Clinical trials: Carotenoid
Terpene Synthases, Carotenoid Modifying Enzymes
Identifying Terpenoid- and Carotenoid-modifying Enzymes in the Human Gut
In this study, the investigators will collect fecal samples from healthy adults. The investigators will extract DNA from these fecal samples and use microbiological techniques to determine whether this DNA encodes enzymes that…
- Trial name
- NCState (NCT07589166)
- Testing
- No Intervention: Observational Cohort
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- North Carolina State University
Healthy
Novel Metabolites of Beta-Carotene and Lycopene
The study (n = 36) will be a parallel design and will be 6 weeks in duration. Participants will start with a 2-week free-living wash-in period where they will be asked to avoid certain carotenoid-rich foods, followed by 4 weeks…
- Trial name
- NCT02550483
- Testing
- Base diet + high beta-carotene tomato juice, Base diet + high lycopene tomato juice
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- USDA Beltsville Human Nutrition Research Center
Wrinkle, Skin Red
Influence of Mango Intake of Skin Health in Postmenopausal Women
This study aims to investigate the effects on 16 weeks of mango intake on skin health in postmenopausal women. Half of the participants will receive 85g portions of mangoes while the other half receive 250g portions of mangos.
- Trial name
- MSS (NCT03590756)
- Testing
- 16 weeks mango intake
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Vitamin A Deficiency, Maternal Mortality
Impact of Maternal Vitamin A or Beta-Carotene Supplementation on Maternal and Infant Mortality in Bangladesh
The purpose of this trial is to determine whether providing women with a weekly oral supplement of vitamin A, either preformed or as beta-carotene, at a dosage equivalent to a recommended intake from early pregnancy through three…
- Conditions
- Vitamin A Deficiency, Maternal Mortality, Infant Mortality
- Trial name
- NCT00198822
- Testing
- Vitamin A or Beta-Carotene Supplements
- Where
- 3 sites in United States, Bangladesh
- Volunteers
- 59,666 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Dietary Assessment, Diet, Food, and Nutrition
Bite Sized Biomarkers
The primary objective of this study is to rigorously evaluate the effectiveness of a Food is Medicine (FIM) intervention using objective biomarkers and to determine the role of nutritional monitoring on the impact and…
- Conditions
- Dietary Assessment, Diet, Food, and Nutrition, Carotenoid Status
- Trial name
- NCT07845383
- Testing
- Bite-sized Biomarkers: Skin carotenoid scores
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Stanford University
Infants
Healthy Term Infants Fed Milk-Based Formulas
This is a prospective, double blind, crossover study in healthy infants randomized to one of two study formulas. The trial will consist of two 21 day study feeding periods separated by a study washout period.
- Trial name
- NCT02069522
- Testing
- Standard Milk-based Formula Containing Carotenoid, Investigational Milk-based Formula Containing Carotenoid
- Where
- 6 sites in United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Healthy
Plant Pigments for Human Health: Impact of Lycopene and Anthocyanins on Bioefficacy of Provitamin A Carotenoids From Carrots
The proposed research will help characterize the impact that simultaneous consumption of anthocyanins and carotenoids has on the bioavailability of the provitamin A carotenoids a-carotene and b-carotene and the non-provitamin A…
- Trial name
- NCT05319548
- Testing
- Purple-Red Carrot Juice, Red Carrot Juice, Purple Carrot Juice
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Vitamin A Deficiency
Bioefficacy of Beta-cryptoxanthin From Biofortified Maize
Since no quantitative information currently exists on how effectively the pro-vitamin A carotenoid (pVAC) β-cryptoxanthin (βCX) is converted to vitamin A (VA) in humans, this proof of principle study aims to compare the efficacy…
- Trial name
- BIOCRYPT (NCT04153968)
- Testing
- β-cryptoxanthin
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Absorption; Chemicals
Safety and Pharmacokinetics of Phaffia Rhodozyma Astaxanthin
Astaxanthin is a xanthophyll carotenoid, a naturally occurring lipid-soluble red pigment. Apart from its coloring ability it is also a strong antioxidative ingredient and contains health-promoting properties.
- Trial name
- NCT03807050
- Testing
- Astaxanthin
- Where
- Israel
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- NextFerm Technologies LTD
Healthy
Provitamin A Absorption and Conversion With Avocados
Vitamin A is necessary in the human diet. The form of vitamin A found in fruits and vegetables is not "active" and must be converted to the active form in the human body.
