Clinical trials: Cardiovascular Disorders
Reperfusion Injury
Remote Ischaemic PreConditioning (RIPC) in Partial Nephrectomy for the Prevention of Ischemia/Reperfusion Injury
"Remote Ischaemic PreConditioning" (RIPC) is performed prior to partial nephrectomy. Postoperative calprotectin dynamics and Blood Oxygen-Level-Dependent (BOLD) MRI are used to to demonstrate the potential renoprotective effect…
- Trial name
- NCT03068689
- Testing
- RIPC
- Where
- Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Psychological Stress, Anxiety
NeuroFinance Human Stress Trial During Financial and Informational Volatility
The NeuroFinance Human Stress Trial (NFHST-2026-001) is a decentralized observational clinical study designed to evaluate how financial market volatility, economic uncertainty, digital media exposure, and information-driven…
- Conditions
- Psychological Stress, Anxiety, Emotional Stress, Autonomic Nervous System Dysfunction
- Trial name
- NFHST (NCT07622589)
- Testing
- Wearable Physiologic Monitoring Platform
- Where
- United States
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Acute Decompensated Heart Failure, Congestive Heart Failure Compensated
Role of USCOM in Adult Patients With Heart Failure
Objective: The Ultrasonic Cardiac Output Monitor (USCOM) is a non-invasive, quantitative method for measuring and monitoring cardiovascular haemodynamic parameters in patients. The aims of this study are: 1.
- Trial name
- NCT02289508
- Testing
- Ultrasonic cardiac output monitor, Echocardiography
- Where
- China
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Arthritis, Vasculitis
Interferon-lambda: Novel Biologics for Controlling Neutrophil-mediated Pathology in Rheumatic Diseases?
Neutrophils emerge as key immune cells in the initiation and perpetuation of immune responses in autoimmune diseases. They display marked abnormalities in phenotype and function in various autoimmune diseases, including systemic…
- Trial name
- ILAND (NCT02498808)
- Where
- United Kingdom
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Liver Fibrosis, Heart Failure
Non-invasive Assessment of Liver Stiffness/Fibrosis by Transient Elastography (Fibroscan) in Patients With Left and/or Right Sided Heart Failure
This study will involve 70 patients who attend the Alfred Hospital with acute or chronic heart failure as well as 30 age and gender matched control subjects.
- Trial name
- NCT00777725
- Testing
- FibroScan
- Where
- Australia
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Monash University
Stroke
Instrumental Gait Analysis on People With Stroke After Rehabilitation With a Synchronized FES and Cycle Ergometer System
Functional electrical stimulation is a modality of motor rehabilitation that consists of the programmed application of bursts of electrical current to the affected neuromuscular region that aims to improve muscle strength…
- Trial name
- NCT04473391
- Testing
- Cycle-ergometer training assisted by FES for lower extremities
- Where
- Chile
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Corporación de Rehabilitación Club de Leones Cruz del Sur
Myocardial Infarction
Complete Lesion Versus Culprit Lesion Revascularization
To investigate the clinical outcomes of acute myocardial infarction (AMI) patients with multivessel disease undergoing percutaneous coronary intervention (PCI) either in infarct-related artery only or in multivessel in Drug…
- Trial name
- COCUA (NCT01180218)
- Testing
- complete revascularization, Culprit revasularization
- Where
- South Korea
- Volunteers
- healthy volunteers welcome
- Sponsor
- Korea University Guro Hospital
Heart Failure, Sarcopenia
Mechanism of Sarcopenia in Heart Failure
The aim of the study is to provide information on the interaction between socioeconomic factors, daily physical activity, nutrition and lifestyle on loss of muscle mass and muscle function in patients with heart failure.
- Conditions
- Heart Failure, Sarcopenia, Cachexia
- Trial name
- MUSCLE-CHF (NCT05063955)
- Where
- Denmark
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Cardiovascular Diseases, Fracture
Prevalence and Risk Factors for Common Diseases
By using national databases in Sweden the aim of the present project is to: 1. Investigate if the incidence of our most common diseases, such as fracture and cardiovascular disease, has changed from 1970-2017 2.
- Conditions
- Cardiovascular Diseases, Fracture, Cancer
- Trial name
- NCT04091035
- Testing
- To describe the incidence of disease and evaluate risk factors
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Anna Nordström
MELAS, LHON
A Dose-escalating Clinical Trial With KH176
Mitochondrial Diseases are rare progressive, multi-system, often early fatal disorders affecting both children and adults. KH176 is a novel chemical entity currently under development for the treatment of inherited mitochondrial…
- Conditions
- MELAS, LHON, Leigh Syndrome, Mitochondrial Disease
- Trial name
- NCT02544217
- Testing
- KH176
- Where
- Belgium
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Khondrion BV
Typical Atrial Flutter, Risk Factors With Future Development of Atrial Flutter
Pulmonary Vein Isolation To Reduce Future Risk Of Atrial Fibrillation In Patients Undergoing Typical Flutter
The purpose is to compare long term occurrence of atrial arrhythmias including atrial fibrillation (AF) and thromboembolic complications including cerebrovascular events (CVE) in patients with typical atrial flutter (AFLT)…
- Trial name
- REDUCE AF (NCT01710150)
- Testing
- CTI ablation alone, CTI ablation and Pulmonary vein isolation (PVI)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Rheumatoid Purpura, Pediatric ALL
Validation of the IgA1 Detection Method With Gradient Glycosylation by Mass Spectrometry as a Potential Marker of Renal Involvement in Pediatric Rheumatoid Purpura
In this ancillary study on the FoxTreg cohort, the study investigators will select variables to input and thus develop two models (Linear Discriminant Analysis and Decision Tree).
- Trial name
- FOXIGA-2020 (NCT04655378)
- Testing
- Mass Sepctrometry
- Where
- 2 sites in France
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Arterial Stiffness, Hypertension
Acute Effect of Individual Variants of Agonist-antagonist and Traditional Agonistic Resistance Training on Cardiovascular Parameters
Prevention and non pharmacological treatment of prehypertension and hypertension stage 1 The effect of individual variants of agonist-antagonist and traditional agonistic resistance training on cardiovascular parameters in…
- Conditions
- Arterial Stiffness, Hypertension, Cardiovascular Diseases
- Trial name
- NCT06047678
- Testing
- Cardiovascular fitness
- Where
- 2 sites in Czechia
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Congenital Heart Disease
Antenatal Investigation of Fetuses With Complex Congenital Heart Defects Using multiOMICS
This study will use multiOMICS study on fetuses with complexe congenital heart defects (CHD) to identify etiological epigenetic factors of these cardiac malformations, related to environmental factors during pregnancy.
- Trial name
- CARDIOMICS (NCT06705543)
- Testing
- multi-omics genetic analyses included exome, multi-omics genetic analyses
- Where
- 2 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Coronary Artery Disease
CO2 as a Stress Agent for Perfusion Imaging
Myocardial perfusion imaging (MPI) is a nuclear scan using a radioisotope to see blood flow to the muscles of the heart when the heart is at rest and when it is under stress.
- Trial name
- CO2 STRESS (NCT02043535)
- Testing
- Delivery of precise levels of carbon dioxide with the RA-MR™ Virtual Sequential Gas Delivery System., Delivery of rubidium radioisotope (Rb-82) using the automated pump/elution system
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Stroke
Treatment of Chronic Stroke With IpsiHand
The ultimate goal of this project is to develop a functioning and clinically feasible method for restoring function to motor-impaired stroke survivors. This ultimate goal will be approached through two different means.
- Trial name
- NCT02552368
- Testing
- IpsiHand Device
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Overweight, Healthy Subjects
Measuring the Impact of Dietary Supplementation With a High Fiber, High Antioxidant Aleurone on Biomarkers of Cardiovascular Disease and Gut Microbiota in Adults With High Body Mass Index
Study hypothesis Aleurone-rich food supplementation modifies cardiovascular and metabolic risk profiles and gut microbiota in subjects with high BMI Primary objectives of the trial are to evaluate whether wheat Aleurone-rich food…
- Trial name
- NCT02067026
- Testing
- Aleurone
- Where
- 2 sites in Italy
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Fondazione Edmund Mach
Stroke, Hemiparesis
Sideways Treadmill Training to Improve Paretic Leg Stepping in Persons Post-Stroke
People who are living in the community following a stroke fall frequently. The ability to take a step in response to a balance disturbance helps to prevent falls but stroke survivors tend not to step with their paretic leg in…
- Trial name
- NCT02516176
- Testing
- treadmill training
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Atrial Fibrillation
A.Fib Emergency Department Study Atrial Fibrillation
Patients with a history of atrial fibrillation (AF) who frequently attend the emergency department (ED) with symptoms may not require emergency treatment, and may be more appropriately managed in an alternative outpatient…
- Trial name
- NCT03127085
- Where
- Canada
- Volunteers
- 297 people, healthy volunteers welcome
- Sponsor
- Queen's University
Pulmonary Embolism, Venous Thromboembolism
Rivaroxaban in Elderly Chinese Venous Thromboembolism Patients
There's no unified recommendation in clinical practice regarding adjusting dosages for different patient types, especially when adverse events occur.
- Conditions
- Pulmonary Embolism, Venous Thromboembolism, Anticoagulant-induced Bleeding
- Trial name
- NCT06194617
- Testing
- Direct oral anticoagulant
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
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