Clinical trials: Cardiovascular System
Cardiac Disease
Comparison of NICOM and Innocor for Non-Invasive Determination of Cardiac Output
Cardiac output (CO) is an important parameter in the diagnosis and therapy of cardiac diseases. The aim of the study at hand was to evaluate NICOM (bioreactance) as a new method for determinion of CO and to compare it to Innocor…
- Trial name
- NCT02331342
- Testing
- NICOM cardiac output measurement, Innocor cardiac output measurement
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Anorexia Nervosa, Cardiac Anomaly
Evaluation of CARdiac Abnormalities by Echocardiography and MRI in Malnourished Patients Suffering From Anorexia Nervosa
Anorexia nervosa is an eating disorder occurring in adolescent females, characterized by voluntary dietary restriction, intense fear of gaining weight, and disturbed body image perception.
- Trial name
- CARERA (NCT03600610)
- Testing
- gadolinium-enhanced cardiac MRI
- Where
- France
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Liver Cirrhosis, Liver Failure
Effects on Plasma Exchange on Functional Capacity of Serum Albumin, Circulatory Dysfunction, Renal and Cerebral Function in Cirrhotic Patients With "Acute-on-chronic Liver Failure"
The purpose of this study is to evaluate the effects on plasma exchange with 5% albumin on albumin functional capacity, cardiocirculatory, renal and cerebral function in cirrhotic patients with "acute-on-chronic liver failure".
- Trial name
- NCT01201720
- Testing
- Plasma exchange with albumin
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Instituto Grifols, S.A.
Congestive Heart Failure
Improvement of Patients With Chronic Heart Failure Using NT-proBNP
This will be a multicentre Phase IV study in which patients with chronic HF who are managed and followed by HF/heart functions clinics will be followed over a period of two years.
- Trial name
- EXIMPROVECHF (NCT00601679)
- Testing
- NT-proBNP guided care
- Where
- 2 sites in Canada
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Vascular Diseases
EndovascuLar RegIstry Evaluating SafeTy, Efficacy and Patient Comfort (ELITE)
A single-center, prospective, cohort analysis of the Femoral Introducer Sheath and Hemostasis (FISH) vascular closure device will study 100 consecutive patients on which the device will be used to close the femoral artery after…
- Trial name
- ELITE (NCT03412942)
- Testing
- FISH SP
- Where
- 3 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Morris Innovative Incorporated
Heart Failure
A Study Designed to Assess the Mass Balance Recovery, Absorption, Metabolism, Excretion of [14C]AZD5462 and the Absolute Bioavailability of AZD5462
A study to investigate how the body breaks down and gets rid of the test medicine, AZD5462. To help investigate this, the test medicine is radiolabelled, which means that the test medicine has a radioactive component (carbon-14)…
- Trial name
- NCT06989983
- Testing
- AZD5462 film-coated tablet, [14C]AZD5462 Solution for Infusion, [14C]AZD5462 Oral Solution
- Where
- United Kingdom
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Hypertension
Telmisartan and Amlodipine Versus Monocomponent Tablets
This study will be an open-label, randomized, two-treatment, two-period, two-sequence crossover study to evaluate the bioequivalence of the amlodipine component of Boehringer Ingelheim Pharma GmbH \& Co.
- Trial name
- NCT01278797
- Testing
- Telmisartan/Amlodipine Combination Tablet, Amlodipine Monocomponent
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Cardiovascular Disease
The Impact of Age and Fitness on Reperfusion Injury and Ischemic Preconditioning to Prevent This Injury
Rationale: Ischaemic preconditioning (IP) refers to the reduction of ischemia-reperfusion injury induced by a brief preceding period of ischemia. Also the arterial endothelium can be protected by IP.
- Trial name
- NCT01606410
- Testing
- IPC
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Heart Failure
Ultra-sound Assisted Management of Heart Failure
The purpose of this study is to evaluate the impact of using hand carried ultrasound measurements of volume status in directing treatment of heart failure patients admitted with acute exacerbation.
- Trial name
- USA-HF (NCT04376424)
- Testing
- Hand Held Ultrasound
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Atheroscleroses, Coronary
Dotatate to Locate Coronary Plaques at High-risk of Myocardial Infarction
To assess whether vulnerable coronary plaques have more uptake of 68Ga-Dotatate than non-vulnerable plaques.
- Trial name
- DOLPHIN (NCT05536960)
- Testing
- 68Ga-Dotatate PET/CT
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Acute Coronary Syndrome
Association Between Uric Acid and Acute Coronary Syndrome
The aim of the study is to acess the association between admission serum uric acid level and in_hospital outcomes in patients with acute coronary syndromes
- Trial name
- NCT05770323
- Testing
- Uric acid level
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Sohag University
Heart Failure, Heart Failure With Preserved Ejection Fraction
Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction
The purpose of this study is to identify changes in heart tissue structure and biological function in patients with heart failure by performing an endomyocardial biopsy (EMB or heart biopsy) during a right heart catheterization…
- Trial name
- NCT06517186
- Where
- 6 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Coronary Artery Disease
Clinical and Angiographic Outcomes of Post-drug-coated Balloon Angioplasty in Native Coronary Lesions
The progression of cardiac revascularization techniques, starting with standard balloon angioplasty (POBA) and progressing to the creation of drug-coated balloons (DCB) and drug-eluting stents (DES).
- Trial name
- NCT06340373
- Testing
- DCB Angioplasty
- Where
- Bangladesh
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiovascular Diseases, Bangladesh
Cardiac Arrest, Sudden Death, Cardiac
Use of Public Access Defibrillators by Untrained Bystanders
Survival from out-of-hospital cardiac arrest is time critical and diminishes rapidly without appropriate intervention. Bystander CPR at least doubles the chances of survival and the additional use of a public access defibrillator…
- Trial name
- NCT03230773
- Testing
- Defibrillator model
- Volunteers
- healthy volunteers welcome
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Out of Hospital Cardiac Arrest
Drone Delivery of Automated External Defibrillators to Lay Users (DAEDALUS): A Proof of Concept Study
Summary in non-technical language Aim(s) of the research We are working on a way to use drones to deliver Automated External Defibrillators (AEDs) - devices that help restart a person's heart by giving it an electric shock.
- Trial name
- DAEDALUS (NCT07430813)
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Surrey
Oedema, Pulmonary
A First Time in Human Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of GSK2798745 in Healthy Subjects and Stable Heart Failure Patients
This study is the first administration of GSK2798745 in humans. This will be a sponsor un-blinded, placebo-controlled study to investigate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of GSK2798745…
- Trial name
- NCT02119260
- Testing
- GSK2798745 solution, GSK2798745 suspension, GSK2798745 capsule
- Where
- 2 sites in United Kingdom
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Vascular Diseases
Autophagy Maintains Vascular Function Through a Novel Glycolysis-linked Pathway Regulating eNOS
Aging is inevitable and is the primary risk factor for developing cardiovascular disease. The molecular mechanisms that drive vascular dysfunction in the context of aging are incompletely understood.
- Trial name
- NCT04200560
- Testing
- Rhythmic Handgrip Exercise, Chronic Exercise Training
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Utah
Diabetes, Weight Gain
The GlasVEGAS Study (Glasgow Visceral & Ectopic Fat With Weight Gain in South AsianS)
South Asians have a much higher risk of diabetes compared to Europeans and investigators don't know why this is. Investigators think that South Asians' capacity to store fat safely under the skin is lower than Europeans, so they…
- Conditions
- Diabetes, Weight Gain, Weight Loss, Cardiovascular Disease
- Trial name
- GlasVEGAS (NCT02399423)
- Testing
- Weight gain, Weight loss
- Where
- United Kingdom
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Heart Failure,Balance
COMPARİSON OF HEART FAİLURE PATİENTS AND HEALTHY PEOPLE İN BALANCE AND GAİT PARAMETERS
We aimed to show the difference between balance and gait parameters in heart failure and healthy individuals.
- Trial name
- NCT03853759
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Hypertension, Cognitive Decline
Implementation of Multifaceted Patient-Centered Treatment Strategies for Intensive Blood Pressure Control in Minimize Cognitive Decline
The study will test a multifaceted strategy for implementing an intensive blood pressure intervention protocol targeting systolic BP <120 mmHg on cognitive decline in racial minority and low-income hypertensive patients in…
- Trial name
- IMPACTS-MIND (NCT04797403)
- Testing
- Stepped-care protocol adapted from the SPRINT intensive-treatment algorithm
- Where
- United States
- Volunteers
- 1,306 people, healthy volunteers welcome
- Sponsor
- Tulane University
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