Clinical trials: Cardiovascular Prevention
Neurocognitive Disorders, Surgery-Complications
Cerebrolysin in Prevention of Postoperative Delirium in Cardiac Surgery
Postoperative delirium (POD) and postoperative neuropsychological dysfunction are frequently noted in critically ill patients undergoing elective or emergency surgery and treated in the intensive care unit (ICU).
- Conditions
- Neurocognitive Disorders, Surgery-Complications, Critical Illness, Brain Damage
- Trial name
- Cereb-POD (NCT05864677)
- Testing
- Cerebrolysin
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Lublin
Atrial Fibrillation
Cognitive Impairment Related to Atrial Fibrillation Prevention Trial
Cognitive and functional decline observed in atrial fibrillation (AF) patients are related to thrombotic and/or cardioembolic events.
- Trial name
- GIRAF (NCT01994265)
- Testing
- Warfarin, Dabigatran
- Where
- 2 sites in Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo
Potentially Inappropriate Medications
PIM Incidence in Older Cardiovascular Patients During COVID-19 Pandemics
The aim of the study is to assess the incidence of potentially inappropriate medication (PIM) administration, polypharmacy, and potential drug-drug-interactions (PDDIs) in cardiovascular patients enrolled in the reimbursement…
- Trial name
- PIM-BARS (NCT05336565)
- Testing
- Electronic medical record analysis
- Where
- Russia
- Volunteers
- 1,000 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Hypertension
Team Lifestyle Immersion Hypertension Control Project
This project is focuses on reducing the risk and progression of hypertension among a population that records high incidence of hypertension and other chronic ailments such as heart disease, diabetes, kidney failure, and obesity…
- Trial name
- TLIP (NCT07201948)
- Testing
- Lifestyle Immersion Intervention that will address Nutrition, Physical Fitness, and BP Self-Monitoring3 Elements:
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Meharry Medical College
Atrial Fibrillation, Stroke
Quality of Anticoagulation With Warfarin in Patient With Atrial Fibrillation for Secondary Stroke Prevention in Korea
The current study aims to assess the quality of anticoagulation with warfarin in real world practice of secondary stroke prevention in Korean patients with Atrial fibrillation (AF) and to explore predictors for poor International…
- Trial name
- NCT02810509
- Where
- 18 sites in South Korea
- Volunteers
- 1,814 people
- Sponsor
- Inje University
Atrial Fibrillation, Obstructive Sleep Apnea
Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting in Patients With Obstructive Sleep Apnea
Background. Atrial fibrillation is one of the most common complications in the postoperative period of coronary artery bypass grafting (CABG) surgery and usually associated with increased length of hospital stay and higher…
- Conditions
- Atrial Fibrillation, Obstructive Sleep Apnea, Coronary Artery Bypass Grafting
- Trial name
- PAFOS (NCT02737215)
- Testing
- CPAP
- Where
- 3 sites in Brazil
- Volunteers
- 144 people
- Sponsor
- Rodrigo Pinto Pedrosa
Coronary Disease, Ischemic Heart Disease
Enhancing the Secondary Prevention of Coronary Artery Disease
People with coronary artery disease can reduce their chance of having a heart attack by making healthy lifestyle choices (diet, exercise, quitting smoking,etc.).
- Trial name
- NCT00175240
- Testing
- Evidence summaries endorsed by local opinion leaders
- Where
- Canada
- Volunteers
- 480 people
- Sponsor
- University of Alberta
Cardiovascular Disease
Simplified Cardiovascular Management Study
The goal of this study is to develop, pilot test, and evaluate a highly simplified but guideline-based program for cardiovascular management for application in resource-scarce settings.
- Trial name
- SimCard (NCT01503814)
- Testing
- Simplified cardiovascular disease management
- Where
- 3 sites in China, India
- Volunteers
- 2,086 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Atrial Fibrillation, Stroke Prophylaxis
Stroke Prophylaxis of AF-patients: Real-life Effectiveness and Safety of Novel Anticoagulants Compared to VKA
The central questions of the study can be summarized as follows: What stroke / death rates are the result of the use of the following treatment strategies: no anticoagulation with vitamin-k-antagonists (VKAs) or novel oral…
- Trial name
- NCT02657616
- Testing
- vitamin-k-antagonists, Novel oral anticoagulants
- Volunteers
- 204,464 people
- Sponsor
- Institut für Pharmakoökonomie und Arzneimittellogistik e.V.
Atrial Fibrillation (AF), Stroke Prevention in Patients With Atrial Fibrillation
OPTION-EMEA Clinical Trial
The OPTION-EMEA post-market study is intended to gather real world clinical data for patients undergoing AF ablation with the FARAPULSE™ Pulsed Field Ablation (PFA) System and subsequent left atrial appendage closure (LAAC) with…
- Conditions
- Atrial Fibrillation (AF), Stroke Prevention in Patients With Atrial Fibrillation, Left Atrial Appendage Closure, Pulsed Field Ablation
- Trial name
- OPTION-EMEA (NCT07349121)
- Testing
- Concomitant pulsed field ablation (PFA) and left atrial appendage closure (LAAC) during one interventional case, Concomitant Pulsed Field Ablation and Left Atrial Appendage Closure
- Where
- 11 sites in Belgium, Croatia and 3 more
- Volunteers
- 500 people
- Sponsor
- Boston Scientific Corporation
Cardiac Surgery, Perioperative Prophylaxis
Microbial Surveillance in Children Hospitalized for Cardiovascular Surgery
the purpose of this study is to determine whether children who are hospitalised waiting for cardiac surgery for several days in pediatric or pediatric surgery department acquire resistant microbial flora, thus necessitating broad…
- Trial name
- NCT00426894
- Testing
- samples from nostrils, mouth, axillas, perianal area and postoperative wound
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Chronic Myeloid Leukemia (CML)
Evaluation of a Cardiovascular Active Prevention in Chronic Myeloid Leukemia on the Cardiovascular Morbi-mortality
According to the French National Cancer Institute, 35 000 new hematologic cancers are observed in France representing 10% of the new cancers.
- Trial name
- PALERMO (NCT03746054)
- Testing
- Optimal medical treatment, usual clinical practice
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Angers
Isolated Noncompaction of the Ventricular Myocardium
Risk Stratification and Early Prevention Strategies for Non-compaction of Ventricular Myocardium (CAPTAIN)
This study intends to retrospectively-prospectively enroll NVM patients from multiple centers to establish a natural population cohort of NVM patients.
- Trial name
- NCT06504056
- Testing
- Diagnosis of NVM
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Heart Disease, Cardiovascular Disease
Strong Hearts: Rural CVD Prevention
Strong Hearts, Healthy Communities is a research study which aims to reduce cardiovascular disease (CVD), improve quality of life, and reduce CVD related health care costs in rural communities.
- Conditions
- Heart Disease, Cardiovascular Disease, Sedentary Lifestyle, Overweight
- Trial name
- NCT02499731
- Testing
- Strong Hearts, Healthy Communities, Strong Hearts, Healthy Women
- Where
- 16 sites in United States
- Volunteers
- 194 people
- Sponsor
- Cornell University
Vascular Headaches, Migraine
A Study of the Effectiveness and Safety of Topiramate for the Prevention of Migraine
The primary purpose of this study is to evaluate the effectiveness and safety of topiramate (an epilepsy medication) compared with placebo in the prevention of migraine.
- Trial name
- NCT00253175
- Testing
- topiramate
- Volunteers
- 211 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Stroke
Mobile Terminal Based Management of Stroke Secondary Prevention Adminstration Effect Research
The investigators want to verify whether mobile application based on stroke strengthen prevention management is more effective than traditional management model or open stroke management platform.
- Trial name
- NCT02618265
- Testing
- Mobile terminal, traditional management, website platform management
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Peking University Third Hospital
Thromboembolism
Factor Xa Inhibitor for Prevention of Venous Thromboembolism in Patients Undergoing Elective Total Knee Replacement
Evaluate the safety and tolerability of escalating oral doses of YM150 in patients undergoing elective primary total knee replacement surgery
- Trial name
- PEARL-1 (NCT00408239)
- Testing
- YM150, enoxaparin
- Where
- 19 sites in Indonesia, Japan and 6 more
- Volunteers
- 367 people
- Sponsor
- Astellas Pharma Inc
ST Segment Elevation Myocardial Infarction, Left Ventricular Thrombus
Prevention of Post-STEMI Left Ventricular Thrombus With Optimized Anticoagulant (EARLYmyo-LVT Ⅱ)
Left ventricular thrombus is a common complication subsequent to ST-segment elevation myocardial infarction (STEMI) that related to increased embolic events.
- Trial name
- NCT03786757
- Testing
- Rivaroxaban
- Where
- China
- Volunteers
- 200 people
- Sponsor
- RenJi Hospital
Prevention, Venous Thromboembolism
Regulation of Coagulation in Orthopedic Surgery to Prevent Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE). A Study of BAY 59-7939 in the Prevention of VTE in Subjects Undergoing Elective Total Knee Replacement.
The purpose of this study is to assess if 10 mg Bay 59-7939, taken once daily as a tablet, is safe and prevents blood clot which may form after a knee replacement operation.
- Trial name
- RECORD 3 (NCT00361894)
- Testing
- Rivaroxaban (BAY59-7939), Enoxaparin
- Where
- 143 sites in Austria, Belgium and 17 more
- Volunteers
- 2,531 people
- Sponsor
- Bayer
Stroke
Study of the Follow-up of Stroke Treated With Anticoagulants
Stroke is a major public health problem as it is very frequent (140,000 cases/year in France), and very serious (leading cause of death, 2nd leading cause of dementia, 3rd leading cause of handicap).
- Trial name
- AOD (NCT03292575)
- Testing
- Anticoagulants
- Where
- France
- Volunteers
- 441 people
- Sponsor
- Centre Hospitalier Universitaire Dijon