Clinical trials: Cardiovascular Risk
Diabetes Mellitus, High Blood Pressure
Comparative Effectiveness of Family vs. Individually Focused Diabetes Education and Support
The objective of this study is to compare the effectiveness of a novel program-Family Support for Health Action (FAM-ACT) - to individual patient-focused diabetes self-management education and support (I-DSMES).
- Conditions
- Diabetes Mellitus, High Blood Pressure, High Blood Sugar, Hypertension
- Trial name
- NCT03812614
- Testing
- FAM ACT, I-DSMES
- Where
- 2 sites in United States
- Volunteers
- 444 people
- Sponsor
- University of Pittsburgh
Stroke, Atrial Fibrillation (AF)
Clinical Relevance of Microbleeds In Stroke
Study I: CROMIS-2 (AF) Prospective cohort study of patients anticoagulated after cardioembolic stroke An observational inception cohort study (n=1425) of patients throughout the United Kingdom (UK) - (79 hospitals) started on…
- Conditions
- Stroke, Atrial Fibrillation (AF), Intracerebral Haemorrhage (ICH)
- Trial name
- CROMIS-2 (NCT02513316)
- Where
- United Kingdom
- Volunteers
- 2,490 people
- Sponsor
- University College, London
Atrial Fibrillation
Assessing the Safety and Efficacy of the LAmbre™ Plus Device
Randomized controlled trial assessing the safety and efficacy of the LAmbre Plus LAA Closure System to rescue the risk of thromboembolism in patients with non-valvular AF.
- Trial name
- REDUCE-AF (NCT06465706)
- Testing
- LAmbre investigational device
- Volunteers
- 1,826 people
- Sponsor
- Kansas City Heart Rhythm Research Foundation
Hypertension and Cardiovascular Risk Factors
Knowledge of Vascular Age Contributes to Improve the Collaboration Between Community Pharmacies and Primary Health Care Physicians in Reducing Blood Pressure in Hypertensive Patients.
Cardiovascular diseases are the main cause of death worldwide and elevated blood pressure (BP), called hypertension (HTN), is the principal and most frequent factor for suffering cardiovascular diseases.
- Trial name
- TOGETHER (NCT06761235)
- Testing
- Standard BP intervention, EVA intervention
- Where
- 6 sites in Austria, Portugal and 1 more
- Volunteers
- 1,246 people
- Sponsor
- Enrique Rodilla
Metabolic Syndrome
Effects of Functional Ingredients in an Acute Metabolic Challenge Context
After an energy-rich meal the blood levels of glucose and lipids undergo a marked temporary increase, triggering a wave of oxidative stress due to the appearance of excess free radicals in adipose and muscle tissues.
- Trial name
- NCT02623608
- Testing
- Reference breakfast, Active Ingredient 1, Active Ingredient 2
- Where
- Sweden
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Lund University
Cardiovascular Diseases, Heart Diseases
Physical Activity and Cardiovascular Risk in Black Girls
To conduct a longitudinal study investigating the physical activity patterns, the psychosocial predictors of physical activity, and the effects of physical activity changes on blood pressure and body fatness in a cohort of…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Hypertension, Obesity
- Trial name
- NCT00005437
- Sponsor
- The University of Texas Health Science Center, Houston
Cardiovascular Disease
Effects of Polyphenolic-rich Dark Chocolate/Cocoa and Almonds on Cardiovascular Disease Risk Factors
The purpose of this study is to investigate the individual and combined effects of dark chocolate/cocoa and almonds on lipids, lipoproteins, antioxidant defense, lipid peroxidation, phenolic acids, inflammatory status, blood…
- Trial name
- CAS (NCT01882881)
- Testing
- Healthy American Control Diet, Dark Chocolate/Cocoa Diet, Almond Diet
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Penn State University
Plaque Psoriasis
Long-Term Safety Study of Deucravacitinib Versus Ustekinumab in Participants With Psoriasis (PRAGMATYK)
A study to evaluate the long-term safety of Deucravacitinib versus Ustekinumab in participants with psoriasis
- Trial name
- NCT07116967
- Testing
- Deucravacitinib, Ustekinumab
- Where
- 411 sites in United States, Argentina and 23 more
- Volunteers
- 3,040 people
- Sponsor
- Bristol-Myers Squibb
Hypertension, Diabetes
Study of a Community Based Approach to Control Cardiovascular Risk Factors in India
The study is a 2 year community based cluster randomized controlled trial to assess the role that a community health worker led intervention, in concert with physician education, can play in controlling the principal…
- Conditions
- Hypertension, Diabetes, Smoking, Cardiovascular Diseases
- Trial name
- SEHAT (NCT02115711)
- Testing
- Community health worker
- Where
- India
- Volunteers
- 1,242 people
- Sponsor
- University Hospitals Cleveland Medical Center
Ischemic Stroke
Stenting vs. Aggressive Medical Management for Preventing Recurrent Stroke in Intracranial Stenosis
PRIMARY HYPOTHESIS: Compared with intensive medical therapy alone, intracranial angioplasty and stenting combined with intensive medical therapy will decrease the risk of the primary endpoint by 35% over a mean follow-up of two…
- Trial name
- SAMMPRIS (NCT00576693)
- Testing
- intracranial angioplasty and stenting, intensive medical management
- Where
- 50 sites in United States
- Volunteers
- 451 people
- Sponsor
- Medical University of South Carolina
Coronary Artery Disease
Risk Factors of Individuals With Coronary Artery Disease
It would be useful to study coronary arteriovenous difference of various markers in patients who are undergoing coronary angiography for suspected coronary artery disease.
- Trial name
- NCT00260104
- Where
- China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Nanjing Medical University
In-Stent Restenosis, Coronary Artery Disease
VAP-Measured Lipid Subfractions and In-Stent Restenosis After PCI
This multicenter observational study investigates whether lipid and lipoprotein subfractions measured by Vertical Auto Profile (VAP) are associated with coronary in-stent restenosis after percutaneous coronary intervention (PCI).
- Trial name
- NCT07533656
- Testing
- No intervention
- Where
- China
- Volunteers
- 3,600 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Congenital Aortic Stenosis
Cardiac Imaging in Adults With Congenital Aortic Stenosis
The CAS study is a prospective observational cohort study investigating the effects of congenital aortic stenosis (ConAoS) on the left ventricular function and the prevalence, pattern and expanse of left ventricular hypertrophy…
- Trial name
- CAS (NCT05252351)
- Where
- Netherlands
- Volunteers
- 75 people
- Sponsor
- Erasmus Medical Center
Healthy Diet, Cardiovascular Risk Factor
Effects of Proportioning Meat and Plant-based Protein-rich Foods on Cardiovascular Disease Risk Factors (S58)
This project will assess the effects of consuming different proportions of red meat (RM) and plant-based, protein-rich foods (nuts, seeds, and soy products - NSS) incorporated into a U.S.
- Trial name
- NCT04820829
- Testing
- High RM, low NSS, Moderate RM, Moderate NSS, Low RM, High NSS
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Purdue University
Liver Cirrhosis, Venous Thromboembolism
Risk Factors and Outcomes of Acute Venous Thromboembolism in Cirrhotic
patient with liver cirrhosis was supposed to have autoanticoagulation which approved to be wrong, with absence of conventional method to detect all abnormalities in coagulation state.
- Trial name
- NCT03580577
- Testing
- thromboelastography
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
QT-prolongation
Drug Interactions With Risk of QT-prolongation in a General Hospital
In this epidemiological point prevalence study, medication profiles of patients with haloperidol treatment will be checked for drug interactions with risk of QT-prolongation.
- Trial name
- NCT02043912
- Testing
- Haloperidol
- Where
- Belgium
- Volunteers
- 222 people
- Sponsor
- KU Leuven
Epilepsy, Seizure
Late-Onset Seizures: Trial of Vascular Risk Investigation and Treatment
A growing body of evidence suggests patients with late-onset seizures are at an increased risk of stroke, but the potential for reducing cardiovascular morbidity through risk factor screening and management is unknown.
- Trial name
- LOSTIT (NCT07116330)
- Testing
- Vascuar risk factor screening (blood pressure, medical history, BMI, laboratory tests)
- Where
- 3 sites in Sweden
- Volunteers
- 420 people
- Sponsor
- Sahlgrenska University Hospital
Venous Thromboembolism
Efficacy of Sodium Heparin for Prophylaxis of Venous Thromboembolism in Surgical Patients
The aim of this study is to verify, through clinical examination and doppler, the non-inferiority of the drug test (heparin sodium 5.000UI/0.25 mL - HIPOLABOR) in relation to the drug compared (heparin sodium 5.000USP/mL - APP)…
- Trial name
- NCT00934167
- Testing
- heparin sodium - Hipolabor, Heparin sodium - APP
- Where
- Brazil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Azidus Brasil
Cardiovascular Diseases, Dyslipidemias
Effects of Nattokinase on Inflammation and Cardiovascular Risk Markers in Patients With Dyslipidemia
The study aims to evaluate the effect of the nattokinase enzyme on inflammation and markers of cardiovascular risk in participants with dyslipidemia.
- Conditions
- Cardiovascular Diseases, Dyslipidemias, Inflammation
- Trial name
- NCT06183307
- Testing
- Nattokinase
- Where
- Brazil
- Volunteers
- 48 people
- Sponsor
- Universidade Federal Fluminense
Fatty Liver Disease
Portal Hypertension in Non-alcoholic Fatty Liver Disease: Association With Cardiovascular Risk and Identification of Non-invasive Biomarkers (THESIS)
Non-alcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver disease in our environment. Preliminary data suggest that portal hypertension may exist in the initial phases of NAFLD due to mechanisms that…
- Trial name
- THESIS (NCT04191044)
- Testing
- A complete cardiovascular and liver characterization will be carried out
- Volunteers
- 170 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla