors To Understand Low Blood Sugar in Type 1 Diabetes
This is a single-site study using wearable sensor technology (CGM and smartwatch) to better explain low blood sugars in patients living with type 1 diabetes.
- Trial name
- Wear WOLF (NCT06727071)
- Testing
- Hyperglycemic clamp
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Diego
Coronary Artery Disease, Hypertriglyceridemia
Efficacy of LCQ908 on Cardiovascular Risk
This is a study designed to evaluate the potential for the pradigastat (LCQ908) to impact cardiovascular risk.
- Trial name
- NCT01474434
- Testing
- pradigastat (LCQ908)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Novartis Pharmaceuticals
Carotid Artery Stenosis
Comparison of Staged Angioplasty and Routine Single-stage Stenting (CAS) in the Treatment of Carotid Artery Stenosis
The purpose of this study is to evaluate the efficacy and safety of staged carotid angioplasty v.s. routine single-stage carotid artery stenting in Chinese patients with carotid artery stenosis at high hyperperfusion risk in…
- Trial name
- STEP (NCT02224209)
- Testing
- Abbott EPD systems (Accunet/Emboshield), a balloon, stent, a balloon, stent
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Beijing Tiantan Hospital
Hypotension
PeRsonalized Blood prEssure Management on Postoperative Complications and Mortality in hIgh-risk Patients Undergoing Major Non-cardiac Surgery
High-risk populations, particularly elderly individuals and patients with cardiovascular comorbidities, exhibit markedly elevated incidences of postoperative myocardial injury (MINS), acute kidney injury (AKI), and mortality.
- Trial name
- PREMIUM (NCT06952387)
- Testing
- Personalized blood pressure management, Routine blood pressure management
- Where
- 7 sites in China
- Volunteers
- 1,624 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Diabetes and Risk of Diabetic Foot Ulcer
Pressure and Diabetic Foot
Diabetic foot ulcer (DFU) is a worldwide burden in the management of patients with diabetes. Peripheral neuropathy has a key role in the physiopathology of DFU.
- Trial name
- PIV & MPP (NCT03213093)
- Testing
- Measure of cutaneous microcirculation
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Venous Thromboembolism
RIVET - Retrospective Cohort Study on the Risk of Venous Thromboembolism
The risk of venous thromboembolism (VTE) associated with the use of chlormadinone acetate (CMA) compared to the gold-standard progestin levonorgestrel (LNG) as component of combined oral contraceptives (COC) is currently unknown.
- Trial name
- RIVET-RCS (NCT02828904)
- Where
- Germany
- Volunteers
- 124,000 people, healthy volunteers welcome
- Sponsor
- Center for Epidemiology and Health Research, Germany
Cardiovascular Diseases, Myocardial Infarction
Effect of Drug Therapy on Reinfarction Risk in Women
To evaluate the safety of calcium-channel blockers in the secondary prevention of myocardial infarction in women.
- Conditions
- Cardiovascular Diseases, Myocardial Infarction, Heart Diseases
- Trial name
- NCT00005389
- Sponsor
- University of Washington
Psoriasis, Cardiovascular Diseases
Prevalence and Risk Factors asSOciated With CArdiac comorbiDIty in psoriAsis
In a prospective cohort study (n = 1.000), the investigators aim to investigate the correlation between cardiac biomarkers and advanced echocardiography and determine whether these are prognostic markers of heart disease in…
- Conditions
- Psoriasis, Cardiovascular Diseases, Cardiovascular Risk Factor, Cardiovascular Pathology
- Trial name
- PSOCADIA (NCT04950218)
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- Herlev and Gentofte Hospital
Behavior Change Interventions, Cardiovascular Diseases
Primary Care - Prescribing Lifestyle Adjustments for Cardiovascular Health
Prescribing lifestyle changes to patients who are at risk of cardiovascular disease, may be an extremely cost effective mechanism of improving health for the individual themselves and the NHS.
- Conditions
- Behavior Change Interventions, Cardiovascular Diseases, Cardiovascular Risk Factor, Behavior, Health
- Trial name
- P-PLAC 2 (NCT04113213)
- Testing
- Lifestyle Prescription (LRx)
- Where
- United Kingdom
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of South Wales
Atrial Fibrillation
Benefit-Risk Of Arterial THrombotic prEvention With Rivaroxaban for Atrial Fibrillation in France
The purpose of the study is to compare the one-year and two-year risk of each of the following individual outcomes: Stroke and systemic embolism (SE), major bleeding and death between new users of anticoagulant for Stroke…
- Trial name
- BROTHER (NCT02864758)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939), Vitamin K antagonists, dabigatran (Pradaxa)
- Where
- France
- Volunteers
- 99,999 people
- Sponsor
- Bayer
Cardiac Rupture
Clinical Risk Score Predicting the Cardiac Rupture in Patients With ST-elevation Myocardial Infarction
The purpose of this study is to validate a practical risk score to predict the mechanical complication of ST-elevation myocardial infarction (STEMI).
- Trial name
- NCT02484326
- Testing
- Grouping by different risk stratification
- Where
- China
- Volunteers
- 3,779 people
- Sponsor
- Chinese PLA General Hospital
Atherosclerosis, Cardiovascular Risk Factor
Early Vascular Ageing in the YOUth
This is a single-center observational study on adolescents to determine predictors of the early steps of the formation of atherosclerosis and to quantify their influence on Intima-Media-Thickness of the carotid artery and the…
- Conditions
- Atherosclerosis, Cardiovascular Risk Factor, Cardiovascular Diseases, Cardiovascular Pathology
- Trial name
- EVA4YOU (NCT04598685)
- Where
- Austria
- Volunteers
- 1,517 people, healthy volunteers welcome
- Sponsor
- VASCage GmbH
Cardiovascular Diseases, Heart Diseases
Risk Factors for CV Disease in a Dialysis Cohort
To investigate whether traditional risk factors and novel risk factors predict higher risk of atherosclerotic cardiovascular disease (ASCVD) in a prospective study of incident dialysis patients.
- Conditions
- Cardiovascular Diseases, Heart Diseases, Atherosclerosis, Kidney Failure, Chronic
- Trial name
- NCT00006297
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Anxiety, Depression
REmote Web Assisted Care for Heart Failure Patients With Implantable Cardioverter Defibrillators
Aim and Background: Although implantable cardioverter defibrillators (ICD) save lives, many ICD-patients experience psychosocial complications such as anxiety disorders, depression and reduced quality of life after…
- Conditions
- Anxiety, Depression, Quality of Life
- Trial name
- REACH-ICD (NCT01589913)
- Testing
- ICD-Forum
- Where
- 7 sites in Germany
- Volunteers
- 118 people
- Sponsor
- Wuerzburg University Hospital
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