Clinical trials: Cardiovascular Outcomes
Heart Failure, Diastolic
Muscle, Essential Amino Acids, and eXercise in Heart Failure
Half of heart failure patients have preserved ejection fraction (HFpEF). Like patients with reduced ejection fraction (HFrEF), HFpEF patients suffer from exercise intolerance (low VO2max), which reduces physical function, quality…
- Trial name
- MAAX-HF (NCT03312387)
- Testing
- Exercise, Essential Amino Acids
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Arizona State University
Heart Failure, Systolic, Morality
Impact of Cardiac Rehabilitation on Acute Heart Failure Patients With Cognitive Impairment
In heart failure patients, neuropsychological disorders have been prospectively linked to frequent hospitalizations, recurrent cardiac events, and mortality.
- Conditions
- Heart Failure, Systolic, Morality, Cognitive Impairment
- Trial name
- NCT05726565
- Testing
- multidisciplinary cardiac rehabilitation
- Where
- Taiwan
- Volunteers
- 247 people
- Sponsor
- Chang Gung Memorial Hospital
Mitral Regurgitation
Molecular Mechanisms of Mitral Regurgitation-Aim 2
The investigators hypothesize that MR in humans is characterized by adrenergic overdrive, reactive nitrogen species, and an antifibrotic phenotype that relate to the severity of adverse LV remodeling prior to surgery and outcome…
- Trial name
- P1A2 (NCT01052532)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Alabama at Birmingham
Myocarditis, Cardiac Sarcoidosis
Inflammatory Cardiomyopathy Bern Registry
Inflammatory cardiomyopathies are associated with inflammation and impaired function of the heart muscle and encompass myo- and pericarditis and cardiac sarcoidosis.
- Conditions
- Myocarditis, Cardiac Sarcoidosis, Pericarditis
- Trial name
- FlamBer (NCT04774549)
- Where
- Switzerland
- Volunteers
- 1,125 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Complex Regional Pain Syndrome I of Upper Limb, Pain
THE EFFECTS OF FUNCTIONAL ELECTRICAL STIMULATION-ASSISTED BICYCLE ERGOMETRY IN PATIENTS DIAGNOSED WITH COMPLEX REGIONAL PAIN SYNDROME.(CRPS)
The goal of this clinical study is to evaluate the effectiveness of functional electrical stimulation (FES)-assisted cycling in patients with post-stroke Complex Regional Pain Syndrome (CRPS) Type 1.
- Trial name
- CRPS (NCT07570199)
- Testing
- Functional Electrical Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Zeynep Nur Köseoğlu
Stroke
Smart Ankle-Foot Orthosis to Improve Stroke Outcomes: Smart AFO
The Smart Ankle-Foot Orthosis (Smart AFO) system is an investigational system that combines a diagnostic ankle-foot orthosis with a mobile application to assist clinicians in optimizing an AFO user's gait by adjusting AFO…
- Trial name
- NCT05619484
- Testing
- Smart AFO
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Orthocare Innovations, LLC
Takotsubo Cardiomyopathy
Hyperglycemia in Patients With Takotsubo Syndrome
Patients with Takotsubo cardiomiopathy (TTC) have over-inflammation and over-sympathetic tone. However, these conditions could cause higher rate of heart failure (HF) events and deaths at 2 years of follow-up.
- Trial name
- NCT04684004
- Testing
- To report number of HF events and deaths
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Campania Luigi Vanvitelli
Colorectal Cancer, Cardiovascular Disease
Study to Develop a Prediction Model to Understand the Effect of Low-dose Aspirin on Cancer That Develops in the Colon and/or the Rectum, Diseases That Affects the Heart or Blood Vessels and Safety Outcomes in European Countries. The Study is Also Called PEACOS Model EU
In this study researchers want to learn more about the effect of low-dose Aspirin on cancer that develops in the colon (the longest part of the large intestine) and/or the rectum (the last several inches of the large intestine…
- Conditions
- Colorectal Cancer, Cardiovascular Disease, Bleeding
- Trial name
- PEACOCS (NCT03904732)
- Testing
- Acetylsalicylic Acid (Aspirin, BAYE4465)
- Where
- United Kingdom
- Volunteers
- 2,000,000 people
- Sponsor
- Bayer
ST Elevation Myocardial Infarction
Comparison of Clinical Outcomes of IVUS -Guided and Angiography-guided PCI in Patients With Acute STEMI
To compare the long-term clinical outcomes of IVUS-guided vs angiography-guided PCI in patients with acute STEMI
- Trial name
- NCT04929158
- Testing
- Intravascular Ultrasound (IVUS) -guided Primary Percutaneous Intervention (PCI)
- Where
- China
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Acute Myocardial Infarction (AMI), Type 2 Diabetes Mellitus (T2DM)
SGLT2 Inhibitor Use After Acute Myocardial Infarction in Patients With Type 2 Diabetes: A Nationwide Cohort Study
This observational, retrospective cohort study aims to evaluate the impact of sodium-glucose cotransporter 2 (SGLT2) inhibitor use after acute myocardial infarction (AMI) in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- SGLT2i-AMI (NCT07198191)
- Testing
- SGLT2 inhibitors (e.g., dapagliflozin, empagliflozin), DPP4 inhibitors
- Where
- South Korea
- Volunteers
- 200,000 people
- Sponsor
- Yonsei University
Heart Failure
Carbohydrate Antigen 125-guided Therapy in Heart Failure
Preliminary data suggest a potential role for monitoring and up-titrate pharmacological therapy of plasma levels of antigen carbohydrate 125 (CA125) following and admission for acute heart failure (AHF).
- Trial name
- CHANCE-HF (NCT02008110)
- Testing
- CA125 guided strategy, Standard treatment strategy
- Where
- Spain
- Volunteers
- 360 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Hemorrhagic Stroke, Acute
Predictive Value of Human Microbiome and Serological Markers for Clinical Outcome of Cerebral Hemorrhage
Objective: To explore the predictive value of characteristic disorder of intestinal flora for clinical prognosis in patients with intracerebral hemorrhage.
- Conditions
- Hemorrhagic Stroke, Acute, Outcomes, Metabolites
- Trial name
- NCT05551923
- Testing
- intestinal flora disturbance
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Ventricular Fibrillation, Ventricular Tachycardia
Understanding Outcomes With the EMBLEM™ S-ICD in Primary Prevention Patients With Low Ejection Fraction
This study assesses the 18-month incidence of inappropriate shocks in subjects implanted with the EMBLEM Subcutaneous Implantable Defibrillator (S-ICD) for primary prevention of sudden cardiac death.
- Conditions
- Ventricular Fibrillation, Ventricular Tachycardia, Low Cardiac Output
- Trial name
- UNTOUCHED (NCT02433379)
- Testing
- EMBLEM S-ICD System
- Where
- 110 sites in United States, Belgium and 11 more
- Volunteers
- 1,173 people
- Sponsor
- Boston Scientific Corporation
Pain, Depressive Symptoms
Assessing Pain as a Mediator of Behavior Change in Post-coronary Angioplasty Patients
The focus of this secondary data analysis is to determine whether pain due to a combination of both cardiac and non cardiac sources operates as a mediator of behavior change, an area that has not been previously evaluated.
- Conditions
- Pain, Depressive Symptoms, Quality of Life
- Trial name
- NCT01469780
- Where
- United States
- Volunteers
- 660 people
- Sponsor
- Weill Medical College of Cornell University
ASD2(Secundum Atrial Septal Defect)
Outcomes of Transcatheter ASD Closure Guided by 3D-TEE
Atrial Septal Defect (ASD) is a common cardiac diagnosis among adults.Three-dimensional transesophageal echocardiography (3D-TEE) improve the visualization of ASD, its rims and surrounding structures and can be used for guidance…
- Trial name
- NCT03867708
- Testing
- ASD device closure
- Sponsor
- Assiut University
Aortic Valve Disease
Neurocognitive Assessment in TAVI
Severe aortic stenosis is a common heart condition affecting elderly patients. Degeneration of the aortic valve (oneway valve between the heart and the aorta) causes high resistence to blood flow, resulting in strain on the heart…
- Trial name
- NEAT TAVI (NCT06120946)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- Brighton and Sussex University Hospitals NHS Trust
Cardiogenic Shock, Euthyroid Sick Syndrome
Factors Influencing Outcomes in ECMO and Impella Patients: Metabolic and Thyroid Hormone Dynamics
This prospective, single-center, consecutive observational study evaluates clinical, metabolic, and endocrine factors influencing survival and clinical outcomes in adult patients undergoing temporary mechanical circulatory…
- Conditions
- Cardiogenic Shock, Euthyroid Sick Syndrome, Critical Illness
- Trial name
- NCT07885618
- Where
- Hungary
- Volunteers
- 160 people
- Sponsor
- Gottsegen National Cardiovascular Institute
Diabetes Mellitus, Type 2, Acute Coronary Syndrome
Cardiovascular Outcomes Study of Alogliptin in Patients With Type 2 Diabetes and Acute Coronary Syndrome
The purpose of this study is to evaluate the cardiovascular outcomes of alogliptin, once daily (QD), compared with placebo, in addition to standard of care, in patients with type 2 diabetes mellitus and acute coronary syndrome.
- Trial name
- EXAMINE (NCT00968708)
- Testing
- Alogliptin
- Where
- 908 sites in United States, Argentina and 48 more
- Volunteers
- 5,380 people
- Sponsor
- Takeda
Health Promotion, Cardiovascular Health
Health Impact 360: Advancing Physical, Social, and Mental Health Toward Cardiovascular Disease Prevention in Community Settings
The purpose of this clinical trial is to evaluate an evidence-based intervention, Health Impact 360, toward the promotion of cardiovascular health (CVH), including physical, mental, and social health outcomes, among adults living…
- Trial name
- HI360 (NCT07034352)
- Testing
- Health Impact 360, Usual care - Wait list control
- Where
- 7 sites in United States
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Cardiovascular Diseases, Inflammation
Evaluation of Volume Status in Peritoneal Dialysis Patients
Patients with kidney failure on dialysis have a much higher risk of developing cardiovascular disease as compared to the general population.
- Conditions
- Cardiovascular Diseases, Inflammation, Peritoneal Dialysis
- Trial name
- NCT00182338
- Where
- Canada
- Volunteers
- 22 people
- Sponsor
- McMaster University
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