Clinical trials: Cardiovascular Outcomes
Coronary Artery Disease
Clinical and Procedural Outcomes of Ostial Left Anterior Descending Artery Intervention With or Without Crossover to Left-main
Prospective interventional study evaluating clinical and procedural outcomes of patients with ostial left anterior descending artery lesion PCI alone or crossover with left main artery
- Trial name
- NCT05933473
- Testing
- Percutaneous coronary intervention
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cardiac Arrest
Code Blue Outcomes & Process Improvement Through Leadership Optimization Using Teleintensivists-Simulation
This multicenter randomized trial will employ in-situ cardiac arrest simulations ("mock codes") to test whether using telemedicine technology to add an intensive care physician as the "copilot" for cardiac arrest resuscitation…
- Trial name
- COPILOT-Sim (NCT03000829)
- Testing
- Tele-intensivist consultation, Simulated "observation" by ICU physician
- Where
- 7 sites in United States
- Volunteers
- 1,001 people
- Sponsor
- Intermountain Health Care, Inc.
Medication Adherence, Hypertension
Evaluation of a Decision Support Tool
Investigators will conduct a randomized trial with patients, through one-on-one interviews, to evaluate their understanding of and willingness to use a decision support tool and to determine if receiving and discussing the…
- Conditions
- Medication Adherence, Hypertension, Decision Making, Shared, Patient-Centered Outcomes Research
- Trial name
- PRIMA (NCT02060981)
- Testing
- Control, Interview Only, Interview plus decision support tool
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Brigham and Women's Hospital
Cardiovascular Disease
Effectiveness of an E-health Educational Intervention for Cardiovascular Disease Adults in Improving Outcomes
Cardiovascular disease (CVD) is the leading cause of death globally and e-health educational programs have been proved to be effective support to CVD clients.
- Trial name
- NCT02350192
- Testing
- e-health educational intervention (eHEI)
- Where
- 2 sites in Hong Kong
- Volunteers
- 438 people
- Sponsor
- Chinese University of Hong Kong
Pain, Chronic Pain
A Study of the Impact of Genetic Testing on Clinical Decision Making and Patient Care
The purpose of this study is to evaluate the impact of genetic testing on healthcare decisions and patient outcomes for patients suffering from pain, cardiovascular problems, Arthritis, Type II Diabetes, and/or Mental Health…
- Conditions
- Pain, Chronic Pain, Mental Disorders, Cardiovascular Diseases
- Trial name
- REVOLUTION (NCT02487888)
- Testing
- Unblinded to Genetic Testing Results, Blinded to Genetic Testing Results
- Where
- 31 sites in United States
- Volunteers
- 100,000 people
- Sponsor
- Proove Bioscience, Inc.
Angina
Optical Coherence Tomography to Improve Clinical Outcomes During Coronary Angioplasty
Coronary artery stenting has evolved as an effective treatment for angina and involves stretching up narrowings within the heart arteries using a balloon (coronary angioplasty) before implanting a small metal scaffold (stent) to…
- Trial name
- NCT02065102
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Royal Infirmary of Edinburgh
Atrial Fibrillation
Artificial Intelligence Models to Predict Clinically Relevant Cardiovascular Outcomes
Atrial fibrillation (AF) is a frequent and clinically relevant problem among the events that may occur during the hospitalization period in patients with cardiovascular disease.
- Trial name
- PERCARD (NCT06847100)
- Testing
- Blood withdrawal
- Where
- 4 sites in Finland, Germany and 1 more
- Volunteers
- 273 people
- Sponsor
- Centro Cardiologico Monzino
Acute Myocardial Infarction With ST Elevation, Anterior Wall Myocardial Infarction
Deferred Stenting in Patients With Anterior Wall STEMI
Trial Name) Impact of Immediate SteNt ImplaNtatiOn Versus Deferred Stent ImplAntaTION on Clinical Outcomes in Patients with AnteRior Wall ST-segment Elevation Myocardial Infarction (INNOVATION-CORE) Objectives) To evaluate the…
- Trial name
- INNOVATIONCORE (NCT03744000)
- Testing
- Immediate stenting, Deferred stenting
- Where
- South Korea
- Volunteers
- 185 people
- Sponsor
- Korea University Anam Hospital
Acute Myocardial Infarction, Heart Failure
Dapagliflozin Effects on Cardiometabolic Outcomes in Patients With an Acute Heart Attack.
This study will evaluate the effect of dapagliflozin versus placebo, given once daily in addition to Standard of Care (SoC) therapies for patients with myocardial infarction (MI), for hospitalisation for heart failure (HHF)…
- Trial name
- DAPA-MI (NCT04564742)
- Testing
- Dapagliflozin
- Where
- 103 sites in Sweden, United Kingdom
- Volunteers
- 4,017 people
- Sponsor
- AstraZeneca
Type 2 Diabetes Mellitus, Acute Coronary Syndrome
Association Between Time in Range and In-hospital Outcomes in Type 2 Diabetic Patients With Acute Coronary Syndrome
The aim of this study is to use real-time continuous glucose monitoring (real-time CGM) system to get a 14-days blood glucose profile of the hospitalized type 2 diabetes mellitus (T2DM) patients with acute coronary syndrome…
- Trial name
- NCT05389254
- Testing
- continuous glucose monitoring system, capillary blood glucose monitoring
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Ningbo No. 1 Hospital
COVID-19 Pandemic, Pulmonary Disease, Chronic Obstructive
COVID-19, Patients' Evolution and the Influence of the Pandemic on Health Care and Outcomes in Chronic Diseases
Objectives: 1.- To evaluate the changes in health care and use of services in patients with chronic diseases such as chronic obstructive pulmonary disease (COPD), heart failure and major depression between 2017-2019 and the years…
- Conditions
- COVID-19 Pandemic, Pulmonary Disease, Chronic Obstructive, Heart Failure, Congestive, Depressive Symptoms
- Trial name
- NCT05168722
- Testing
- No interventions
- Where
- 5 sites in Spain
- Volunteers
- 2,220 people
- Sponsor
- Hospital Galdakao-Usansolo
Congenital Heart Defect, Heart Defects, Congenital
Fetal Cardiac Anomalies at Anomaly Scan: Detection and Pregnancy Outcomes - Assiut 2026
Congenital heart defects are among the most common congenital anomalies and cause significant perinatal morbidity and mortality. Prenatal detection allows counseling, multidisciplinary planning and optimization of delivery.
- Trial name
- NCT07832851
- Volunteers
- 200 people
- Sponsor
- Assiut University
Aortic Valve Stenosis
OUTcomes Evaluation of Current Therapeutic STrategies for Severe Aortic Valve steNosis anD the agING Population in ITALY
In 2015 the Italian Ministry of Health invited the Cardiac Research Hospitals of Italy to constitute a Cardiac Network. The aim of the network is to facilitate and promote scientific and technological research in the setting of…
- Trial name
- OUTSTANDING (NCT05778773)
- Testing
- TAVR (Transcatheter Aortic Valve Replacement), AVR (Aortic Valve Replacement)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- IRCCS Policlinico S. Donato
Ventricular Tachycardia
Outcomes of Functional Substrate Mapping of Ventricular Tachycardia
The goal of this registry database is to demonstrate the safety and effectiveness of functional ventricular tachycardia (VT) ablation using SENSE protocol in patients with ischaemic VT.
- Trial name
- VTFM (NCT05708131)
- Where
- 8 sites in United States, Greece and 2 more
- Volunteers
- 70 people
- Sponsor
- Mid and South Essex NHS Foundation Trust
Myocardial Infarction
Bone Marrow Derived AC 133+ and Mono-Nuclear Cells (MNC) Implantation in Myocardial Infarction (MI) Patient
Although a percutaneous coronary intervention (PCI) can be used to open up the blocked artery and restore blood flow to the heart muscle after myocardial infarction, there may be a significant amount of heart tissue that has been…
- Trial name
- NCT01187654
- Testing
- AC133, MNC, CONTROL
- Where
- Iran
- Volunteers
- 80 people
- Sponsor
- Royan Institute
Infective Endocarditis (IE)
Outcomes of Surgical Treatment in Patients With Infective Endocarditis
Infective endocarditis (IE) is a severe disease associated with significant morbidity and mortality despite advances in antimicrobial therapy and cardiac surgery.
- Trial name
- ETCEI (NCT07529730)
- Testing
- Data collection
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria
Diabetes, Asthma
Integrated Care (IC) Models for Patient-Centered Outcomes
Multiple chronic conditions (MCC) are widely recognized as the U.S. public health challenge of the 21st century. These physical and behavioral health conditions take a large toll on those living with chronic diseases, including…
- Conditions
- Diabetes, Asthma, Chronic Obstructive Pulmonary Disease, Hypertension
- Trial name
- IC (NCT03451630)
- Testing
- High-Touch, High-Tech, Optimal Discharge Planning
- Where
- United States
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Acute Coronary Syndrome
Researches of Retinal Artery Lesions and Acute Coronary Syndrome
This study is to investigate the relationship between staging of retinal artery lesions and the prognosis of acute coronary syndrome (ACS) in a Chinese population.
- Trial name
- REACS (NCT02415452)
- Testing
- drug-eluting stent implantation
- Volunteers
- 660 people
- Sponsor
- Capital Medical University
Coronary Artery Disease
Influencing Factors and Outcomes of DCB Angioplasty
This ambiprospective observational study evaluates the long-term safety and efficacy of Paclitaxel Drug-Coated Balloon (DCB) angioplasty in approximately 20,000 patients withcoronary artery lesions in large vessels.
- Trial name
- FWHZ-DCB (NCT06620458)
- Where
- China
- Volunteers
- 5,000 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Asymptomatic Patients With Type 2 Diabetes Mellitus, Atherosclerosis
The CRONOS-ADM Registry
The CRONOS-ADM (Coronary CT angiography evaluation for clinical outcomes in asymptomatic patients with type 2 diabetes mellitus) registry is a large, prospective observational registry of demographic, clinical and laboratory data…
- Conditions
- Asymptomatic Patients With Type 2 Diabetes Mellitus, Atherosclerosis, Coronary Artery Disease, Cardiovascular Disease
- Trial name
- NCT02070926
- Where
- South Korea
- Sponsor
- Seoul St. Mary's Hospital
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