Clinical trials: Cardiovascular System
Venous Thrombosis
A Study of MK-2060 in Healthy Participants (MK-2060-016)
The goal of the study is to learn about the safety of MK-2060 and if people tolerate it when MK-2060 is given in different forms.
- Trial name
- NCT06582602
- Testing
- MK-2060
- Where
- 2 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Coronary Heart Disease, Myocardial Infarction
Prospective Coronary Heart Disease Cohort
To evaluate the biomarkers for the prognosis of coronary heart disease, patients with coronary heart disease will be recruited and followed up for at least 2 years.
- Trial name
- NCT05699629
- Where
- China
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Shandong First Medical University
Cardiovascular Diseases, Heart Diseases
Evaluating the Effectiveness of a Family Heart Health Educational Program (The FIT-Heart Study)
The primary objective of the FIT Heart Study was to test the effectiveness of a hospital-based standardized screening and educational intervention targeted to family members of patients hospitalized with CVD, to increase…
- Trial name
- FIT-Heart (NCT00728637)
- Testing
- Family Passport to Heart Health Program, General Educational Materials
- Where
- United States
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Columbia University
Coronary Artery Disease, Coronary Microvascular Disease
Whole-Heart Myocardial Blood Flow Quantification Using MRI
This study hopes to provide significant technical improvement in a Myocardial Blood Flow (MBF) cardiac magnetic resonance (CMR) quantification technique to address challenges and technical limitations for MBF CMR.
- Trial name
- NCT03064295
- Testing
- Myocardial Perfusion Cardiac MRI., Contrast, Pharmacologic Stress Agent
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Menopause
Effects of the Concentrated Extract of Soy on Coagulation Factors After Menopause
Hypoestrogenism, common in menopause, is responsible for systemic and metabolic changes affecting women's wellness, favoring hot flashes, urogenital atrophy and bone mass loss.
- Trial name
- NCT00925639
- Testing
- Isoflavone
- Where
- Brazil
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Hyperfibrinolysis, Cesarean Section Complications
The Incidence of Hyperfibrinolysis During Vaginal Delivery and Cesarean Section
This study aims to find out if there are common major changes in coagulation immediately after delivery of the newborn during Cesarean (C) -section and vaginal birth.
- Conditions
- Hyperfibrinolysis, Cesarean Section Complications, Coagulation Defect; Bleeding, Peripartum Haemorrhage
- Trial name
- NCT05975112
- Testing
- Coagulation tests (TEG, Levels of F1, F2, hs-D-dimer, Plasminogen, PAI 1+2), SpHb before discharge
- Where
- Austria
- Volunteers
- 780 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Cardiovascular Disease
The Effects of Peanuts and Peanut Products on Glucose Control and Vascular Function
Pilot study data have demonstrated that peanuts ameliorate the postprandial glucose and insulin response when incorporated into an acute high fat/high glucose meal.
- Trial name
- NCT01405300
- Testing
- Control, Peanut
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Penn State University
Atrial Fibrillation (AF), Obesity & Overweight
Exercise and Dietary Lifestyle Intervention on Reducing Atrial Fibrillation Burden, Cardiac and Body Fat Mass.
Atrial fibrillation (AF) is the most common cardiac arrhythmia and is strongly associated with obesity and excess body fat. Lifestyle interventions, including exercise and dietary modification, may reduce AF burden, but long-term…
- Trial name
- MOVE-AF (NCT07430007)
- Testing
- Tailored Exercise and Dietary Lifestyle Program, Usual Clinical Care
- Where
- 4 sites in Finland
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Hypertension, Blood Pressure
Long-term Accuracy and Stability of Blood Pressure Measurements From a Smartwatch: Prospective Validation Study
The aim of the study is to perform an experimental validation of the long-term accuracy of blood pressure measurement using the Samsung Galaxy Smartwatch
- Trial name
- BPLONG (NCT06098092)
- Testing
- Long-term non-invasive Blood pressure monitoring
- Where
- 2 sites in Czechia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Pulmonary Disease, Pulmonary Hypertension
Natural History Study of Biomarkers in Pulmonary Arterial Hypertension
Background: High blood pressure in the lungs, known as pulmonary arterial hypertension (PAH), is a rare disorder. Some people have disease-associated PAH and some have PAH from an unknown cause.
- Trial name
- NCT01730092
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Type 2 Diabetes Mellitus
Vascular Function and Biomarker Assessments in Healthy Volunteers and in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the vascular function and biomarkers in healthy volunteers and type 2 diabetic patients.
- Trial name
- NCT04744636
- Testing
- Other
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut de Recherches Internationales Servier
Peripheral Arterial Disease
Effects of Canola Oil on Blood Vessel Function in Peripheral Arterial Disease
The fatty acid composition of canola oil will have beneficial acute and chronic effects on vascular function in individuals with peripheral arterial disease.
- Trial name
- NCT01250275
- Testing
- traditional canola oil, high oleic canola oil, soybean oil
- Where
- Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
COVID-19 Infection
ESICM UNITE COVID-19 Project (UNITE-COVID)
COVID-19 is arguably the biggest challenge critical care medicine has been confronted with since its conception. Critical care services around the world are flooded by patients presenting with severe respiratory failure who…
- Trial name
- UNITE-COVID (NCT04836065)
- Where
- Belgium
- Volunteers
- 4,995 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Hypertension, Overweight
The Effects of Aronia Juice Polyphenols on Cardiovascular Disease Risk
The existing scientific evidence from both in vitro and clinical trials supports the notion that polyphenols can modulate platelet function.
- Trial name
- AMARCord (NCT02800967)
- Testing
- Pure Aronia juice, Aronia juice-based beverage
- Where
- Serbia
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Adolescent Behavior, Lifestyle Modification
A Family-centred Approach Enhancing Cardiovascular Health in Ugandan Adolescents and Their Families
The FaCe-D Study, with funding from the Canadian Institute for Health Research (CIHR) through Global Alliance for Chronic Diseases (GACD) aims to adapt and implement an evidence-based family centred approach (FCA) to prevent…
- Conditions
- Adolescent Behavior, Lifestyle Modification, Cardiovascular Disease Other
- Trial name
- FaCe-D (NCT07265453)
- Testing
- The immediate (treatment) arm, will receive the FaCe-D intervention comprising of 'HOME VISITS, DIET, PHYSICAL ACTIVITY AND HEALTH MESSAGING, Control Arm - standard of care
- Where
- 2 sites in Uganda
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- MRC/UVRI and LSHTM Uganda Research Unit
Diabetic Foot Ulcer
Clinical Outcomes After Treatment With RestrataTM Wound Matrix in Diabetic Foot Ulcers (DFU)
The primary objective of this study is to determine the outcomes of patients who receive a certain type of skin substitute called RestrataTM Wound Matrix (Restrata™).
- Trial name
- NCT03312595
- Testing
- Restrata TM Wound Matrix
- Where
- 5 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Acera Surgical, Inc.
Healthy, Peripheral Vascular Disease
The Effect of Heat on Blood and Oxygen Flow Readings Part 2
This is the second part of a research study in order to determine if using a specialized pulse oximetry probe with external heat pack will help obtain oxygen saturation (SaO2) and heart rate (HR) during monitoring for patients…
- Conditions
- Healthy, Peripheral Vascular Disease, Vasoconstriction
- Trial name
- NCT01992939
- Testing
- Specialized pulse oximetry probe with external heat pack, Standard of Care Pulse Oximetry Probe
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- VA Pittsburgh Healthcare System
Traumatic Brain Injury, Subarachnoid Hemorrhage
Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury
The purpose of this study is to examine the safety and feasibility of using hyperpolarized metabolic MRI to study early brain metabolism changes in subjects presenting with head injury and suspected non-penetrating traumatic…
- Trial name
- NCT06103201
- Testing
- Hyperpolarized 13C-Pyruvate
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Malaria, Pregnancy Malaria
Cardiac Safety of Dihydroartemisinin-Piperaquine Amongst Pregnant Women in Tanzania
Sulfadoxine-pyrimethamine (SP) is currently recommended by the World Health Organization for use as intermittent preventive treatment against malaria in pregnancy (IPTp) in areas of moderate to high malaria transmission.
- Conditions
- Malaria, Pregnancy Malaria, Cardiotoxicity, Cardiac Safety
- Trial name
- NCT02909712
- Testing
- sulfadoxine-pyrimethamine (SP), dihydroartemisinin-piperaquine (DHA-PQP)
- Where
- Tanzania
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Stroke
Upper Limb Movement Quality Following Stroke
The aim of this study is to monitor the daily upper limb movement of persons with stroke, and to relate these quantities to measures of recovery and impairment.
- Trial name
- NCT06497881
- Where
- Israel
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Adi Negev-Nahalat Eran
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