Clinical trials: Cardiovascular Risks
Hypertension, African Americans
Giving a Low Carbohydrate Diet to Overcome Hypertension
This study will test the preliminary efficacy of adding a very low carbohydrate dietary intervention to the evidence-based DPP-GLB on blood pressure reductions for lower-income AA men and women in a community-based clinic.
- Conditions
- Hypertension, African Americans, Diet, Carbohydrate-Restricted, Risk Reduction Behavior
- Trial name
- GLOH (NCT04230928)
- Testing
- Very low carbohydrate diet, Standard DPP-GLB diet, Standard DPP-GLB program modules
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Cardiovascular Diseases
Improved Cardiovascular Disease hEALth Service Delivery in Australia: Cluster Randomised Controlled Trial (IDEAL Study)
The IDEAL study is a randomized controlled trial among people referred to pathology services to have blood cholesterol measured. Study participants will have cardiovascular risk factors (e.g.
- Trial name
- IDEAL (NCT04896021)
- Testing
- Cardiovascular disease risk assessment, Usual care assessment
- Where
- Australia
- Volunteers
- 2,761 people, healthy volunteers welcome
- Sponsor
- Menzies Institute for Medical Research
Cardiovascular (CV) Risk
Lions Hearts: A Community Approach to Multigenerational Cardiovascular Disease Risk
This pilot study evaluates the feasibility, acceptability, and preliminary effectiveness of Lion Hearts, a community-based, family-centered physical activity intervention designed to improve cardiovascular health among…
- Trial name
- NCT07147387
- Testing
- Lion Hearts Family-Based Physical Activity Program
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Penn State University
Hypertensive Disease, Deficiency of Vitamin D3
Effect of Vitamin D3 on Cardiovascular Risk Factors
The aim of this study is to investigate whether a supplementation of Vitamin D3 can be used to reduce atherosclerotic risk factors.
- Trial name
- NCT01501916
- Testing
- Vitamin D3
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Cardiovascular Risk Factor, Stress
Stress-reduction Wellness Program for Midlife Black Women (B-SWELL)
This research study examines the unique cultural and gender-based factors that influence how midlife Black women experience stress and incorporate healthy lifestyle behaviors into daily life.
- Conditions
- Cardiovascular Risk Factor, Stress, Self Efficacy, Depressive Symptoms
- Trial name
- B-SWELL (NCT04404478)
- Testing
- B-SWELL: Midlife Black Women's Stress Reduction Wellness Program, WE: Wellness program for Midlife Black Women
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Blood Pressure, Hypertension
Intervention With Riboflavin to Improve Vascular Health and ENdothelial Functioning in Genetically at- Risk Adults
High blood pressure is the leading risk factor for heart disease and stroke. Approximately 12% of the population have a particular genetic factor (known as the TT genotype) which increases the risk of high blood pressure.
- Trial name
- InteRVENE (NCT05488106)
- Testing
- Riboflavin 1.6mg/d, Riboflavin 5mg/d, Riboflavin 20mg/d
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Hormone Therapy Induced Morphologic Change, Surgical Menopause
Hormone Therapy on Serum Ischemia Modified Albumin in Menopausal Women
Women suffer from cardiovascular diseases 10 years later than men, therefore female sex has been considered as a 'protective factor'.
- Trial name
- NCT04424108
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Cardiovascular Disease
The Impact of Patient Involvement in Decision-Making About Heart Disease Prevention
The purpose of this study is to determine whether providing patients with information about their global coronary heart disease (CHD) risk and effective risk-reducing strategies allows them to make appropriate decisions about…
- Trial name
- NCT00315978
- Testing
- Heart-to-Heart Decision Aid
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of North Carolina
Cardiovascular Disease
Postprandial Effects of Walnut Components Versus Whole Walnuts on Cardiovascular Disease (CVD) Risk Reduction
The purpose of this study is to evaluate the acute, postprandial effects and mechanism of action of various walnut components (separated nut skins, de-fatted nut meat, nut oil) versus whole walnuts on oxidative stress…
- Trial name
- NCT00938340
- Testing
- Walnut "meat", Walnut Oil, Walnut Skins
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Penn State University
Endothelial Dysfunction, Acute Myocardial Infarction (AMI)
Validation of Cor-IS Impedance Spectroscopy Against Ultrasound Flow-Mediated Dilation
This prospective observational study evaluated the Cor-IS bioelectrical impedance spectroscopy technique for the assessment of endothelial function by comparison with ultrasound-based brachial artery flow-mediated dilation (FMD).
- Conditions
- Endothelial Dysfunction, Acute Myocardial Infarction (AMI), Cardiovascular Risk Factors (e.g., Hypertension), Flow Mediated Dilation
- Trial name
- NCT07882550
- Testing
- Cor-IS FMD, Ultrasound FMD
- Where
- Greece
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Sodium Excess, Racial Disparities
Vascular Effects of Acute Sodium (VEAS) Study
This IRB will cover a current clinical trial (NCT04244604) that was started at Auburn University (AU IRB#19-390), the Principal Investigator's prior institution, and is supported by his NIH Career Development Award (NHLBI…
- Conditions
- Sodium Excess, Racial Disparities, Blood Pressure, Cardiovascular Risk Factor
- Trial name
- NCT04244604
- Testing
- Low Sodium Meal (140 mg sodium chloride), High Sodium Meal (2500 mg sodium chloride)
- Where
- 2 sites in United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Indiana University
Cardiovascular Disease
Cardiovascular Disease and the Effects of a Cross-curricular Physical Activity Intervention
The purpose of this study is to investigate the effects of a cross-curricular physical activity intervention on cardiovascular disease risk factors in 11-14 year olds.
- Trial name
- NCT00998478
- Testing
- Activity Knowledge Circuits
- Where
- United Kingdom
- Volunteers
- 192 people, healthy volunteers welcome
- Sponsor
- University of Glamorgan
Menopause, Depression
Depression, Aging, Stress and Heart Health Study
Depression is a known risk factor for cardiovascular disease (CVD), and this comorbidity contributes significantly to the morbidity and mortality of women.
- Conditions
- Menopause, Depression, Heart Disease in Women, Stress
- Trial name
- DASHH (NCT05570721)
- Testing
- Trier Social Stress Test
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Physical Activity
Evaluation of Energy Expenditure and Cardiovascular Health Effects From Tai Chi and Walking Exercise
Cardiovascular diseases (CVD) accounted for major mortality and morbidity rates in Hong Kong (HK) other than cancer. Increasing energy expenditure through regular exercise participation has been found to lower the risk of CVD…
- Trial name
- NCT02163798
- Testing
- 12-week instructor-led Tai Chi training program, 12-week instructor-led brisk walking training program
- Where
- Hong Kong
- Volunteers
- 374 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Cardiovascular Risk Factors, Serious Mental Illness
Reducing Disparities in Cardiovascular Health in Community Mental Health Settings: Optimizing Implementation Strategies
In this trial, the investigators will examine the uptake of the evidenced-based IDEAL Goals program, a heart disease risk reduction program, while testing different implementation strategies with our partners in Michigan and…
- Trial name
- NCT06674616
- Testing
- Replicating Effective Programs, Coaching, Facilitation
- Where
- 2 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Type 2 Diabetes Mellitus
Carotid Wall Texture as a Cardiovascular Risk Biomarker in Type 2 Diabetes Mellitus
This study aims to compare carotid intima-media thickness (CIMT) and layer-specific texture characteristics of the carotid wall between individuals with Type 2 diabetes mellitus (T2DM) and normoglycemic controls, to assess the…
- Trial name
- NCT07373938
- Testing
- SCORE2, SCORE2-Diabetes, Ultrasound Assessment
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Obesity, Smoking
Africa and Middle East Cardiovascular Epidemiological Study
This is a cross-sectional, epidemiological study to determine the prevalence of cardiovascular risk factors such as obesity, smoking, dyslipidemia, diabetes mellitus and hypertension in patients attending General Practice clinics…
- Conditions
- Obesity, Smoking, Dyslipidemia, Diabetes Mellitus
- Trial name
- ACE (NCT01243138)
- Where
- 73 sites in Algeria, Cameroon and 12 more
- Volunteers
- 4,386 people, healthy volunteers welcome
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Obesity, Cardiovascular Disease
Role of Cardiometabolic Risk Factors in Childhood Bone Development
The proposed research brings together complementary expertise to systematically elucidate the longitudinal effects of (1) total and regional body fat and (2) the metabolic impairment that accompanies obesity on bone development…
- Conditions
- Obesity, Cardiovascular Disease, Type 2 Diabetes, Osteoporosis
- Trial name
- NCT02355717
- Testing
- Observational Study
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Augusta University
Ischemic Stroke, Coaching
Telerehabilitation-Based Coaching Interventions (TeleSCoP) for Patients With Ischemic Stroke
Ischemic stroke has high morbidity and mortality worldwide. Stroke patients experience physical, psychological, and social problems, and require rehabilitation.
- Trial name
- NCT05940350
- Testing
- Telerehabilitation Stroke Coaching of Program (TeleSCoP) group
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Menopausal Women
Study of Early Hormone Replacement Therapy on Risk Factors for Sudden Cardiac Death
As an ancillary study to the KEEPS study (see ClinicalTrials.gov Identifier: NCT00154180), the primary purpose is to measure effects of estrogen vs.
- Trial name
- KEEPS (NCT00580775)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Yale University
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