Clinical trials: Cardiovascular Disorder
Diabetes Mellitus, Diabetic Retinopathy
A Systematic Study of Retinal Structure and Function in Diabetic Macular Oedema
Diabetic retinopathy(DR) is a sight threatening condition that occurs in persons with diabetes. DR arises as a consequence of damage to the retinal blood vessels and is related to the high and fluctuating sugar levels in the…
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Diabetic Macular Edema
- Trial name
- NCT02876393
- Where
- United Kingdom
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Queen's University, Belfast
Sudden Cardiac Death, Implantable Defibrillator User
Implantable Cardioverter Defibrillators - Improving Risk Stratification
Worldwide three million people a year die from sudden cardiac death (SCD). In most cases there is no warning and the heart is stopped by a sudden arrhythmia.
- Conditions
- Sudden Cardiac Death, Implantable Defibrillator User, Myocardial Infarction, Arrhythmias, Cardiac
- Trial name
- ICD-IRS (NCT01944514)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Peripheral Arterial Disease, Diabetes Mellitus
SPECT/CT Imaging of Skeletal Muscle Perfusion
This study will use SPECT/CT imaging to assess the effect of percutaneous revascularization treatments in patients with Peripheral arterial disease and diabetes mellitus, in whom the disease can progress more quickly than in…
- Trial name
- NCT02791204
- Testing
- SPECT/CT imaging following revascularization procedures, SPECT/CT imaging
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Yale University
Diabetic Retinopathy
Vascular Remodeling and the Effects of Angiogenic Inhibition in Diabetic Retinopathy
The retinal vasculature changes dramatically in patients with diabetic retinopathy especially between non-proliferative and proliferative disease. The retinal vasculature can be imaged and quantified using special dyes.
- Trial name
- NCT00411333
- Testing
- triamcinolone acetonide (Kenalog)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Eye Institute (NEI)
Arrhythmias, Cardiac
Effect of Monitoring System Design on Response Time to Cardiac Arrhythmias
To increase the potential for timely detection and treatment of cardiac events, hospitals have implemented a number of different cardio-respiratory monitoring methods for at-risk patients.
- Trial name
- NCT02466633
- Testing
- In-hospital cardiac monitoring method
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Duke University
Pre-Eclampsia, Eclampsia
Catestatin and Hypertension in Pregnancy
Catestatin is a kind of protein involved with cardiovascular disease. Accumulated evidence shows that Catestatin may be a predictor of primary hypertension, but whether it plays the same role in pregnant hypertensive disorders…
- Conditions
- Pre-Eclampsia, Eclampsia, Hypertension, Pregnancy-Induced, Hypertension in Pregnancy
- Trial name
- NCT03200743
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Yuchen Pan
Diabetic Foot Ulcers
Omeza Products in Combination With Standard of Care for the Treatment of Diabetic Foot Ulcers
This study is to evaluate the efficacy of OCM™ used in combination with off-loading devices for the treatment of diabetic foot ulcers.
- Trial name
- NCT05417425
- Testing
- Omeza collagen matrix, Omeza lidocaine lavage, Omeza skin protectant
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Omeza, LLC
Rheumatoid Arthritis
RHYTHM (Formerly Escape II Myocardium)
For aim 1, the proposed studies will be performed in 150 patients with RA and 25 subjects without RA (healthy volunteers) who will function as controls.
- Trial name
- RHYTHM (NCT01548768)
- Testing
- TNF inhibitors, DMARDs
- Where
- United States
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Columbia University
Deep Venous Thrombosis
Doppler Ultrasound Imaging of Plastic Surgery Patients for DVT Detection
This prospective controlled study examines the use of Doppler ultrasound as a means to screen elective plastic surgery patients for the presence of deep venous blood clots both before and after surgery.
- Trial name
- NCT02123550
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Swanson Center
Severe Cardiomyopathy, Angina, Unstable
Hemodynamics During the Soccer Championship 2012
The purpose of this study is to determine in soccer fans whether and to which extend positive or negative emotions during the European soccer Championship affects Central Hemodynamics, Arterial Stiffness, Heartrate and…
- Conditions
- Severe Cardiomyopathy, Angina, Unstable, Myocardial Infarction, Angina, Stable
- Trial name
- NCT01617863
- Where
- 4 sites in Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Obesity
Macronutrient Relations and Weight Loss in Obese Subjects
The burden of overweight and obesity has dramatically increased during the last decades. High carbohydrate intake, particularly refined carbohydrates, probably increase the risk of obesity, type 2 diabetes, and metabolic…
- Trial name
- NCT00868387
- Testing
- energy-restricted, CHO-restricted diet, energy-restricted, CHO-rich diet
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Pulmonary Hypertension
Development of an Algorithm to Detect Pulmonary Hypertension Using an Electronic Stethoscope
The major goal of the study is to determine whether phonocardiography (using the Eko DUO stethoscope which can capture a three lead ECG reading) can present features that relate to the presence of PH diagnosed by echocardiography…
- Trial name
- NCT05873387
- Testing
- Use of Eko DUO stethoscope (paired ECG/PCG)
- Where
- 3 sites in United States
- Volunteers
- 2,420 people, healthy volunteers welcome
- Sponsor
- Eko Devices, Inc.
Cardiovascular Diseases
A First-in-human Study of YN001 in Healthy Volunteers
This will be a single center, randomized, double-blind, placebo-controlled, single ascending dose and multiple ascending dose study in healthy adult subjects.
- Trial name
- NCT05635084
- Testing
- YN001
- Where
- Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Beijing Inno Medicine Co., Ltd.
Coronary Artery Disease, Coronary Disease
The Effect of Hand Reflexology on Anxiety and Vital Signs With Angiography
This study was planned to determine the effect of hand reflexology on anxiety and vital signs in patients undergoing coronary angiography.
- Trial name
- NCT04956055
- Testing
- Reflexology
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marmara University
Atrial Fibrillation
Imaging-based, Non-invasive Diagnosis of Persistent Atrial Fibrillation
The main objective of the present project is to develop an imaging-based tool to determine the origin and cause of persistent atrial fibrillation (AF).
- Trial name
- imATFIB (NCT03584126)
- Testing
- Electrocardiography, ecocardiography and MRI.
- Where
- Romania
- Volunteers
- 123 people, healthy volunteers welcome
- Sponsor
- County Clinical Emergency Hospital Cluj-Napoca
Takotsubo Cardiomyopathy
Life-style Interventions for Modulating the Brain Phenotype of Takotsubo Cardiomyopathy
Takotsubo cardiomyopathy presents like a heart attack and is typically triggered by intense emotional or physical stress. Recovery of this condition varies and many patients continue to suffer from symptoms such as fatigue and…
- Trial name
- BREAKOUT (NCT05530135)
- Testing
- Exercise program, Cognitive behavioural therapy, Standard clinical care
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Diabetic Foot
BE Study of Metformin GSK 850mg
A randomized, balanced, open label, crossover, two period, two treatment, two sequence, single dose, oral bioequivalence study under fasting condition.
- Trial name
- BA/BE 198/11 (NCT01710540)
- Testing
- Metformin GSK 850mg, Gluocophage 850mg
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Giant Cell Arteritis (GCA)
Mapping B-cell Biology Across the Cardiovascular Territories of Giant Cell Arteritis: Towards a New Therapeutic Approach (RituxiMAP GCA)
B cells are a component of the immune system which appear be important in causing all forms of cardiovascular disease. Until now, it has not been possible to directly study these cells in living patients (essential to assess…
- Trial name
- RituxiMAP GCA (NCT07269938)
- Testing
- Zirconium Zr 89 labelled rituximab
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Stroke, Cerebro-vascular Accident
Studying Fatigue and Movement After Stroke
The goal of this observational study is to learn how neuromuscular fatigue develops after stroke and how changes in brain activity, muscle activity, and their interaction contribute to reduced motor performance in stroke…
- Conditions
- Stroke, Cerebro-vascular Accident, Ischemia Stroke, Hemorrhage Stroke
- Trial name
- NCT07594938
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Ischemic Stroke
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LWP779 in Healthy Participants
This study is a randomized, double-blind, placebo-controlled clinical trial featuring both single ascending dose (SAD), food effect and multiple ascending dose (MAD) phases intended to evaluate the safety, tolerability, PK, PD…
- Trial name
- NCT07371455
- Testing
- LWP779
- Where
- Australia
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Longwood Pharmaceuticals (Hangzhou) Co., Ltd.
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