Clinical trials: Cardiovascular Disorders
Premature Ventricular Contractions
Use of MIBG Scan Images in PVC Ablations
The purpose of this study is to assess if Single Photon Emission Computed Tomography (SPECT) demonstrating cardiac innervation can be integrated into current electrophysiology voltage mapping system and provide improved guidance…
- Trial name
- PVC-MIBG (NCT02279030)
- Testing
- MIBG nuclear scan
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Alzheimer's Disease, Vascular Dementia
MRS and DTI of White Matter in Alzheimer's Disease
The white matter change of the Alzheimer's disease could be studied by diffusion tensor image and MR spectroscopy to see the microstructral and biochemical change.
- Trial name
- NCT00172900
- Where
- Taiwan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Hypertension (HTN), Cardiometabolic Diseases
Genetic Architecture of Natriuretic Peptides and Blood Pressure Response
Natriuretic peptides (NPs) are hormones produced by the heart and play an important role in maintaining cardiovascular health and have favorable metabolic benefits.
- Trial name
- NCT07118592
- Testing
- Low Salt Diet, High Salt Diet, Saline Infusion
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cardiovascular Diseases, Heart Failure
Longitudinal Validation of CIRC Technologies
Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization.
- Conditions
- Cardiovascular Diseases, Heart Failure, Ischemic Heart Disease, Non-ischemic Cardiomyopathy
- Trial name
- NCT07081711
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Peripheral Artery Disease
Improving Mobility in Peripheral Artery Disease Using an Ankle Foot Orthosis
This study will determine whether an ankle foot orthosis (AFO) improves walking performance in participants with PAD from its first use.
- Trial name
- NCT02902211
- Testing
- Ankle foot orthosis, Control/standard of care
- Where
- 2 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
HIV Infection, Cardiovascular Risk
Postprandial Endothelial Dysfunction After a High-Fat Meal in HIV-infected Men
The purpose of this study is to examine the postprandial (anytime after a meal) effect of different dietary fats on endothelial function in HIV-infected and HIV-uninfected men.
- Conditions
- HIV Infection, Cardiovascular Risk, HIV Infections
- Trial name
- PERTH (NCT00846599)
- Testing
- Omega-3 study meal, Saturated fat study meal
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tufts University
Transthyretin Amyloid Cardiomyopathy (ATTR-CM)
Thailand ATTR-CM Registry
The investigators of this registry aim to study the natural history, clinical presentation, characteristics, and imaging findings of patients diagnosed with ATTR amyloidosis in Thailand longitudinally.
- Trial name
- NCT06338696
- Testing
- No intervention
- Where
- 8 sites in Thailand
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Coagulopathy, Congenital Heart Disease
FFP Usage in Pediatric CV Surgery
When small children undergo heart surgery with the heart-lung machine, in the past, blood products to help the blood clot such as Fresh Frozen Plasma (FFP) was routinely used in children under 10kg.
- Trial name
- NCT05819788
- Where
- Canada
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Essential Hypertension
Fimasartan (BR-A-657) Single Oral Dose in Healthy Subjects
The objective of this study is to determine the safety and tolerability and to determine the Pharmacokinetic and Pharmacodynamic (PK/PD) of ascending single oral dose of BR-A-657 in healthy male subjects.
- Trial name
- NCT01289886
- Testing
- BR-A-657
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Hypertension and Dyslipidemia
A Clinical Trial to Evaluate the Tolerability and Pharmacokinetics of CKD-386(2) 80/20/10mg
A Clinical Trial to evaluate the Pharmacokinetics and Tolerability of CKD-386(2)
- Trial name
- NCT04987970
- Testing
- CKD-386(2), D013, D326, D337
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Stroke, Not Specified as Hemorrhage or Infarction, Angina Pectoris
Clinical Study of Medicinal Product Cardionat® Using in Health Athlete Volunteers
The objective of this study is to evaluate the long-term plasma and urine pharmacokinetic parameters of Cardionat®, capsules 250 mg, when used in healthy athlete volunteers. The study consists of four steps: Step 1.
- Trial name
- NCT02758912
- Testing
- оral intake of study drug capsules; study drug - Cardionat ® (trimethylhydrazinium propionate dihydrate), oral capsules 250 mg
- Where
- Russia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Burnasyan Federal Medical Biophysical Center
Obesity, Diabetes
Effect of Pomegranate Extract Intake on Body Composition and Blood Pressure.
Pomegranate has gained widespread popularity since the health effects of the whole fruit, as well as its juices and extracts, have been studied in relation to a variety of chronic conditions such as hypertension, diabetes…
- Conditions
- Obesity, Diabetes, Cardiovascular Disease
- Trial name
- NCT02017132
- Testing
- Pomegranate extract
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Single-ventricle, Fontan Procedure
Hemodynamic, Vascular and Muscular Parameters of Exercise Capacity in Single-Ventricle Patients With Fontan Procedure
After the Fontan procedure applied in patients with a functional or anatomical single ventricle, patients are faced with significant morbidity and mortality risk.
- Conditions
- Single-ventricle, Fontan Procedure, Hemodynamic Instability, Arterial Stiffness
- Trial name
- NCT05011565
- Testing
- Demographic and Clinical Characteristics, Maximal Exercise Capacity, Submaximal Exercise Capacity, Hemodynamic Parameters, Muscle Strength, Muscle Oxygenation, Vascular Function
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Stroke, Cognitive Decline
Biomarkers Related to PSCI: An fNIRS Study
This is an fNIRS study performed to identify biomarkers related to post-stroke cognitive impairment.
- Trial name
- NCT06703307
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dingqun Bai
DM1
Induction of Pluripotent Stem Cells From Human Fibroblasts of DM1 Patients
The objective of the study is the modelisation of human cardiomyocyts from pluripotent stem cells in order to study the cardiac alterations induced by CTG expansions.
- Trial name
- NCT02084407
- Testing
- Clinical examination, skin biopsy, blood and urine sampling
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Institut de Myologie, France
Hypertension in Pregnancy
Treatment of Severe Hypertension With ICG Directed Therapy
The purpose of the study is to compare the usefulness of Impedence Cardiography (ICG) directed therapy in treating severe range hypertension in pregnant women at term.
- Trial name
- NCT04748107
- Testing
- Impendence Cardiography
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Marshall University
Medication Adherence
A BCT Intervention for Medication Adherence Among Individuals on Statins
The purpose of this project is to identify the minimum effective dose (MED) of a multi-component behavioral change intervention required to increase levels of medication adherence among participants on primary prevention statin…
- Trial name
- NCT05273736
- Testing
- 5 Behavioral Change Techniques
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Northwell Health
Paroxysmal Atrial Fibrillation
Atrial Electromechanical Function in Endurance Athletes With and Without Atrial Fibrillation
This study evaluates cardiac structure and function differences between healthy endurance trained athletes with atrial fibrillation and healthy age matched endurance trained athletes without atrial fibrillation.
- Trial name
- NCT03305744
- Where
- Canada
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Chest Pain
Magnetocardiography (MCG) in the Diagnosis of Chest Pain Syndrome
The purpose of this research study is to evaluate a better way of diagnosing heart artery disease, heart attack and damage to the heart muscle early on.
- Trial name
- NCT00572949
- Where
- United States
- Volunteers
- 398 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Stroke, Hemiplegia
Robot-Assisted Stroke Rehabilitation Based on Patient-Therapist Interactions
Our study goal is to assess natural patient-therapist interactions in order to map such human-human activities to robot-human interactions.
- Conditions
- Stroke, Hemiplegia, Healthy
- Trial name
- Baxter (NCT02806843)
- Testing
- Rehab InterCap system and 3D Kinect
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
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