Clinical trials: Caries, Dental
Pulpitis - Irreversible, Caries
Endodontic-Restorative Pre-Radiation Therapy of Head and Neck Cancer Patients
Pilot study involving 20 patients undergoing dental treatment prior to radiation therapy. Comparison of outcome parameters to existing data of age and gender matched patients.
- Conditions
- Pulpitis - Irreversible, Caries, Head and Neck Cancer
- Trial name
- EndoRest (NCT04996641)
- Testing
- Root canal treatment and crown
- Where
- United States
- Sponsor
- Abramson Cancer Center at Penn Medicine
Dental Caries
Postoperative Hypersensitivity Randomized Comparative Effectiveness Research Trial
Postoperative hypersensitivity (POH) is a problem for many patients as determined by the recent Practitioners Engaged in Applied Research and Learning (PEARL) study of POH following occlusal caries restoration.
- Trial name
- POH RCERT (NCT01268605)
- Testing
- Restoration with a dentin bonding agent (DBA), Restoration with a resin modified glass ionomer liner (RMGI)
- Where
- 41 sites in United States
- Volunteers
- 341 people
- Sponsor
- Pearl Network
Dental Caries
Evaluation of the Effect of Self-Assembling Peptide P11-4
Dental caries is a biofilm-mediated, sugar-driven, multifactorial, dynamic disease that results in the phasic demineralization and remineralization of dental hard tissues.
- Trial name
- NCT05667545
- Testing
- Peptide
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Egymedicalpedia
Dental Caries in Children
A Comparative Clinical and Radiographic Study Of Collagen Based Pulpotomy in Cariously Exposed Vital Primary Molars
To assess post operative pain and survival rate after collagen based pulpotomy versus MTA pulpotomy in children with vital primary molars.
- Trial name
- NCT05829304
- Testing
- MTA based pulpotomy, Collagen based pulpotomy
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- sherouk atef elsayed
Dental Caries in Children, Dental Diseases
Articaine Efficacy and Safety for 3 Years Old Children
The primary purpose of this study is to determine the local anesthetic efficacy and safety of 4% Articaine compared 2% Mepivicaine in 3 years old children, by using infiltration technique for primary teeth that required…
- Conditions
- Dental Caries in Children, Dental Diseases, Pulp Disease, Dental, Behavior, Child
- Trial name
- NCT05839548
- Testing
- Mepivacaine 2% with epinephrine 1:100,000, Articaine (4%) with epinephrine 1:100,000
- Where
- Saudi Arabia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Qassim Health Cluster
Migraine Disorders
TREXIMA and RELPAX Gastric Scintigraphy Inside and Outside a Migraine
An evaluation of tablet disintegration and absorption and gastric transit of sumatriptan and naproxen sodium from a TREXIMA tablet and eletriptan from a RELPAX 40mg tablet.
- Trial name
- NCT00385008
- Testing
- Combination Product (sumatriptan succinate / naproxen sodium), RELPAX(eletriptan) 40mg Tablet
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- GlaxoSmithKline
Dental Caries
Miswak Versus Standard Measures to Prevent the Incidence of Caries Young Egyptian Adults: A Randomized Controlled Clinical Trial
Objectives: Aim of the study The objective is to conduct an RCT to evaluate the effectiveness of miswak in comparison with standard caries preventive measures for the prevention of new carious lesions in high caries risk…
- Trial name
- NCT03732040
- Testing
- miswak stick, Miswak plus tooth brushing and tooth paste, Standard preventive measures (tooth brushing , interdental cleaning and mouth rinse use containing CHX and Fluoride)
- Where
- Egypt
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Dental Caries Prevention by a Natural Product
The objective is to conduct an RCT to evaluate the effectiveness of Licorice in comparison to standard caries preventive measures for the prevention of new carious lesions in high caries risk patients.
- Trial name
- NCT03763578
- Testing
- Licorice
- Where
- Egypt
- Volunteers
- 81 people
- Sponsor
- Cairo University
Prevention of Dental Caries
Effectiveness of Different Preventive Regimens in Cariogram Parameters and DMF Scores of High Caries Risk Patients: A Randomized Control Trial
66 Participants will be divided into three groups according to the tested regimen (A), where (A1) represents participants exposed to fluoride toothpaste, (A2) represents participants exposed to regimen including fluoride…
- Trial name
- NCT04032184
- Testing
- Fluoride toothpaste, fluoride toothpaste and chlorhexidine mouthwash, fluoride toothpaste, chlorhexidine mouthwash, MI varnish
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University
Caries, Periodontal Diseases
Third Molar: Caries, Periodontal Disease and Quality of Life
Caries and periodontal disease are chronic diseases of the oral cavity. The incidence of caries and periodontal disease can vary depending on the position of the third molar, The aim of this study was to verify possible…
- Trial name
- NCT04024644
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Dental Caries
A Clinical Study of KH001 for Pulp Preservation and Safety in Deep Dentin Caries
The Purpose of this Study is to Evaluate Pulp Preservation and Safety of KH001 in the Administration of Deep Dentin Caries.
- Trial name
- NCT07751016
- Testing
- KH001
- Where
- South Korea
- Volunteers
- 36 people
- Sponsor
- Seoul National University Dental Hospital
Dental Caries in Children
The Effectiveness of Dental Health Home Visits on Caries Prevention in Young Children
Tooth decay affects 75% of Malaysian preschool children, most of which remain untreated. Untreated decay can cause pain, and impair nutritional status and physical growth.
- Trial name
- NCT04885348
- Testing
- Intervention Group (Dental Home Visits + Dental Home Education Leaflets), Control Group (Dental Home Education Leaflets)
- Volunteers
- 329 people, healthy volunteers welcome
- Sponsor
- Ministry of Education, Malaysia
Dental Caries
DPBRN Longitudinal Study of Dental Restorations Placed on Previously Un-restored Surfaces
The purpose of this study is to assess the quality and expected lifespan of fillings recorded in the DPBRN "Reasons for placing the first restoration on permanent tooth surfaces" study, and the factors affecting how long the…
- Trial name
- NCT01201408
- Where
- 7 sites in United States, Denmark
- Volunteers
- 9,291 people, healthy volunteers welcome
- Sponsor
- Dental Practice-Based Research Network
Reversible Pulpitis, Dental Caries
Effect of Hemostatic Agents on TheraCal PT Pulpotomy Success in Primary Molars
Dental caries in primary teeth can sometimes lead to inflammation of the dental pulp, the soft tissue inside the tooth. When the pulp remains capable of healing, pulpotomy may be performed to preserve the tooth until its natural…
- Conditions
- Reversible Pulpitis, Dental Caries, Primary Molar Pulpotomy, Dental Pulp Exposure
- Trial name
- CEHA-TP RCT (NCT07876934)
- Testing
- 2.5% Sodium Hypochlorite applied to pulpal tissue/stumps for 3 minutes to achieve hemostasis prior to TheraCal PT placement during primary molar pulpotomy and 15% Ferric Sulfate (Astringedent™ 15.5%)
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Reem Mohamed Gaber
Toothbrushing, Dental Plaque
BEhavioral EConomics for Oral Health iNnovation Trial
This Phase II stratified randomized prevention trial will assess the efficacy of a behavioral economic theory-based financial incentive drawing program versus a control regimen to promote early childhood caries (ECC) preventive…
- Conditions
- Toothbrushing, Dental Plaque, Parent-Child Relations, Oral Hygiene
- Trial name
- BEECON (NCT03576326)
- Testing
- Drawing Incentive
- Where
- United States
- Volunteers
- 244 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Caries, Dental, Cariostatic Agents
Reducing Bacteria That Cause Tooth Decay
The purpose of the study is to determine the effect of a two-step mouth rinsing procedure on reducing the germs (mutans Streptococci) that cause tooth decay.
- Trial name
- NCT03062605
- Testing
- Iodine (Betadine), NaOCL
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Dental Caries
Grape Seeds Versus Standard Measures for Prevention of Caries Incidence
The objective is to conduct an randomized controlled clinical trial to evaluate the effectiveness of grape seeds extract mouth wash in comparison with standard caries preventive measures for the prevention of new carious lesions…
- Trial name
- NCT03724578
- Testing
- Grape Seed Extract mouth wash, standard preventive measures, antimicrobial and fluoride mouth wash
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries Class II
A 2-year Clinical Impact of Bulk-fill Low-viscosity Resin Composite Liners in Class II Restorations.
This randomized clinical trial evaluated the clinical performance of class II resin composite restorations using bulk-fill high-viscosity ormocer versus methacrylate-based with or without a thin layer of bulk-fill low-viscosity…
- Trial name
- NCT06032689
- Testing
- Xtra-fill, x-base, Admira fusion x-tra
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University
Molar Incisor Hypomineralization, Enamel Hypoplasia
Resin Infiltration Treatment for MIH
The investigators aimed to evaluate changes in mineralisation degree, colour, and size of the lesion after Icon® in permanent teeth with MIH in 6 months.
- Conditions
- Molar Incisor Hypomineralization, Enamel Hypoplasia, Enamel Caries, Anterior Teeth
- Trial name
- NCT04685889
- Testing
- Resin infiltration
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Dental Caries, Non-cavitated Occlusal Caries
Detection of Non-cavitated Occlusal Caries Lesions by Visual Inspection, LF, QLF and NILT
This study aims to evaluate and compare the diagnostic accuracy of visual examination using ICDAS-II and three adjunctive optical methods-laser fluorescence (LF), near-infrared light transillumination (NILT), and quantitative…
- Trial name
- NCT07532291
- Testing
- Diagnostic assessment of occlusal caries
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Neslihan Atmaca
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