Clinical trials: Caries; Initial
White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Clinical Evaluation of the Efficacy of SPR-G Barrier Coat Versus Fluoride Varnish Versus MI Paste in the Treatment of Early White Spot Lesions in Pediatric Patients
In-Vivo randomized clinical trial to compare between the clinical performance of fluoride varnish versus MI paste (CPP_ACP) and the PRG- Barrier coat material concerning enamel remineralization, arrest of active early lesions…
- Trial name
- NCT05202821
- Testing
- PRG Barrier Coat, Fluoride varnish, MI paste
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
White Spot Lesion of Tooth
Incidence of White Spot Lesions Around Ceramic Brackets Compared With Metal Brackets
The main objective of this study was to investigate the relation between ceramic brackets and the development of white spot lesions (WSLs) compared to that associated with conventional metal brackets.
- Trial name
- NCT05764187
- Testing
- Orthodontic fixed appliance therapy
- Where
- Jordan
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Dental Caries, Fissure Sealant
The Effect of an Adhesive System on the Retention and Caries Prevention for Fissure Sealants in Permanent Molars
Background: Resin-based fissure sealants (FS) are recommended to prevent pit-and-fissure caries development or prevent the progression of enamel caries lesion to frank cavitation into dentine.
- Trial name
- ResinFS (NCT06608563)
- Testing
- Fissure sealant without adhesive system (NO BOND), Fissure sealant with adhesive system (BOND)
- Where
- Ireland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Dental Diseases
Evaluation of the Initial Color Match of Different Single-shade Composites
The aim of this study was to evaluate the initial colour match of anterior non-carious cervical lesions restored with different single-shade resin composites, namely Omnichroma (Tokuyama) and Charisma Topaz One (Kulzer).
- Trial name
- NCT06473727
- Testing
- Omnichoroma, Charisma Topaz One
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
White Spot Lesion of Tooth
Reminerlization Potential of Innovative Biomimetic Material in Caries White Spot Lesions
to remineralize the white spot caries lesions after orthodontic treatment , the investigator will use two different materials ( Clinpro tooth creme versus Gc tooth mousse) and will compare between their effects in…
- Trial name
- NCT03823612
- Testing
- Clinpro Tooth Creme, GC tooth mousse
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries in Children, Vital Pulp Therapy
Comparative Evaluation of Melatonin Versus MTA on Vital Pulp Therapy in Young Permanent First Molars: An in Vivo Study
The process of dental caries is dynamic and can be either reversible or irreversible depending on the balance between protective and pathologic factors in the oral cavity.
- Trial name
- NCT06372561
- Testing
- Mineral trioxide aggregate (dressing material), Melatonin (dressing material)
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
White Spot Lesion of Tooth
Effect of Different Pastes on Remineralization of Early Caries Lesions in Primary Teeth
This study is a randomized controlled trial involving 118 children ages between 4 and 5 years to assess the remineralization effect of Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) on white spot lesions in primary…
- Trial name
- NCT03526276
- Testing
- CPP-ACP paste, Fluoride toothpaste, Both (Fluoride and CPP-ACP)
- Where
- Jordan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Jordan University of Science and Technology
Dental Caries, White Spot Lesion
A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome
The goal of this clinical trial is to compare the treatment effect of vitamin D supplementation and topical fluorides in the population having vitamin D deficiency and Initial Carious Lesions (ICL) on the progression of ICL in…
- Conditions
- Dental Caries, White Spot Lesion, Initial Caries, Incipient Enamel Caries
- Trial name
- Incipient (NCT06172764)
- Testing
- Vitamin D supplements along with behavioral modification, Topical fluoride application and Vitamin D supplements along with behavioral modification, Topical fluoride application along with behavioral modification
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
White Spot Lesion of Tooth, Tooth Color
Toothpastes With Different Contents and Tooth Color
This study aims to investigate the color tone and fluorescence changes that may occur during fixed orthodontic treatment with brackets in patients' teeth using toothpaste with different properties.
- Conditions
- White Spot Lesion of Tooth, Tooth Color, Dentistry, Orthodontic Appliances, Fixed
- Trial name
- NCT06833970
- Testing
- Colgate use, Curaprox use, ROCS use
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Taner OZTURK, DDS, MS
Initial Caries
Early Detection of Initial Caries Using Fluorescent Starch Nano-particles Compared With Salivary Biomarkers
Dental caries is one of the most prevalent chronic oral diseases worldwide and remains a major public health concern. The disease begins with microscopic demineralization of enamel, which is reversible if diagnosed at an early…
- Trial name
- NCT07732127
- Testing
- Fluorescent Starch Nano-particles
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Menoufia University
White Spot Lesion of Tooth
Combined Application of Diode Laser and Different Remineralizing Agents on White Spot Lesions
Dental caries is a very common condition, and although it has become less common, it still represents a serious public health risk.
- Trial name
- Whitespot (NCT05871619)
- Testing
- Remin Pro, X Pur Remin, Fluoride varnish
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Caries; Initial
Diagnostic Accuracy of DIAGNOdent Compared to ICDAS II
There is a paradigm shift in conservative dentistry by substituting the surgical model with the medical model of treatment. Early detection of initial carious lesions will aid in clinical decision making during management …
- Trial name
- NCT05127356
- Testing
- DIAGNOdent, ICDAS II
- Where
- Egypt
- Volunteers
- 193 people, healthy volunteers welcome
- Sponsor
- Cairo University
Caries,Dental, Pit and Fissure Caries
Retention of a Flowable Resin-based Sealant With Two Types of Adhesives
The aim of the present study is to compare the use of two adhesives for the placement of occlusal sealants, evaluating their retention on the occlusal surfaces.
- Conditions
- Caries,Dental, Pit and Fissure Caries, Sealant Dental
- Trial name
- NCT04945382
- Testing
- Scotchbond Universal 3M, Single Bond 3M
- Where
- Peru
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National University of San Marcos, Peru
Dental Caries Extending Into Dentin
Clinical Evaluation of Extensive Direct Composite Restorations With Polyethylene Fiber
The aim of this clinical trial was to compare the clinical performances of composite resin restorations with/without the polyethylene fiber to the first permanent molar teeth with extensively carious pediatric patients.
- Trial name
- NCT04612543
- Testing
- Genial Posterior Composite with Polyethylene Fiber, Genial Posterior Composite
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kafkas University
Dental Caries
DPBRN Reasons for Placing the First Restoration on Permanent Tooth Surfaces
The purpose of this study was to document the reasons for placing the first restoration ("filling") on a previously un-restored surface in a permanent ("adult") tooth.
- Trial name
- NCT00847470
- Where
- 7 sites in United States, Denmark
- Volunteers
- 5,810 people, healthy volunteers welcome
- Sponsor
- Dental Practice-Based Research Network
Dental Caries
Prevention of Dental Caries Lesions With Fluoride Varnish in Erupting First Permanent Molars
The aim of this study is to determine the effectiveness of fluoride varnishes in the prevention of dental caries lesions in erupting permanent first molars, in high-risk patients.
- Trial name
- NCT02592278
- Testing
- Fluoride Varnish, Control Group
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Universidad Iberoamericana
Initial Dental Caries
Dentifrice With Innovative Remineralizing Technology
Objective: The aim of this study is to evaluate in vivo dentifrices containing different active ingredients in fluoride (F) retention in saliva and dental biofilm.
- Trial name
- REFIX (NCT04730908)
- Testing
- DENTIFRICE
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
White Spot Lesion of Tooth
Remineralizing Effect of Different Silver-containing Agents on Initial Caries Lesions in Primary Teeth in Children
The aim of the present work is to study the effect of the application of Silver diamine fluoride (SDF) and a novel green synthesized Nano-silver fluoride (NSF) on early enamel lesions in primary teeth.
- Trial name
- NCT06489093
- Testing
- NSF, SDF+KI, Control group
- Where
- Bulgaria
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Plovdiv Medical University
Caries; Initial, Caries Active
Clinical Effectiveness of Bioactive Silica Based With Calcium Toothpaste
This study will be conducted to Clinically evaluate Bioactive Silica Based with calcium booster (Refix technology) toothpaste and Sodium Fluoride varnish versus conventional fluoride toothpastes in management of white spot…
- Trial name
- NCT07120243
- Testing
- Toothpaste Product, Varnishes, Fluoride
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rawda Hesham Abd ElAziz
White Spot Lesion
Fluoride Controlled-release System for Initial Lesions of Caries
OBJECTIVE: To evaluate in vivo the efficacy of fluoride-containing dentifrice incorporated in a controlled-release system (F-CSL, patent pending) in the remineralization of white spot lesions of caries in caries-active…
- Trial name
- NCT05139966
- Testing
- Mouthwash Product
- Where
- Brazil
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba