Clinical trials: Cardiovascular Outcomes
Hypoxic-Ischemic Encephalopathy
PAEAN - Erythropoietin for Hypoxic Ischaemic Encephalopathy in Newborns
Double-blind, placebo controlled Phase III trial of erythropoietin for hypoxic ischaemic encephalopathy in infants receiving hypothermia.
- Trial name
- PAEAN (NCT03079167)
- Testing
- Epoetin Alfa, Normal saline
- Where
- 24 sites in Australia, New Zealand and 1 more
- Volunteers
- 313 people
- Sponsor
- University of Sydney
Pulmonary Hypertension, Valvular Heart Disease
Sildenafil for Secondary Pulmonary Hypertension Due to Valvular Disease
The purpose of this study is to evaluate the clinical efficacy of the mid-term treatment with sildenafil in patients with persistent moderate or severe pulmonary hypertension (PH) after a heart valve intervention.
- Trial name
- SIOVAC (NCT00862043)
- Testing
- Sildenafil Citrate
- Where
- 18 sites in Spain
- Volunteers
- 200 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Aneurysm Cerebral, AVM
This Three-year Observational Study Involves Patients of All Ages Undergoing Endovascular Treatment for Various Cerebral or Spinal Vascular Conditions. It Aims to Assess Pre- and Post-operative Clinical Conditions, Report Complications, and Identify Preoperative Indicators of Treatment Outcomes. Pat
This three-year observational study involves patients of all ages undergoing endovascular treatment for various cerebral or spinal vascular conditions.
- Conditions
- Aneurysm Cerebral, AVM, DAFV, ESDC
- Trial name
- ONIRIC (NCT06805721)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Rheumatoid Arthritis, Cardiovascular Disease
Vitamin D and Cardiovascular Events in Rheumatoid Arthritis
The aim of the study is to evaluate cardiovascular events during long-term follow-up in Rheumatoid Arthritis. The primary outcome "any cardiovascular event" will be evaluated using systematic audits of patient records, and will…
- Trial name
- NCT02932644
- Testing
- Baseline serum vitamin D level below 50 nmol/l, Baseline serum vitamin D level at or above 50 nmol/l
- Volunteers
- 160 people
- Sponsor
- Odense University Hospital
Kidney Failure, Chronic, Arrhythmias, Cardiac
HOLT-ED: Holter-monitoring in End-stage Renal Disease
The main objective of this prospective cohort study is to assess arrhythmia burden and glycemic variability in a multicenter cohort of patients with end-stage renal disease using a sufficient observation period in order to…
- Conditions
- Kidney Failure, Chronic, Arrhythmias, Cardiac, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT04876963
- Testing
- Holter-monitor
- Where
- 3 sites in Denmark
- Volunteers
- 268 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiac Surgical Procedures, Coronary Artery Disease
Clinical Outcomes in Patients Treated With SternaLock Blu
The primary objective of this study is to evaluate the rate of deep sternal wound infection at 30 days post-operative following a full median sternotomy in patients treated with SternaLock Blu for rigid sternal fixation.
- Conditions
- Cardiac Surgical Procedures, Coronary Artery Disease, Heart Valve Diseases
- Trial name
- SECURE (NCT03709693)
- Testing
- SternaLock Blu
- Where
- 4 sites in United States
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
ST Elevation Myocardial Infarction (STEMI) Patients
ST Elevation Myocardial Infarction Hemodynamic OutComes: Role of Non-Invasive Cardiac System (SHOCk-NICaS) Study
Proposed novel solution for high-risk heart disease Overall in-hospital mortality among ST elevation myocardial infarction (STEMI) patients is 3-4%, but >50% patients experiencing cardiogenic shock (CS) secondary to STEMI die in…
- Trial name
- SHOCk-NICaS (NCT04586764)
- Testing
- Non-Invasive Cardiac System
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- University of Manitoba
Hospitalization
Orthostatic Hypotension in Hypertensive Patient Hospitalized in Internal Medicine
The two scientific societies FADOI and SIIA have decided to start a collaborative study protocol that, through the application of a simple and homogeneous method to diagnose orthostatic hypotension, aims to estimate prevalence…
- Trial name
- IP-OP (NCT05247060)
- Testing
- no experimental intervention
- Where
- 33 sites in Italy
- Volunteers
- 1,000 people
- Sponsor
- Fadoi Foundation, Italy
Hypertension, Self-Care Practices
Telemedicine-Based Behavioral Intervention to Improve Self-Care Among Hypertensive Patients
The goal of this quasi-experimental clinical study is to learn whether a telemedicine-based behavioral intervention can improve self-care practices among adult patients with hypertension receiving care at teaching hospitals in…
- Conditions
- Hypertension, Self-Care Practices, Medication Adherence, Hospital Admission
- Trial name
- NCT07412106
- Testing
- Telemedicine-Based Behavioral Counseling
- Volunteers
- 320 people
- Sponsor
- Bahir Dar University
Heart Failure
Patient-Reported Outcome Measurement in Heart Failure Clinic
This is a randomized study evaluating the effect of routinely collecting a standardized questionnaire of heart failure health status during heart failure clinic visits.
- Trial name
- PRO-HF (NCT04164004)
- Testing
- Kansas City Cardiomyopathy Questionnaire-12
- Where
- United States
- Volunteers
- 1,249 people
- Sponsor
- Stanford University
Cardiopulmonary Arrest
Effect of ETI Performance on CPR Outcomes
This is a clinical observation study based on analysis of video-clip data of cardiopulmonary resuscitation (CPR) for out-of hospital cardiac arrest (OHCA) in emergency department.
- Trial name
- NCT04451733
- Testing
- Endotracheal intubation
- Where
- South Korea
- Volunteers
- 250 people
- Sponsor
- Konkuk University Medical Center
Heart Disease, Heart Failure
Non-interventional Study on Guideline Directed Medical Therapy for Patients With Heart Failure (HF) in Germany
Heart failure (HF) is a global public health issue that affects more than 63 million people worldwide. The clinical and economic burden of HF on health care systems is substantial.
- Conditions
- Heart Disease, Heart Failure, Cardiovascular Disease, Heart Failure, Systolic
- Trial name
- PHRASE-HF (NCT06675552)
- Where
- 6 sites in Germany
- Volunteers
- 338 people
- Sponsor
- AstraZeneca
Heart Failure
Testing the Effects of Telehealth Monitoring on Rehospitalization and Self Care for Heart Failure Patients in Home Care
We are testing the use of telehealth technology that includes self monitoring of blood pressure, weight, blood sugar, and oxygen levels for patients with heart failure who are receiving home care.
- Trial name
- NCT00300261
- Testing
- Telehealth monitoring
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- University of Pennsylvania
Alpha-Thalassemia, Beta-Thalassemia
FLOWER: Following Longitudinal Outcomes With Epidemiology for Rare Diseases
FLOWER is a completely virtual, nationwide, real-world observational study to collect, annotate, standardize, and report clinical data for rare diseases.
- Conditions
- Alpha-Thalassemia, Beta-Thalassemia, Amyloidosis, Amyotrophic Lateral Sclerosis
- Trial name
- NCT06539169
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- xCures
Pulmonary Embolism and Thrombosis, Deterioration, Clinical
A Predictive Tool for Predicting Adverse Outcomes in Acute Pulmonary Embolism Patients Using CTPA.
This study collected clinical, laboratory, and CT parameters of acute patients with acute pulmonary embolism from admission to predict adverse outcomes within 30 days after admission into hospital.
- Trial name
- NCT05098769
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shengjing Hospital
Coronary Artery Disease
ANDREAS Registry (Assessment of Novel Drug-coated Balloon Revascularization: Effectiveness, Angiographic Outcomes, and Safety)
The primary objective of this protocol is to develop a comprehensive, multicenter international prospective registry to capture long-term clinical outcomes for adult patients undergoing percutaneous coronary intervention (PCI)…
- Trial name
- NCT07559903
- Where
- 19 sites in United States, Germany and 1 more
- Volunteers
- 5,000 people
- Sponsor
- Emory University
Coronary Disease
Long Term Efficacy and Safety of Firebird Sirolimus-Eluting Stent In Complex Coronary Lesions
The purpose of this study is to investigate the long term efficacy and safety of firebird sirolimus-eluting stent for treatment of complex coronary Lesions.
- Trial name
- FIREMAN (NCT00552656)
- Testing
- Firebird(TM) Sirolimus-Eluting Stent
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Xijing Hospital
Stroke
Balloon Guide Catheter to Optimize Outcomes in Stroke Thrombectomy of the Internal Carotid Artery
To investigate whether using balloon guide catheter with flow arrest during mechanical thrombectomy, compared to non-flow arrest, improves the rate of first pass expanded Thrombolysis in Cerebral Infarction score (eTICI 2c-3)…
- Trial name
- NCT07192029
- Testing
- Balloon guide catheter combined with conventional thrombectomy treatment, Standard guide catheter or neurovascular sheath combined with conventional thrombectomy treatment
- Where
- 3 sites in China
- Volunteers
- 364 people
- Sponsor
- Xuanwu Hospital, Beijing
Atrial Fibrillation
Surgical vs Percutaneous LAAO
Atrial fibrillation is the most common cardiac arrythmia globally. Its prevalence ranges between 2-4% worldwide. It is associated with significant morbidity and mortality.
- Trial name
- NCT05420701
- Testing
- TEE
- Volunteers
- 260 people
- Sponsor
- Chinese University of Hong Kong
Peripheral Arterial Disease
DANCE Partner: Inflammatory Biomarker Analysis by Femoropopliteal Revascularization Method and Treatment Outcomes
This is a prospective, multi-center, observational registry to document the baseline, 24-hour and 30-day inflammatory response and procedural outcomes out to 12 month follow-up after femoropopliteal angioplasty or…
- Trial name
- NCT02469532
- Testing
- Balloon Angioplasty, Atherectomy System
- Where
- 6 sites in United States
- Volunteers
- 31 people
- Sponsor
- Mercator MedSystems, Inc.
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