Clinical trials: Cardiovascular Diseases Risk
Cardiovascular Diseases, Cardiovascular Risk Factor
The Effect of Endothelin and L-Arginine on Racial Differences in Vasoconstriction
The goal of the study is to examine the possible mechanisms of impaired cutaneous microvascular function through local heating along with administration of vasoconstrictors.
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Vasoconstriction
- Trial name
- NCT03679780
- Testing
- BQ-788, BQ-123, L-Arginine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Pulmonary Embolism
Novel α2-Antiplasmin Inactivation for Lysis of Intravascular Thrombi (NAIL-IT) Trial
Phase II trial of TS23
- Trial name
- NAIL-IT (NCT05408546)
- Testing
- TS23
- Where
- 13 sites in United States
- Volunteers
- 64 people
- Sponsor
- Translational Sciences, Inc.
Vascular Risk, Aging Disorder
Aging of the Vascular Wall
Demographic aging is predicted to be one of the most significant social changes of the 21st century. Aging is a slow, multifactorial process that progressively impacts the integrity of cells, tissues, and organs.
- Trial name
- VITAL (NCT07122427)
- Testing
- Graft collection
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Acute Coronary Syndrome
Canadian Ticagrelor Survey
This study is designed to evaluate the effectiveness of the current ticagrelor risk minimisation strategy in Canada through a prescriber knowledge and understanding (KAU) survey of selected important identified safety concerns…
- Trial name
- NCT01757483
- Where
- Canada
- Volunteers
- 244 people
- Sponsor
- AstraZeneca
Renal Cell Carcinoma (Kidney Cancer), Kidney Cancers
Targeted Abdominal CT in Conjunction With Lung Cancer Screening
Early detection through screening can improve cancer survival by identifying it when it's most treatable. The NHS now offers Lung Cancer Screening (LCS) assessments to people aged 55-74 who have ever smoked.
- Conditions
- Renal Cell Carcinoma (Kidney Cancer), Kidney Cancers, AAA - Abdominal Aortic Aneurysm, Renal Stones
- Trial name
- TACTICAL1 (NCT07171190)
- Testing
- Lung Cancer Screening Invitation Intervention, Abdominal scan intervention
- Where
- United Kingdom
- Volunteers
- 6,272 people, healthy volunteers welcome
- Sponsor
- University of Cambridge
Coronary Artery Disease
Bioflow-DAPT Study
BIOFLOW-DAPT is a prospective, multi-center, international, two-arm randomized controlled clinical study. A total of 1'948 subjects will be randomized 1:1 to receive either Orsiro Mission or Resolute Onyx.
- Trial name
- NCT04137510
- Testing
- Percutaneous coronary intervention
- Where
- 53 sites in Australia, Austria and 16 more
- Volunteers
- 1,948 people
- Sponsor
- Biotronik AG
Hypertension, Diabetes Mellitus Type 2
County Medical Community-based, Cardiovascular Risk Stratified Integrated Care Model: a Pragmatic Cluster Randomised Control Trial
The goal of this cluster randomized trial is to evaluate the effectiveness of the RISIMA model based on an integrated county healthcare consortium implemented by multi-level family health teams (FHTs)on patients with diabetes…
- Conditions
- Hypertension, Diabetes Mellitus Type 2, Cardiovascular Diseases
- Trial name
- C-RISIMA (NCT06302127)
- Testing
- Team-based care, Risk-stratified care pathway, Strengthened health education
- Where
- 3 sites in China
- Volunteers
- 2,560 people
- Sponsor
- Peking University
Mitral Regurgitation
Cardiovalve Transfemoral System - FIM Study
The Cardiovalve system is a replacement valve delivered through a transfemoral access and transseptal approach and is intended for symptomatic patients with Mitral regurgitation for whom surgical options are not feasible.
- Trial name
- NCT03958773
- Testing
- Cardiovalve transfemoral Mitral valve system
- Where
- Lithuania
- Volunteers
- 10 people
- Sponsor
- Cardiovalve Ltd.
Extracorporeal Membrane Oxygenation Complication, Hemorrhage
Platelets and Extracorporeal Membrane Oxygenation Veno-venous
In severe lung or heart disease, ExtraCorporeal Membrane Oxygenation (ECMO) may be used temporarily and can be responsible for major haemorrhagic complications. Thrombocytopenia and possibly thrombopathy promote bleeding.
- Conditions
- Extracorporeal Membrane Oxygenation Complication, Hemorrhage, Blood Platelet Disorder, Thrombosis
- Trial name
- PLAT-VV-ECMO (NCT07580469)
- Testing
- blood draws
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Toulouse
Inflammatory Arthritis, Cardiovascular Risk Factor
Pharmacist CVD Intervention for Patients With Inflammatory Arthritis
Cardiovascular disease (CVD) (disease of the heart and blood vessels) is one of the leading causes of death and disability in Canada today. The majority of CVD cases are caused by factors that can be controlled.
- Conditions
- Inflammatory Arthritis, Cardiovascular Risk Factor, Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- RxIALTA (NCT03152396)
- Testing
- CV risk assessment and modification of global risk
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Epidemiology Coordinating and Research Centre, Canada
Hypertension, Atherosclerotic Cardiovascular Disease
Polygenic Risk Score Implementation and Stratification for Managing Blood Pressure
In a multi-ethnic population, a genome-wide polygenic risk score (PRS) for systolic blood pressure (SBP), incorporating over one million common genetic variants, predicts blood pressure (BP) traits and the risk of adverse…
- Trial name
- PRISM-BP (NCT06962488)
- Testing
- Regular Care, SBP PRS Dissemination
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Alabama at Birmingham
Cardiovascular (CV) Risk
Cardiometabolic Effects of Low-Fat and Full-Fat Dairy
The purpose of this study is to find out if full-fat dairy and low-fat dairy have similar effects on risk factors for heart disease and diabetes.
- Trial name
- NCT07605442
- Testing
- Full-fat dairy, Low-fat dairy
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Penn State University
Diabetes, Weight Gain
The GlasVEGAS Study (Glasgow Visceral & Ectopic Fat With Weight Gain in South AsianS)
South Asians have a much higher risk of diabetes compared to Europeans and investigators don't know why this is. Investigators think that South Asians' capacity to store fat safely under the skin is lower than Europeans, so they…
- Conditions
- Diabetes, Weight Gain, Weight Loss, Cardiovascular Disease
- Trial name
- GlasVEGAS (NCT02399423)
- Testing
- Weight gain, Weight loss
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Hypertension
Renal Denervation for Uncontrolled Hypertension
This is a study investigating the safety and usefulness of the Renal Denervation Procedure in reducing high blood pressure in people whose blood pressure is not adequately controlled despite already being treated with 2 blood…
- Trial name
- RDNP-2012-02 (NCT02016573)
- Testing
- Renal Denervation
- Sponsor
- Baker Heart and Diabetes Institute
Nutrition, Diet Modification
Validation of a Diet Risk Screening Tool
Cardiovascular disease (CVD) is responsible for 1 in 4 deaths in the US annually. Nutrition is an important part of prevention and management of CVD and other chronic diseases, but only about 25% of patients with a chronic…
- Conditions
- Nutrition, Diet Modification, Preventive Medicine, Cardiovascular Diseases
- Trial name
- DRS (NCT03805373)
- Testing
- Diet Assessment Survey
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Penn State University
Congenital Hypothyroidism
Influence of Initial Levothyroxine Dose on Neurodevelopmental and Growth Outcomes in Congenital Hypothyroidism
The primary objective of this study is to evaluate the risk-benefit profile of long-term treatment of two different initials treatment schemes with L-T4 on the neurodevelopmental and auxological outcomes in children with…
- Trial name
- NCT05371262
- Testing
- Levothyroxin
- Volunteers
- 72 people
- Sponsor
- Federico II University
Leukemia, Lymphoma
Interleukin-2 Following Bone Marrow Transplantation in Treating Patients With Hematologic Cancer
RATIONALE: Interleukin-2 may stimulate a person's white blood cells to kill cancer cells. PURPOSE: Phase I trial to study the effectiveness of interleukin-2 following bone marrow transplantation in treating patients who have…
- Conditions
- Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00003962
- Testing
- aldesleukin
- Where
- United States
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Coronary Artery Disease, Atherosclerosis
Measuring Athlete's Risk of Cardiovascular Events 3 (MARC-3)
Regular endurance exercise is widely known to improve cardiovascular health and reduce the risk of heart disease. Yet several imaging studies have shown that male endurance athletes have a higher prevalence of coronary artery…
- Trial name
- MARC-3 (NCT07625488)
- Where
- 2 sites in Netherlands
- Volunteers
- 250 people
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease, Non-Obstructive Coronary Atherosclerosis
VIsualization of Coronary Artery Disease for Modification of RISK Factors
The VICAD-RISK study assesses if visualization of coronary CT angiography (CTA) images in participants with non-obstructive coronary artery disease will improve LDL lowering, reduce reporting of side effects by cholesterol…
- Trial name
- VICAD-RISK (NCT06413641)
- Testing
- Follow up at general practice, Consultation, Visualization of CTA images
- Where
- 5 sites in Denmark
- Volunteers
- 273 people
- Sponsor
- Aarhus University Hospital
Acute Coronary Syndrome, Bleeding
The Risk of Major Bleeding With Novel Anti-platelets: A Comparison of Ticagrelor With Clopidogrel in a Real World Population of 5000 Patients Treated for Acute Coronary Syndrome
A retrospective real world analysis of bleeding events with ticagrelor compared to clopidogrel in ACS patients.
- Conditions
- Acute Coronary Syndrome, Bleeding, Novel Anti-platelets, Ticagrelor
- Trial name
- ROBOT-ACS (NCT02484924)
- Testing
- Ticagrelor
- Where
- United Kingdom
- Volunteers
- 5,225 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
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