Clinical trials: Cardiovascular Outcomes
Hypoplastic Left Heart Syndrome
SVRII Family Factors Study
The purpose of this study is to learn about the relationship between family factors and developmental and psychosocial outcomes in children with congenital heart disease at 6 years of age.
- Trial name
- NCT01582529
- Where
- 11 sites in United States, Canada
- Volunteers
- 187 people
- Sponsor
- Medical College of Wisconsin
Refractory Angina, Raised Lipoprotein(a)>50mg/dL or >500mg/L
Lipoprotein Apheresis in Refractory Angina Study
The goal of this study is to determine the impact of apheresis on clinical parameters and symptoms of patients with refractory angina and raised Lp(a).
- Trial name
- NCT01796912
- Testing
- Lipoprotein Apheresis
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Imperial College London
Peripheral Arterial Disease
Outcomes of Rivaroxaban and Aspirin in PAD After Endovascular Revascularization
Assessing the outcomes of using Rivaroxaban plus Aspirin in patients with Lower Extremity Peripheral Arterial Disease after Endovascular Revascularization
- Trial name
- NCT05308030
- Testing
- Rivaroxaban and Aspirin
- Volunteers
- 100 people
- Sponsor
- Assiut University
Out of Hospital Cardiac Arrest, Cardiac Arrest (CA)
Prehospital ETI in OHCA
This prospective observational study evaluated the association of prehospital endotracheal intubation (ETI) status with return of spontaneous circulation (ROSC), 28-day survival, and favorable neurological outcome in adult…
- Conditions
- Out of Hospital Cardiac Arrest, Cardiac Arrest (CA), Endotracheal Intubation, Prehospital Airway Management in Patients With Cardiac Arrest
- Trial name
- ETIOHCA (NCT07524881)
- Testing
- Demographics, Comorbidities, Prehospital Variables
- Where
- Turkey (Türkiye)
- Volunteers
- 297 people
- Sponsor
- Haseki Training and Research Hospital
Myocardial Ischaemia, Severely Calcified Coronary Stenoses
Implementation of a Standardized Algorithm for Coronary Calcification With Plaque Modification
In this study, the doctors will follow a set of rules that is called an algorithm. An algorithm is a step-by-step approach that doctors use to guide them when making decisions about the best way to treat their patients.
- Conditions
- Myocardial Ischaemia, Severely Calcified Coronary Stenoses, Coronary Calcification
- Trial name
- CYCLOPES (NCT06678594)
- Testing
- Calcium modification
- Where
- Ireland
- Volunteers
- 500 people
- Sponsor
- Royal College of Surgeons, Ireland
Diabetes Mellitus, Cardiovascular Diseases
Improving Neurologic Outcomes in People With Diabetes Who Are Undergoing Heart Surgery
Preliminary studies have shown that people with diabetes who undergo heart surgery may have a higher risk of developing cognitive functioning problems, including memory problems, than people without diabetes who undergo heart…
- Trial name
- NCT00836329
- Testing
- Intensive Glucose Management, Traditional Glucose Management:
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Sleep Apnea Syndromes, Cardiovascular Diseases
The Link Between Clinical and Physiological Sleep Data and Health-related Outcomes
Emerging evidence suggests that sleep-related disturbances such as sleep-disordered breathing (e.g. sleep apnea), sleep fragmentation, abnormal sleep architecture, and periodic limb movements (PLMs) are closely linked with…
- Conditions
- Sleep Apnea Syndromes, Cardiovascular Diseases, Sleep Initiation and Maintenance Disorders, Nocturnal Myoclonus Syndrome
- Trial name
- NCT03383354
- Testing
- Sleep-related disturbances (exposure)
- Where
- Canada
- Volunteers
- 5,000 people
- Sponsor
- Sunnybrook Health Sciences Centre
Type 2 Diabetes
Emulation of the REWIND Cardiovascular Outcomes Trial in Healthcare Claims Data.
Investigators are building an empirical evidence base for real world data through large-scale emulation of randomized controlled trials.
- Trial name
- NCT07417631
- Testing
- Dulaglutide, Sitagliptin
- Where
- United States
- Volunteers
- 300,000 people
- Sponsor
- Brigham and Women's Hospital
Fabry Disease
Extension Study of TKT028 Evaluating Safety and Clinical Outcomes of Replagal® in Adult Patients With Fabry Disease
This study will evaluate safety and clinical outcomes of treatment with Replagal in adult participants with Fabry disease who have completed Study TKT028 (NCT00864851).
- Trial name
- NCT01124643
- Testing
- Replagal
- Where
- 9 sites in United States, Australia and 5 more
- Volunteers
- 35 people
- Sponsor
- Shire
Atherosclerotic Cardiovascular Disease
A Retrospective Cohort Study Evaluating Major Adverse Cardiovascular Events and Cardiovascular Outcomes in Adults With Atherosclerotic Cardiovascular Disease Without Prior Ischemic Events (OPTIMUS RISK - Netherlands)
This study will evaluate cardiovascular outcomes among individuals with clinically established atherosclerotic cardiovascular disease (ASCVD) who have not previously experienced a myocardial infarction (MI) or ischemic stroke.
- Trial name
- NCT07905508
- Where
- Netherlands
- Volunteers
- 180,000 people
- Sponsor
- Sanofi
Pregnancy Induced Hypertension, Pregnancy Related
SD-OCT Measurement of the Human Retina in Pregnancy With Pre-existing or De Novo Hypertension and Without Hypertension
The complications of long-standing severe and acute severe elevations in systemic blood pressure (hypertension) may involve large vessels as well as smaller vessels, these latter comprising what is known as the microcirculation.
- Trial name
- NCT04286217
- Volunteers
- 155 people
- Sponsor
- University of Calgary
Heart Failure, Community Acquired Pneumonia
Collaborative Healthcare Professionals Approach in Monitoring of Patient Centered Outcomes Through Pathways
The aim of this study is to determine if by providing a collaborative, integrated pathway-based healthcare compared to the usual healthcare, whether or not this would be superior in reducing the length of hospital stay across…
- Conditions
- Heart Failure, Community Acquired Pneumonia, Venous Thromboembolism, Acute Kidney Injury
- Trial name
- CHAMP-Path (NCT01561885)
- Testing
- Pathway-Based Care
- Where
- Saudi Arabia
- Volunteers
- 341 people
- Sponsor
- Majed Aljeraisy
Atrial Fibrillation, Persistent, Ganglionated Plexi
Ganglion Plexus Ablation in Persistent Atrial Fibrillation
This study aims to investigate the long-term efficacy and safety of incorporating ganglionated plexus ablation into radiofrequency ablation strategies for persistent atrial fibrillation.
- Conditions
- Atrial Fibrillation, Persistent, Ganglionated Plexi, Catheter Ablation
- Trial name
- NCT06181578
- Testing
- ganglionated plexus ablation
- Volunteers
- 50 people
- Sponsor
- Ning Zhou
Pregnancy, Down Syndrome
Comparison of Aneuploidy Risk Evaluations
This is a prospective, multi-center observational study designed to compare the test results of the Verinata Health Prenatal Aneuploidy Test to results of conventional prenatal screening for fetal chromosome abnormalities in…
- Conditions
- Pregnancy, Down Syndrome, Edwards Syndrome, Patau Syndrome
- Trial name
- CARE (NCT01663350)
- Where
- 26 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- Verinata Health, Inc.
Heart Disease Congenital
Genomic Basis of Neurodevelopmental and Brain Outcomes in Congenital Heart Disease (CHD Brain and Genes)
Approximately 400 Congenital heart disease patients will participate in the research study which will include one or more research visits for neurodevelopmental testing, brain MRI, and collection of medical history including…
- Trial name
- NCT03070197
- Testing
- Exposure of interest: Brain MRI, Exposure of interest: neurodevelopmental assessments
- Where
- 8 sites in United States
- Volunteers
- 196 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Retinal Vein Occlusions
Anatomic Outcomes Following Ozurdex Injections
Ozurdex(TM) has recently been FDA approved for use in macular edema secondary to retinal vein occlusion. It remains unclear how quickly the drug works and for how long as the initial studies did not have frequent anatomic…
- Trial name
- NCT01282411
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Barnes Retina Institute
Aortic Valve Stenosis
REdo Transcatheter Aortic VALVE Implantation for the Management of Transcatheter Aortic Valve Failure
Transcatheter aortic valve implantation (TAVI) is a key-hole technique to replace an aortic heart valve that is narrowed and/or leaking.
- Trial name
- REVALVE (NCT06557798)
- Testing
- Any commercially available Edwards or Medtronic transcatheter aortic valve with the TAV-in-TAV (Redo TAVI) indication, Surgical explantation and aortic valve replacement, Conservative management
- Where
- 63 sites in Denmark, Finland and 9 more
- Volunteers
- 550 people
- Sponsor
- The Leeds Teaching Hospitals NHS Trust
Arrhythmia
Ambulatory Surgical Center Implantable Cardioverter-Defibrillator Outcomes Registry
The primary objectives for the registry is to evaluate the overall incidence of serious complications or adverse events for primary implants and replacement devices, and assess the cost and time efficiency for both physicians and…
- Trial name
- ASC ICD Reg (NCT03604133)
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- QuesGen Systems Inc
Pregnancy, Postpartum
HIIT vs MICT During Pregnancy and Health and Birth Outcomes in Mothers and Children
Regular exercise during pregnancy and postpartum leads to health benefits for mother and child. Inactivity during pregnancy and after delivery is now treated as risky behavior.
- Conditions
- Pregnancy, Postpartum, Childbirth, Health Status
- Trial name
- HIIT MAMA (NCT05009433)
- Testing
- High intensity interval training program for pregnant women, Moderate intensity continuous training program for pregnant women, Standard obstetric care with extended education on healthy lifestyle
- Where
- Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Gastrointestinal Cancers, Frailty
Longitudinal Geriatric Vulnerability, Chemotherapy Toxicity, and Functional Outcomes in Older Adults With Gastrointestinal Cancer
Older adults with gastrointestinal cancers may be more likely to experience side effects from chemotherapy and difficulties with everyday activities. These problems are not always explained by age alone.
- Conditions
- Gastrointestinal Cancers, Frailty, Sarcopenia in Elderly, Malnutrition Elderly
- Trial name
- VITAL-GI (NCT07184047)
- Testing
- Standard-of-Care Systemic Chemotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 132 people
- Sponsor
- Ankara Etlik City Hospital
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