Clinical trials: Carnosine
Healthy
Effect of Zinc Carnosine on Intestinal Permeability in Healthy Volunteers
Zinc carnosine is a food supplement which is available in the health food shops. The investigators wish to see if it can reduce intestinal swelling in people who take non-steroidal anti-inflammatory (anti-swelling) drugs (NSAIDs…
- Trial name
- NCT00149149
- Testing
- Zinc Carnosine coadministered with Indomethacin
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Gastroesophageal Reflux (GER), Infants
Polaprezinc (Zinc L-carnosine) in Infants With Gastroesophageal Reflux
The goal of this clinical trial is to evaluate efficacy and safety of Zinc-L carnosine/Polaprezinc in infants with GER. Researchers will compare Zinc-L carnosine/Polaprezinc to a placebo (a look-alike substance that contains no…
- Trial name
- GER (NCT06678997)
- Testing
- Zinc-L carnosine/Polaprezinc, Thickened formula
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Roma La Sapienza
Multiple Sclerosis, Exercise Therapy
Carnosine Loading and Periodized Training in MS and HC
Increasing evidence favours exercise therapy as an efficient tool to counteract inactivity related secondary symptoms in MS. Furthermore, exercise therapy may affect MS-associated muscle contractile and energy supply…
- Conditions
- Multiple Sclerosis, Exercise Therapy, Dietary Supplement
- Trial name
- NCT03418376
- Testing
- Beta-alanine supplementation, Exercise intervention
- Where
- Belgium
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Hasselt University
Multiple Sclerosis
Oral Carnosine for Neuromuscular Performance in Multiple Sclerosis
Low levels of tissue carnosine and mitochondrial dysfunction appears to accompany multiple sclerosis (MS), with oral carnosine might be applicable to tackle impaired bioenergetics and oxidative stress in MS, and perhaps win back…
- Trial name
- CARMUS (NCT03995810)
- Testing
- Carnosine, capsulle, 2 g/day, 8 weeks
- Where
- Serbia
- Volunteers
- 3 people
- Sponsor
- University of Novi Sad, Faculty of Sport and Physical Education
Metabolic Diseases, Type 2 Diabetes, Cardiovascular Disease
Effect of Carnosine on Diabetes and Cardiovascular Risk Factors
Carnosine is a naturally occurring compound with a potential health benefits. In animal studies, carnosine supplementation reduces manifestation of chronic civilization diseases, regulates subclinical inflammation, protein…
- Trial name
- Carnorisk (NCT02011100)
- Testing
- Carnosine
- Where
- 2 sites in Slovakia
- Volunteers
- 28 people
- Sponsor
- Jozef Ukropec
Breast Cancer Female, Dysphagia
Zinc-L-Carnosine Prevents Dysphagia in Breast Cancer Patients Undergoing Adjuvant Radiotherapy
Irradiation of level III and IV draining nodes in breast cancer patients is often associated with dysphagia, requiring treatment with FANS and/or steroids.
- Conditions
- Breast Cancer Female, Dysphagia, Adjuvant Radiotherapy
- Trial name
- NCT03997188
- Testing
- Hepilor
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Cynthia Aristei
Poor Glycemic Control, Cardiovascular Risk Factors
The Potential of Carnosine Supplementation in Optimising Cardiometabolic Health
The investigators hypothesise that carnosine supplementation will improve: 1. glycaemic control 2. cardiovascular risk factors 3.
- Conditions
- Poor Glycemic Control, Cardiovascular Risk Factors, Cognitive Function 1, Social
- Trial name
- NCT02917928
- Testing
- carnosine
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Monash University
Spinal Cord Injuries
Beta-alanine Supplementation and Its Effects on Performance, Muscle Carnosine Content and Safety in Athletes With Spinal-cord Injury
Paralympians competing in wheelchair sports may experience a very high glycolytic demand (and therefore acidotic environment) in their upper-body muscles, particularly in high-intensity disciplines.
- Trial name
- NCT02604927
- Testing
- Beta-alanine, Dextrose
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Schizophrenia
Carnosine and Cognitive Training in Schizophrenia
This is a double-blind placebo-controlled trial to evaluate the effects of the combination of a cognition enhancing drug, i.e carnosine, with cognitive training in patients with schizophrenia.
- Trial name
- CACTIS (NCT02686697)
- Testing
- L-Carnosine, Cognitive Training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Abraham Reichenberg
Gastroesophageal Reflux Disease
Efficacy of Zinc L-carnosine in Maintaining Remission of Gastroesophageal Reflux Disease
Gastroesophageal reflux disease (GERD), according to the Montreal classification, is defined as a condition that develops when the reflux of stomach contents causes troublesome symptoms and/or complications.
