Clinical trials: Carious Lesion
HIV Infections
A Study to Evaluate of the Efficacy of Enfuvirtide During the Induction Phase of Therapy
We hypothesize that using a potent antiretroviral such as Enfuvirtide during the induction phase of HAART therapy will lead to faster clearance of virus and infected cells, and lower number of minority variant HIV-1 strains.
- Trial name
- NCT00344760
- Testing
- Enfuvirtide, Efavirenz, lamivudine, and tenofovir
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Maryland, Baltimore
Evaluations, Diagnostic Self, Antimicrobial
ZnO Nanoparticles Coated Orthodontic Molar Tube
Orthodontic treatment is an elective procedure to improve the patient's dentofacial appearance. The complex design of fixed appliances provides a platform that leads to increased plaque accumulation around orthodontic brackets.
- Conditions
- Evaluations, Diagnostic Self, Antimicrobial, Orthodontic Appliance Complication, Bacterial Overgrowth
- Trial name
- ZnONPs (NCT06089720)
- Testing
- Zinc oxide nanoparticle coated orthodontic molar tubes (experimental), orthodontic molar tubes (control)
- Where
- Iraq
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Dental Caries in Children
Experimental Research on Deep Carious Lesion Treatment of Molars
Maintaining dental pulp vitality is crucial for tooth preservation and functionality. Untreated dental caries may lead to pulp necrosis and infection, affecting children's growth and well-being.
- Trial name
- VITAPULP (NCT03626740)
- Testing
- TheraCal, MTA
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Carol Davila University of Medicine and Pharmacy
Dental Caries in Primary Teeth, Full-Coverage Restorations in Pediatric Dentistry
CLINICAL PERFORMANCE OF PEDIATRIC CROWNS IN PRIMARY MOLAR
The aim of this study is to compare the clinical success of three different types of prefabricated crowns commonly used in primary molar teeth: nanohybrid composite crowns, zirconia crowns, and stainless steel crowns.
- Trial name
- NCT07426445
- Testing
- Prefabricated Zirconia Crown, Prefabricated Nanohybrid Composite Crown
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Izmir Katip Celebi University
Dental Caries, Oral Microbial Colonization
Maternal Consumption of Xylitol to Reduce Early Childhood Decay (MaXED Study)
The purpose of this study is to determine if the Childsmile programme (www.child-smile.org) with the additional maternal use of xylitol is more effective at reducing dental decay in children than a Childsmile program alone.
- Trial name
- MaXED (NCT01038479)
- Testing
- Xylitol consumption, Childsmile preventative programme
- Where
- United Kingdom
- Volunteers
- 1,064 people, healthy volunteers welcome
- Sponsor
- NHS Fife
Carious Cervical Lesions
Self-Cure vs. Highly Filled Flowable Composite in Carious Cervical Lesions: 18-Month RCT
The aim of the study is to compare and evaluate the clinical performance of a self cure composite system versus a highly filled flowable composite in the restoration of carious cervical lesions over an 18 months follow up period.
- Trial name
- NCT07576673
- Testing
- Class V Restoration - Polofil, Class V Restoration - Stela
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Dental Caries
Effect of Curodont™ Repair in Patients With Early Approximal Carious Lesions
The purpose of this study is to evaluate the therapeutic benefit of Curodont Repair for the treatment of early approximal carious lesions compared to fluoride.
- Trial name
- NCT02101255
- Testing
- Curodont Repair, Fluoride
- Where
- Switzerland
- Volunteers
- 25 people
- Sponsor
- Credentis AG
Dental Caries
Evaluation of Prefabricated CAD/CAM PEEK Crowns Used in Primary Molars
Fifty healthy cooperative children will be randomly allocated to two groups. Group I (test group) will receive CAD/CAM PEEK crowns, while group II (control group) will receive SSC.
- Trial name
- NCT06583759
- Testing
- Full coverage Crowns
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Alexandria University
Dental Caries, Dental Restoration Failure
Clinical Performance of Posterior Composite Tooth Fillings in Adults
The purpose of this study is to determine whether a new tooth-colored composite material is effective for load-bearing dental fillings.
- Trial name
- NCT03175627
- Testing
- Filtek One, Filtek Z250
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Dental Caries in Children
Efficacy of Silver Diamine Fluoride and Its Parental Perception
This randomized clinical trial aims to compare the effectiveness of two topical fluoride application protocols, namely 38% silver diamine fluoride and sodium fluoride with added casein phosphopeptide-amorphous calcium phosphate…
- Trial name
- NCT04213573
- Testing
- silver diamine fluoride, MI Varnish
- Where
- Iraq
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Caries,Dental
Fluoridated Milk and Enamel Caries in Adolescents
The goal of this trial is to investigate whether low daily doses of fluoridated milk, in addition to oral hygiene routines with fluoridated toothpaste, can prevent caries development in adolescents' teeth.
- Trial name
- NCT06684405
- Testing
- sodium sodium fluoride solution (0.75 mg for subjects aged 12 and 1.0 mg for subjects aged 13), Subjects in the control group received a daily dose of 0.5 ml sterile water to be added to 200 ml of milk.
- Where
- Sweden
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Malmö University
Dental Caries in Children
Evaluation of New Different Herbal Mouthwashes Against Caries Forming Bacteria, RCT
The goal of this randomized controlled trial is to compare three different types of mouthwash, Moringa, Star anis, and Indian Costus 90 children participated in this study divided into 3 groups according to the type of mouthwash…
- Trial name
- NCT05623605
- Testing
- Moringa mouthwash, star anise mouthwash, Indian costus mouth wash
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Nahda University
Early Childhood Caries, Dental Caries in Children
Treatment of Early Childhood Caries Using Silver Diammine Fluoride and Sodium Fluoride Tricalciumphosphate and the Effects on Oral Health Related Quality of Life
There is still a need for the assessment of different minimal intervention strategies and treatments focusing on the prevention and arrest of carious lesions of primary molars The evidence-based clinical practice guideline on…
- Conditions
- Early Childhood Caries, Dental Caries in Children, Dental Caries Extending Into Dentin, Dental Caries
- Trial name
- NCT05772039
- Testing
- Topical application of 38% Silver Diammine Fluoride Solution, Topical application of 5% Sodium Fluoride with functional Tricalcium phosphate Varnish
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Universiti Sains Malaysia
Dental Caries
Reproducibility of Interactive Cariogram Software Versus Manual Caries Risk Assessment Form
Reproducibility of Interactive Cariogram Software versus Manual Caries Risk Assessment Form on Clinician Decision: observational study
- Trial name
- NCT03342066
- Testing
- reproducability of caries risk assessment
- Where
- Egypt
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries, Knowledge
Implementation of Oral Health Educational Program on Orphan Children
Oral diseases are most prevalent among children. Orphans children are one of the most vulnerable groups to diseases especially oral diseases.
- Conditions
- Dental Caries, Knowledge, Practice
- Trial name
- NCT06428474
- Testing
- Health education
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Pharos University in Alexandria
Root Caries
Effectiveness on SDF Solution and PVP-I Combined NaF Varnish in Preventing Root Caries in Elders
The main objective of this study is to compare the effectiveness and cost-effectiveness of 4-monthly application of 10% povidone iodine solution followed by 5% sodium fluoride varnish with those of annual application of 38%…
- Trial name
- NCT03654820
- Testing
- PVP-I solution combined with NaF varnish, SDF solution
- Where
- China
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Carious Teeth
The Effect of Cryotherapy on Treatment Outcomes for Pulpotomy
The goal of this clinical trial is to investigate the effect of cryotherapy on treatment outcome for pulpotomny in permanent mature carious posterior teeth.
- Trial name
- NCT07303010
- Testing
- Addition of Cryotherapy on pulpotomy
- Where
- Thailand
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Sirawut Hiran-us
Dental Caries
Effectiveness of Fluoride Varnish in Prevention of Dental Caries in School Children
Despite the availability of free health dental service in Sri Lanka, the prevalence and severity of dental caries among 6year old school children stand at a very high level according to the results of national oral health survey…
- Trial name
- NCT02877888
- Testing
- fluoride varnish 22600ppm
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of Peradeniya
Caries, Tooth Decay
Improving Oral Health With Serious Games
This study investigated if computer games can be effective at changing the way children take care of their teeth. We a museum exhibit with 3D virtual reality games called "Attack of the S.
- Conditions
- Caries, Tooth Decay, Cavities, Gingivitis
- Trial name
- AOTSM (NCT02027597)
- Testing
- Attack of the S. Mutans, Follow-up, SnowWorld
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of Washington
Dental Fluorosis, Dental Caries
Effect of pH and Fluoride Concentration of Dentifrices on Caries Control
This study aims to assess the overall effect of pH and fluoride concentration of liquid dentifrices in the control of children dental caries of a fluoridated area, through visual inspection and the quantitative light-induced…
- Trial name
- EPHFCDCC (NCT01049503)
- Testing
- Low fluoride and conventional dentifrices with different pH
- Where
- Brazil
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
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