Clinical trials: Cardiovascular Outcomes
Venous Thromboembolism
Treatment Patterns Among Patients With Venous Thromboembolism in the United States
The purpose of this study is to assess outpatient treatment patterns following hospitalization for venous thromboembolism (VTE). VTE is a condition that occurs when blood clot forms in the vein.
- Trial name
- NCT05795062
- Testing
- apixaban, warfarin
- Where
- United States
- Volunteers
- 13,945 people
- Sponsor
- Pfizer
MI Related Malignant Ventricular Arrhythmia
Effect of Radiofrequency Ablation in Patients With Ventricular Arrhythmia Undergoing CABG
Patients with myocardial infarction related potential malignant ventricular arrhythmia have high risk of sudden death. The aim of this clinical trial is evaluating therapeutic efficacy of unipolar or bipolar radiofrequency…
- Trial name
- RACAVA (NCT02991170)
- Testing
- unipolar or bipolar radiofrequency ablation+CABG, CABG
- Where
- 3 sites in China
- Volunteers
- 180 people
- Sponsor
- Beijing Anzhen Hospital
Atrial Fibrillation, Septic Shock
Effects of Chronic Antihypertensive Therapy on Clinical Outcomes in Septic Shock
Retrospective two-cohort study to determine the effect of chronic antihypertensive therapy on new onset atrial fibrillation and clinical outcomes in septic shock.
- Trial name
- NCT02876341
- Where
- United States
- Volunteers
- 133 people
- Sponsor
- Rush University Medical Center
Essential Hypertension
Effects of Valsartan vs Amlodipine and Low BP on Kidney Outcomes in Essential Hypertension
The Valsartan Antihypertensive Long-term Use Evaluation (VALUE) trial tested the hypothesis that for the same blood-pressure control, valsartan would reduce cardiac morbidity and mortality more than amlodipine in hypertensive…
- Trial name
- VALUE (NCT06395194)
- Testing
- Cardiac outcomes on treatment with valsartan, Cardiac outcomes on treatment with amlodipine
- Volunteers
- 15,313 people
- Sponsor
- Oslo University Hospital
Transcatheter Aortic Valve Implantation (TAVI)
Setting a Benchmark for Resource Utilization and Quality of Care in Patients Undergoing TAVI in Europe
Non-interventional, multi-center, international registry in patients with severe aortic stenosis (sAS) undergoing transcatheter aortic valve implantation (TAVI).
- Trial name
- BENCHMARK (NCT04579445)
- Testing
- Education on tailored Quality Improvement measures
- Where
- 28 sites in Austria, Czechia and 5 more
- Volunteers
- 2,408 people
- Sponsor
- Institut für Pharmakologie und Präventive Medizin
Out-Of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation
PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE)
The PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) study is a pilot feasibility trial evaluating the implementation of pre-hospital targeted temperature management (TTM) using a wearable surface…
- Conditions
- Out-Of-Hospital Cardiac Arrest, Cardiopulmonary Resuscitation, Death, Sudden, Cardiac, Therapeutic Hypothermia
- Trial name
- PRECEDENCE (NCT07421882)
- Testing
- CarbonCool® Cooling Vest
- Where
- Singapore
- Volunteers
- 50 people
- Sponsor
- Singapore General Hospital
Thrombotic Thrombocytopenic Purpura (TTP), Immune Thrombotic Thrombocytopenic Purpura
Retrospective Epidemiological Study of Patients in the National Cohort of the French TMA Center
Immune thrombotic thrombocytopenic purpura (iTTP) is a rare, life-threatening disorder characterized by microangiopathic hemolytic anemia, severe thrombocytopenia, and ischemic organ damage due to microvascular thrombosis.
- Conditions
- Thrombotic Thrombocytopenic Purpura (TTP), Immune Thrombotic Thrombocytopenic Purpura, Thrombotic Microangiopathies, Microangiopathy, Thromboic
- Trial name
- TWILIGHT (NCT07205861)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hypertension,Essential
Health Expenses and Outcomes of the DASH Diet in Egyptian Patients With Hypertension
DASH diet can reduce hypertension and decrease health expenses
- Trial name
- NCT06499194
- Testing
- DASH diet
- Where
- Egypt
- Volunteers
- 364 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Aneurysm Cerebral, AVM
This Three-year Observational Study Involves Patients of All Ages Undergoing Endovascular Treatment for Various Cerebral or Spinal Vascular Conditions. It Aims to Assess Pre- and Post-operative Clinical Conditions, Report Complications, and Identify Preoperative Indicators of Treatment Outcomes. Pat
This three-year observational study involves patients of all ages undergoing endovascular treatment for various cerebral or spinal vascular conditions.
- Conditions
- Aneurysm Cerebral, AVM, DAFV, ESDC
- Trial name
- ONIRIC (NCT06805721)
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Hypertensive Disorders of Pregnancy (HDP)
Postpartum Home Visiting (HEART at Home)
The goal of this clinical trial is to learn whether HEART at Home (Home-based Engagement And Remote Treatment for Hypertension), a home-based postpartum hypertension care program, is feasible and acceptable for people with high…
- Trial name
- HEART at Home (NCT07833904)
- Testing
- HEART at Home
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Washington University School of Medicine
Stroke
1-year Clinical Outcomes in Recombinant Tissue Plasminogen Activator (Rt-PA) Treated Chinese Acute Ischaemic Stroke (AIS) Patients
The objective of the study is to find out the 1-year clinical outcomes among Acute Ischaemic Stroke (AIS) patients who were treated with intravenous (IV) Recombinant Tissue Plasminogen Activator (rt-PA) within 4.5 hours of…
- Trial name
- NCT05395338
- Testing
- rt-PA
- Where
- China
- Volunteers
- 12,551 people
- Sponsor
- Boehringer Ingelheim
Coronary Artery Disease
FFR Versus IVUS With Angiography-Derived FFR for Clinical Outcomes in Patients With Coronary Artery Disease
To compare the clinical outcomes of fractional flow reserve (FFR)-guided strategy versus intravascular ultrasound (IVUS)-guided stent implantation after angiography-derived FFR-based decision-making.
- Trial name
- FLAVOUR III (NCT06218485)
- Testing
- Intravascular ultrasound-guided stent implantation after angiography-derived FFR-based decision-making, Fractional flow reserve-guided PCI strategy
- Where
- 32 sites in China, South Korea
- Volunteers
- 1,942 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Heart Failure
Heart Failure Optimization at Home to Improve Outcomes (Hozho): A Pragmatic Clinical Trial in Navajo Nation
Heart failure causes significant morbidity and mortality, particularly in Navajo Nation. There are well-established evidence of improved mortality and lower heart failure hospitalizations with certain pharmacotherapies for heart…
- Trial name
- Hozho (NCT05792085)
- Testing
- EHR-based GDMT Optimization
- Where
- 2 sites in United States
- Volunteers
- 103 people
- Sponsor
- University of Pennsylvania
Type 2 Diabetes Mellitus
A Study to Assess Cardiovascular Outcomes Following Treatment With Omarigliptin (MK-3102) in Participants With Type 2 Diabetes Mellitus (MK-3102-018)
The purpose of this study is to evaluate the cardiovascular (CV) safety profile of omarigliptin in participants with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT01703208
- Testing
- Omarigliptin
- Volunteers
- 4,202 people
- Sponsor
- Merck Sharp & Dohme LLC
Atrial Fibrillation, Obesity
Association of Obesity and Cardiovascular Outcomes in Atrial Fibrillation
In this study, the investigators evaluated the association between various measures of adiposity [BMI and waist circumference (WC)] and clinical outcomes in Asian patients with AF who were prescribed OAC, using a nationwide…
- Conditions
- Atrial Fibrillation, Obesity, Prognosis, Anticoagulants
- Trial name
- Paradox (NCT05645913)
- Testing
- Oral anticoagulant
- Where
- South Korea
- Volunteers
- 56,272 people, healthy volunteers welcome
- Sponsor
- Ajou University School of Medicine
Aorta Thoracic Ascending Dissection, Dissection of Descending Aorta
Clinical Profiles and Outcomes of Acute Aortic Dissection in the Chinese Patients
Clinical profiles and outcomes of patients with acute aortic dissection have not yet been evaluated in China. The aim of this study is to establish clinical registry of acute aortic dissection in China and to analyze clinical…
- Trial name
- CPOAADCP (NCT01606943)
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Xijing Hospital
Chronic Subdural Hematoma
Surgical Management of Chronic Subdural Hematoma: Clinical Outcomes Following Single VS Double Burr Holes Evacuation
This study aims to evaluate and compare the clinical and radiological outcomes of patients with chronic subdural hematoma (CSDH) undergoing surgical evacuation using either single or double burr-hole craniostomy.
- Trial name
- NCT07688473
- Testing
- Chronic Subdural Hematoma Evacuation
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD))
MIRAGE Study: Clinical Outcomes of the Mamba Sirolimus-Eluting PTCA Balloon
This Clinical Evaluation Report (CER) covers the Mamba Sirolimus-Eluting PTCA Balloon catheter intended for the treatment of coronary artery disease in de novo or in-stent restenosis lesions.
- Trial name
- NCT07326735
- Testing
- Mamba Sirolimus-Eluting PTCA Balloon, Percutaneous Coronary Angioplasty with Sirolimus-Coated Balloon
- Where
- 2 sites in Burma, Malaysia
- Volunteers
- 360 people
- Sponsor
- Frisch Medical Device Private Limited
Out-of-hospital Cardiac Arrest (OHCA)
Out-of-hospital Cardiac Arrest Epidemiology and Outcomes in Western Lithuania 2022-2028
Out-of-hospital cardiac arrest rate is common problem, because of high mortality rate. It is not clear incidence rate, epidemiology and outcomes in Lithuania
- Trial name
- NCT07622082
- Testing
- Protocol based
- Volunteers
- 4,000 people
- Sponsor
- Lithuanian University of Health Sciences
Atrial Fibrillation
EUropean Real World Outcomes With Pulsed Field AblatiOn
Background: Real world clinical evidence using pulsed field ablation (PFA) for atrial fibrillation (AF) ablation is still scarce. In particular, data on longer term outcome from multi-center experience is missing.
- Trial name
- EU-PORIA (NCT05823818)
- Testing
- Catheter Ablation
- Where
- Germany
- Volunteers
- 1,233 people
- Sponsor
- Cardioangiologisches Centrum Bethanien
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