Clinical trials: Cardiovascular Physiological Phenomena
ICU Acquired Weakness, Sepsis
ICU Combined Assessment of Cardio-Respiratory Exercise
This study aims to investigate how sepsis and critical illness can impair the cardiovascular system and microcirculation in intensive care unit (ICU) patients, which can lead to long-lasting muscle weakness/dysfunction or…
- Conditions
- ICU Acquired Weakness, Sepsis, Shock, Critical Illness
- Trial name
- ICU-CARE (NCT06193980)
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of Manitoba
Type 1 Diabetes
Inspiratory Muscle Strength Training in Adults With Type 1 Diabetes
Adults with type 1 diabetes have elevated cardiovascular disease risk, and systolic blood pressure is a leading modifiable contributor to that risk.
- Trial name
- NCT07859943
- Testing
- High-Resistance Inspiratory Muscle Strength Training
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Florida State University
Sleep Deprivation
Effects of Sleep Loss on Endothelial Function and Cytokine Levels in Internal Medicine Residents
Work requirements for medical trainees result in substantial sleep loss. Sleep loss has been associated with increased levels of certain inflammatory hormones that could have negative impact on blood vessel function.
- Trial name
- NCT00272233
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Yale University
PARKINSON DISEASE (Disorder)
Brief Title: Aerobic Training on Cerebrovascular Function, Cognition and Gait in Parkinson's Disease
This randomized controlled trial will investigate the effects of a 12-week supervised aerobic training program on cerebrovascular function, peripheral vascular health, cardiovascular autonomic modulation, cognition, non-motor…
- Trial name
- CardioParkinso (NCT07478146)
- Testing
- Aerobic training, Usual Care
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Raphael Mendes Ritti Dias
Obesity, Cardiovascular Physiological Phenomena
Metabolic Effects of Natriuretic Peptide Hormones
Accumulating evidence suggests that the natriuretic peptide (NP) hormonal system has important effects on metabolism. However, more information is needed to better understand the effects of NPs on metabolism in humans.
- Conditions
- Obesity, Cardiovascular Physiological Phenomena, Metabolism
- Trial name
- MENP (NCT03397966)
- Testing
- recombinant human BNP(1-32)
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Rheumatoid Arthritis
High-intensity Interval Exercise in Rheumatoid Arthritis
Cardiovascular performance and overall fitness can be improved by high-intensity aerobic activity, and these benefits may be achievable by persons with rheumatic diseases.
- Trial name
- RA-HIIT (NCT05768165)
- Testing
- High intensity exercise
- Where
- 2 sites in Sweden
- Volunteers
- 87 people
- Sponsor
- Vastra Gotaland Region
Prostate Cancer
Effect of Androgen Deprivation Therapy on Cardiovascular Function in Prostate Cancer
The aim of this project is to determine whether androgen deprivation therapy (ADT) decreases left ventricular function in prostate cancer patients.
- Trial name
- NCT03275181
- Testing
- Transthoracic Echocardiography, Arterial blood pressure, Submaximal Exercise
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Kansas State University
Stroke
Understanding Changes in Heart Function After Exercise in People With Stroke
Little is known about how exercise can affect heart function in stroke survivors. This study will look at changes in cardiovascular fitness and function after 6 months of exercise.
- Trial name
- NCT01189045
- Testing
- Aerobic Exercise Program, Non-aerobic Exercise Program
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Type 2 Diabetes
Effect of Aerobic Interval Training on Cardiovascular Function in Type 2 Diabetes
The study objectives are: 1. To compare cardiovascular function in type 2 diabetes patients vs. healthy controls. 2. To compare the effect of 8 weeks of aerobic interval training versus continuous moderate exercise on…
- Trial name
- NCT01883258
- Testing
- High intensity aerobic interval training, Continuous moderate intensity exercise
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of Florida
Triglyceride Metabolism, Cardiovascular Function
Ability of Grape Seed Proanthocyanidins to Reduce Postprandial Triglycerides in Humans
Grape seed proanthocyanidins have been reported to possess a hypotriglyceridemic effect after an acute or chronic consumption in rodents.
