Clinical trials: Cardiovascular Risk Reduction
Posttraumatic Stress Disorder
Investigating Cardiac Health of Adults With Trauma
This project examines the impact of a healthy lifestyle intervention, specifically designed for adults with posttraumatic stress and identified cardiovascular risks.
- Trial name
- I - CHAT (NCT05700201)
- Testing
- Lifestyle / Healthy Behavior Intervention, standard care
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Nova Southeastern University
Coronary Heart Disease, Cardiac Rehabilitation
Reducing Risk in Cardiac Rehabilitation: Partners Together in Health (PaTH) Intervention Study
The objective of the proposed study, using an experimental, two-group (n = 30 couples in each group) repeated measures design, was to pilot test the effects of the PaTH Intervention versus a usual care group in improving the…
- Trial name
- PaTH (NCT00926848)
- Testing
- Partners Together in Health (PaTH) Intervention
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Physical Activity
WalkLink: Internet-based Walking Program
The investigators propose a randomized controlled trial based on the Social Networks for Activity (SNAP) Model to evaluate: (1) the effectiveness of an internet-based fitness walking program delivered to patients with risk…
- Trial name
- WalkLink (NCT01142804)
- Testing
- Group
- Where
- United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Dyslipidemia, Overweight and Obesity
Intermittent Cottonseed Oil Consumption
Cardiovascular disease risk factors, including higher BMIs and poor cholesterol profiles, are on the rise and contribute to the United States' growing disease burden.
- Conditions
- Dyslipidemia, Overweight and Obesity, Nutrition, Healthy
- Trial name
- NCT07246408
- Testing
- CSO-30, CSO-20, Control
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Blood Pressure, Endothelial Dysfunction
Impact of Oranges on Cardiovascular Health
Cardiovascular disease (CVD) is the leading cause of deaths in the Western world. Established risk factors include high LDL cholesterol, high blood pressure and diabetes.
- Conditions
- Blood Pressure, Endothelial Dysfunction, Cardiovascular Disease Risk Reduction
- Trial name
- NCT01935362
- Testing
- Citrus supplement
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Hypertension (HTN), Vascular Diseases
The BASIC-S Feasibility Study for Vascular Risk Reduction
Vascular risk factors drive stroke, heart disease, and dementia, but translating lifestyle guidelines into routine clinical care remains challenging.
- Conditions
- Hypertension (HTN), Vascular Diseases, Stroke, Dementia
- Trial name
- BASIC-S (NCT07755631)
- Testing
- BASIC-S Intervention, Standard / Usual Care
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Andrew Appleton
Pregnancy Related, Hypertension
The Path to Optimal Black Maternal Heart Health: Comparing Two CVD Risk Reduction Interventions (Change of HEART)
The overarching goal of our proposal is to reduce disparities in perinatal cardiovascular disease risk factors among Black women utilizing a community-driven, social ecological framework.
- Conditions
- Pregnancy Related, Hypertension, Obesity, Racism
- Trial name
- NCT05499507
- Testing
- COH, COH+
- Where
- United States
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- Temple University
Alzheimer Disease (AD), Cardio Vascular Disease
Arlington Longitudinal Optimal Healthy Aging Study (ALOHA)
The Arlington Longitudinal Optimal Healthy Aging (ALOHA) Study is a community-based research project led by the Marymount University Center for Optimal Aging (MCOA).
- Conditions
- Alzheimer Disease (AD), Cardio Vascular Disease, Mild Cognitive Impairment (MCI), Frailty Syndrome
- Trial name
- ALOHA (NCT07180147)
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Marymount University
Long QT Syndrome, Abnormalities, Drug-Induced
Reducing the Risk of Drug-Induced QT Interval Lengthening in Women
This research will determine if oral progesterone attenuates drug-induced QT interval lengthening in a) Postmenopausal women 50 years of age or older, and b) Premenopausal women studied during the ovulation phase of the menstrual…
- Trial name
- NCT03834883
- Testing
- Progesterone, Ibutilide
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Indiana University
Atrial Fibrillation (AF), Heart Failure With Mildly Reduced Ejection Fraction (HFmrEF)
An AI-ECG-Based Approach for Dynamic Assessment of Heart Failure Risk and Myocardial Recovery Following Atrial Fibrillation Ablation
Background Artificial intelligence-enabled electrocardiography (AI-ECG) has emerged as a promising digital biomarker for detecting latent myocardial dysfunction and predicting cardiovascular risk.
- Trial name
- NCT07708818
- Where
- South Korea
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Ewha Womans University Mokdong Hospital
Cardiovascular Risk Reduction of Having a Coronary Event
A Novel Approach to Cardiovascular Health by Optimizing Risk Management (ANCHOR)
Study Purpose and Design The goal of this study is to improve CVD risk in a primary care adult population, with the following primary objectives 1.
- Trial name
- ANCHOR (NCT01620996)
- Testing
- Minimal Intervention, Motivational Interviewing, Motivational Enhancement
- Where
- Canada
- Volunteers
- 1,708 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Human Immunodeficiency Virus Infection
Mechanisms of Immune Reconstitution & Reduced Immune Activation Following Darunavir-based ART
Potent HIV suppression with Darunavir-based antiretroviral therapy (ART) will lead to repopulation of gastrointestinal-associated lymphoid tissue (GALT) cluster of differentiation (CD)4+ T-cell populations, normalization of…
- Trial name
- NCT01869634
- Testing
- darunavir with ritonavir and fixed-dose viread+emtricitabine daily
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Cardiovascular Disease Risk Reduction
Flavonoids, Blood Pressure and Blood Vessel Function
The primary aim of this placebo-controlled study is to determine whether flavonoids beneficially affect markers of cardiovascular disease risk in healthy subjects at elevated cardiovascular risk.
- Trial name
- FASTCHECK (NCT01530893)
- Testing
- Flavanone - supplement, Flavanone - food, Isoflavone - supplement
- Where
- United Kingdom
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Cancer, Cardiovascular Diseases
ActivityChoice: Implementing Clinic-Based Physical Activity Program Choices for Cancer Survivors
Cardiovascular disease, the number one leading cause of death in the United States, is highly prevalent in cancer survivors. Physical activity can reduce risk, and referrals to programs addressing survivors' choices are highly…
- Conditions
- Cancer, Cardiovascular Diseases, Physical Inactivity
- Trial name
- NCT05870176
- Testing
- Enhanced Referral, Standard Referral
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Tobacco Use Cessation
Telephone Counseling for Tobacco Cessation
The purpose of this study is to determine whether giving more structured information to patients over the phone about quitting tobacco helps to increase the chance that they will try to quit.
- Trial name
- NCT01489579
- Testing
- Telephone Counseling for Tobacco Cessation, Usual Care
- Where
- United States
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Hypertension, African Americans
Giving a Low Carbohydrate Diet to Overcome Hypertension
This study will test the preliminary efficacy of adding a very low carbohydrate dietary intervention to the evidence-based DPP-GLB on blood pressure reductions for lower-income AA men and women in a community-based clinic.
- Conditions
- Hypertension, African Americans, Diet, Carbohydrate-Restricted, Risk Reduction Behavior
- Trial name
- GLOH (NCT04230928)
- Testing
- Very low carbohydrate diet, Standard DPP-GLB diet, Standard DPP-GLB program modules
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Stroke, Risk Reduction
CHM Teabag Decrease Stroke Risk Among Hong Kong Elderly
This stepped wedge cluster randomized controlled trial aims to examine the efficacy and safety of CHM teabag in decreasing stroke risk by machine-learning-based retinal image analysis in elderly population.
- Conditions
- Stroke, Risk Reduction, Elderly
- Trial name
- NCT05801575
- Testing
- Chinese Herbal Medicine (CHM) teabag
- Where
- China
- Volunteers
- 912 people, healthy volunteers welcome
- Sponsor
- Hong Kong Baptist University
Blood Pressure, High, Cardiovascular Risk Factor
Efficacy of a Brief Intervention on Reduction of Systolic Blood Pressure
This study examines the efficacy of individualized counseling letters to reduce systolic blood pressure level of ≥ 130 mmHg in individuals aged between 40 and 65 years.
- Trial name
- NCT03077373
- Testing
- Counseling letter
- Where
- Germany
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Cardiovascular Diseases, Coronary Heart Disease
Meta-analysis of Oat Fiber and Cardiovascular Risk Reduction
Oat fibre has been shown to lower cholesterol and may have cardioprotective effects. However, whether this translates to actual cardiovascular risk reduction is unclear, as there is a lack of controlled human trials.
- Trial name
- NCT05171283
- Testing
- Oats or Oat Fibre
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Worksite Health Promotion, Lifestyle Risk Reduction
Worksite Wellness Within Long-term Care Facilities
The goal of this proposed study is to test the feasibility and preliminary efficacy of worksite wellness program designed to reduce worker stress (job and personal) and improve cardiovascular disease among long-term care workers.
- Conditions
- Worksite Health Promotion, Lifestyle Risk Reduction, Cardiovascular Diseases, Occupational Stress
- Trial name
- NCT04166643
- Testing
- WHHIP PLUS, Education only control
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore