Clinical trials: Cardiovascular System
Cardiovascular Diseases
The Effects of Unfiltered (Turkish) Coffee Consumption on Cardiovascular Risk Parameters
Purpose/Objective: The aim of this study is to investigate the impact of boiled unfiltered (Turkish) coffee consumption on the plasma cardiovascular risk parameters of healthy subjects.
- Trial name
- NCT03495336
- Testing
- coffee abstention phase, LR Coffee consumption, DR Coffee consumption
- Where
- Cyprus
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Eastern Mediterranean University
Cerebrovascular Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis)
A SAD/MAD Study of Safety, Tolerability and Pharmacologic Activity of BT200 in Normal Volunteers
Study BT200-01 is a first in human (FIH) study in male and female normal human volunteers (NHVs) that uses an Integrated Protocol Design.
- Conditions
- Cerebrovascular Stroke, Large-Artery Atherosclerosis (Embolus/Thrombosis), Intracranial Arteriosclerosis
- Trial name
- NCT04103034
- Testing
- BT200, Desmopressin
- Where
- Austria
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Band Therapeutics
Health Problems in Pregnancy, Pregnancy Outcomes
Peking University Birth Cohort in Weifang (PKUBC-WF)
The PKUBC-WF is a prospective cohort study carried out in Weifang city of Shandong, China. The primary aim of this study is to investigate the short-term and long-term effects of pre-pregnant and prenatal exposure on maternal and…
- Conditions
- Health Problems in Pregnancy, Pregnancy Outcomes, Gestational Diabetes, Gestational Hypertension
- Trial name
- NCT06234332
- Testing
- No Interventions
- Where
- China
- Volunteers
- 2,800 people, healthy volunteers welcome
- Sponsor
- Peking University
Coronary Artery Disease, Coronary Artery Bypass Graft (CABG)
Hyperpolarized 13C Pyruvate-MRI and FDG-PET in a Single Exam for the Prognosis of Ischemic Cardiomyopathy
This prospective, non-blinded, single-center, translational research study aims to validate a multimodal advanced imaging exam for cardiac viability.
- Trial name
- FDG PET-HP MRI (NCT06814587)
- Testing
- Hyperpolarized 13C Pyruvate Magnetic Resonance Imaging (HP-13C MRI), [¹⁸F]Fluorodeoxyglucose Positron Emission Tomography (FDG-PET), SPECT MPI (Single Photon Emission Computed Tomography Myocardial Perfusion Imaging)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Stroke, Hemiparesis
Telerehabilitation Through Serious Games in Virtual Reality in a Stroke Population (AutoRReVi)
After a stroke, individuals present with motor and/or cognitive impairments. These impairments limit activity, restrict participation and affect quality of life.
- Conditions
- Stroke, Hemiparesis, Cognitive Impairment, Healthy Subjects
- Trial name
- AutoRReVi (NCT04694833)
- Testing
- Motor and cognitive virtual reality-based assessments, Motor and cognitive virtual reality-based serious games
- Where
- Belgium
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Stroke
Reproducibility of fNIRS Parameters During Walking
Brain activation can be studied using the Functional Near InfraRed Spectroscopy (fNIRS). It was shown that CPF activation during walking and during dual task could be different in stroke patients and in healthy subjects.
- Trial name
- REPROXY (NCT04882930)
- Testing
- Functional Near-Infrared Spectroscopy (fNIRS)
- Where
- 3 sites in France
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Régional d'Orléans
Diabetic Foot Ulcer, Diabetic Wound
Peer Support for Patients With Diabetic Foot Ulcers
The objective of the study is to develop a peer support program that helps improve ulcer care in patients with a diabetic foot ulcer (DFU).Diabetes, peripheral arterial disease (PAD), foot ulceration, and subsequent amputation…
- Conditions
- Diabetic Foot Ulcer, Diabetic Wound, Diabetes Mellitus, Type 2, Diabetic Foot
- Trial name
- NCT06004219
- Testing
- Peer counseling group
- Where
- 3 sites in United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Cardiovascular Disease
Effectiveness of Non-pharmacological Interventions in Patients With Cardiovascular Risk Factors in Primary Care
The principal objective is analyzed whether a selective intervention no pharmacological (use of ABPM +/- prescription of physical exercise) for cardiovascular risk factors in patients with high cardiovascular risk in primary…
- Trial name
- NCT03452709
- Testing
- therapeutic exercise, ABPM ambulatory blood pressure monitoring
- Where
- Spain
- Volunteers
- 3,656 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia
Cerebral Amyloid Angiopathy, Intracranial Hemorrhages
Multimodal Biomarkers for Diagnosis and Prognosis in CAA
By combination of plasma (Aβ40, Aβ42, total tau, and phosphorylated tau, etc.), genetic (ApoE ε2 or ε4 allele), MRI (cerebral perfusion, microbleeds, cortical superficial siderosis, enlarged perivascular space, etc.) and PET…
- Conditions
- Cerebral Amyloid Angiopathy, Intracranial Hemorrhages, Alzheimer Disease
- Trial name
- CAA (NCT03969732)
- Testing
- 1. amyloid PET；2. T807 PET
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Acute Coronary Syndrome, Chest Pain
Comparison of Accelerated Diagnostic Pathways for Acute Chest Pain in Emergency Departments in the United Arab Emirates
This is a prospective four-site cohort study, which will accrue adults with symptoms concerning for acute coronary syndrome over a period of 12 months.
- Trial name
- NCT05532787
- Testing
- Application of acute chest pain risk stratification scores (HEART and EDACS)
- Where
- 5 sites in United Arab Emirates
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Zayed Military Hospital
Stroke
Non-use After Stroke: Influence of Applied Force and Precision When Reaching With the Paretic Upper Limb
After a stroke, 80% of patients have an upper limb deficit, limiting activity. Some develop a non-use: they can, but do not, use their paretic limb.
- Trial name
- OPTISTROKE (NCT04747587)
- Testing
- Reaching Session
- Where
- 2 sites in France
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Blood Pressure, Cardiovascular Risk Factor
The Acute Effect of Egg-Based High Protein Meal on Hypertensive Response to Exercise
The primary purpose of this study is to explore the effect of high versus normal egg-based protein meals on acute exercise-induced elevated blood pressure.
- Trial name
- S47 (NCT03073252)
- Testing
- Normal Protein, HIgh Protein
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Purdue University
Atrial Fibrillation (AF)
Comparative Study on the Safety and Efficacy of Using AccuSafe Transseptal Guidewire Versus Traditional Transseptal Needle for Transseptal Puncture in non-or Free- Guidance
1. Research Title: Comparative study on the safety and effectiveness of AccuSafe transseptal guidewire versus traditional transseptal needle for transseptal puncture without X-ray guidance 2.
- Trial name
- NCT07515040
- Testing
- Transseptal puncture needle
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Nanchang University
Coronary Artery Disease, Genetic Predisposition to Disease
Genetic Risk Stratification for Primary Prevention of CAD in Men and Pre & Post-menopausal Women
The investigators propose to genotype males and females at age 40 years and older, who are asymptomatic and without known heart disease (N=2000).
- Trial name
- NCT05169840
- Testing
- Genetic Risk Score for Coronary Artery Disease
- Where
- 3 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Hospital and Medical Center, Phoenix
Sepsis, Sepsis and Septic Shock
Hemodynamic Venous Congestion Ultrasound (VExUS) by ICU Nurses in Sepsis Patients.
Sepsis is a serious condition where the body's immune response to infection overreacts, leading to organ damage and death. Venous congestion, a buildup of blood in the veins, can occur in sepsis and contribute to organ injury.
- Conditions
- Sepsis, Sepsis and Septic Shock, Sepsis at Intensive Care Unit, Intensive Care Nurses
- Trial name
- VEXIVAN (NCT07406750)
- Testing
- Education in performing hemodynamic diagnostic ultrasound of venous congestion, Hemodynamic diagnostic ultrasound of venous congestion
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Region Örebro County
Cardiovascular (CV) Risk
Democratizing Access to Cleaner Residential Air
The purpose of this research study is to determine whether the use of in-home air filtration to reduce exposure to air pollution benefits health.
- Trial name
- DACRA (NCT07629518)
- Testing
- Portable air purifiers with HEPA filtration
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Douglas Brugge
Erectile Disfunction, Coronary Artery Disease (CAD)
"Erectile Function After PCI in MI and Non-MI Patients"
The goal of this observational study is to assess changes in patients' erectile function after percutaneous coronary intervention (PCI) using a standard IIEF (International Index of Erectile Function) questionnaire at 1, 3, and 6…
- Conditions
- Erectile Disfunction, Coronary Artery Disease (CAD), Diabete Mellitus, Anxiety
- Trial name
- ERECT-PCI (NCT07444697)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Visceral Obesity, Non-Alcoholic Fatty Liver Disease
Effect of a Multi-ingredient on Visceral Adiposity and Non-alcoholic Fatty Liver Disease in Individuals With Abdominal Obesity
The aim of this study is to validate the efficacy of specific combination of different natural histidine-related amino acids in the reduction of visceral fat and liver steatosis, as well their associated comorbidities, in…
- Trial name
- FATHIS (NCT05807204)
- Testing
- Multi-ingredient of L-histidine, L-serine, L-carnosine and N-Acetylcysteine
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Safety Issues, Communication
Personal Protective Equipment Affect Team Performance During Medical Emergencies
Safety of healthcare professionals working in high-risk environments is of upmost importance. Personal protective equipment (PPE) may affect the performance of individuals and teams by altering their senses, manual skills and…
- Conditions
- Safety Issues, Communication, Cardiopulmonary Arrest
- Trial name
- PPE-TEAM (NCT04742426)
- Testing
- WHO recommended PPE, Super-safe setup
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Roman Sýkora
Stroke, Aphasia
Links Between Motor Abilities and Language Ability Deficits in Patients With Post-stroke Aphasia
Aphasia is a language disorder that affects oral and written expression and/or comprehension. It's one of the most disabling consequence of stroke.
- Trial name
- MOTOLANG-AVC (NCT05776368)
- Testing
- Syntactic comprehension battery (BCS), Montreal Cognitive Assessment (MOCA), Purdue Pegboard Test
- Where
- 3 sites in France
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon