Clinical trials: Cardiovascular Outcomes
Cardiovascular Diseases, Heart Failure, Congestive
Evaluating the Relationship Between Fatty Acids and Heart Disease
Cardiovascular disease (CVD) affects millions of people in the United States; each year, more people die from CVD than from any other disease.
- Conditions
- Cardiovascular Diseases, Heart Failure, Congestive, Atrial Fibrillation, Cerebrovascular Accident
- Trial name
- NCT00404872
- Where
- 4 sites in United States
- Volunteers
- 4,766 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Coronary Artery Disease, Heart Valve Diseases
Centrifugation vs. Multiple-pass Hemofiltration of the Residual Cardiopulmonary Bypass Volume
Traditional cardiac surgery requires patient connection to the Cardiopulmonary Bypass (CPB) apparatus which takes over the function of the heart and lungs while the surgeon performs the necessary surgery.
- Trial name
- NCT01416792
- Testing
- Centrifugation, Multiple-pass hemofiltration
- Where
- Canada
- Volunteers
- 61 people
- Sponsor
- University of Saskatchewan
Mitral Regurgitation, Mitral Valve Regurgitation
Cardiovascular Outcomes Assessment of the MitraClip Percutaneous Therapy for Heart Failure Patients With Functional MR
The COAPT Continued Access Study (CAS) is an extension of the COAPT RCT under the same IDE (G120024). COAPT CAS was a single-arm, prospective, multicenter continued access registry that enrolled heart failure patients with…
- Trial name
- COAPT CAS (NCT07227675)
- Testing
- MitraClip® NT System
- Where
- 32 sites in United States
- Volunteers
- 162 people
- Sponsor
- Abbott Medical Devices
Pressure Ulcer, Foot Ulcer, Diabetic
Use of Santyl Within an Accountable Care Organization
This study is designed to assess the comparative effectiveness of SANTYL® versus standard of care in the treatment of pressure ulcers and diabetic foot ulcers within the continuum of care of an ACO.
- Trial name
- NCT02716519
- Testing
- Santyl, Standard Care
- Where
- United States
- Sponsor
- Smith & Nephew, Inc.
NonST Elevation Myocardial Infarction, Myocardial Infarction
Fractional Flow Reserve Versus Angiographically Guided Management to Optimise Outcomes in Unstable Coronary Syndromes
Background: In patients with acute non-ST elevation myocardial infarction (NSTEMI) coronary arteriography is usually recommended however visual interpretation of the coronary angiogram is subjective.
- Trial name
- FAMOUS NSTEMI (NCT01764334)
- Testing
- Fractional flow reserve
- Where
- 6 sites in United Kingdom
- Volunteers
- 350 people
- Sponsor
- NHS National Waiting Times Centre Board
Stroke
Pilot Study on Comparisons Between the Effectiveness of Mobile Video-guided and Paper-based Home Exercise Programs of Patients With Stroke Randomized Controlled Trial
This is a pilot study and a randomized, controlled, assessor-blinded clinical trial for patients who will complete the inpatient Stroke Rehabilitation Program in the Department of Medical and Geriatrics of Tai Po Hospital and…
- Trial name
- NCT03509363
- Testing
- Stroke physiotherapy home exercise video
- Where
- Hong Kong
- Volunteers
- 56 people
- Sponsor
- Tai Po Hospital
Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation
REPRESENT-PF Registry
This pragmatic, prospective, single-arm, multi-center, observational registry will evaluate the safety and effectiveness of PFA for the treatment of atrial fibrillation in underrepresented minority patients using FDA approved…
- Trial name
- REPRESENT-PF (NCT07535268)
- Testing
- FARAWAVE Pulsed Field Ablation Catheter
- Where
- 2 sites in United States
- Volunteers
- 275 people
- Sponsor
- Vivek Reddy
Heart Failure, Congestive Heart Failure
Personalized Voice Activated Wellness Assistants for Patients With Heart Failure
The Alexa+ Study will compare the use of the Amazon Echo Dot with Alexa voice technology in patients with chronic heart failure to those receiving standard of care heart failure management on changes in health and…
- Trial name
- NCT03707275
- Testing
- Alexa+, Standard of Care Arm
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Medstar Health Research Institute
Pulmonary Hypertension
Persistent Pulmonary Hypertension After Percutaneous Mitral Commissurotomy
To identify clinical, echocardiographic, and hemodynamic parameters which can predict persistent PH after PMC, and also to determine the impact of persistent PH on the clinical outcomes.
- Trial name
- NCT04083729
- Testing
- Percutaneous Mitral Commissurotomy
- Volunteers
- 62 people
- Sponsor
- Assiut University
Intracranial Aneurysm, Transradial Access(TRA)
Application of Brachial Plexus Block in Patients Undergoing Cerebral Aneurysm Embolization Via Transradial Approach
The aim of this study was toinvestigate the effect of BPB on outcome of upper extremity arteries in patients undergoing interventional embolization of intracranial aneurysms via TRA.
- Trial name
- ABPBCAETRA (NCT06035692)
- Testing
- Ropivacaine
- Where
- China
- Volunteers
- 176 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
End Stage Renal Disease, Myocardial Microvascular Disease
Myocardial Microvascular Disease in ESRD
Cardiovascular diseases are the leading cause of mortality in patients with end stage renal disease (ESRD). They often have myocardial ischemia (a major predictor of mortality) on non invasive testing (Stress echocardiography…
- Trial name
- MICROCARD (NCT01291771)
- Testing
- Invasive FFR + CFR measurements are performed during coronary angiography using a pressure guide wire
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Type 2 Diabetes Mellitus, Hypertension (Without Type 2 Diabetes Mellitus)
Empowering Primary Care Providers and Patients to Improve Chronic Disease Outcomes: The EMPOWER Participatory Action Research (EMPOWER - PAR)
BACKGROUND Chronic disease management (CDM) presents enormous challenges to the primary care workforce due to the rising epidemic of cardiovascular risk factors.
- Trial name
- NCT01545401
- Testing
- EMPOWER-PAR Intervention
- Where
- Malaysia
- Volunteers
- 1,545 people
- Sponsor
- Ministry of Health, Malaysia
Atrial Fibrillation
Clinical and Healthcare Outcomes From Real-World Use in the United States of a Companion AI During AF Ablation
Observational, multi-center, clinical device registry for US patients with a primary goal to observe the clinical outcomes in patients who are mapped with Volta Medical's VX1 or AF-Xplorer systems during AF ablation procedures.
- Trial name
- COMPANION AI (NCT06056271)
- Testing
- AF Ablation
- Where
- 4 sites in United States
- Volunteers
- 400 people
- Sponsor
- Volta Medical
Stroke, Seizures
Epilepsy Watch After Vascular Events: Frequency, Outcomes, and Risk Markers
This research aims to determine the frequency of seizures in patients following a stroke, identify risk factors associated with post-stroke seizures, and characterize EEG changes linked to these seizures.
- Conditions
- Stroke, Seizures, EEG Power Spectra, Serum Biomarkers
- Trial name
- EY-WAVEFORMS (NCT06922734)
- Where
- Slovenia
- Volunteers
- 602 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Maribor
Aortic Stenosis
Does Cardiac REhabilitation Improve Functional, Independence, Frailty and Emotional outCOmes Following Trans Catheter Aortic ValvE Replacement?
The aim of this pilot study is to assess function, independence, frailty and emotional status in 30 patients who have been accepted for TAVI.
- Trial name
- RECOVER-TAVR (NCT02921880)
- Testing
- Cardiac Rehabilitation
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
ST Elevation (STEMI) Myocardial Infarction of Other Sites, Repolarization Indices
Relation of Total Ischemic Time to Repolarization Indices and Their Impact on Outcomes Among STEMI Patients Undergoing Primary PCI
1. Evaluate The impact of early versus late presentation on electrocardiographic ventricular repolarization indices. 2. To assess the association between repolarization indices among early, late presentation in relation to…
- Conditions
- ST Elevation (STEMI) Myocardial Infarction of Other Sites, Repolarization Indices, Total Ischemic Time, Primary Percutaneous Coronary Intervention
- Trial name
- NCT07175259
- Testing
- Echocardiography
- Volunteers
- 500 people
- Sponsor
- Assiut University
Cardiovascular Disease, Stroke
Heart Outcomes Prevention Evaluation-3
Heart disease and stroke are major causes of death and disability worldwide and are largely preventable. Cholesterol and blood pressure are major cardiovascular risk factors.
- Trial name
- HOPE-3 (NCT00468923)
- Testing
- Candesartan/HCT, Rosuvastatin
- Where
- Canada
- Volunteers
- 12,705 people, healthy volunteers welcome
- Sponsor
- Population Health Research Institute
Kidney Transplantation
Impact of Arterial Stiffness and Central Aortic Blood Pressure on Kidney Transplant Outcomes
People with CKD have higher prevalence of cardiovascular disease. The mechanism behind this increased risk is complex but there is strong evidence that changes in arterial stiffness play a central role.
- Trial name
- NCT02000869
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Ischemic Stroke, Transient Ischemic Attack (TIA)
NUTRITION: Natural Tocotrienol Against Ischemic Stroke Event
A natural form of vitamin E called tocotrienol (TCT), found in many common foods such as barley, decreases stroke size in animal models.
- Trial name
- NUTRITION (NCT01578629)
- Testing
- Vitamin E tocotrienol (TCT) capsules ; Low dose Aspirin
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Andrew Slivka
Cerebrovascular Disease, Intracranial Aneurysm
Investigation of Hemodynamics and Radiomics Based on High Resolution Magnetic Resonance Imaging for Predicting the Outcomes of Intracranial Dissecting Aneurysm
This study aims to conduct a comprehensive analysis by integrating clinical factors, aneurysm morphological characteristics, and factors reflecting pathophysiological processes (such as hemodynamic and radiomics features), in…
- Conditions
- Cerebrovascular Disease, Intracranial Aneurysm, Intracranial Arterial Dissection
- Trial name
- NCT07335029
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Beijing Neurosurgical Institute
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