Clinical trials: Carotenoid
Bioavailability
Effect of Iron and Zinc Supplementation on B-carotene Bioavailability in Healthy Males
In vitro studies found supplemental levels of iron and zinc to inhibit the micellization and cellular uptake of β-carotene. Here, we investigated this in vivo, in a double-blind 3-arm crossover human trial.
- Trial name
- NCT05840848
- Testing
- Control beta-carotene supplement plus iron Supplement, Control beta-carotene supplement plus zinc Supplement
- Where
- Germany
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Biological Availability, Carotenoids
Bioavailability of Carotenoids From Orange Juice in a Cross-over Study in Healthy Subjects.
Commercially available fruit juices are obtained after applying industrial technologies to preserve and extend the shelf-life by inactivation of microorganism and enzymes. These are traditional thermal treatment (eg.
- Conditions
- Biological Availability, Carotenoids, Lutein, Humans
- Trial name
- NCT04744233
- Testing
- Orange juice
- Where
- 2 sites in Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Instituto de Ciencia y Tecnología de Alimentos y Nutrición
Overweight, Obesity
The Effect of PD01 on Cardiovascular Health and Microbial Environment
This randomized, placebo-controlled trial aims to determine the effects of daily administration of a carotenoid-producing Bacillus strain PD01 over a 6-week period on cardiovascular health biomarkers, microbiota composition and…
- Trial name
- NCT02622425
- Testing
- PD01
- Where
- Netherlands
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Human Microbiome
Oral Probiotics on the Shift in Gut Microbiome and Skin Carotenoid Levels
The purpose of this study is to determine how probiotics affects circulating carotenoid levels.
- Trial name
- NCT04841694
- Testing
- Probiotic
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Healthy
Novel 13C Carotenoids for Absorption and Metabolism Studies in Humans
Tomatoes contain several compounds which may be beneficial for human health and prevention of disease, although this relationship is poorly understood and very controversial.
- Trial name
- NCT01692340
- Testing
- Isotopically labeled lycopene, phytoene or phytofluene
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Overweight
The Juice Study: Sensitivity of Skin Carotenoid Status to Detect Change in Intake
This study is designed to see if drinking a tomato-based vegetable juice will increase skin carotenoids.
- Trial name
- NCT03202043
- Testing
- High dose vegetable juice, Medium dose vegetable juice, Low dose vegetable juice
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- USDA Grand Forks Human Nutrition Research Center
Vitamin A Deficiency
Retinol Equivalence of Plant Carotenoids in Children
To determine vitamin A value of beta-carotene in oil capsule, spinach, and golden rice. The experiments will be conducted in children (ages 7-9) with/without adequate vitamin A nutrition.
- Trial name
- NCT00082420
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Aging, Well Aging
Age Related Effects Consuming Phaeodactylum Tricornutum
Investigation of the microalgae Phaeodactylum as food with regard to the uptake of omega-3 fatty acids and effects on various blood parameters in relation to age.
- Trial name
- MIA_E (NCT05120791)
- Testing
- microalgae phaeodactylum, From the Microalgae phaeodactylum the extracted beta-Glucan (especially chrysolaminarin), A combination of the vegetable bouillon, the microalgae and the beta-Glucan
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Skin Carotenoids
Assessment of the Effects of a Daily Supplement 4Life Transfer Factor Vista Containing AREDS2 Formula on Skin Carotenoid Levels Using a Non-invasive Detection
The goal of the clinical study is to evaluate the impact of daily use of a dietary supplement TF Vista containing AREDS2 formula ingredients, astaxanthin (Haematococcus pluvialis) microalgae, bilberry (Vaccinium myrtillus) fruit…
- Trial name
- NCT07513597
- Testing
- Dietary Supplement
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- 4Life Research, LLC
Eye Fatigue, Diet, Healthy
Lutein Supplementation in Healthy Children
This is a single site, randomized, double-blind placebo controlled parallel arm study assessing the effects of 6 months lutein supplementation on cognitive and visual outcomes in healthy children exposed to excessive digital…
- Conditions
- Eye Fatigue, Diet, Healthy, Cognitive Change
- Trial name
- NCT05314647
- Testing
- lutein
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Northcentral University
Achievement, Weight Change
INTEGRATED CHILDHOOD ACTIVITY AND NUTRITION (ICAN) STUDY
This study is a multi-functional integrated research and education project to prevent losses in academic achievement, cognitive function, and behavioral health among at-risk youth.
