Clinical trials: Cardiovascular Outcomes
Coronary Artery Disease (CAD), Calcific Coronary Arteriosclerosis
Overviewing Real-World Outcomes to Boost Interventional Management of CAlcified Coronary Lesions: the OROBICA Registry.
The OROBICA (Overviewing Real-World Outcomes to Boost Interventional Management of CAlcified Coronary Lesions) Registry is a multicenter, ambispective, real-world observational study designed to evaluate clinical, procedural…
- Conditions
- Coronary Artery Disease (CAD), Calcific Coronary Arteriosclerosis, Intravascular Lithotripsy; Rotational Atherectomy; OFDI, Orbital Atherectomy
- Trial name
- OROBICA (NCT07566403)
- Testing
- Percutaneous coronary intervention with or without stent implantation
- Where
- Italy
- Volunteers
- 3,000 people
- Sponsor
- Papa Giovanni XXIII Hospital
Cardiac Arrhythmia
The Objective of This Multicentre Study is to Collect Operative Data on the Related Clinical Functional Outcomes and Complications and of Market Approved Alcis Electrophysiology Catheters to Demonstrate Safety and Performance of These Devices in a Real-world Setting
The objective of this multicentre study is to collect operative data on the related clinical functional outcomes and complications and of market approved Alcis electrophysiology catheters to demonstrate safety and performance of…
- Trial name
- NCT05314218
- Testing
- Electrophysiology catheters and cables
- Where
- 2 sites in France
- Volunteers
- 168 people
- Sponsor
- Alcis
Atrial Fibrillation
Home Monitoring for Thoracic Surgery Patients
Background and Importance: When patients transition from hospital to home following surgery, perceived complications or poorly controlled pain can result in emergency department visits and readmissions.
- Trial name
- NCT04340960
- Testing
- Home Monitoring
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Western University, Canada
Acute Ischemic Stroke
Effect of Human Urinary Kallidinogenase on Inflammatory Factors in Acute Ischemic Stroke (KIF-AIS)
The goal of this clinical trial is to explore the changes in the expression levels of inflammatory factors before and after the early treatment of Human Urinary Kallidinogen (HUK) in the acute ischemic stroke.
- Trial name
- NCT06696703
- Testing
- Human urinary kininogenase(HUK)
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Cardiovascular Disease
Cerebrovascular Outcomes in Ischemic Heart Disease
This project will examine the association between (cardio)vascular disease, blood supply to the brain, and cerebrovascular endothelial activation.
- Trial name
- IHD (NCT02715661)
- Testing
- exercise
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Pulmonary Embolism and Thrombosis
An International Pulmonary Embolism Registry Using EKOS
This registry is designed to understand acoustic pulse thrombolysis (APT) treatment regimens used as standard of care globally for pulmonary embolism.
- Trial name
- KNOCOUT PE (NCT03426124)
- Testing
- EkoSonic Endovascular System with thrombolytic
- Where
- 80 sites in United States, Austria and 6 more
- Volunteers
- 1,480 people
- Sponsor
- Boston Scientific Corporation
Acute Ischemic Stroke, Large Vessel Occlusion
Inflammatory Markers and Prognosis After Cerebral Thrombectomy in Large Vessel Occlusion
The goal of this observational study is to describe the local change in interleukin-6 (IL-6) across a blood clot in adults with acute ischemic stroke caused by anterior circulation large vessel occlusion who are undergoing…
- Trial name
- IMPACT-LVO (NCT07754942)
- Testing
- Prospective Mechanical Thrombectomy Cohort
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Zhongshan Hospital Xiamen University
Fabry Disease
A Study of Agalsidase Alfa Enyzme Replacement Therapy in Chinese Children and Adults With Fabry Disease
Fabry Disease is a rare blood disorder that some people are born with. People with Fabry disease have low levels of an enzyme called alpha-galactosidase A. This enzyme helps to cut down fat-like substances.
- Trial name
- NCT07187440
- Testing
- No intervention
- Where
- 18 sites in China
- Volunteers
- 200 people
- Sponsor
- Takeda
Cardiac Arrest, Out-Of-Hospital Cardiac Arrest
The Effect of Prehospital Combination of Epinephrine, Vasopressin, and Steroid in OHCA
This project is a randomized controlled clinical research design, The hypothesis P-I-C-O of the study is: For adult patients in the Taipei City and New Taipei City communities who have suffered sudden non-traumatic death and have…
- Conditions
- Cardiac Arrest, Out-Of-Hospital Cardiac Arrest, Emergency Medical Services
- Trial name
- REVIVES (NCT06203847)
- Testing
- Combination group, Standard group
- Where
- Taiwan
- Volunteers
- 1,344 people
- Sponsor
- National Taiwan University Hospital
Stroke, Fatigue Symptom
Sleep-Disordered Breathing in the Acute Phase After Stroke and Neuropsychiatric Outcomes
In people who have had a stroke or a transient ischemic attack (TIA), it is common to have problems with breathing patterns during sleep, particularly a condition called obstructive sleep apnea.
- Conditions
- Stroke, Fatigue Symptom, Obstructive Sleep Apnea, Sleep Disordered Breathing (SDB)
- Trial name
- NCT06811948
- Where
- Sweden
- Volunteers
- 340 people
- Sponsor
- Blekinge County Council Hospital
Acute Coronary Syndrome
Telemedical vs. Conventional Prehospital Care in Acute Coronary Syndromes
Telemedically supported paramedic care of acute coronary syndromes was compared to a historical control period of solely conventional on-scene physician care.
- Trial name
- NCT03132935
- Testing
- Telemedical support
- Where
- Germany
- Volunteers
- 221 people
- Sponsor
- RWTH Aachen University
Cardiovascular Diseases, Cardiovascular Diseases Risk
Cor360: Clinician-Facing Broad-Spectrum Cardiac Phenotyping and Risk Assessment Using COR® Wearable ECG to Inform Outcomes-Oriented Care Pathways
Cor360 is an observational study evaluating whether extended wearable electrocardiogram (ECG) data can support broad-spectrum cardiac phenotyping and risk assessment beyond conventional single-purpose ambulatory rhythm…
- Conditions
- Cardiovascular Diseases, Cardiovascular Diseases Risk, Cardiac Conduction System Disease, Bundle/Fascicular Abnormalities
- Trial name
- Cor360 (NCT07775976)
- Testing
- COR Wearable ECG Monitoring, Cor360 Clinician-Facing Decision-Aid Reporting
- Where
- 2 sites in United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Peerbridge Health, Inc
Kawasaki Disease, Macrophage Activation Syndrome (MAS)
MASKd: a Study on Kawasaki Disease (KD) Complicated by Macrophage Activation Syndrome (MAS)
Kawasaki Disease (KD) is one of the most common vasculitides in childhood and represents a leading cause of acquired heart disease in developed countries.
- Trial name
- NCT07491926
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Meyer Children's Hospital IRCCS
Chest Pain, Acute Coronary Syndrome
Shared Decision Making in the Emergency Department: Chest Pain Choice Trial
Our long-term goal is to promote evidence-based patient-centered evaluation in the acute setting to more closely tailor testing to disease risk.
- Trial name
- CPC (NCT01969240)
- Testing
- Chest Pain Choice Decision Aid
- Where
- 5 sites in United States
- Volunteers
- 898 people
- Sponsor
- Mayo Clinic
Coronary Disease, Stroke
Assessing Outcomes of Enhanced Chronic Disease Care Through Patient Education and a Value-based Formulary Study
The purpose of this study is to determine the effect of two novel interventions; (1) a value-based formulary which eliminates copayment for selected high-value medications (proven to prevent heart attacks, stroke, and…
- Conditions
- Coronary Disease, Stroke, Chronic Kidney Disease, Heart Failure
- Trial name
- ACCESS (NCT02579655)
- Testing
- Copayment Elimination, Personalized Education
- Where
- Canada
- Volunteers
- 4,764 people
- Sponsor
- University of Calgary
Gastrointestinal Hemorrhage, Cardiovascular Diseases
Study of the Risk Factors and Outcomes After Gastrointestinal Bleeding
The purpose of this multicenter, two component observational and standardized case-control study is to evaluate risk factors of gastrointestinal (GI) bleeding with a prospective 3-month and 12-month follow-up to examine outcomes…
- Trial name
- NCT02514304
- Where
- Canada
- Volunteers
- 4,745 people
- Sponsor
- Population Health Research Institute
ST Elevation Myocardial Infarction
Effect of Statin Preloading in STEMI in Improving PCI Outcomes
To compare the effect of a single high dose of atorvastatin versus rosuvastatin preloading on microvascular coronary perfusion as determined by CTFC in patients with ST-segment elevation myocardial infarction (STEMI) undergoing…
- Trial name
- NCT04974814
- Testing
- Rosuvastatin 40mg, Atorvastatin 80mg, Control Test
- Where
- Egypt
- Volunteers
- 99 people
- Sponsor
- Beni-Suef University
Hypertension, Pulmonary
Evaluation of Inhaled Iloprost Effects Using the Breelib Nebulizer, on Clinical Outcomes and Physical Activity of Patients With Advanced Pulmonary Arterial Hypertension
The main aim of the observational VENTASTEP study was to investigate the association between changes in clinical outcome measures and changes in device outcome measures in PAH patients using the new Breelib nebulizer in a real…
- Trial name
- VENTASTEP (NCT03293407)
- Testing
- Iloprost (Ventavis, BAYQ6256), Breelib nebulizer
- Where
- Germany
- Volunteers
- 31 people
- Sponsor
- Bayer
Orthostatic Hypotension, Postprandial Hypotension
Orthostatic And Postprandial Hypotension In Hospitalized Older Adults (HOPE65)
The goal of this observational study is to determine how often orthostatic hypotension and postprandial hypotension occur in adults aged 65 years and older who are hospitalized in internal medicine departments.
- Trial name
- HOPE65 (NCT07485998)
- Where
- Slovenia
- Volunteers
- 500 people
- Sponsor
- University Medical Centre Ljubljana
Kidney Transplant, DCD Kidney
NRP + ex Situ HMPO2 vs NRP Alone in DCD Kidney Transplantation
The goal of this clinical trial is to learn if the combination of Normothermic Regional Perfusion (NRP) at the time of organ procurement with ex situ Hypothermic Oxygenated Perfusion (HMPO2) of kidneys recovered from donors after…
- Trial name
- OxyPerf (NCT07779187)
- Testing
- Ex situ hypothermic oxygenated machine preservation
- Where
- 3 sites in Sweden
- Volunteers
- 214 people
- Sponsor
- Karolinska University Hospital
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