- Trial name
- GERDILOR (NCT03467438)
- Testing
- Zinc-l-carnosine
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Exercise, Fatigue
Effect of Beta-Alanine on Heart Rate Response
Beta-alanine, as a method to increase muscle carnosine, has been shown to enhance muscle buffering capacity and delay fatigue. Various fatigue tests have been utilized to examine the effectiveness of beta-alanine supplementation.
- Trial name
- NCT01745016
- Testing
- Beta-alanine
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Persian Gulf Syndrome
Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI)
The purpose of this study is to perform a randomized double-blind, placebo-controlled, 12 week study of the effects of carnosine on cognitive, psychometric, autonomic, and muscle strength outcomes in 100 GWI subjects.
- Trial name
- NCT00810368
- Testing
- Carnosine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Georgetown University
Muscle Function
β-alanine Supplementation on Knee Extensor Contractile and Force Properties
Carnosine (made by bonding β-alanine and histidine) has been suggested to contribute to the extension of physical exercise, counteracting the decline in muscle performance due to fatigue.
- Trial name
- NCT02819505
- Testing
- beta-alanine
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Nottingham Trent University
Diabetic Neuropathies
Role of Carnosine in Combination With Vitamin B Complex in Preventing the Progression of Diabetic Neuropathy in Type 2 Diabetes Patients
Evaluation of the influence of oral administration of carnosine in combination with vitamin B Complex in preventing the progression of diabetic neuropathy in type 2 diabetes patients.
- Trial name
- NCT05422352
- Testing
- Carnosine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Beni-Suef University
Nutrition
Impact of Food Process and Mastication on Nutrient Bioavailability
This project aims at assessing the impact of heat treatment on the bioavailability of meat carnosine and amino acids, the interaction between masticatory efficiency and heat treatment of meat on the bioavailability of carnosine…
- Trial name
- DREAM (NCT02709837)
- Testing
- Nutritional
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Schizophrenia, Schizoaffective Disorder
L-carnosine for Schizophrenia
The investigators' hypothesis is that oral L-carnosine treatment (as compared with placebo) will enhance cognitive abilities (specifically: measures of attention, executive function, working memory, visuospatial ability and…
- Trial name
- NCT00177177
- Testing
- L-carnosine (dietary supplement)
- Where
- 4 sites in United States
- Volunteers
- 84 people
- Sponsor
- University of Pittsburgh
Peripheral Neuropathy, Cancer
L-carnosine Prophylactic Effect on Oxaliplatin Induced Peripheral Neuropathy in GIT Cancer Patients
This study evaluates the prophylactic effect of exogenous L-CARNOSINE in Oxaliplatin induced peripheral neuropathy, Thus half of the patients will receive L-CARNOSINE with Oxaliplatin and the other half will not receive…
- Trial name
- NCT02808624
- Testing
- L-CARNOSINE
- Where
- Egypt
- Volunteers
- 65 people
- Sponsor
- Cairo University
Peripheral Arterial Disease
Effects of Carnosine In Patients With Peripheral Arterial Disease Patients
The purpose of this study is to determine whether carnosine (a food ingredient found in chicken and red meat) supplementation (2 g) for 6 months in participants with non-claudication and claudication peripheral arterial disease…
- Trial name
- CIPHER (NCT06480760)
- Testing
- Carnosine
- Where
- 3 sites in United States
- Volunteers
- 144 people
- Sponsor
- Shahid Baba
Oxidative Stress
Pharmacokinetics of Carnosine
The absorption kinetics of dietary carnosine (β-alanyl-L-histidine) will be determined in the healthy adults.
- Trial name
- NCT00721708
- Testing
- pure carnosine, Beef, Chicken
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Tufts University
Subjective Cognitive Impairment, Mild Cognitive Impairment
Molecular Mediators of Physical Exercise and Carnosine Induced Effects in Patients With Preclinical and Early Stage Neurodegenerative Disease
The purpose of this study is to investigate the beneficial effects of regular exercise and the impact of food supplement carnosine on cognitive, motoric and metabolic functions as well as on specific biologically active…
- Conditions
- Subjective Cognitive Impairment, Mild Cognitive Impairment, Parkinson Disease, Healthy Volunteers
- Trial name
- NCT03330470
- Testing
- exercise, carnosine supplementation, stretching
- Where
- 3 sites in Slovakia, Taiwan
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Slovak Academy of Sciences