Clinical trials: Cardiovascular Effects
Coronary Artery Disease, Percutaneous Coronary Intervention
Different Doses of Colchicine on hsCRP
Colchicine reduced atherothrombotic cardiovascular events in the COLCOT and LoDoCo2 studies. US Food and Drug Administration approved colchicine as the first anti-inflammatory drug for cardiovascular diseases on June, 2023.
- Trial name
- NCT06078904
- Testing
- Colchicine 0.5 MG, Colchicine 0.375 MG, Colchicine 0.25 MG
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Cardiovascular Disease
Simplified Cardiovascular Management Study
The goal of this study is to develop, pilot test, and evaluate a highly simplified but guideline-based program for cardiovascular management for application in resource-scarce settings.
- Trial name
- SimCard (NCT01503814)
- Testing
- Simplified cardiovascular disease management
- Where
- 3 sites in China, India
- Volunteers
- 2,086 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Stroke
Effect Of Breather On Pulmonary And Physical Function In Post Stroke Survivors
Stroke is the second major cause of death and disability worldwide with over 13 million new cases annually. Egypt, a low-middle-income country, is the most populated nation in the Middle East with a high overall crude prevalence…
- Trial name
- NCT05678816
- Testing
- BREATHER, physiotherapy prgramme for rehabilitation of stroke patients
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Myocardial Infarction
Sevoflurane and Percutaneous Coronary Intervention by Stent
Increase in CK-MB after percutaneous coronary angioplasty more than 100% of baseline can represents a problem to the patients resulting in increase of morbidity and mortality.
- Trial name
- NCT02671084
- Testing
- sevoflurane
- Where
- Brazil
- Volunteers
- 701 people
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
STEMI
Intensive Statin Treatment for STEMI Patients Undergoing Primary PCI
This is a retrospective, randomized, parallel, open-labeled, controlled study to find out whether STEMI patients undergoing emergency PCI can benefit from intensive atorvastatin treatment compared with routine treatment.
- Trial name
- NCT01033058
- Testing
- atorvastatin
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Beijing Chao Yang Hospital
Ischemic Stroke, Vagus Nerve Stimulation
Effect Of Robotic Rehabilitation And Vagus Nerve Stimulation In Ischemia Stroke Patients
This study was conducted in patients with ischemic stroke; This study was conducted to examine the effect of robotic rehabilitation and transcutaneous auricular vagal nerve stimulation applied in addition to robotic…
- Conditions
- Ischemic Stroke, Vagus Nerve Stimulation, Robotic Rehabilitation, Autonomic Nervous System
- Trial name
- ERRVNS (NCT06381089)
- Testing
- Robotic Rehabilitation, Transcutaneous Auricular Vagal Nerve Stimulation
- Volunteers
- 40 people
- Sponsor
- SEFA HAKTAN HATIK
Migraine Without Aura
Effect of PACAP38/VIP on Migraineurs Measured by Magnetic Resonance
The purpose of this study is to examine and compare the effect of pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal polypeptide (VIP) on intracranial arteries and neuronal activity in…
- Trial name
- NCT01471990
- Testing
- Pituitary Adenylate Cyclase-Activating Polypeptide-38, Vasoactive Intestinal Peptide
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Myocardial Ischemic Reperfusion Injury, End Stage Heart Disease
Remote Ischemic Preconditioning With Postconditioning in Heart Transplantation Surgery
The purpose of this study is to determine whether remote ischemic preconditioning with postconditioning (RIPC+RIPostC) reduces myocardial injury and improves clinical outcomes in heart transplantation surgery.
- Conditions
- Myocardial Ischemic Reperfusion Injury, End Stage Heart Disease, Heart Failure, Cardiomyopathy
- Trial name
- NCT02149316
- Testing
- RIPC+RIPostC, control
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Heart Failure
Effects of CCM-therapy in Patients With Heart Failure
The effects of Cardiac Contractility Modulation (CCM) treatment are observed in patients with heart failure.
- Trial name
- CCM-HF (NCT02895048)
- Where
- Germany
- Volunteers
- 184 people
- Sponsor
- Stiftung Institut fuer Herzinfarktforschung
Fabry Disease
Open-Label Extension Study of the Long-Term Effects of Migalastat HCL in Patients With Fabry Disease
This is an open-label extension study intended to provide continued treatment with migalastat hydrochloride (HCl) for participants with Fabry disease who completed treatment of a previous migalastat HCl study.
- Trial name
- NCT02194985
- Testing
- migalastat HCl 150 mg
- Where
- 28 sites in United States, Argentina and 13 more
- Volunteers
- 84 people
- Sponsor
- Amicus Therapeutics
Coronary Arterial Disease (CAD), Angina (Stable)
The Effect of Sublingual Nitroglycerin on Absolute Coronary Blood Flow
The goal of this clinical trial is to investigate the effect of sublingual nitroglycerin on absolute coronary blood flow in adult patients undergoing coronary angiography.
- Trial name
- FLOW-NITRO (NCT06823843)
- Testing
- Glycerin trinitrate (GTN)
- Where
- Belgium
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- VZW Cardiovascular Research Center Aalst
Patient Comfort, Anxiety
Family Support Weaning from Mechanical Ventilation in Cardiovascular Surgery
Mechanical ventilation support is used to ensure airway clarity in patients after surgery.If patients are not informed about mechanical ventilation treatment in the pre -operation period, panic, anxiety and comfort may be…
- Conditions
- Patient Comfort, Anxiety, Patient Satisfaction
- Trial name
- NCT05820789
- Testing
- Family support
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kastamonu University
Friedreich's Ataxia
An Open-label Study of the Effects of Acetyl-L-Carnitine on Cardiovascular Outcomes in Friedreich's Ataxia
The purpose of this study is to learn how treatment with acetyl-L-carnitine (ALCAR) will affect the hearts of patients with Friedreich's Ataxia as well as how it may affect other symptoms of Friedreich's Ataxia such as…
- Trial name
- NCT01921868
- Testing
- Acetyl-L-Carnitine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of South Florida
Coronary Artery Disease, Percutaneous Coronary Intervention
Effect and Efficacy of Xpedition™/Alpine™, Everolimus-eluting Stent for Coronary Atherosclerosis
The objectives of this study are 1. To establish a prospective registry of the whole patients who received percutaneous coronary intervention with Xience Xpedition™/Alpine™ stent 2.
- Conditions
- Coronary Artery Disease, Percutaneous Coronary Intervention, Acute Coronary Syndrome, Angina Pectoris
- Trial name
- HOST-ALPINE (NCT02845804)
- Testing
- Alpine
- Where
- 20 sites in South Korea
- Volunteers
- 1,533 people
- Sponsor
- Seoul National University Hospital
Dyslipidemia, Metabolic Syndrome (MetS)
Polyunsaturated Fatty Acids-based Bars Effect on Metabolic Syndrome Patients
This study aimed to manage dyslipidemia through Polyunsaturated fatty acids based bar among patients with metabolic syndrome.
- Trial name
- NCT07627555
- Testing
- Jelly Candy, PUFA Bar
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- University of Lahore
Rheumatoid Arthritis
Effect of Monoclonal Anti-IL6 Antibody (Tocilizumab) on the Cardiovascular Risk in Patients With Rheumatoid Arthritis
The purpose of this study is to determine whether tocilizumab changes the cardiovascular risk factors on patients with arthritis rheumatoid.
- Trial name
- TOCRIVAR (NCT01752335)
- Testing
- Braquial ecography
- Where
- Spain
- Volunteers
- 28 people
- Sponsor
- Hospital Universitario de Canarias
Stroke
Comparison of Tele-rehabilitation Versus In-clinic Rehabilitation for Upper Limb Motor Function Stroke Patients
To determine the effects of Tele-rehabilitation versus in-clinical rehabilitation for upper limb motor function and spasticity in chronic ischemic stroke patients.
- Trial name
- NCT05875818
- Testing
- In-clinic Rehabilitation, Tele-rehabilitation
- Where
- Pakistan
- Volunteers
- 68 people
- Sponsor
- Superior University
Prediabetes / Type 2 Diabetes, Sedentary Behaviors
Effects of Exercise Snacks on Clinical and Health Outcomes
Physical inactivity and prolonged sedentary behavior are major health concerns, especially for individuals with chronic conditions such as diabetes and prediabetes.
- Conditions
- Prediabetes / Type 2 Diabetes, Sedentary Behaviors, Physical Inactivity
- Trial name
- NCT07609290
- Testing
- Exercise Snacks
- Where
- Taiwan
- Volunteers
- 58 people
- Sponsor
- Chimei Medical Center
Adrenal Incidentalomas, Cushing Syndrome
Effect of Metyrapone on Cardiovascular Risk Factors in Patients With Adrenal Incidentalomas and Cushing's Syndrome
Drug interventional, controlled, randomized open-label, parallel-group, multicenter study in patients with bilateral adrenal incidentalomas associated with subclinical Cushing's syndrome
- Trial name
- NCT06801249
- Testing
- Metarapone, Standardized antihypertensive therapy
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Vascular Disease, Vascular Disease Risk
Effect of Atorvastatin (Lipitor) on Gene Expression in People With Vascular Disease
This study will determine if the drug Atorvastatin (Lipitor) changes the genetic material found in blood cells of people with vascular (blood vessel) disease.
- Trial name
- NCT00293748
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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