Clinical trials: Cardiovascular Function
Mental Health Disorders
Examining the Effect of Mental Health Disorders on Vascular Function and Exercise Tolerance
Specific Aim #1: Examining the impact of mental health disorders (PTSD and GAD) on peripheral vascular function and sympathetic nervous system activity in young individuals.
- Trial name
- NCT03216980
- Testing
- PTSD/GAD Antioxidant, Healthy Control Antioxidant
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Stroke
A Study on the Effectiveness Evaluation in Stroke Patients Using Lower Limb Assistive Walking Devices
The main purpose of this clinical trial is to evaluate the effectiveness and safety of the MI-R1 walking machine in lower limb motor function training for stroke patients. The main question is to answer: 1.
- Trial name
- NCT06564480
- Testing
- MI-R1 lower limb walking machine assisted training device, Walking rehabilitation training under the guidance of therapists
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Hypertension, Sodium Excess
Effects of Salt on Serum Osmolarity and Hemodynamics Parameters
Diets containing excessive salt (>12 g/day) have negative effects on kidney and cardiovascular system. Considering this known fact, the investigators aimed to study if the amount of the water taken with excessive salt had any…
- Conditions
- Hypertension, Sodium Excess, Oxidative Stress, Inflammation
- Trial name
- NCT03314727
- Testing
- High salt (NaCl) intake
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Koç University
Cardiovascular Risk Factor
Short Term Ketone Supplementation and Cardiometabolic Health
The purpose of this research study is to determine if short-term consumption of a dietary ketone drink, which increases the blood circulation concentrations of beta-hydroxybutyrate, a ketone, affects blood vessel health and…
- Trial name
- NCT04236388
- Testing
- Ketone drink
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Cognitive Function 1, Social, Competence
Heart Rate Variability and Cognitive Load on Image-Based Virtual Reality Instructional Design in Otolaryngology
This study aims to compare heart rate variation, cognitive load, and learning outcomes of novel image-based virtual reality with traditional video in learning for otolaryngology.
- Conditions
- Cognitive Function 1, Social, Competence, Heart Rate Fast, Learning, Spatial
- Trial name
- NCT03501641
- Testing
- image-based virtual reality learning, video-based learning
- Where
- Taiwan
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Liver Failure
Study to Evaluate if the Drug Vasopressin Protects the Kidneys for Patients Undergoing Liver Transplant
The purpose of this study is evaluate the medication vasopressin for its ability to preserve kidney function in patients undergoing liver transplantation.
- Trial name
- NCT00886262
- Testing
- Vasopressin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Muscle Weakness
Respiratory Muscle Training in Subacute Stroke Patients
This study is divided for development in two complementary work packages justified by the need to incorporate new strategies to optimize rehabilitation outcomes in stroke patients.
- Trial name
- RETORNUS (NCT02125760)
- Testing
- Inspiratory Muscle Training (IMT), High-intensity IMT
- Where
- Spain
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Parc de Salut Mar
Retinal Vein Occlusion, Macular Edema
Efficacy of an Intravitreal DEX Implant in Retinal Vein Occlusion Following Treatment With Anti-VEGF Injections.
To test the efficacy of a 0.7 mg intravitreal dexamethasone implant (Ozurdex®) on macular function and recalcitrant macular edema associated with retinal vein occlusion following treatment with 2 or more prior intravitreal…
- Trial name
- NCT01449682
- Testing
- Ozurdex
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Retina Macula Institute
Cardiovascular Diseases, Endothelial Dysfunction
Effect of Polyphenol Extract on Cardiovascular Health Markers: a 4 Way Randomised Crossover Study
Endothelial dysfunction is an early predictor of cardiovascular events in at-risk patients. It is characterized by impaired endothelium-dependent dilation and is primarily caused by reduced nitric oxide bioavailability secondary…
- Conditions
- Cardiovascular Diseases, Endothelial Dysfunction, Blood Pressure
- Trial name
- Activ Acute (NCT05220059)
- Testing
- Polyphenol extract
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Heart Rate Variability
Effects of Arm Crank Versus Treadmill Exercises on Heart Rate Variability in Adult Subjects.
Cardiovascular response to exercise affects the capacity of all body organs depending upon intensity, duration and mode of exercises.
- Trial name
- NCT03068182
- Testing
- Arm crank, Treadmill, Exercise
- Where
- Saudi Arabia
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Imam Abdulrahman Bin Faisal University
Cerebral Arterial Diseases
Hemodynamic and Functional Characteristics of the Cerebral Circulation in Obesity
This prospective study is intended to explore differences in the cerebral hemodynamics and vascular functional characteristics between obese and normo-constituted patients; as well as the changes in the hemodynamic and functional…
- Trial name
- HemOB (NCT06067113)
- Testing
- Supraaortic and transcranial duplex
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Stroke, Acute
The Effects of Early Mobilization in Stroke Patients on Functional Status, Psychological Distress, and Quality of Life
This study aims to investigate the effects of an early mobilization intervention in improving functional status, psychological distress, and quality of life in stroke patients.
- Trial name
- NCT05381220
- Testing
- early mobilization
- Where
- 2 sites in Taiwan
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Hypertension
Endothelin Receptor Function and Acute Stress
Our bodies respond differently to stress. Animal studies by the investigators have found that endothelin-1 plays a role in regulating blood pressure in response to stress.
- Trial name
- End-Stress (NCT02116335)
- Testing
- Bosentan
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Augusta University
Cardiovascular Diseases, Vascular Diseases
Influence of Age, Weight and Ethnic Background on Blood Pressure
Hypertension, also known as high blood pressure, is a chronic medical condition, in which the blood pressure is elevated. This is a common condition, which can lead to severe complications such as cardiovascular disease, heart…
- Conditions
- Cardiovascular Diseases, Vascular Diseases, Hypertension
- Trial name
- AWE (NCT03014791)
- Testing
- Brief lifestyle/medical history questionnaire, Anthropometric measures, Blood pressure and arterial stiffness
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Hypertension
Phase 1 PK Study to Evaluate the PK of CIN-107 in Subjects With Hepatic Impairment
The goal of this Phase 1, open-label, single-dose, parallel-group study is to evaluate the pharmacokinetics (PK) of a single 10-mg oral dose of baxdrostat in subjects with varying degrees of hepatic function.
- Trial name
- NCT05961397
- Testing
- baxdrostat
- Where
- 5 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hypertension
Equol Supplementation on Blood Pressure and Vascular Function
We propose to perform a 24-week randomized, double-blind a placebo-controlled trial among 207 non-equol producing postmenopausal women with prehypertension to examine the effectiveness of equol (10mg and 20mg/d) on 24h ambulatory…
- Trial name
- NCT02515682
- Testing
- High equol group, Low equol group
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Stroke Rehabilitation
Vibratory Perturbation-based Pinch Task Training for Stroke Patients
The investigator assumed that perturbed-event-induced vibrotactile cueing enable more precision arm movement adjustment, sensory function and dexterity improvement in the spastic arm.
- Trial name
- NCT03798340
- Testing
- Vibratory perturbed task-specific movement training, Traditional task-oriented facilitation, Sensorimotor training
- Where
- Taiwan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Type 2 Diabetes, Obesity
Exercise Training and Cardiovascular Function in Obesity and in Type 2 Diabetes
Obesity and diabetes increase cardiovascular risk by complex and incompletely known mechanisms. The aims of this study are : 1. to compare cardiac and vascular functions at rest and during exercise in 4 groups of age-matched men…
- Trial name
- NCT00264589
- Testing
- 8 weeks individualized training program
- Where
- France
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Prehypertension, Healthy
Aronia Berry Consumption on Blood Pressure
Aronia berries are a native North American berry with high naturally occurring anthocyanins among other polyphenols. Based on their polyphenol composition, there is growing interest in the potential for Aronia berries to elicit…
- Trial name
- ABP (NCT03434574)
- Testing
- Aronia extract
- Where
- 2 sites in United Kingdom
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- King's College London
Healthy
The Effects of Low Dose Ketamine on Cardiovascular Function
Low dose ketamine is used for pain management and for the treatment of anxiety and depression. Prior studies on low dose ketamine have noted short-term (minutes to hours) increases or decreases in blood pressure.
- Trial name
- NCT04429685
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center