- Conditions
- Achievement, Weight Change, Cognition, Fitness
- Trial name
- ICAN (NCT07011602)
- Testing
- 8-week Physical Activity and Nutrition Program
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Retinal Ageing
Carotenoid Supplementation and Normal Ocular Health
Normal ageing affects vision as a result of preretinal and retinal changes. Photoreceptors, the light sensitive cells in the retina, degenerate and the rods (responsible for night vision) are most susceptible to damage with…
- Trial name
- NCT02147171
- Testing
- VisionAce
- Where
- United Kingdom
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Retinal Drusen, Age-related Macular Degeneration
Evaluation of a New Eye-specific Multivitamin Formula in Participants at Risk of Age-related Macular Degeneration (AMD)
The aim of this study is to evaluate the clinical benefits in visual function from dietary supplementation of the Lumega-Z carotenoid liquid-supplement in participants with drusen and at risk of AMD.
- Conditions
- Retinal Drusen, Age-related Macular Degeneration, Macular Degeneration
- Trial name
- AMD (NCT03946085)
- Testing
- Lumega-Z, AREDS2
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Guardion Health Sciences, Inc.
Vitamin A Deficiency
Vitamin A Equivalence of the Provitamin A in Biofortified Bananas
The objective will be to quantify the vitamin A equivalence of the provitamin A in transgenic biofortified bananas.
- Trial name
- NCT02702622
- Testing
- Provitamin A-biofortified transgenic bananas
- Volunteers
- healthy volunteers welcome
- Sponsor
- Iowa State University
Age-Related Macular Degeneration
Effects of Goji vs. Fiber on Macular Degeneration
The goal of this project is to conduct a clinical trial in 60 participants ranging from age 65-95 who are at risk for age-related macular degeneration (AMD).
- Trial name
- GOJI (NCT06237127)
- Testing
- Goji berry, Fiber
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Dietary Modification, Cardiovascular Disease
Feeding the Rainbow to Investigate Endothelial Dysfunction
The primary purpose of this study is to compare the change in blood carotene concentration between a food-based versus nutritional supplement-based intervention.
- Trial name
- FRIED (NCT01175577)
- Testing
- Chlorophyll complex, Standard Process, Betatene, sold as "Full Spectrum Carotenoid Complex", Small carotenoid-rich meals
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Bastyr University
Vitamin A Deficiency
Beta-carotene Absorption and Bioconversion to Vitamin A From Biofortified Cassava Gari
The goal of the research study is to determine the absorption, metabolism, and bioconversion of carotenoids such as beta-carotene to vitamin A from gari made with biofortified cassava compared to a mixture of red palm oil and…
- Trial name
- NCT02210507
- Testing
- Biofortified cassava gari, White cassava gari, White cassava gari + red palm oil
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Focus of Study: Carotenoid Absorption
Comparison of Carotenoid Bioavailability From Fresh Papaya, Tomato and Carrot
The goal of this study is to determine if papaya fruits are an exceptionally good food source for carotenoids in humans, particularly when compared more common carotenoid sources like carrots and tomatoes.
- Trial name
- NCT01748916
- Testing
- Papaya, Carrot, Tomato
- Where
- 2 sites in United States, Costa Rica
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Carotenoid Status, Gut Microbiome
Probiotics for Enhanced Tissue Carotenoid Status in Premenopausal Women
Carotenoids are yellow-orange fat soluble plant pigments primarily obtained from the diet that serve as an accurate biomarker for fruit and vegetable intake.
- Conditions
- Carotenoid Status, Gut Microbiome, Skin Health
- Trial name
- ProCar (NCT04511052)
- Testing
- Probiotic, Carotenoid supplement
- Where
- Canada
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- McGill University
Nutrient Deficiency, Pregnancy Related
Lutein & Zeaxanthin in Pregnancy - Carotenoid Supplementation During Pregnancy: Ocular and Systemic Effects
This study is designed to test the hypotheses that (1) the third trimester of pregnancy is a period of maternal systemic and ocular carotenoid depletion; (2) prenatal supplementation with 10 milligrams of lutein and 2 milligrams…
- Trial name
- L-ZIP (NCT03750968)
- Testing
- Carotenoid Group, Control Group
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Paul S. Bernstein