Clinical trials: Cardiovascular System
Prehypertension, Hypertension
Equity in Prevention and Progression of Hypertension by Addressing Barriers to Nutrition and Physical activitY
The goal of this study is to test an intervention to prevent high blood pressure among rural, Black adults living in Alabama. Black adults in this region have one of the highest rates of high blood pressure in the US.
- Conditions
- Prehypertension, Hypertension, Blood Pressure
- Trial name
- EPIPHANY (NCT05367544)
- Testing
- Health Education, Individual-Level Peer Support, Community-Level Peer Support
- Where
- United States
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Research With Clinical Staff in Stroke Rehabilitation
Usability Study of OnTrack Tools
Aims: Assess the usability of OnTrack Tools, a clinician facing interface to manage stroke survivors using the OnTrack rehabilitation system.
- Trial name
- NCT05330234
- Testing
- OnTrack Tools
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Childhood Obesity, Type 2 Diabetes
Cardiovascular Risk Factors, Body Composition, Fitness Levels And Quality Of Life In Overweight And Obese 8-17 Year Olds
This project will address the important area of childhood obesity and the risk of cardiovascular disease associated with obesity.
- Conditions
- Childhood Obesity, Type 2 Diabetes, Hypercholesterolemia, Hypertension
- Trial name
- NCT02024399
- Testing
- Exercise
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Stony Brook University
Cardiovascular Disease, Hyperhomocysteinemia
Prevalence Of Hyperhomocysteinemia In Thai Chronic Kidney Disease (CKD) Patients
It is well recognized that patients with chronic kidney disease (CKD) have an increased risk for cardiovascular disease (CVD) and hyperhomocysteinemia appears to be a predictor of future CVD events.
- Trial name
- NCT01391416
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Bangkok Metropolitan Administration Medical College and Vajira Hospital
Infection, Hypervolemia
Observational Study to Evaluate Peripheral IntraVenous Analysis (PIVA) in Euvolemic, Hypovolemic, and Hypervolemic Emergency Department Patients
The overall goal of this multicenter project is to characterize the expected normal range of Peripheral IntraVenous Volume Analysis (PIVA) values during a euvolemic state, and how those ranges may be altered by comorbidities; the…
- Conditions
- Infection, Hypervolemia, Hypovolemia, Septic Shock
- Trial name
- PIVA (NCT03736421)
- Testing
- Peripheral Intravenous Analysis (PIVA), Non-invasive fluid response measure, Passive leg raise (PLR)
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Paralytic Stroke, Cough
Diaphragmatic Function in Stroke Patients.
This study attempts to elucidate whether stroke patients with dysphagia have reduced diaphragm movement during voluntary coughing, and also during deep inspiration and expiration than stroke patients without dysphagia.
- Trial name
- NCT01637649
- Where
- South Korea
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Coagulopathy, Mesothelioma
Thromboelastography During Surgery for Malignant Pleural Mesothelioma
Surgery for malignant pleural mesothelioma is complex and prolonged, and may involve significant blood loss with considerable blood and product transfusion.
- Trial name
- NCT01912547
- Testing
- Blood draw for TEG analysis
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Heart Failure
Improving Goal Directed Medical Therapy for Device Clinic Patients With Reduced EF at UOHI: a QI Initiative (VIGILANT)
This is a quality improvement initiative with the goal of optimizing heart failure (HF) patients seen through the outpatient cardiac implantable electronic device clinic at the University of Ottawa Heart Institute (UOHI).
- Trial name
- VIGILANT (NCT05085249)
- Where
- Canada
- Volunteers
- 2,479 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Acute Coronary Syndrome
Antithrombotic Effects of Ticagrelor Versus Clopidogrel
The purpose of this study is to determine whether treatment with ticagrelor (plus aspirin and bivalirudin) is more effective than treatment with clopidogrel (plus aspirin and bivalirudin).
- Trial name
- NCT01642238
- Testing
- Ticagrelor + ASA + Bivalirudin, Clopidogrel + ASA + Bivalirudin
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Juan J Badimon
Wheelchair Users
Development of the GameCycle Exercise System: Phase II
The purpose of this research project is to further develop and test the effectiveness of a novel exercise system for wheelchair users, the Game Cycle.
- Trial name
- NCT00232609
- Testing
- GameCycle Exercise System
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- VA Pittsburgh Healthcare System
Hereditary Angioedema (HAE)
Phase 1 Study to Assess the Safety, Tolerability, and Pharmacokinetics of Recombinant Human C1 Esterase Inhibitor in Healthy Adult Subjects
This trial is looking to gain information about the safety and tolerability of an investigational treatment (SHP623) in healthy adult volunteers.
- Trial name
- NCT02663687
- Testing
- Recombinant human C1 esterase inhibitor, SHP623
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Shire
Fabry Disease
A Phase I, Randomized, Single-Blind, Four-Period Cross-Over, Placebo-Controlled, Dose-Escalation Study to Evaluate the Safety and Pharmacokinetics of Single Oral Doses of GR181413A/AT1001 in Healthy Japanese Subjects
GR181413A/AT1001 (migalastat hydrochloride) is a low molecular weight iminosugar, an analog of the terminal galactose group that is cleaved from the substrate GL-3.
- Trial name
- NCT01853852
- Testing
- GR181413A/AT1001 solution, GR181413A/AT1001 capsule, Potable water
- Where
- Australia
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Amicus Therapeutics
Atherosclerosis, Menopause
Estrogen Exposure and Atherosclerosis in Postmenopausal Women
One hundred Spanish postmenopausal women accepted to be investigated for cardiovascular risk actors including clinical features, serum biochemical parameters, single nucleotide polymorphisms for estrogen receptor, and imaging…
- Conditions
- Atherosclerosis, Menopause, Estrogens, Carotid Intima-media Thickness
- Trial name
- NCT02951949
- Where
- Spain
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Coronary Artery Disease
Comparative Pharmacokinetics Study of Clopidogrel and Aspirin Fixed-dose Combination Versus Separate Combination
The purpose of this study is to compare pharmacokinetics between fixed-dose combination and separate combination of clopidogrel 75mg/aspirin 100mg.
- Trial name
- NCT01663038
- Testing
- Clopidogrel, Fixed dose combination of clopidogrel/Aspirin, Aspirin
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Hypertension, Diet, Mediterranean
Analysis of Bioparametric Measures for Correlating Daily Habits and Reducing Blood Pressure
To study the effects of the use of a mobile application plus recommendations based on a Mediterranean diet on the intake of micronutrients from natural sources (not drugs) on health indicators, cardiovascular parameters (blood…
- Conditions
- Hypertension, Diet, Mediterranean, Cardiovascular Diseases, Exercise
- Trial name
- NCT04828655
- Testing
- Use of a mobile application based on machine learning with the aim of improving health and body composition parameters.
- Where
- Spain
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alicante
Stroke, Traumatic Brain Injury
Validation of an Obstacle Course Used in Patients With Muscle Tightness
This study is being conducted to compare healthy patients versus patients with muscle tightness in their leg(s) after an acquired brain injury using walking trials time, a balance test, and foot pressure data.
- Conditions
- Stroke, Traumatic Brain Injury, Multiple Sclerosis, Spasticity
- Trial name
- NCT00776048
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Myocarditis
Myocarditis Post Vaccination or Multi System Inflammatory Syndrome
BNT162b2 vaccine has become one of the most prevalent vaccines against the COVID-19 and is currently the main vaccine used in Israel. Since marketing and the beginning of use of the vaccine, we and others have reported.
- Trial name
- MyoVax (NCT05288426)
- Testing
- No intervention
- Where
- Israel
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Long QT Syndrome
Effect of Oral GS-6615 on Dofetilide-Induced QT Prolongation, Safety, and Tolerability in Healthy Adults
This study will evaluate the effect of oral GS-6615 on QTc interval in healthy adults with dofetilide-induced QTc prolongation.
- Trial name
- NCT02365532
- Testing
- GS-6615, Dofetilide
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gilead Sciences
Hypotension, Point of Care Ultrasound
Sonography in Hypotension and Cardiac Arrest in the Emergency Department.
This study is designed to determine if there is any relationship between performing an abdominal ultrasound on patients who present with hypotension and their clinical outcomes (as measured by 7, 30 day and discharge mortality).
- Conditions
- Hypotension, Point of Care Ultrasound, Shock
- Trial name
- SHoC-ED (NCT01419106)
- Testing
- Ultrasound (A point of care ultrasound protocol)
- Where
- 6 sites in Canada, South Africa
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Horizon Health Network
Ischemic Stroke
Transcranial Direct Current Stimulation (tDCS)-Enhanced Stroke Recovery
The purpose is to determine whether application of a non-invasive battery powered device called transcranial direct current stimulation (tDCS) can improve recovery of hand weakness after stroke beyond what is achievable with…
- Trial name
- NCT01007136
- Testing
- tDCS
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
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