- Trial name
- NCT01432210
- Testing
- Post-prandial Feeding Study
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Healthy
Bioavailability of Carotenoids and Flavonoids From Fresh Oranges and Orange Juice.
The study was designed as a randomized 2-way cross-over study to assess the bioavailability of carotenoids and flavonoids from sweet oranges and orange juice.
- Trial name
- NCT02380144
- Testing
- Fresh orange fruit and pasteurized fruit juice
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Healthy
The CARO Study - Bioefficacy of Beta-Carotene in Oil and in a Mixed Diet in Healthy Subjects
A controlled dietary intervention study will be carried out based on the stable isotope method the investigators have developed to quantify both the absorption of beta-carotene and its bioconversion to retinol in oil and in a…
- Trial name
- NCT00128752
- Testing
- absorption and conversion of beta-carotene in human gastrointestinal (GI) tract
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Nutrition Status
A Study to Assess the Impact of a Nutritional Supplement on Wellbeing and Nutrient Absorption
The objective of this placebo controlled randomized research is to demonstrate the health benefits of a carotenoid nutritional supplement as compared to placebo in terms of nutrient levels, quality of life, feelings, of wellness…
- Trial name
- NCT06749808
- Testing
- Carotenoid Nutritional Supplement
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pharmanex
Lung Cancer
Carotene and Retinol Efficacy Trial
The Carotene and Retinol Efficacy Trial (CARET) was a randomized, double-blind, placebo-controlled trial of the cancer prevention efficacy and safety of a daily combination of 30 mg of beta-carotene and 25,000 IU of retinyl…
- Trial name
- CARET (NCT00712647)
- Testing
- Beta Carotene and Retinol
- Volunteers
- 18,314 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Inflammatory Markers
Lycopene-rich Juice Intervention to Reduce Inflammatory Markers Among Adults With Obesity
The purpose of this research is to see whether a finger scanning device can accurately measure carotenoids, the colorful substances in fruits and vegetables, in people's skin.
- Trial name
- NCT07120035
- Testing
- Lycopene-rich juice
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- East Carolina University
Ileostomy; Functional Disturbance, Healthy
Carotenoid Absorption and Metabolism From Green-leafy Vegetable Matrices
Absorption and metabolism of carotenoids from two types of spinach preparations will be investigated in two study groups, short bowel/ileostomy and healthy, respectively.
- Trial name
- Popeye (NCT02450227)
- Testing
- Spinach - Whole leaf (10 mg lutein), Spinach - Minced (10 mg/lutein)
- Where
- 2 sites in Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Healthy Nutrition, Healthy Diet
Baylor Infant and Toddler Biomarker of Nutrition Study
Young children rely on their foods and drinks for the nutrients they need to grow, like energy, protein, vitamins, and minerals.
- Trial name
- BITBONS (NCT05869760)
- Testing
- Carotenoid Intake, Serum carotenoid concentrations
- Where
- United States
- Volunteers
- 208 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Carotenoid Status, Gut Microbiome
Probiotics for Enhanced Tissue Carotenoid Status in Premenopausal Women
Carotenoids are yellow-orange fat soluble plant pigments primarily obtained from the diet that serve as an accurate biomarker for fruit and vegetable intake.
- Conditions
- Carotenoid Status, Gut Microbiome, Skin Health
- Trial name
- ProCar (NCT04511052)
- Testing
- Probiotic, Carotenoid supplement
- Where
- Canada
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- McGill University
Eating Behavior
Healthy Online Parental Education Project to Increase Fruit and Vegetable Intake and Active Playtime Among Toddlers
The research proposal will be an 8-week randomized control trial (RCT) to examine the efficacy of an eHealth intervention, namely Healthy Parental Online Education (HOPE), on fruit and vegetable intake and active playtime among…
- Trial name
- HOPE (NCT05085041)
- Testing
- Multi-Component eHealth Intervention, namely Healthy Online Parental Education (HOPE)
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Vitamin A Deficiency
Vitamin A Absorption From Cassava in Women
The purpose of this study is to determine the vitamin A equivalents in high-carotenoid varieties of cassava.
- Trial name
- FL-80 (NCT01381276)
- Testing
- Beta-Carotene bio-fortified cassava porridge without oil, Beta-Carotene bio-fortified cassava porridge with oil, White cassava porridge with retinyl palmitate reference dose
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center