Clinical trials: Cardiovascular Dysfunction
Covid19, Angiogenesis
Endothelial Damage and Angiogenesis Biomarkers During COVID-19
Severe SARS-CoV-2 disease is characterized by a progressive hypoxemic respiratory failure. Autopsies from these patients show severe endothelial damage with extensive vascular thrombosis, microangiopathy, and occlusion of…
- Conditions
- Covid19, Angiogenesis, Endothelial Dysfunction, Cardiovascular Morbidity
- Trial name
- NCT04609332
- Testing
- Endothelial damage and angiogenic biomarkers
- Where
- Chile
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Chile
Preeclampsia
Exosome Cargo From Preeclampsia Patients
Although extensively studied, the cause of preeclampsia remains uncertain other than it is thought that the placenta plays a critical role in the development of preeclampsia.
- Trial name
- NCT04154332
- Testing
- Sample collection
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Obesity
Effects of Weight Loss on Vascular Function in Obese Subjects
To evaluate the effect of weight loss on vascular function in obese with poor cardiovascular health. The investigators will evaluate the effects of weight loss on total and central body adiposity, blood pressure, central…
- Trial name
- NCT04198519
- Testing
- Weight Loss
- Where
- 2 sites in Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mario Fritsch Neves
Ischemia and No Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction
The DISCOVER INOCA Prospective Multi-center Registry
The overall objective of this multi-center registry is to identify specific phenotypes of INOCA with both an anatomic evaluation (coronary angiography and intravascular imaging) and physiologic assessment with the Abbott…
- Conditions
- Ischemia and No Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction, Coronary Vasospasm, Endothelial Dysfunction
- Trial name
- DISCOVER INOCA (NCT05288361)
- Testing
- Coroventis Coroflow Cardiovascular System and PressureWire™ X Guidewire
- Where
- 9 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yale University
Aging, Mortality
Longevity Metrics AI/ML Development Study
This study builds AI models that score diagnostic screening tests, and that predict screening results, clinical judgment, and life expectancy.
- Conditions
- Aging, Mortality, Cardiovascular Disease Prevention, Metabolic Syndrome
- Trial name
- NCT07808619
- Testing
- AIML scored health screening battery
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Longevity Metrics, Inc.
Heart Failure, Congestive
Skeletal Muscle Dysfunction in Heart Failure
Patients suffering from congestive heart failure report reduced exercise capacity. This skeletal muscle dysfunction is also detectable when using small muscle groups which should not put any demand on the heart.
- Trial name
- NCT00156234
- Testing
- One-knee extension ergometer
- Where
- 2 sites in Norway
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Ullevaal University Hospital
Heart Failure, Dilated Cardiomyopathy
Brain Function and Perfusion in Patients With Heart Failure
The investigators will evaluate the determinants of cerebral impairment in patients with non-ischemic heart failure compared to controls, and its relation to cognitive function.
- Conditions
- Heart Failure, Dilated Cardiomyopathy, Perfusion, Cognitive Impairment
- Trial name
- BRAIN-HF (NCT01756014)
- Where
- Netherlands
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Heart Failure, Congenital Heart Defects
Right Ventricular Failure in Congenital Heart Defects
Usually, "heart failure" refers to myocardial insufficiency of the left ventricle. However, in patients with congenital heart defects, often predominantly the right ventricle is affected.
- Trial name
- NCT00266201
- Where
- 9 sites in Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Competence Network for Congenital Heart Defects
Cognitive Impairment, Dementia
Determinants of Cognitive Impairment Among Geriatrics
This study aims to explore the determinants of cognitive impairment among Indonesian geriatrics in an Old Age Home.
- Conditions
- Cognitive Impairment, Dementia, Hearing Impairment, Vision Impairment and Blindness
- Trial name
- NCT03669536
- Where
- Indonesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Tarumanagara University
Erectile Dysfunction
Investigation of Serum Sclerostin Levels in Patients With Erectile Dysfunction
This prospective, observational case-control study aims to investigate the potential role of sclerostin-a molecule associated with cardiovascular pathologies-in the vascular pathogenesis of erectile dysfunction (ED).
- Trial name
- SOST-ED: Serum (NCT07902362)
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Medipol University
Cardiovascular Diseases, Endothelial Dysfunction
Impact of Consuming Plant Sterols on Endothelial Function and Blood Pressure
The purpose of the research is to assess the impact of co-consuming plant sterols-enriched food product as part of a healthy eating pattern diet on endothelial function (brachial artery FMD, vasodilation-related and…
- Conditions
- Cardiovascular Diseases, Endothelial Dysfunction, Metabolic Syndrome, Diet Modification
- Trial name
- NCT03723330
- Testing
- plant sterols, healthy diet
- Where
- Singapore
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Mild Cognitive Impairment, Alzheimer's Disease
The Swedish BioFINDER Study
The present study aims at combining biochemical methods with various types of imaging techniques to identify the pathophysiology of Alzheimer's disease (AD).
- Conditions
- Mild Cognitive Impairment, Alzheimer's Disease, Dementia With Lewy Bodies, Vascular Dementia
- Trial name
- NCT01208675
- Where
- 2 sites in Sweden
- Volunteers
- 1,150 people, healthy volunteers welcome
- Sponsor
- Skane University Hospital
Cerebrovascular Disease, Stroke
Genetic Studies to Identify Stroke Subtypes and Outcome
This study will characterize the gene response of the body's immune and inflammatory cells to stroke. There is a wide variation in stroke risk, stroke outcome, and response to clot-busting therapy for stroke.
- Trial name
- NCT00357513
- Where
- 3 sites in United States
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cardiovascular Diseases, Hypertension
Vascular Dysfunction in Hypertensive Postmenopausal Women
The purpose of this study is to investigate the role of ET-1 in mediating vasoconstrictor tone in hypertensive postmenopausal women (PMW) alone and in combination with a commonly prescribed Angiotensin II (ANG II) antagonist.
- Trial name
- NCT03371823
- Testing
- Normotensive, Hypertensives
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Right Ventricular Dysfunction, Cardiopulmonary Diseases
Right Heart and Lung Blood Flow During Exercise (RIGHT-NET 2.0)
RIGHT-NET 2.0 is a multicenter observational study with a retrospective-prospective design that builds on the original RIGHT-NET study.
- Conditions
- Right Ventricular Dysfunction, Cardiopulmonary Diseases, Pulmonary Hypertension
- Trial name
- RIGHT-NET 2 (NCT07851610)
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- IRCCS SYNLAB SDN
Ischemia Reperfusion Injury, Endothelial Dysfunction
Short Term Statin Treatment and Endothelial Dysfunction Due to Ischemia and Reperfusion Injury
Rationale: Apart from their cholesterol lowering effects, statins have cholesterol-independent pleiotropic actions, such as upregulation of 5'-ectonucleotidase and up-regulation of NO-synthase that may increase tolerance against…
- Trial name
- NCT00987974
- Testing
- rosuvastatin, atorvastatin 3 days, rosuvastatin 7 days
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Atherosclerosis, Cognitive Decline
Advancing Postmenopausal Preventive Therapy
Advancing Postmenopausal Preventive Therapy (APPT) is a randomized, double-blinded, placebo-controlled trial designed to determine the effects of tissue selective estrogen complex (TSEC) therapy on the progression of subclinical…
- Trial name
- APPT (NCT04103476)
- Testing
- Oral bazedoxifene 20 mg / conjugated estrogens 0.45 mg
- Where
- United States
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Exposure to Pollution, Heart Failure
Effects of Air Pollution Exposure Reduction by Filter Mask on Heart Failure
Exposure to air pollution is associated with increase in cardiovascular morbidity and mortality. Controlled human exposure studies have demonstrated impaired vascular function and heart rate variability on healthy volunteers.
- Trial name
- NCT01960920
- Testing
- Filtered diesel exhaust, Unfiltered diesel exhaust, Clean air
- Where
- Brazil
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Telomere Shortening, Aging
TA-65 and Aging Associated Microvascular Dysfunction
The goal of this clinical trial is to test whether activation of telomerase with a dietary supplement (TA-65) improves microvascular function.
- Conditions
- Telomere Shortening, Aging, Vascular Diseases
- Trial name
- NCT05598359
- Testing
- TA-65
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Acute Coronary Syndrome, Acute Coronary Syndrome With Renal Dysfunction
Latent TGF-β-binding Proteins Affect the Fibrotic Process in Renal Impairment and Cardiac Dysfunction
The project is planed to explore the impact of LTBP4 and other matrix protein and potentially related biomarkers on renal outcomes, cardiac outcomes and all-cause mortality in patients with suspected acute coronary syndrome (ACS).
- Trial name
- NCT04998227
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital