Clinical trials: Carnosine
Gastroesophageal Reflux (GER), Infants
Polaprezinc (Zinc L-carnosine) in Infants With Gastroesophageal Reflux
The goal of this clinical trial is to evaluate efficacy and safety of Zinc-L carnosine/Polaprezinc in infants with GER. Researchers will compare Zinc-L carnosine/Polaprezinc to a placebo (a look-alike substance that contains no…
- Trial name
- GER (NCT06678997)
- Testing
- Zinc-L carnosine/Polaprezinc, Thickened formula
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Roma La Sapienza
Metabolic Diseases, Type 2 Diabetes, Cardiovascular Disease
Effect of Carnosine on Diabetes and Cardiovascular Risk Factors
Carnosine is a naturally occurring compound with a potential health benefits. In animal studies, carnosine supplementation reduces manifestation of chronic civilization diseases, regulates subclinical inflammation, protein…
- Trial name
- Carnorisk (NCT02011100)
- Testing
- Carnosine
- Where
- 2 sites in Slovakia
- Volunteers
- 28 people
- Sponsor
- Jozef Ukropec
Inflammation, Sarcopenia
From the Gut to the Strut: Reducing Inflammation for Healthy Muscles
This research aims to evaluate the effectiveness of a dietary supplement on reducing inflammation and improving muscle health. The product is a food supplement notified to the Ministry of Health consisting of…
- Conditions
- Inflammation, Sarcopenia, Gut Permeability
- Trial name
- NCT05730985
- Testing
- Miotrof® formula
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Azienda di Servizi alla Persona di Pavia
Dietary Modification
Creatine, Carnitine and Carnosine in Vegetarians
Balanced vegetarian diets are popular and contain health-promoting characteristics. A balanced lacto-ovo-vegetarian diet differs in nutrient intake from an omnivorous diet, e.g.
- Trial name
- NCT03194334
- Testing
- Vegetarian diet, creatine, Beta-alanine
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Ghent
Schizophrenia
Carnosine and Cognitive Training in Schizophrenia
This is a double-blind placebo-controlled trial to evaluate the effects of the combination of a cognition enhancing drug, i.e carnosine, with cognitive training in patients with schizophrenia.
- Trial name
- CACTIS (NCT02686697)
- Testing
- L-Carnosine, Cognitive Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Abraham Reichenberg
Diabetic Neuropathies
Role of Carnosine in Combination With Vitamin B Complex in Preventing the Progression of Diabetic Neuropathy in Type 2 Diabetes Patients
Evaluation of the influence of oral administration of carnosine in combination with vitamin B Complex in preventing the progression of diabetic neuropathy in type 2 diabetes patients.
- Trial name
- NCT05422352
- Testing
- Carnosine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Peripheral Neuropathy, Cancer
L-carnosine Prophylactic Effect on Oxaliplatin Induced Peripheral Neuropathy in GIT Cancer Patients
This study evaluates the prophylactic effect of exogenous L-CARNOSINE in Oxaliplatin induced peripheral neuropathy, Thus half of the patients will receive L-CARNOSINE with Oxaliplatin and the other half will not receive…
- Trial name
- NCT02808624
- Testing
- L-CARNOSINE
- Where
- Egypt
- Volunteers
- 65 people
- Sponsor
- Cairo University
Spinal Cord Injuries
Beta-alanine Supplementation and Its Effects on Performance, Muscle Carnosine Content and Safety in Athletes With Spinal-cord Injury
Paralympians competing in wheelchair sports may experience a very high glycolytic demand (and therefore acidotic environment) in their upper-body muscles, particularly in high-intensity disciplines.
- Trial name
- NCT02604927
- Testing
- Beta-alanine, Dextrose
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Nutrition
Impact of Food Process and Mastication on Nutrient Bioavailability
This project aims at assessing the impact of heat treatment on the bioavailability of meat carnosine and amino acids, the interaction between masticatory efficiency and heat treatment of meat on the bioavailability of carnosine…
- Trial name
- DREAM (NCT02709837)
- Testing
- Nutritional
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Oxidative Stress
Pharmacokinetics of Carnosine
The absorption kinetics of dietary carnosine (β-alanyl-L-histidine) will be determined in the healthy adults.
- Trial name
- NCT00721708
- Testing
- pure carnosine, Beef, Chicken
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Tufts University
Gulf War Illness, Persian Gulf War Syndrome
Study of Gulf War Illness (GWI) by Comparing GWI and Healthy Veterans
Determine if: genetic differences of CNDP1 gene the previously defined GWI/Chronic Fatigue Syndrome (GWI/CFS) cerebrospinal fluid proteome contents psychometric other variables can differentiate between veterans of the 1990-1991…
- Trial name
- NCT00810225
- Where
- United States
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Gastroesophageal Reflux Disease
Efficacy of Zinc L-carnosine in Maintaining Remission of Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD), according to the Montreal classification, is defined as a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications.
- Trial name
- GERDILOR (NCT03467438)
- Testing
- Zinc-l-carnosine
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Muscle Weakness, Muscle; Fatigue, Heart
The Impact of Beef on Muscle Fatigue in Older Adults
The goal of this controlled-feeding cross-over diet intervention is to compare a beef diet to a vegetarian diet on muscle fatigue in older adults.
- Conditions
- Muscle Weakness, Muscle; Fatigue, Heart, Older Adults
- Trial name
- NCT05860088
- Testing
- Beef Diet, Vegetarian Diet
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Indiana University
Muscle Function
β-alanine Supplementation on Knee Extensor Contractile and Force Properties
Carnosine (made by bonding β-alanine and histidine) has been suggested to contribute to the extension of physical exercise, counteracting the decline in muscle performance due to fatigue.
- Trial name
- NCT02819505
- Testing
- beta-alanine
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Subjective Cognitive Impairment, Mild Cognitive Impairment
Molecular Mediators of Physical Exercise and Carnosine Induced Effects in Patients With Preclinical and Early Stage Neurodegenerative Disease
The purpose of this study is to investigate the beneficial effects of regular exercise and the impact of food supplement carnosine on cognitive, motoric and metabolic functions as well as on specific biologically active…
- Conditions
- Subjective Cognitive Impairment, Mild Cognitive Impairment, Parkinson Disease, Healthy Volunteers
- Trial name
- NCT03330470
- Testing
- exercise, carnosine supplementation, stretching
- Where
- 3 sites in Slovakia, Taiwan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences
Visceral Obesity, Non-alcoholic Fatty Liver
Effect of Multi-ingredient on Visceral Adiposity & Non-alcoholic Fatty Liver Disease in Postmenopausal Women With Abdominal Obesity
This study aims to evaluate the effect of daily intake of a specific combination of different natural histidine-related amino acids in combination with dietary recommendations, in the reduction of visceral fat, as well as their…
- Conditions
- Visceral Obesity, Non-alcoholic Fatty Liver, Postmenopausal
- Trial name
- FATHIS+ (NCT06377631)
- Testing
- Multi-ingredient of L-histidine, L-serine, L-carnosine and N-Acetylcysteine
- Where
- 2 sites in Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Exercise Training, Carnosine
The Influence of Exercise on Tissue Beta-alanine Uptake and Carnosine Synthesis Rates
B-alanine supplementation is highly efficient in increasing intramuscular carnosine content, leading to improved physical performance, especially in high-intensity exercises (HIIE).
- Conditions
- Exercise Training, Carnosine, Dietary Supplements
- Trial name
- NCT04936737
- Testing
- Beta-alanine supplementation, High intensity interval exercise
- Where
- Brazil
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Healthy
Effect of β-alanine Supplementation on Muscle Carnosine
Carnosine is a natural acid buffering substance of muscle. The primary objective of this study is to test whether a nutritional supplement of beta-alanine enhances carnosine content in muscle.
- Trial name
- LitmusMagnet (NCT00813553)
- Testing
- beta-alanine
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Peripheral Arterial Disease
Carnosine for Peripheral Arterial Disease Patients
Oral supplementation of L-carnosine will increase muscle carnosine, stabilize HIF1-alpha promote angiogenesis, and thus improve the functioning of lower extremities in PAD patients.
- Trial name
- CAR-PAD (NCT05371145)
- Testing
- Carnosine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Shahid Baba
Multiple Sclerosis
Oral Carnosine for Neuromuscular Performance in Multiple Sclerosis
Low levels of tissue carnosine and mitochondrial dysfunction appears to accompany multiple sclerosis (MS), with oral carnosine might be applicable to tackle impaired bioenergetics and oxidative stress in MS, and perhaps win back…
- Trial name
- CARMUS (NCT03995810)
- Testing
- Carnosine, capsulle, 2 g/day, 8 weeks
- Where
- Serbia
- Volunteers
- 3 people
- Sponsor
- University of Novi Sad, Faculty of Sport and Physical Education