Clinical trials: Cardiovascular Outcomes
Obstructive Hypertrophic Cardiomyopathy (oHCM)
Mavacamten Outcomes in Hypertrophic Cardiomyopathy (HCM) and the Associated Patient and Physician Experiences in the US
The purpose of this study is to understand the real-world clinical outcomes and treatment patterns of adults with obstructive hypertrophic cardiomyopathy (HCM) treated with mavacamten, and to understand patient and physician…
- Trial name
- SPARC-HCM (NCT07557498)
- Testing
- Mavacamten
- Where
- United Kingdom
- Volunteers
- 362 people
- Sponsor
- Bristol-Myers Squibb
Myocardial Infarction (MI)
Impact of Pre-Hospital and Hospital Delays on Myocardial Infarction Outcomes
The goal of this prospective observational study is to investigate the impact of pre-hospital and hospital delays on the outcomes of myocardial infarction (MI) patients admitted to Al-Kadhimiya Teaching Hospital, Baghdad.
- Trial name
- PHHD-MI (NCT06738498)
- Where
- Iraq
- Volunteers
- 200 people
- Sponsor
- Al-Nahrain University
End Stage Renal Disease
Vascular Access Choice and Outcomes in the Elderly and Very Elderly With End Stage Renal Disease in China
The purpose of the study is to evaluate the clinical outcomes and cost-effectiveness of different vascular access(arteriovenous fistula, tunneled cuffed catheter and arteriovenous graft) in the elderly and very elderly with…
- Trial name
- ACCESS-China (NCT02272374)
- Testing
- AVF creation, TCC placement, AVG creation
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Shanghai Changzheng Hospital
Subarachnoid Hemorrhage, Aneurysmal
Pilot Study of Ketamine Sedation for Aneurysmal Subarachnoid Hemorrhage
Aneurysmal subarachnoid hemorrhage (aSAH) is bleeding into the space between the brain and the tissues that surround the brain as a result of a ruptured aneurysm and is a type of stroke associated with high morbidity and…
- Trial name
- PENDULUM (NCT05032118)
- Testing
- Ketamine Hydrochloride, Propofol
- Sponsor
- Jenna L Leclerc MD, PhD
Social Determinant of Health, Intracranial Aneurysms
Risk Analysis of Intracranial Aneurysm Rupture Through Social Determinants of Health
Intracranial aneurysms (IA) are arterial malformations affecting about 3% of the overall population. Rupture is the most severe complication, as it is associated with nearly 30% of death or severe disability.
- Conditions
- Social Determinant of Health, Intracranial Aneurysms, Subarachnoid Hemorrhage, Treatment Outcomes
- Trial name
- ARAMISS (NCT06866210)
- Where
- France
- Volunteers
- 1,800 people
- Sponsor
- Nantes University Hospital
Coronary Artery Disease
Retrospective Study of the Impact of Drug Eluting Stents
The purpose of this study is to determine whether the use of drug eluting stents is associated with higher rates of death, myocardial infarction, and major bleeding.
- Trial name
- NCT00487604
- Where
- United States
- Volunteers
- 9,800 people
- Sponsor
- Providence Health & Services
Atrial Fibrillation and Flutter, Mechanical Mitral Valve Prosthesis
Impact of Education Level on Clinical Outcomes in Self-INR Managed Patients
Oral anticoagulation (OAC) is indicated in a wide variety of clinical conditions including atrial fibrillation (AF), mechanical valve prosthesis (MVP), deep vein thrombosis and pulmonary embolism.
- Trial name
- NCT06187155
- Testing
- INR self-management
- Where
- Egypt
- Volunteers
- 586 people
- Sponsor
- Cairo University
Stroke, Atheroscleroses
A Cohort Study on Cardiovascular and Cerebrovascular Outcomes
A standardized tool for grading carotid atherosclerotic plaques-dubbed Carotid Plaque-RADS (Reporting and Data System)-has recently been developed.
- Trial name
- NCT07178015
- Testing
- ultrasound scanning
- Where
- China
- Volunteers
- 855 people
- Sponsor
- Sun Yat-sen University
Overweight and Obesity, Vitamin D Deficiency
Magnesium and Vitamin D Supplementation and Cardiometabolic Outcomes
The purpose of this study is to investigate the effects of a combined vitamin D and magnesium supplementation on parathyroid hormone and cardiometabolic health in persons living with obesity.
- Conditions
- Overweight and Obesity, Vitamin D Deficiency, Magnesium Deficiency, Cardiovascular Risk Factor
- Trial name
- NCT03134417
- Testing
- Vitamin D and magnesium, Vitamin D
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Drexel University
Perimenopause, Menopause
CARAMEL Observational Study
CARAMEL is a project funded by the European Commission under the Horizon Europe programme. Its aim is to develop a personalized prevention approach based on state-of-the-art artificial intelligence models for cardiovascular risk…
- Conditions
- Perimenopause, Menopause, Cardiovascular (CV) Risk, Women (Between 30 to 60 Years Old)
- Trial name
- CARAMEL-OS (NCT07695376)
- Where
- 6 sites in Colombia, Croatia and 3 more
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Biogipuzkoa Health Research Institute
Choroid Disease, Carotid Stenosis
Ophthalmologic Outcomes in Patients With Carotid Artery Stenosis
The retinal vessels have been shown to reflect vascular changes inherent to systemic pathologies, even when no ocular disease is identified.
- Conditions
- Choroid Disease, Carotid Stenosis, Carotid Atherosclerosis, Retinal Disease
- Trial name
- NCT05623293
- Testing
- eye - Optcial coherence tomography
- Where
- Portugal
- Volunteers
- 40 people
- Sponsor
- Universidade do Porto
Coronary Heart Disease, Stroke
Examining the Long-Term Risks of Oophorectomy
At the time of hysterectomy for benign disease, the overall health benefits of preserving ovarian function in a large population of women have not been established.
- Conditions
- Coronary Heart Disease, Stroke, Breast Cancer, Ovarian Cancer
- Trial name
- NCT00655447
- Where
- United States
- Volunteers
- 32,175 people, healthy volunteers welcome
- Sponsor
- Parker, William H., M.D.
Stroke, Intracerebral Haemorrhage
The Planetary Outcomes After Intracranial Haemorrhage Study
Over twelve million strokes occur worldwide every year, and stroke is the second most common cause of death globally. Strokes happen because blood supply to the brain is damaged.
- Conditions
- Stroke, Intracerebral Haemorrhage, Subarachnoid Haemorrhage (SAH)
- Trial name
- PLOT-ICH (NCT06731751)
- Testing
- Management of spontaneous intracranial haemorrhage
- Volunteers
- 1,000 people
- Sponsor
- University of Cambridge
Type 2 Diabetes
Emulation of the REWIND Cardiovascular Outcomes Trial in Healthcare Claims Data.
Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials.
- Trial name
- NCT07417631
- Testing
- Dulaglutide, Sitagliptin
- Where
- United States
- Volunteers
- 300,000 people
- Sponsor
- Brigham and Women's Hospital
Sleep, Atrial Fibrillation
Impact of Sleep Quality on Outcomes After Cardiac Surgery
Sleep is a basic human need and is essential for good quality of life, good health. In fact, humans spend one third of their life time in sleeping or attempting to do so.
- Conditions
- Sleep, Atrial Fibrillation, Delirium, Postoperative, Complications, Postoperative
- Trial name
- NCT06527105
- Testing
- Eye masks and ear plugs
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Amrita Institute of Medical Sciences & Research Center
Cardiac Valve Disease, Coronary Artery Disease
Nasal Oxygen Therapy After Cardiac Surgery
NOTACS aims to determine if prophylactic use of high-flow nasal therapy (for a minimum of 16 hours after tracheal extubation, inclusive of up to one hour off randomised therapy for transfers around the hospital and/or physio…
- Conditions
- Cardiac Valve Disease, Coronary Artery Disease, Respiratory Failure
- Trial name
- NOTACS (NCT05308719)
- Testing
- High Flow Nasal Therapy
- Where
- United Kingdom
- Volunteers
- 1,280 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Coronary Artery Disease
Short-term Outcomes of Elective High-risk PCI With Extracorporeal Membrane Oxygenation Support: a Single-centre Registry
Background Revascularization of complex coronary artery disease, including multivessel coronary artery disease, left main stenosis, bifurcation stenosis and chronic total occlusions (CTO) can be performed by Percutaneous Coronary…
- Trial name
- NCT05387902
- Testing
- Extracorporeal Membrane Oxygenation
- Where
- Netherlands
- Volunteers
- 25 people
- Sponsor
- Robert Jan van Geuns
Diabetes, Myocardial Infarction
Look AHEAD: Action for Health in Diabetes
The Look AHEAD study is a multi-center, randomized clinical trial to examine the long-term effects of a lifestyle intervention designed to achieve and maintain weight loss.
- Conditions
- Diabetes, Myocardial Infarction, Stroke, Kidney Diseases
- Trial name
- LookAHEAD (NCT00017953)
- Testing
- Lifestyle Intervention, Diabetes Support and Education
- Where
- 18 sites in United States
- Volunteers
- 5,145 people
- Sponsor
- Wake Forest University Health Sciences
Spatial Neglect, Deficits in Attention Motor Control and Perception
Prism Adaptation Therapy for Spatial Neglect
The purpose of this research study with a randomized controlled design is to examine the effects of prism adaptation treatment on two visual-spatial recovery components.
- Trial name
- NCT00989430
- Testing
- Prism Adaptation Treatment
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Kessler Foundation
Dilated Cardiomyopathy
Therapy With Verapamil or Carvedilol in Chronic Heart Failure
The aim of this study is to compare the effect of treatment with verapamil or carvedilol on long-term outcomes in stable, chronic heart failure secondary to non-ischemic cardiomyopathy.
- Trial name
- NCT00374465
- Testing
- Verapamil, Carvedilol
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Silesia
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