Clinical trials: Cardiovascular Dysfunction
Cardiomyopathy, Renal Impairment
Study to Determine How Cialis Effects the Renal Function in Response to Volume Expansion in Preclinical Systolic Cardiomyopathy (Aim2)
To determine the effect of 12 weeks of chronic PDEV inhibition with Tadalafil versus placebo on basal cardiorenal and humoral function and on the integrated cardiorenal and humoral response to acute sodium loading in subjects…
- Trial name
- Aim2 (NCT01970176)
- Testing
- Tadalafil
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mayo Clinic
Ischemic Cardiomyopathy
Study of Efficacy and Safety of Percutaneous Coronary Intervention to Improve Survival in Heart Failure
This study will assess whether percutaneous coronary intervention (angioplasty of the heart arteries) can improve survival and reduce hospitalization in patients with heart failure due to coronary disease, who have been treated…
- Trial name
- REVIVED-BCIS2 (NCT01920048)
- Testing
- Percutaneous Coronary Intervention, Drug Therapy for Heart Failure, Device Therapy for Heart Failure
- Where
- 40 sites in United Kingdom
- Volunteers
- 700 people
- Sponsor
- King's College London
Obstructive Chronic Bronchitis With Acute Exacerbation
STI Combined to Valsalva Maneuver for the Diagnosis of Left Ventricular Dysfunction in COPD Exacerbations
The aim of this investigation was to assess the value of Systolic Time Intervals (STIs) as a method of detecting Left Ventricular Dysfunction (LVD) in patients admitted to the emergency department for cute exacerbations of…
- Trial name
- STICOPD (NCT02481908)
- Testing
- STI measurements at baseline and under Valsalva maneuver
- Where
- Tunisia
- Volunteers
- 189 people
- Sponsor
- University of Monastir
Right Ventricular Dysfunction
TEE 3D RV Assessment for SAVR, Mini AVR, and TAVR
Three-dimensional echocardiography has become a gold standard to assess right ventricular (RV) function, and investigators plan to use 3D transesophageal echocardiography to assess RV function in 3 types of aortic valve…
- Trial name
- NCT05804240
- Testing
- 3D TEE RVEF
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- Thomas Jefferson University
Compartment Syndrome, Compartment Syndrome Nontraumatic Lower Extremity
From Blast Injury to Multicompartment Dysfunction:
Blast injuries can cause swelling and pressure problems in more than one part of the body. This study will review existing medical records of people treated for blast-related injuries to learn how often these problems affect…
- Conditions
- Compartment Syndrome, Compartment Syndrome Nontraumatic Lower Extremity, Compartment Syndrome Traumatic Upper Extremity, Compartment Syndromes
- Trial name
- BLAST-PCS (NCT07911085)
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Ischemic Cardiomyopathy
Cardiac MRI in Front Line for the Diagnosis of Coronary Artery Disease as the Etiology of Left Ventricular Dysfunction
When a patient is newly diagnosed of systolic dysfunction without obvious etiology (such as rhythmic, ischemic, or valvular disease), most of the time a coronary angiography is performed.
- Trial name
- CAMAREC (NCT03231189)
- Where
- France
- Volunteers
- 415 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Postoperative Complications, Heart Failure
Association Between Portal Flow Pulsatility and Right Ventricular Dysfunction in the Postoperative Period of Cardiac Surgery
Right ventricular dysfunction (RVD) after cardiac surgery is associated with ischemia and myocardial injury. While echocardiographic measures like Tricuspid Annular Plane Systolic Excursion (TAPSE) are frequently used to assess…
- Trial name
- LIFESAVE (NCT06777355)
- Testing
- Transthoracic and Transesophageal echography within 24 hours post cardiac surgery
- Where
- France
- Volunteers
- 32 people
- Sponsor
- CMC Ambroise Paré
Congenital Heart Disease, Heart; Surgery, Heart, Functional Disturbance as Result
Just TRAC It! Transitioning Responsibly to Adult Care Using Smart Phone Technology
The Just TRAC It! study (Transitioning Responsibly to Adult Care using smart phone technology) is a randomized controlled trial designed to evaluate the impact of using smart phone technology in combination with the nurse led…
- Trial name
- NCT03429335
- Testing
- Teaching session, Just TRAC It!, MyHealth Passport
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- University of Alberta
Bradycardia
The Effects of Selective Site Right Ventricular Pacing
This is a pilot study into the effects on heart function when pacing the right ventricle (RV). This study aims to enrol a population with structurally normal hearts.
- Trial name
- PacingRV (NCT02153242)
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Obesity, Diabetes
Role of Adiposomes in Endothelial Dysfunction
The development of type II diabetes (T2D) is strongly associated with obesity and both are well-established risk factors for cardiovascular disease.
- Conditions
- Obesity, Diabetes, Cardiovascular Diseases
- Trial name
- NCT05199454
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Illinois Chicago
Oxidative Stress, Cardiovascular Diseases
Effect of a Specific Aquaporin-1 Inhibitor on Vascular Oxidative Stress in Healthy Volunteers
Bacoxy_II study aims to evaluate the efficacy of a standardized Bacopa monnieri extract, KeenMind®, on vascular oxidative stress.
- Conditions
- Oxidative Stress, Cardiovascular Diseases, Bacopaside II, Bacopa Monnieri
- Trial name
- Bacoxy_II (NCT06059131)
- Testing
- KeenMind
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Parkinson Disease, Parkinsonism
Head-up Tilt Sleeping to Alleviate Orthostatic Hypotension, Supine Hypertension and Nocturia in Parkinson's Disease
Autonomic dysfunction is common and often underrecognized in Parkinson's disease (PD). Orthostatic hypotension (OH) affects up to a third of PD patients and often coincides with supine hypertension.
- Trial name
- NCT05551377
- Testing
- Head-up tilt sleeping
- Where
- 2 sites in Netherlands
- Volunteers
- 50 people
- Sponsor
- Radboud University Medical Center
Duchenne Muscular Dystrophy
Plus Epicatechin Duchenne Muscular Dystrophy in Non-ambulatory Adolescents
This single center open-label pilot study will enroll 15 non-ambulatory children with Duchenne muscular dystrophy at least 8 years of age and who demonstrate pre-clinical cardiomyopathy (defined as a cardiac ejection fraction…
- Trial name
- NCT02964377
- Testing
- (+)- Epicatechin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Craig McDonald, MD
Aortic Valve Stenosis, Left Ventricular Hypertrophy
Effect of Angiotensin II Receptor Blockers (ARB) on Left Ventricular Reverse Remodelling After Aortic Valve Replacement in Severe Valvular Aortic Stenosis
The consequence of aortic valve stenosis (AVS) is increased pressure load on the left ventricle which causes left ventricular (LV) hypertrophy, and myocardial stretch will cause activation of cardiac peptides and activation of…
- Conditions
- Aortic Valve Stenosis, Left Ventricular Hypertrophy, Atrial Fibrillation
- Trial name
- NCT00294775
- Testing
- Candesartan
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Odense University Hospital
Insulin Resistance
Cardiovascular Effects of Metformin on Obesity
It has been shown that asymptomatic obese adolescents can demonstrate abnormal regional myocardial contraction, with preserved global cardiac function.
- Trial name
- NCT01910246
- Testing
- Metformin
- Where
- United States
- Sponsor
- University of California, San Francisco
Coronary Artery Disease
Mainz Registry of Flow-mediated Constriction
The goal of the flow-mediated constriction/ FMC-registry is to investigate whether the measurement of endothelial function using flow-mediated dilation and flow-mediated constriction provides on the presence of coronary…
- Trial name
- NCT01787370
- Where
- Germany
- Volunteers
- 750 people
- Sponsor
- Johannes Gutenberg University Mainz
Cognitive Impairment
Vascular Alteration and Evolution of Cognitive Impairment
In the cross sectional study "Adelahyde 1" which took place between 2001 and 2005, the investigators data suggest that vascular alterations may play a role in the setting of subjective memory complaints.
- Trial name
- ADELAHYDE2 (NCT01351961)
- Testing
- blood sampling, brain MRI and TEP cerebral, Assessment of cognitive functions
- Where
- France
- Volunteers
- 131 people
- Sponsor
- Central Hospital, Nancy, France
Myocardial Infarction Type 2
Targeting Investigation and Treatment in Patients With Type 2 Myocardial Infarction
Type 2 myocardial infarction (MI) is common and associated with poor clinical outcomes, with as many as one in ten experiencing recurrent MI within one year, and only one in three alive at five years.
- Trial name
- TARGET-Type 2 (NCT05419583)
- Testing
- Coronary computed tomography angiography, Invasive coronary angiography, Transthoracic echocardiography
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Coronary Microvascular Dysfunction (CMD), Angina Pectoris With Normal Coronary Arteriogram
Endothelin Role In COronary Microcirculation
Coronary microvascular dysfunction is an important cause of angina in patients who do not have significant blockages in the major coronary arteries.
- Conditions
- Coronary Microvascular Dysfunction (CMD), Angina Pectoris With Normal Coronary Arteriogram, Microvascular Angina
- Trial name
- ERICOM (NCT07670091)
- Testing
- Cardiac MRI, Invasive Coronary Angiogram, Endothelin Receptor Antagonist
- Where
- United Kingdom
- Volunteers
- 45 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Hypotension, Spinal Cord Injury
Effect of Tadalafil (Cialis) on the Cardiovascular System of Spinal Cord Injury (SCI) Males
To address the effect of tadalafil (Cialis) on the cardiovascular system of men with complete spinal cord injury at T-6 and above. The hypothesis is that tadalafil will cause significant hypotension in people with tetraplegia.
- Trial name
- NCT01067391
- Testing
- tadalafil
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
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