Clinical trials: Cardiovascular Dysfunction
Pulmonary Arterial Hypertension, Right Heart Failure
Repurposing Valsartan May Protect Against Pulmonary Hypertension
This is a Phase 2, single-center, randomized placebo controlled trial of valsartan (an angiotensin receptor blocker) in adults with pulmonary arterial hypertension.
- Conditions
- Pulmonary Arterial Hypertension, Right Heart Failure, Right Ventricular Dysfunction, Pulmonary Vascular Disorder
- Trial name
- REVAMP-PH (NCT06053580)
- Testing
- Valsartan 40 mg
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Washington
Endothelial Dysfunction, Hypertension
FFA-Induced Hypertension and Endothelial Dysfunction
The study is a prospective open label study to examine the effects of oral and intravenous fat load on blood pressure, endothelial function, sympathetic activity, and oxidative stress in obese healthy subjects.
- Trial name
- NCT00589888
- Testing
- Intralipid 20% @ 20cc/hour, Intralipid 20%@ 40cc/hour, Normal Saline
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Emory University
Ischemic Heart Disease
Exploration of Cerebral Pathophysiology During and After CABG Using CPB
Purpose: The purpose of this study is to examine cerebral oxidative and inflammatory stress and cerebral hemodynamics during and after coronary artery bypass grafting and correlate with postoperative cognitive function.
- Trial name
- NCT02941380
- Volunteers
- 24 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiovascular Diseases, Metabolic Syndrome
Non-interventional Pre-screening Protocol Aims to Evaluate Participants for Potential Trial Eligibility in Future Clinical Trials/Studies Focusing on Metabolic and Psychiatric Health.
DOVE-MET-COME-100 is a single site prescreening survey study designed to identify adults who may be eligible for future industry-sponsored clinical trials.
- Conditions
- Cardiovascular Diseases, Metabolic Syndrome, Obesity, Prediabetes
- Trial name
- NCT07106879
- Testing
- Blood Work
- Where
- United States
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- Clindove Research LLC
Cardiovascular Diseases, Heart Failure
Novel Echocardiographic Biomarkers Assessing the Myocardial Work in Heart Failure
This study seeks to investigate the clinical value of novel echocardiographic indices, including myocardial work parameters, during the acute phase of heart failure hospitalization.
- Conditions
- Cardiovascular Diseases, Heart Failure, Valvular Heart Disease, Biochemical Dysfunction
- Trial name
- Beyond-MyoHF (NCT05573997)
- Testing
- Investigation of clinical profile, laboratory and novel echocardiographic imaging biomarkers
- Where
- Greece
- Volunteers
- 300 people
- Sponsor
- Aristotle University Of Thessaloniki
Aging, Brain Metabolic Disorder
Monitoring of Brain Metabolites Using Proton and Deuterium MR Techniques
MR pulse for whole brain optimal Deuterium (2H) Metabolic Imaging and EPSI (echo planar spectroscopic imaging) based SLOW-edited 1H-MRSI will be developed and optimized for use at an UHF scanner at 7 Tesla.
- Conditions
- Aging, Brain Metabolic Disorder, Carotid Stenosis, Alzheimer Disease
- Trial name
- SIGNATURES2023 (NCT06705010)
- Testing
- Application of new pulse sequence package SIGNATURES2023 to healthy controls, Application of new pulse sequence package SIGNATURES2023 to 4 groups of patients (pilot)
- Where
- Switzerland
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Stroke, Spinal Cord Diseases
Use of tDCS Stimulation in Neurological and Gynaecological Conditions
The aim of the study is to test the effect of tDCS stimulation on upper and lower limb function in neurological patients and to reduce pain in gynaecological patients.
- Conditions
- Stroke, Spinal Cord Diseases, Nerve Root Disorder, Endometriosis
- Trial name
- tDCS (NCT06891690)
- Testing
- tDSC stimulation
- Where
- Poland
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Microvascular Dysfunction
Elucidating the Role of Microvascular Dysfunction in Heart Disease in Women
The purpose of this study is to determine if women with chest pain and "clean" heart blood vessels have impaired blood flow to the heart due to problems with the small blood vessels that provide blood and oxygen to the heart.
- Trial name
- MVD (NCT00663520)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Diabetes Mellitus, Diabetic Retinopathy
Multicenter RCT of Eye-Brain Imaging in Diabetes Neurovascular Coupling
This study intends to take the critical pathological mechanism of diabetic neurovascular coupling injury (NCI) as the starting point and utilize multi-modal imaging (MMI) technology of the eyes and brain as a means to conduct…
- Conditions
- Diabetes Mellitus, Diabetic Retinopathy, Cognitive Impairment, Neurovascular Coupling
- Trial name
- TCM-MMI (NCT06813274)
- Testing
- hypoglycemic treatment, Tangshen'an Granules, Ginkgo Leaf Tablets
- Where
- 3 sites in China
- Volunteers
- 160 people
- Sponsor
- Hejiang Ye
Diabetes Mellitus, Left Ventricular Dysfunction
Early Assessment of Impaired Cardiac Function in Patients With Diabetes Mellitus
This is a single-center, prospective, observational study to explore the clinical features and risk factors of impaired cardiac function detected by two-dimensional speckle tracking echocardiography in patients with diabetes…
- Trial name
- NCT05484817
- Testing
- Assessment of cardiovascular risk factor, endocrine hormones and related biomarker
- Where
- China
- Volunteers
- 300 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Diastolic Dysfunction, Heart Failure
Assessment of Diastolic Function in High Risk Patients Undergoing Major Vascular Surgery
Patients scheduled for Thoracic Endovascular Aortic Repair (TEVAR) surgery will have transthoracic echocardiography evaluation of left ventricle diastolic function during the perioperative period.
- Conditions
- Diastolic Dysfunction, Heart Failure, Aneurysm Aortic
- Trial name
- NCT03534440
- Where
- Poland
- Volunteers
- 30 people
- Sponsor
- Medical University of Warsaw
Angina Pectoris, Variant
Efficacy Study of Atorvastatin to Treat Variant Angina
The objective of this study is to evaluate effect of statin treatment for vasospastic angina.
- Trial name
- ESAVA (NCT00620204)
- Testing
- atorvastatin
- Where
- South Korea
- Volunteers
- 136 people
- Sponsor
- Samsung Medical Center
Aortic Valve Disorder
2D Strain of Right Ventricle in Peroperative of Cardiac Surgery
Evaluation of the right ventricle (RV) deformation (strain) with 2D speckle tracking technics obtained by echocardiographies (TEE) in peroperative period of cardiac surgery .
- Trial name
- NCT03298932
- Testing
- Aortic valve surgery
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Montpellier
Aging, Frailty
Renal Ageing-sarcopenia Network
Frailty is a syndrome in which the accumulation of small, individually insignificant deficits leads to heightened vulnerability to adverse events and predisposes to potential catastrophic decompensation.
- Conditions
- Aging, Frailty, Hypertension, CKD
- Trial name
- NCT04630132
- Where
- Italy
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Ischaemic Heart Disease, Aortic Stenosis
Remifentanil/Sufentanil for CABG+/-AVR Evaluated by Recovery, Cognitive Function, Haemodynamics and Biochemical Markers.
To evaluate the effect on cognitive function, recovery, cardioprotection and haemodynamics of standard Remifentanil anaesthesia to standard Sufentanil anaesthesia in patients undergoing coronary artery bypass with or without…
- Trial name
- PRECON2 (NCT02053818)
- Testing
- Remifentanil, Sufentanil
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital
Cognitive Impairment
Compensatory and Restorative Rehabilitation Techniques in Stroke
The aim of this randomized controlled trial is to find the combined effects of restorative and compensatory cognitive rehabilitation techniques in mild cognitive impairment after stroke.
- Trial name
- NCT06325085
- Testing
- compensatory and restorative rehabilitation techniques, Traditional cognitive rehabilitation training
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Menopause, Left Ventricular Dysfunction
Menopausal Hormone Therapy And Left Ventricular Function
The purpose of this study is to compare left ventricular stroke volume and heart rate responses to bursts of SNA between PMF using, and not using, MHT.
- Trial name
- NCT07242391
- Testing
- Menopausal Hormone Therapy
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Mayo Clinic
Coronary Artery Disease of Significant Bypass Graft, Metabolic Dysfunction-associated Fatty Liver Disease
Positive Association of US-FLI With the Severity of CAD
As a multisystem disease, metabolic dysfunction-associated fatty liver disease (MAFLD) is closely linked to the onset and progression of coronary heart disease (CHD).
- Conditions
- Coronary Artery Disease of Significant Bypass Graft, Metabolic Dysfunction-associated Fatty Liver Disease, SYNTAX Score, Ultrasonography
- Trial name
- NCT06541132
- Testing
- Observational study without human intervention
- Where
- China
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Chongqing Medical University
ARDS Due to Disease Caused by SARS Co-V-2, Right Ventricular Dysfunction
Cardiopulmonary Effects of Prone Position in CARDS
In coronavirus disease-2019 (COVID-19)-related ARDS (C-ARDS), especially in the severe form, increased shunt rate, impaired ventilation/perfusion ratio (V/Q), hypoxic pulmonary vasoconstriction inhibition, and increased immune…
- Trial name
- NCT06456606
- Testing
- before prone position, the first hour of prone position, the first hour of returning to the supine position
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Liver Surgery, Liver Dysfunction
Octaplas Pediatric Plasma Replacement Trial
The purpose of this study is to investigate the safety, tolerability and efficacy of octaplas in pediatric patients who require replacement of multiple coagulation factors.
- Conditions
- Liver Surgery, Liver Dysfunction, Coagulopathy, Cardiac Surgery
- Trial name
- NCT02050841
- Testing
- octaplas
- Where
- 4 sites in United States
- Volunteers
- 50 people
- Sponsor
- Octapharma