Clinical trials: Care
Transfusion, Age of Blood
Standard Issue Transfusion Versus Fresher Red Blood Cell Use in Intensive Care- A Randomised Controlled Trial
In Australia, blood for transfusion has a "use by" date of 42 days after collection. The actual age of blood given to patients depends on what is available at the time and the rate of usage.
- Trial name
- TRANSFUSE (NCT01638416)
- Testing
- Blood transfusion
- Where
- 60 sites in Australia, Finland and 3 more
- Volunteers
- 4,994 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Hemophilia B
Registry For Patients Treated With BeneFix In Usual Care Setting In Germany
The purpose of this observational study is to describe the incidence of adverse events among patients treated with BeneFix® in usual health care settings in Germany.
- Trial name
- NCT00714415
- Testing
- BeneFIX
- Where
- 21 sites in Austria, Germany
- Volunteers
- 80 people
- Sponsor
- Pfizer
Rotator Cuff Tendinopathy
Study of Efficacy and Safety of Secukinumab in Participants With Moderate-severe Rotator Cuff Tendinopathy
The purpose of the present study was to assess the efficacy of secukinumab 300 mg s.c. (subcutaneous) compared to placebo, each in combination with standard of care, in improving signs, symptoms and physical function in…
- Trial name
- NCT05758415
- Testing
- Secukinumab
- Where
- 24 sites in United States, China and 4 more
- Volunteers
- 60 people
- Sponsor
- Novartis Pharmaceuticals
Hepatitis C, Medication Adherence
Patient-Centered Models of HCV Care for People Who Inject Drugs
People who inject drugs (PWID) have higher rates of hepatitis C virus (HCV) than do other groups. Effective, safe new treatments called direct-acting antiviral agents (DAAs) have been developed recently.
- Trial name
- HERO (NCT02824640)
- Testing
- Patient Navigation, modified Directly Observed Therapy
- Where
- United States
- Volunteers
- 755 people
- Sponsor
- Prisma Health-Upstate
Caregivers of Patients on Hospice Care
Developing and Testing Culturally Based Educational Videos for Puerto Rican and African American Home Hospice Caregivers
The investigators hypothesize that culturally based educational videos for Puerto Rican and African American home hospice caregivers will better inform caregivers in managing symptoms, preparedness, self-efficacy, and competence.
- Trial name
- NCT06024278
- Testing
- Caregiver educational videos for African American caregivers, Caregiver educational videos for Puerto Rican caregivers
- Where
- 3 sites in United States, Puerto Rico
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Cancer, Advance Care Planning
Patient-centered and Efficacious Advance Care Planning in Cancer: the PEACe Comparative Effectiveness Trial
The overall goal of this study is to identify the most effective and efficient advance care planning (ACP) strategy for patients with advanced cancer. The specific aims are to: Aim 1.
- Trial name
- NCT03824158
- Testing
- Facilitated advance care planning (in-person or telephonic), Web-based advance care planning
- Where
- United States
- Volunteers
- 672 people
- Sponsor
- University of Pittsburgh
Subarachnoid Hemorrhage, Intracranial Hemorrhage
Enteral Nutrition and Glycemic Variability Neurological Intensive Care Unit Study
Primary Objective: To determine the effects of a diabetes specific enteral formula compared to a standard formula supplemented with protein (isocaloric and isonitrogenous) on the mean blood glucose and glycemic variability in a…
- Conditions
- Subarachnoid Hemorrhage, Intracranial Hemorrhage, Ischemic Strokes, Subdural Hematoma
- Trial name
- ANUS1014 (NCT01463878)
- Testing
- Glycerna, Jevity - Control Diet
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Eastern Virginia Medical School
Pressure Ulcer, Spinal Cord Injuries
Pressure Ulcer Healing With Microcyn
The purpose of this study is to test how well Microcyn™ works on Stage 3 and Stage 4 pressure ulcers compared to sterile saline among persons with spinal cord injury.
- Trial name
- NCT02001558
- Testing
- Microcyn, Sterile saline
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Alabama at Birmingham
General Surgery
Sugammadex vs Placebo to Prevent Residual Neuromuscular Block
The study is designed to determine whether patients who receive sugammadex immediately after tracheal extubation will exhibit a decrease in the incidence of postoperative residual paralysis and an associated decrease in the…
- Trial name
- NCT02728726
- Testing
- Sugammadex
- Where
- 2 sites in United States
- Volunteers
- 260 people
- Sponsor
- Mayo Clinic
HIV
A Technology-Delivered Peer-to-Peer Support ART Adherence Intervention for Substance-using HIV+ Adults
The "Thrive With Me" (TWM) trial is testing the efficacy of a mobile enhanced website aimed at improving Antiretroviral Therapy (ART) adherence for HIV-positive men who have sex with men (MSM).
- Trial name
- TWM (NCT02704208)
- Testing
- Thrive With Me Control, Thrive With Me Intervention
- Where
- United States
- Volunteers
- 410 people
- Sponsor
- University of Minnesota
Depression
Nurse-led Case Management for Diabetes and Cardiovascular Disease Patients With Depression
This study will evaluate the effectiveness of a nurse-led case management intervention in improving disease control and depression symptoms in adults with diabetes and/or heart disease who are also depressed.
- Trial name
- NCT00468676
- Testing
- Nurse-led case management, Treatment as usual
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- University of Washington
Dementia, Infection, Bacterial
Trial to Reduce Antimicrobial Use In Nursing Home Residents With Alzheimer's Disease and Other Dementias
This is a 52-month study (8 months preparation; 36 months to conduct the trial; 8 months data analyses and manuscript preparation) of a cluster randomized controlled trial (RCT) of an intervention to improve infection management…
- Trial name
- TRAIN-AD (NCT03244917)
- Testing
- TRAIN-AD
- Where
- United States
- Volunteers
- 430 people
- Sponsor
- Hebrew SeniorLife
Gram-negative Bacteremia
Rapid Identification and Phenotypic Susceptibility Testing for Gram-Negative Bacteremia
RAPIDS-GN is a multi-center, prospective, randomized, controlled trial to evaluate the following strategies for patients with confirmed gram-negative bacillus bacteremia (GNB): 1.
- Trial name
- RAPIDS-GN (NCT03218397)
- Testing
- Accelerate PhenoTest™ BC Kit, Standard Culture and AST
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- Duke University
Cirrhosis, Liver
Using Data-Driven Implementation Strategies to Improve the Quality of Cirrhosis Care
This Veteran Affairs (VA) Quality Improvement project aims to understand which data-driven implementation strategies promote evidence based practices that improve high-quality care for Veterans with cirrhosis.
- Trial name
- NCT04178096
- Testing
- Quality Improvement Intervention
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- VA Office of Research and Development
Sickle Cell Disease
Improving Self-Management in Adolescents With Sickle Cell Disease
The objective of this study is to determine the feasibility and acceptability of SCThrive, a an innovative, technology-enhanced, group self-management intervention that uses a mixed in-person and online format and supported by a…
- Trial name
- SCThrive (NCT02851615)
- Testing
- SCThrive Intervention for Adolescents with SCD
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Cancer Screening
Discussing Stopping Cancer Screening and Prognosis With Older Adults
Guidelines recommend not screening adults with <10-year life expectancy for cancer; however, primary care physicians feel uncomfortable talking to older adults about prognosis.
- Trial name
- NCT03480282
- Testing
- Prognosis information and Provider Scripts
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Beth Israel Deaconess Medical Center
Pain
Stepped Care to Optimize Pain Care Effectiveness
Pain is the most common physical symptom in primary care, accounting for an enormous burden in terms of patient suffering, quality of life, work and social disability, and health care and societal costs.
- Trial name
- SCOPE (NCT00926588)
- Testing
- Stepped care
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- US Department of Veterans Affairs
Trapeziometacarpal Arthritis
The Effect of Review of a Decision Aid Prior to the Appointment on Decisional Conflict Compared to Usual Care in the Treatment of Trapeziometacarpal (TMC) Arthritis
The investigators plan a prospective randomized controlled study that compares whether the use of a decision aid results in different scores on variables reflective of the decision-making process, behavior, health outcomes…
- Trial name
- NCT03181724
- Testing
- Decision Aid
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Epilepsy
Valproate Sustained Release Minitablets (Orfiril(R) Long) Once Daily in the Evening
Valproate is the first line therapy in primary generalized seizures. The applied drug contains sodium valproate in sustained release minitablets.
- Trial name
- NCT00870688
- Testing
- sodium valproate
- Volunteers
- 82 people
- Sponsor
- Desitin Arzneimittel GmbH
Medication Adherence
Cell Phone Support to Promote Medication Adherence Among Adolescents and Young Adults With Chronic Illness
Background: Adolescents and young adults (AYAs) with chronic illnesses often struggle to develop illness self-management skills.
- Trial name
- NCT04241627
- Testing
- Cell Phone Support
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Children's Hospital Los Angeles
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