Clinical trials: Cardiovascular Outcomes
Intracerebral Haemorrhage (ICH)
Surgical Evacuation Of Spontaneous Intracerebral Hematoma: Clinical Outcomes and Prognostic Factors
The aim of this study is to assess the safety and efficacy of surgical evacuation of spontaneous intracerebral hemorrhage.
- Trial name
- NCT06816641
- Testing
- Surgical Evacuation of Intracerebral Hemorrhage
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Sohag University
Pain, Postoperative, Opioid Use
Exparel vs. Marcaine ESP Block for Post-cardiac Surgical Pain
The goal of this pilot study is to describe and compare Ultrasound-Guided Erector Spinae Plane (ESP) Blocks using Exparel® (bupivacaine liposome injectable suspension) to Marcaine® (bupivacaine hydrochloride) for pain management…
- Conditions
- Pain, Postoperative, Opioid Use, Perioperative Complication, Heart Diseases
- Trial name
- NCT06077422
- Testing
- bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Rutgers, The State University of New Jersey
Type II Diabetes
Type II Diabetes Influence on Left Ventricular Remodeling and Outcomes in Patients Undergoing Aortic Valve Replacement Surgery.
This project focuses on the physiopathology of left ventricular remodeling associated with type II diabetes in patients with aortic valve stenosis referred for surgical aortic valve replacement.
- Trial name
- DIAPASON (NCT01862237)
- Testing
- Intervention
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Hospices Civils de Lyon
Breast Cancer Females
Short-term Impacts of Endocrine Therapy on Cardiovascular and Brain Health Outcomes in Breast Cancer
Aromatase inhibitors are the most used endocrine therapy for hormone-positive breast cancer. While there is a clear linear relationship between the duration of aromatase inhibitor use and the cumulative incidence of…
- Trial name
- STRIVE (Acute) (NCT06781762)
- Testing
- N/A (Usual Care)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Chronic Kidney Diseases, Cardiovascular Diseases
Treating Metabolic Acidosis in Chronic Kidney Disease to Prevent Adverse Kidney and Cardiovascular Outcomes
Upon completion, this project will determine if treatment of metabolic acidosis in non-diabetic study participants with reduced kidney function (chronic kidney disease [CKD] stage 3) associated with high blood pressure…
- Conditions
- Chronic Kidney Diseases, Cardiovascular Diseases, Hypertension
- Trial name
- NCT06545461
- Testing
- Fruits and Vegetables (F+V), Sodium Bicarbonate (NaHCO3), Usual Care
- Volunteers
- 108 people
- Sponsor
- Donald Wesson
Varicose Veins
3-4 Year Outcomes Following Endovenous Steam Ablation for Venous Insufficiency
The aim of this study is to evaluate the long-term effects of endovenous steam ablation (EVSA). Postoperative data at 3-4 year follow-up will be collected from patients treated with EVSA.
- Trial name
- NCT02944331
- Testing
- Endovenous steam ablation
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- Lovisenberg Diakonale Hospital
Peripheral Arterial Disease, Chronic Limb Ischemia
Improving Radiological Outcomes in Arterial Disease - A Pilot Evaluation of the Pedra Tissue Perfusion Monitoring System
The Pedra Technologies' PedraTM device is a non-invasive, diagnostic device intended to measure foot perfusion by assessing blood flow.
- Trial name
- IROAD (NCT03294902)
- Testing
- Pedra Tissue Perfusion Monitor
- Where
- United Kingdom
- Volunteers
- 68 people
- Sponsor
- Pedra Technology, PTE LTD
Severe Aortic Stenosis, Transcatheter Aortic Valve Replacement
Open-label, Randomized Trial in Participants Undergoing TAVR to Determine Safety & Efficacy of Bivalirudin vs UFH
The objective of this study is to assess the safety and efficacy of using bivalirudin instead of unfractionated heparin (UFH) in transcatheter aortic valve replacements (TAVR).
- Conditions
- Severe Aortic Stenosis, Transcatheter Aortic Valve Replacement, Aortic Valve Replacement
- Trial name
- BRAVO 2/3 (NCT01651780)
- Testing
- Bivalirudin, Unfractionated Heparin
- Where
- 33 sites in Canada, France and 5 more
- Volunteers
- 803 people
- Sponsor
- The Medicines Company
Coronary Artery Disease
Benefit of Elevation of HDL-C on Cardiovascular Outcomes in Women
Several risk factors including high cholesterol contribute to heart disease. We know that lowering triglycerides and raising HDL (protective cholesterol) in men reduces the risk for heart disease.
- Trial name
- NCT00590629
- Testing
- Niaspan
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Cedars-Sinai Medical Center
Hypogonadism
Cardiovascular Outcomes of Low Testosterone
This study plans to learn more about heart and vascular aging in men. In some men as they get older, testosterone levels fall below the normal range for young men. Also, as men get older cardiovascular health worsens.
- Trial name
- CardioVOLT (NCT02758431)
- Testing
- Acyline, Testosterone Gel, Arimidex
- Where
- United States
- Volunteers
- 232 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
MI Related Malignant Ventricular Arrhythmia
Effect of Radiofrequency Ablation in Patients With Ventricular Arrhythmia Undergoing CABG
Patients with myocardial infarction related potential malignant ventricular arrhythmia have high risk of sudden death. The aim of this clinical trial is evaluating therapeutic efficacy of unipolar or bipolar radiofrequency…
- Trial name
- RACAVA (NCT02991170)
- Testing
- unipolar or bipolar radiofrequency ablation+CABG, CABG
- Where
- 3 sites in China
- Volunteers
- 180 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation
MANAGE-AF Registry -MANAGEment of Atrial Fibrillation Outcomes Registry (MANAGE-AF)
The purpose of this research is to learn more about the normal care of patients with a new or pre-existing diagnosis of atrial fibrillation (AF).
- Trial name
- MANAGE-AF (NCT05978466)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- CorVita Science Foundation
Hypertension, Diabetes Mellitus, Type 2
Proteus Discover in Subjects With Uncontrolled Hypertension and Type 2 Diabetes
The purpose of this study was to evaluate the efficacy of a new digital health offering, Proteus Discover to lower blood pressure and glycated hemoglobin in patients with uncontrolled hypertension and type 2 diabetes.
- Conditions
- Hypertension, Diabetes Mellitus, Type 2, Hypercholesterolemia
- Trial name
- NCT02827630
- Testing
- Proteus Discover, Usual Care
- Volunteers
- 118 people
- Sponsor
- Proteus Digital Health, Inc.
Covid19, Thrombosis Embolism
COVID-19 Registry to Assess Frequency, Risk Factors, Management, and Outcomes of Arterial and Venous Thromboembolic Complications
Novel coronavirus 2019 (COVID-19) has emerged as a major international public health concern. While much of the morbidity and mortality associated with COVID-19 has been attributed to acute respiratory distress syndrome (ARDS) or…
- Conditions
- Covid19, Thrombosis Embolism, DVT, Pulmonary Embolism
- Trial name
- CORONA-VTE NET (NCT04535128)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 11,000 people
- Sponsor
- Brigham and Women's Hospital
Type2 Diabetes, NASH - Nonalcoholic Steatohepatitis
A Study of MSDC-0602K to Assess Glycemic Control and Cardiovascular Outcomes in Patients With Pre-T2D or T2D and NAFLD/NASH
This is a randomized, double-blind study of MSDC-0602K or placebo in subjects with pre-T2D or T2D and evidence of NAFLD/NASH.
- Conditions
- Type2 Diabetes, NASH - Nonalcoholic Steatohepatitis, Nonalcoholic Steatohepatitis, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT03970031
- Testing
- MSDC-0602K
- Volunteers
- 1,800 people
- Sponsor
- Cirius Therapeutics, Inc.
Type 2 Diabetes Mellitus, Hypertension (Without Type 2 Diabetes Mellitus)
Empowering Primary Care Providers and Patients to Improve Chronic Disease Outcomes: The EMPOWER Participatory Action Research (EMPOWER - PAR)
BACKGROUND Chronic disease management (CDM) presents enormous challenges to the primary care workforce due to the rising epidemic of cardiovascular risk factors.
- Trial name
- NCT01545401
- Testing
- EMPOWER-PAR Intervention
- Where
- Malaysia
- Volunteers
- 1,545 people
- Sponsor
- Ministry of Health, Malaysia
Chronic Subdural Hematoma
GET-UP Trial: Impact of an Early Out-of-bed Paradigm in Postoperative Outcomes of Chronic Subdural Hematomas
Compare rates of medical complications, recurrence and outcome in 2 randomized groups of patients with surgical chronic subdural hematomas.
- Trial name
- GET-UP (NCT03788005)
- Testing
- Early mobilization
- Where
- Portugal
- Volunteers
- 208 people
- Sponsor
- Centro Hospitalar do Porto
Cardiovascular Surgery, Postoperative Recovery
Virtual Reality Supported Mindfulness Meditation After Cardiovascular Surgery
The early postoperative period following cardiovascular surgery is often associated with increased anxiety, stress, and physiological instability.
- Conditions
- Cardiovascular Surgery, Postoperative Recovery, Anxiety, Stress
- Trial name
- VR-MIND-CVS (NCT07523594)
- Testing
- Virtual Reality-Supported Mindfulness Meditation
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Kutahya Health Sciences University
Multiple Myeloma and Plasma Cell Neoplasm
Busulfan, Cyclophosphamide, and Autologous Stem Cell Transplant in Treating Patients With Multiple Myeloma
RATIONALE: Giving high-dose chemotherapy before an autologous stem cell transplant stops the growth of cancer cells by stopping them from dividing or killing them.
- Trial name
- NCT00941720
- Testing
- busulfan, cyclophosphamide, autologous hematopoietic stem cell transplantation
- Where
- United States
- Volunteers
- 71 people
- Sponsor
- Case Comprehensive Cancer Center
Gait, Hemiplegic, Quality of Life
Effect of Using a Lower Limb Robotic Device for Patients With Chronic Stroke
This study will investigate if a lower limb robotic device can be used in a community setting to increase the amount of physical activity that individuals undertake following stroke and consequently improve biomechanical…
- Conditions
- Gait, Hemiplegic, Quality of Life, Vascular Stiffness, Stroke
- Trial name
- NCT03104127
- Testing
- Alter G Bionic Leg, Normal therapy (physiotherapy)
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- University of Winchester
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