- Trial name
- NCT01688154
- Testing
- 35 mg/Kg of grape seed proanthocyanidins extract (2 capsules), 2 empty capsules
- Where
- 2 sites in Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Obesity
Beige Fat, Energy, and the Natriuretic Peptide System
Obese individuals experience an increased risk of cardiovascular and metabolic diseases. Evidence from genetic studies indicate that the natriuretic peptide (NP) system may protect against these diseases.
- Trial name
- NCT04357964
- Where
- 2 sites in United States
- Volunteers
- 137 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Lassa Fever
Cardiovascular Function and Ribavirin PK/PD in Lassa Fever in Lassa Fever
Arenaviruses are included in the World Health Organisation R\&D Blueprint list of high priority pathogens, since this virus group includes several epidemic-prone highly pathogenic viruses for which there are inadequate…
- Trial name
- NCT04285034
- Where
- Nigeria
- Volunteers
- 158 people
- Sponsor
- University of Oxford
Down Syndrome, Obstructive Sleep Apnea Syndrome
Obstructive Sleep Apnea and Neurocognitive and Cardiovascular Function in Children With Down Syndrome
Many individuals with Down syndrome (DS) have breathing problems during sleep. This is called obstructive sleep apnea syndrome (OSAS).
- Trial name
- TRIO (NCT01808508)
- Testing
- Continuous positive airway pressure
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Children's Hospital of Philadelphia
Infant, Premature, Diseases, Circulatory and Respiratory Physiological Phenomena
Dose-finding for Dobutamine During Transitional Circulation in Very Preterm Infants
Single centre, dose finding trial to establish the minimum effective dose of dobutamine required to treat hemodynamic insufficiency, defined as low superior vena cava (SVC) flow, in infants below 33 weeks' gestation during…
- Trial name
- NeoCirc-002 (NCT06878742)
- Testing
- Intravenous dobutamine 5 mcg/kg/min, Intravenous dobutamine 7.5 mcg/kg/min, Intravenous dobutamine 10 mcg/kg/min
- Where
- 3 sites in Spain
- Volunteers
- 30 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Carnosine
Carnosine Supplementation and Cardiovascular Function
Carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine. It was originally discovered in skeletal muscle where it is present in larger amounts than in other tissues, but it is also found in high…
- Trial name
- NCT05723939
- Testing
- Carnosine supplementation, Controls
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Atrial Fibrillation
High-intensity Interval Training in Patients With Atrial Fibrillation
A key characteristic of the heart is its regular rhythm. When the heart is exposed to irregular electric impulses, such as with atrial fibrillation (AF), detrimental effects can occur affecting the ability of the heart to pump…
- Trial name
- HIIT-AF (NCT05354271)
- Testing
- High-intensity interval training, Moderate-intensity continuous training
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- Liverpool John Moores University
COPD, Cognitive Impairment
Cerebral and Cardiac Blood Flow During Exercise in Patients With COPD
Heart disease and conditions related to the blood vessels are responsible for a large proportion (over a quarter) of the deaths in people with chronic obstructive pulmonary disease (COPD).
- Trial name
- REFLEX-COPD (NCT04138563)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Cardiovascular Function
Investigation of the Influence of Gender on Cardiovascular Function
Inflammation is a key initiating and damaging factor in many illnesses including infection, arthritis and cancer but also of particular relevance to this study in diseases of the heart and blood vessels (i.e.
- Trial name
- NCT01582321
- Testing
- Typhoid vaccine, Cantharidin
- Where
- United Kingdom
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Exercise, Cardiovascular Function, Fatigue, Muscular Power
Physiological Responses to Maximal 4-s Sprint Interval Cycling
The optimal recovery duration depends on the intensity of exercise and in the present study the intensity was maximal power for 4-s while cycling an 'Inertial Load' ergometer (ILE).
- Trial name
- NCT04448925
- Testing
- inertial-load exercise (ILE)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Aging
Role of Flavanols In Cardiovascular Function in Healthy Aging
Groups of naturally occurring compounds called flavonoids are found in foods such as fruits and vegetables, red wine, tea, dark chocolate and cocoa products.
- Trial name
- NCT01395277
- Testing
- High Flavanol first then Low Flavanol, Low Flavanol first then High Flavanol
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin