Clinical trials: Cardiovascular Dysfunction
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
Diastolic Dysfunction, Hypertension
Simvastatin and Diastolic Dysfunction
Diastolic dysfunction (DD) is an increasingly frequent condition in hypertensive individuals whose treatment remains unclear. Its presence is related to higher morbidity and mortality independent of blood pressure levels.
- Trial name
- NCT01061450
- Testing
- Simvastatin
- Where
- Brazil
- Volunteers
- 55 people
- Sponsor
- Brasilia Heart Study Group
Diastolic Heart Failure
Metoprolol XR in Heart Failure With Normal Ejection Fraction
In contrast to the treatment of HF with reduced EF, information to guide the pharmacological therapy of patients with HFNEF are lacking and there is no evidence based treatment for patients with HFNEF.
- Trial name
- HFNEF (NCT03882710)
- Testing
- Metoprolol XR
- Where
- India
- Volunteers
- 102 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Chronic Heart Failure
Effects of Ivabradine on Cardiovascular Events in Patients With Moderate to Severe Chronic Heart Failure and Left Ventricular Systolic Dysfunction. A Three-year International Multicentre Study
The primary objective of this study is to demonstrate the superiority of ivabradine over placebo in the reduction of cardiovascular mortality or hospitalisation for worsening heart failure in patients with moderate to severe…
- Trial name
- SHIFT (NCT02441218)
- Testing
- Ivabradine
- Where
- 2 sites in France, Sweden
- Volunteers
- 6,505 people
- Sponsor
- Institut de Recherches Internationales Servier
Cardiomyopathy, Renal Impairment
Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Systolic Cardiomyopathy (Aim2)
To determine the effect of 12 weeks of chronic PDEV inhibition with Tadalafil versus placebo on basal cardiorenal and humoral function and on the integrated cardiorenal and humoral response to acute sodium loading in subjects…
- Trial name
- Aim2 (NCT01970176)
- Testing
- Tadalafil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Congestive Heart Failure, Cognitive Impairment
Cognitive Training in Heart Failure Study (CogTrain-HF)
The daily routine in clinical settings often showed cognitive impairments in patients with congestive heart failure, particularly in terms of executive functions, episodic memory, perceptual speed and attention.
- Trial name
- CogTrain-HF (NCT02415517)
- Testing
- Cognitive training, Test of general knowledge
- Where
- 2 sites in Germany
- Volunteers
- 107 people
- Sponsor
- Universität des Saarlandes
Aortic Stenosis, Aortic Valve Disease
Role of Aortic Valve Composition in Pathophysiology and Diagnosis of Aortic Stenosis
The study aims to evaluate composition differences of aortic valves in different stages and phenotypes of aortic stenosis using non-invasive imaging and histology.
- Conditions
- Aortic Stenosis, Aortic Valve Disease, Aortic Valve Calcification
- Trial name
- COMP-AS (NCT06136689)
- Where
- 2 sites in Poland
- Volunteers
- 55 people
- Sponsor
- Medical University of Warsaw
Preeclampsia (PE), Endothelial Dysfunction
Does Nicotine Influence the Risk of Preeclampsia?
This prospective cohort study explores the long-term impact of pre-pregnancy smoking on vascular health in women predisposed to preeclampsia, conducted at the Medical University of Graz.
- Conditions
- Preeclampsia (PE), Endothelial Dysfunction, Hypertension in Pregnancy
- Trial name
- PRE_Smoking (NCT06645340)
- Testing
- This high-risk cohort underwent the same measurements during pregnancy: endothelial function, arterial stiffness, retinal microvasculature profile, measurement of Neprilysin, cotinine, telomere length
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Graz
Hypertension
Amlodipine Versus Valsartan for Improvement of Diastolic Dysfunction Associated With Hypertension
Hypertensive patients are at increased risk of developing LV hypertrophy and myocardial fibrosis, which cause diastolic dysfunction.
- Trial name
- NCT02973035
- Testing
- Amlodipine, Valsartan
- Where
- 4 sites in South Korea
- Volunteers
- 104 people
- Sponsor
- Asan Medical Center
Congestive Heart Failure, LV Dysfunction
Dual Site Left Ventricular (LV) Pacing
The purpose of this study is to compare Dual LV (left ventricular) pacing to standard single LV pacing (BiV pacing) to see if Dual LV pacing: 1. Improves the way the heart's left ventricle functions 2.
- Trial name
- DIVA (NCT00944125)
- Testing
- Dual Site LV Pacing, BiV Pacing
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Wake Forest University Health Sciences
Spinal Cord Injuries, Endothelial Dysfunction
Testosterone Deficiency and Endothelial Dysfunction After Spinal Cord Injury
Heart attacks and strokes are among the most common causes of premature death in individuals living with spinal cord injury (SCI) and appear to occur earlier in life.
- Conditions
- Spinal Cord Injuries, Endothelial Dysfunction, Testosterone Deficiency
- Trial name
- NCT07227740
- Testing
- Intra-arterial Infusion of Vasoactive Agents, Intra-arterial Vitamin C Infusion, Blood Sampling
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Craig Hospital
Acute Kidney Injury, Uremic; Toxemia
Prognostic Role of the Uremic Toxin Indoxyl Sulfate on Vascular and Cardiac Functions During Acute Kidney Injury
Acute kidney injury (AKI) is a frequent disease in conventional hospital departments and in intensive care units. It's associated with a high risk to develop chronic kidney disease (CKD), even after a single small AKI episode.
- Conditions
- Acute Kidney Injury, Uremic; Toxemia, Vascular Dysfunction, Cardiac Dysfunction
- Trial name
- VASC-AKI (NCT05659589)
- Testing
- blood sample
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Atrial Fibrillation, Dementia
PLUG Dementia Trial and MRI PLUG Dementia Sub-Study
PLUG Dementia Trial: Patients will be screened at Intermountain Medical Center and at Intermountain affiliated anticoagulation clinics in the Salt Lake City region.
- Conditions
- Atrial Fibrillation, Dementia, Cognitive Decline
- Trial name
- NCT03091855
- Testing
- Questionnaire, Magnetic Resonance Imaging
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Intermountain Health Care, Inc.
Myocardial Infarction, Acute Coronary Syndrome
Pleiotropic Effects of Dapagliflozin in Patients With Acute Coronary Syndromes
Type 2 diabetes mellitus (T2DM) is one of the most important risk factors for atherosclerotic heart disease. Strategies focused solely on glycemic control have failed to demonstrate vascular events reduction in this population.
- Conditions
- Myocardial Infarction, Acute Coronary Syndrome, Diabetes, Ventricular Dysfunction
- Trial name
- NCT06286878
- Testing
- Dapagliflozin
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- University of Sao Paulo
Heart Failure With Preserved Ejection Fraction, Hypertrophic Cardiomyopathy
Cardiomyopathies and Heart Muscle Diseases: Cardiac Imaging in the Evaluation of Myocardial Fibrosis Transition
Heart scarring, also known as fibrosis, plays a major role in a lot of heart muscle abnormalities. These abnormalities of the heart muscle can lead to major issues such as symptoms of heart failure, dangerous heart rhythm…
- Conditions
- Heart Failure With Preserved Ejection Fraction, Hypertrophic Cardiomyopathy, Cardiac Sarcoidosis, Hypertensive Heart Disease
- Trial name
- CHIEFTain (NCT06409585)
- Testing
- 68Ga-FAPI or 18F-AlF-FAPI cardiac PET-MR, Echocardiogram, Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Aging, Arterial Stiffness
Inorganic Nitrate Supplementation on Cerebrovascular Aging and Arterial Stiffness Study
This study investigates the effect of dietary inorganic nitrate supplementation on 1) large elastic artery stiffness and hemodynamics and 2) cerebrovascular function in middle-aged and older adults.
- Conditions
- Aging, Arterial Stiffness, Endothelial Dysfunction, Hypertension
- Trial name
- INCA (NCT03617302)
- Testing
- Experimental: Nitrate-containing
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce, PhD
Acute Myocardial Infarction
CARISMA : Cardiac Arrhythmias and Risk Stratification After MyoCardial Infarction
The purpose of this study is to assess the incidence of tachy- and bradyarrhythmic episodes in patients with acute myocardial infarction with depressed ventricular function and to determine the predictive value of several…
- Trial name
- NCT00145119
- Where
- Netherlands
- Volunteers
- 312 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Right Ventricular Dysfunction
Evaluation of Right Ventricular Function Post Mitral Valve Operations
We aim to determine the function of Right ventricle post mitral valve surgeries in patients with pulmonary hypertension using transthoracic echocardiography3- and 6-months post-operatively to detect the effect of mitral valve…
- Trial name
- NCT05620992
- Testing
- Echocardiography
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Heart Failure, Acute Kidney Injury
Viral Illness in Pediatric Critical Care: Incidence Timing & Severity of Associated Heart Dysfunction & Acute Kidney Injury
The purpose of this study is to be able to better describe the incidence, timing and severity of myocardial dysfunction and acute kidney injury (AKI) following a documented respiratory viral illness (RSV, adenovirus…
- Trial name
- MyDAKI-01 (NCT01924663)
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- University of Saskatchewan
Obstructive Sleep Apnea, Hypertension
Effects of Antihypertensive Drugs in Patients With Hypertension and Obstructive Sleep Apnea (OSA)
The aim of the present study is to compare the effects of different types of antihypertensive drugs (angiotensin II receptor blockers and long-acting calcium channel blockers) in patients with hypertension and obstructive sleep…
- Trial name
- NCT01028534
- Testing
- Olmesartan and Azelnidipine
- Where
- 2 sites in Japan
- Volunteers
- 150 people
- Sponsor
- Kyoto University, Graduate School of Medicine
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