Clinical trials: Cardiovascular Disorders
Cardiovascular Diseases
Evaluating the Effect of Neighborhood Environments on Cardiovascular Risk Factors
Cardiovascular disease (CVD) is one of the main causes of death in the United States. Research has shown that individuals who maintain an active lifestyle are less likely to develop CVD.
- Trial name
- NCT00361673
- Where
- 2 sites in United States
- Volunteers
- 1,140 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Aortic Stenosis
Comparison of Evolut FX Versus Sapien 3 Ultra Resilia.
To compare outcome in patients randomized to treatment with Evolut FX versus Sapien 3 Ultra Resilia.
- Trial name
- COMPARE-TAVI (NCT06470022)
- Testing
- Medtronic Evolut FX, Edwards Sapien 3 Ultra Resilia
- Where
- Denmark
- Volunteers
- 1,370 people, healthy volunteers welcome
- Sponsor
- Christian Juhl Terkelsen
Aging, Sarcopenia
A Prospective Cohort Study of Aged People for Chronic Diseases
This study is a hospital-based, prospective cohort study to elucidate the predictive factors including muscle and fat mass for chronic diseases and mortality in elderly persons aged 60 years and older.
- Trial name
- HAPPY (NCT02640872)
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Acute Coronary Syndrome, Angina Pectoris
Diagnostic Performance of Artificial Intelligence Algorithms in Prediction of Acute Coronary Syndrome Based on White Blood Cell Properties
The goal of this observational study is to evaluate whether artificial intelligence (AI) algorithms can predict or exclude acute coronary syndrome (ACS) in adults using data generated by routine hematology testing.
- Conditions
- Acute Coronary Syndrome, Angina Pectoris, NSTEMI - Non-ST Segment Elevation MI, STEMI - ST Elevation Myocardial Infarction
- Trial name
- NCT06384846
- Where
- Austria
- Volunteers
- 3,350 people, healthy volunteers welcome
- Sponsor
- RobotDreams GmbH
Stenoses, Carotid Artery
Selective Versus Routine Shunting in Carotid Endarterectomy Patients
The project involves prospectively randomizing patients to either routine carotid shunting or selective carotid shunting during Carotid endarterectomy (CEA) under general anesthesia (GA) to see the difference in post-op…
- Trial name
- NCT00967486
- Testing
- Carotid endarterectomy with routine shount, Carotid endarterectomy with selective shunt
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- CAMC Health System
Cardiovascular Diseases
In Vitro And Ex Vivo Anti-Inflammatory Activities Of Salmon Polar Lipids
The aim of this project is to study the effects of a new-developed food-supplement that contains bioactive polar lipids derived from organic farmed Irish salmon for the beneficial promotion of cardiovascular health.
- Trial name
- NCT03603769
- Testing
- Food supplement capsules containing Salmon-Polar Lipids
- Where
- Ireland
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Congenital Cardiovascular Malformation
Newborn Screening for Critical Congenital Heart Disease
Previous studies have examined the usefulness of pulse oximetry or oxygen saturation to screen for left-sided cardiac lesions. These studies have shown that the occurrence of critical congenital cardiac malformations among…
- Trial name
- NCT01765205
- Testing
- Pulse Oximetry using the INVOS (In Vivo Optical Spectroscopy) Cerebral/Somatic Oximeter
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Florida
Tricuspid Valve Insufficiency
Behaviour of Tricuspid Valve Regurgitation in Volume and/or Pressure Loaded Right Heart
Right-sided heart disease has an important impact on the prognosis of patients with valvular heart disease. Up to now, Tricuspid Valve Regurgitation (TR) and right heart hemodynamics have not been extensively investigated.
- Trial name
- NCT01444222
- Where
- Belgium
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Autoimmune Diseases, Cardiovascular Disorders
Mesenchymal Stem Cells for the Treatment of Various Chronic and Acute Conditions
This multi-arm, multi-site study investigates the safety, tolerability, and efficacy of stem cell therapy for the treatment of various acute and chronic conditions.
- Conditions
- Autoimmune Diseases, Cardiovascular Disorders, Diabetes Complications, Integumentary Disease
- Trial name
- NCT04684602
- Testing
- PrimePro™/ PrimeMSK™
- Where
- United States
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Thomas Advanced Medical LLC
Venous Thrombosis
A Study of MK-2060 in Healthy Participants (MK-2060-016)
The goal of the study is to learn about the safety of MK-2060 and if people tolerate it when MK-2060 is given in different forms.
- Trial name
- NCT06582602
- Testing
- MK-2060
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Coronary Heart Disease, Myocardial Infarction
Prospective Coronary Heart Disease Cohort
To evaluate the biomarkers for the prognosis of coronary heart disease, patients with coronary heart disease will be recruited and followed up for at least 2 years.
- Trial name
- NCT05699629
- Where
- China
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Shandong First Medical University
Cardiovascular Diseases, Heart Diseases
Evaluating the Effectiveness of a Family Heart Health Educational Program (The FIT-Heart Study)
The primary objective of the FIT Heart Study was to test the effectiveness of a hospital-based standardized screening and educational intervention targeted to family members of patients hospitalized with CVD, to increase…
- Trial name
- FIT-Heart (NCT00728637)
- Testing
- Family Passport to Heart Health Program, General Educational Materials
- Where
- United States
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Columbia University
Coronary Artery Disease, Coronary Microvascular Disease
Whole-Heart Myocardial Blood Flow Quantification Using MRI
This study hopes to provide significant technical improvement in a Myocardial Blood Flow (MBF) cardiac magnetic resonance (CMR) quantification technique to address challenges and technical limitations for MBF CMR.
- Trial name
- NCT03064295
- Testing
- Myocardial Perfusion Cardiac MRI., Contrast, Pharmacologic Stress Agent
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Menopause
Effects of the Concentrated Extract of Soy on Coagulation Factors After Menopause
Hypoestrogenism, common in menopause, is responsible for systemic and metabolic changes affecting women's wellness, favoring hot flashes, urogenital atrophy and bone mass loss.
- Trial name
- NCT00925639
- Testing
- Isoflavone
- Where
- Brazil
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Hyperfibrinolysis, Cesarean Section Complications
The Incidence of Hyperfibrinolysis During Vaginal Delivery and Cesarean Section
This study aims to find out if there are common major changes in coagulation immediately after delivery of the newborn during Cesarean (C) -section and vaginal birth.
- Conditions
- Hyperfibrinolysis, Cesarean Section Complications, Coagulation Defect; Bleeding, Peripartum Haemorrhage
- Trial name
- NCT05975112
- Testing
- Coagulation tests (TEG, Levels of F1, F2, hs-D-dimer, Plasminogen, PAI 1+2), SpHb before discharge
- Where
- Austria
- Volunteers
- 780 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Cardiovascular Disease
The Effects of Peanuts and Peanut Products on Glucose Control and Vascular Function
Pilot study data have demonstrated that peanuts ameliorate the postprandial glucose and insulin response when incorporated into an acute high fat/high glucose meal.
- Trial name
- NCT01405300
- Testing
- Control, Peanut
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Penn State University
Atrial Fibrillation (AF), Obesity & Overweight
Exercise and Dietary Lifestyle Intervention on Reducing Atrial Fibrillation Burden, Cardiac and Body Fat Mass.
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is strongly associated with obesity and excess body fat. Lifestyle interventions, including exercise and dietary modification, may reduce AF burden, but long-term…
- Trial name
- MOVE-AF (NCT07430007)
- Testing
- Tailored Exercise and Dietary Lifestyle Program, Usual Clinical Care
- Where
- 4 sites in Finland
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Hypertension, Blood Pressure
Long-term Accuracy and Stability of Blood Pressure Measurements From a Smartwatch: Prospective Validation Study
The aim of the study is to perform an experimental validation of the long-term accuracy of blood pressure measurement using the Samsung Galaxy Smartwatch
- Trial name
- BPLONG (NCT06098092)
- Testing
- Long-term non-invasive Blood pressure monitoring
- Where
- 2 sites in Czechia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Pulmonary Disease, Pulmonary Hypertension
Natural History Study of Biomarkers in Pulmonary Arterial Hypertension
Background: High blood pressure in the lungs, known as pulmonary arterial hypertension (PAH), is a rare disorder. Some people have disease-associated PAH and some have PAH from an unknown cause.
- Trial name
- NCT01730092
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Type 2 Diabetes Mellitus
Vascular Function and Biomarker Assessments in Healthy Volunteers and in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the vascular function and biomarkers in healthy volunteers and type 2 diabetic patients.
- Trial name
- NCT04744636
- Testing
- Other
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut de Recherches Internationales Servier
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