Clinical trials: Caries Prevention
White Spot Lesions, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Assessing the Effects of Resin Infiltration and Resin Modified Glass Ionomer on the Color Changes of White Spot Lesions in a Clinical and Laboratory Setting
The goal of this clinical trial is to assess the efficacy of "Icon® resin infiltration" and "VanishTM XT varnish" in restoring the appearance of white spot lesions WSLs in healthy children affected with anterior white spot…
- Conditions
- White Spot Lesions, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth, Enamel Hypomineralization
- Trial name
- RI (NCT06696105)
- Testing
- Resin infiltration, Vanish XT varnish (resin modified glass ionomer restoration)
- Where
- 2 sites in Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Dental Caries
Povidone Iodine for Caries Prevention
The goal of this clinical trial is to learn if Povidone Iodine works to prevent tooth decay and suppress the mouth germs responsible for tooth decay. The main questions it aims to answer are: 1.
- Trial name
- NCT07741409
- Testing
- Povidone Iodine 5% Soln,Top,Kit, Probiotics
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Jeffrey A. Banas
Pressure Ulcer, Nursing Caries
Care Package for Preventing Pressure Ulcers in ICU Patients
The aim of this study is to evaluate the effectiveness of the care package (CP) developed to prevent pressure injury (PI) in patients in intensive care and to evaluate the effect of the training given to nurses on their knowledge…
- Trial name
- NCT06509399
- Testing
- care package
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Secondary Caries
Effect of Bioactive Restorative Materials on Secondary Caries Prevention
This manuscript presents a 24-month randomised clinical trial evaluating the effectiveness of bioactive restorative materials in preventing secondary caries compared with conventional composite restorations.
- Trial name
- BARM (NCT07619378)
- Testing
- Fuji IX GP Glass Ionomer Cement, Beautifil II Giomer, Cention N
- Where
- Saudi Arabia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Jouf University
Dental Hygiene, Probiotics, Periodontitis
Probiotic Nanofiber Floss and Subgingival Pathogen Suppression
This randomized, double-blind, crossover clinical trial evaluated the effect of a probiotic-containing nanofiber dental floss on subgingival red complex periopathogens and gingival health in periodontally healthy individuals.
- Conditions
- Dental Hygiene, Probiotics, Periodontitis, Prevention of Dental Caries, Gingivitis and Periodontal Diseases
- Trial name
- NCT07149493
- Testing
- Probiotic nanofiber floss
- Where
- Czechia
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- St. Anne's University Hospital Brno, Czech Republic
Dental Caries in Children
Supportive Caries Preventive Programme in Children Undergoing Dental General Anaesthesia
Early childhood caries is a persistent problem often leading to dental treatment under general anaesthesia (GA). Thus, this study was to investigate the preventive effect of two additional intensive oral hygiene appointments…
- Trial name
- NCT05110534
- Testing
- additional oral hygiene appointments
- Where
- Germany
- Volunteers
- 406 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Dental Caries, Early Childhood Caries
Oral Health and Dental Caries Prevention Intervention for Children in Romania
During 2019-2020, the National Oral Health Survey evaluated a significant sample of children aged 5, 6 and 12 years, gathering baseline data on oral health.
- Conditions
- Dental Caries, Early Childhood Caries, Quality of Life
- Trial name
- Smilebright (NCT06441500)
- Testing
- Daily tooth brushing programme
- Where
- 5 sites in Romania
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Medicine and Pharmacy "Victor Babes" Timisoara
Caries Prevention
Effectiveness of Using (Vanish XT) in Prevention of Occlusal Caries: a RCT
Despite the continuous effort to prevent and treat dental caries, it continues to be one of the most common chronic diseases in both children and adults.
- Trial name
- NCT04579536
- Testing
- Light curable resin modified glass ionomer varnish, Vanish White Varnish
- Where
- Saudi Arabia
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz University
Pit and Fissure Caries, Glass Ionomer Cements
Glass Ionomer Sealant Versus Fluoride Varnish on Occlusal Caries Prevention
The current study compares the efficacy of glass ionomer fissure sealant versus topical application of 5% sodium fluoride varnish in prevention of occlusal caries among preschool children.
- Conditions
- Pit and Fissure Caries, Glass Ionomer Cements, Tooth, Deciduous, Child
- Trial name
- NCT04163354
- Testing
- 5% sodium fluoride varnish (NaF), Glass ionomer sealant (GIS)
- Where
- Hong Kong
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dental Caries in Children
Efficacy and Safety Evaluation of Anti-Caries Varnish
The purpose of the study is to determine the efficacy \& safety of Advantage Anti-Caries Varnish for primary prevention. The objectives are: 1) To determine if Advantage Anti-Caries Varnish (test varnish) is superior to an active…
- Trial name
- NCT04947527
- Testing
- Test varnish
- Where
- United States Minor Outlying Islands
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC
White Spot Lesion of Tooth
Caries Prevention Potential of Pearl Powder Versus CPP-ACP on Enamel White Spot Lesions
to evaluate the caries prevention potential of pearl powder against CPP-ACP in enamel white spot lesions.
- Trial name
- NCT03973554
- Testing
- pearl powder, CPP-ACP
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Ruba Alaa El Din Adel El Damarisy
Dental Caries
A Clinical Trial to Assess the Safety and the Anti-caries Efficacy of COL 101 (Arginine) Non-fluoride Dentifrices in Comparison With 0.24% Sodium Fluoride (1100 Ppm F) Dentifrice Control in 10 to 14-year-old Children
The objective of this study is to assess the safety and to evaluate the anti-caries efficacy of COL101 (arginine) non-fluoride dentifrices compared to a 0.24% sodium fluoride dentifrice in 10-14 year-old children over a one year…
- Trial name
- NCT04750902
- Testing
- 0.24% Sodium Fluoride Dentifrice, 1.5% Arginine Dentifrice, 4.0% Arginine Dentifrice
- Where
- 9 sites in United States, Puerto Rico
- Volunteers
- 2,025 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Sodium Fluoride
The Effect of Sodium Fluoride Application on the Prevention of Radiation Caries in NPC Patients
To evaluate the efficacy of sodium fluoride to preventing radiation caries for patients with nasopharyngeal carcinoma receiving radiotherapy.
- Trial name
- NCT06174012
- Testing
- Sodium Fluoride
- Volunteers
- 135 people
- Sponsor
- Sun Yat-sen University
Dental Caries
Grape Seeds Versus Standard Measures for Prevention of Caries Incidence
The objective is to conduct an randomized controlled clinical trial to evaluate the effectiveness of grape seeds extract mouth wash in comparison with standard caries preventive measures for the prevention of new carious lesions…
- Trial name
- NCT03724578
- Testing
- Grape Seed Extract mouth wash, standard preventive measures, antimicrobial and fluoride mouth wash
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Fluoride Varnish Randomized Clinical Trial
The purpose of this study is to compare the efficacy of fluoride varnish (FV) applied once or twice a year with counseling to counseling alone in preventing early childhood caries (ECC) (tooth decay in children under the age of…
- Trial name
- NCT00066963
- Testing
- Fluoride Varnish
- Where
- United States
- Volunteers
- 376 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Caries Reduction, Caries Prevention
Effect of the Consumption of Probiotics in the Reduction of Incidence of Carious Lesions in Preschool Children
Probiotics are microorganisms that when administered in adequate amounts can confer health benefits. In vitro and clinical studies support the idea that lactobacilli have protective effects on oral health.
- Trial name
- Probiotics (NCT01648075)
- Testing
- Experimental: Probiotic enriched milk
- Where
- Chile
- Volunteers
- 261 people
- Sponsor
- University of Chile
Dental Caries, Oral Disease
Fluoride Varnish Community Trial
This cluster-randomized controlled community trial aimed to assess the efficacy and costs of fluoride varnish application for caries prevention in a high-risk population in South Africa.
- Conditions
- Dental Caries, Oral Disease, Costs
- Trial name
- NCT03429829
- Testing
- Flairesse varnish
- Where
- 2 sites in South Africa
- Volunteers
- 513 people, healthy volunteers welcome
- Sponsor
- DMG Dental Material Gesellschaft mbH
Dental Caries
Longitudinal Evaluation of Minimally Invasive Protocols for Dental Caries in Brazilian Schoolchildren
This multicenter longitudinal interventional study aims to evaluate minimally invasive protocols for the prevention and control of dental caries in Brazilian schoolchildren under routine public health conditions.
- Trial name
- NCT06999005
- Testing
- Fluoride Varnish Application (Preventive Protocol), Fluoride Varnish for Active Enamel Lesions, Atraumatic Restorative Treatment (ART) Sealant
- Where
- Brazil
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- University of Nove de Julho
Dental Caries
Early Childhood Caries Prevention at a Pediatric Clinic
This purpose of this study was to evaluate effectiveness of a risk-based dental caries prevention program conducted by dental personnel at an urban pediatric primary care clinic serving largely low-income residents of Baltimore…
- Trial name
- NCT00497029
- Testing
- fluoride varnish, patient education
- Where
- United States
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Early Childhood Caries (ECC)
Goal Attainment-Based Parent Education for ECC Prevention
Preventing early childhood caries (ECC) requires improving parental knowledge and behavior, as parents play a critical role in establishing oral and dental health practices during early childhood.
- Trial name
- GAT-ECC (NCT07460271)
- Testing
- Structured Parent Education
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University